JP2009502779A5 - - Google Patents
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- Publication number
- JP2009502779A5 JP2009502779A5 JP2008522759A JP2008522759A JP2009502779A5 JP 2009502779 A5 JP2009502779 A5 JP 2009502779A5 JP 2008522759 A JP2008522759 A JP 2008522759A JP 2008522759 A JP2008522759 A JP 2008522759A JP 2009502779 A5 JP2009502779 A5 JP 2009502779A5
- Authority
- JP
- Japan
- Prior art keywords
- hgh
- complex
- biocompatible polymer
- peg
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 229920000249 biocompatible polymer Polymers 0.000 claims 10
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 5
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000009036 growth inhibition Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- 208000012766 Growth delay Diseases 0.000 claims 1
- 206010053759 Growth retardation Diseases 0.000 claims 1
- 239000000854 Human Growth Hormone Substances 0.000 claims 1
- 208000020221 Short stature Diseases 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims 1
- 235000011130 ammonium sulphate Nutrition 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000037182 bone density Effects 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 230000007812 deficiency Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 231100000001 growth retardation Toxicity 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000036558 skin tension Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/187,522 US20050281778A1 (en) | 2003-03-28 | 2005-07-22 | Human growth hormone conjugated with biocompatible polymer |
| PCT/US2005/046791 WO2007018583A2 (en) | 2005-07-22 | 2005-12-20 | Human growth hormone conjugated with biocompatible polymer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502779A JP2009502779A (ja) | 2009-01-29 |
| JP2009502779A5 true JP2009502779A5 (https=) | 2009-03-12 |
Family
ID=36808363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008522759A Pending JP2009502779A (ja) | 2005-07-22 | 2005-12-20 | 生体適合性ポリマーに結合させたヒト成長ホルモン |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050281778A1 (https=) |
| EP (1) | EP1915179A2 (https=) |
| JP (1) | JP2009502779A (https=) |
| KR (1) | KR20080041661A (https=) |
| AU (1) | AU2005335186A1 (https=) |
| CA (1) | CA2616187A1 (https=) |
| WO (1) | WO2007018583A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7547445B2 (en) * | 1998-03-19 | 2009-06-16 | Surmodics, Inc. | Crosslinkable macromers |
| WO2006102659A2 (en) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | CONJUGATES OF AN hGH MOIETY AND A POLYMER |
| US9840546B2 (en) * | 2008-04-03 | 2017-12-12 | Biosteed Gene Expression Tech. Co., Ltd. | Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof |
| US10064951B2 (en) | 2012-03-30 | 2018-09-04 | Hanmi Science Co., Ltd. | Liquid formulation of highly concentrated long-acting human growth hormone conjugate |
| CN116421566B (zh) * | 2023-02-16 | 2024-10-22 | 高邮市人民医院 | 一种含聚乙二醇化重组人生长激素的制剂 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0401384B1 (en) * | 1988-12-22 | 1996-03-13 | Kirin-Amgen, Inc. | Chemically modified granulocyte colony stimulating factor |
| US5766897A (en) * | 1990-06-21 | 1998-06-16 | Incyte Pharmaceuticals, Inc. | Cysteine-pegylated proteins |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| US5597709A (en) * | 1994-01-27 | 1997-01-28 | Human Genome Sciences, Inc. | Human growth hormone splice variants hGHV-2(88) and hGHV-3(53) |
| US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| AP2004003050A0 (en) * | 2001-11-20 | 2004-06-30 | Pharmacia Corp | Chemically modified human growth hormone conjugates |
-
2005
- 2005-07-22 US US11/187,522 patent/US20050281778A1/en not_active Abandoned
- 2005-12-20 KR KR1020087004205A patent/KR20080041661A/ko not_active Withdrawn
- 2005-12-20 CA CA002616187A patent/CA2616187A1/en not_active Abandoned
- 2005-12-20 EP EP05855362A patent/EP1915179A2/en not_active Withdrawn
- 2005-12-20 WO PCT/US2005/046791 patent/WO2007018583A2/en not_active Ceased
- 2005-12-20 JP JP2008522759A patent/JP2009502779A/ja active Pending
- 2005-12-20 AU AU2005335186A patent/AU2005335186A1/en not_active Abandoned
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