JP2009502203A5 - - Google Patents
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- Publication number
- JP2009502203A5 JP2009502203A5 JP2008525183A JP2008525183A JP2009502203A5 JP 2009502203 A5 JP2009502203 A5 JP 2009502203A5 JP 2008525183 A JP2008525183 A JP 2008525183A JP 2008525183 A JP2008525183 A JP 2008525183A JP 2009502203 A5 JP2009502203 A5 JP 2009502203A5
- Authority
- JP
- Japan
- Prior art keywords
- bcl
- protease
- human
- immunoglobulin
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 12
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 12
- 108060003951 Immunoglobulin Proteins 0.000 claims 12
- 102000018358 immunoglobulin Human genes 0.000 claims 12
- 241001465754 Metazoa Species 0.000 claims 6
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 6
- 108700019146 Transgenes Proteins 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 229940088872 Apoptosis inhibitor Drugs 0.000 claims 4
- 101100381517 Mus musculus Bcl2 gene Proteins 0.000 claims 4
- 239000000158 apoptosis inhibitor Substances 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 230000009261 transgenic effect Effects 0.000 claims 4
- 102000005927 Cysteine Proteases Human genes 0.000 claims 3
- 108010005843 Cysteine Proteases Proteins 0.000 claims 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 3
- 102000005741 Metalloproteases Human genes 0.000 claims 3
- 108010006035 Metalloproteases Proteins 0.000 claims 3
- 102000035195 Peptidases Human genes 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102000012479 Serine Proteases Human genes 0.000 claims 3
- 108010022999 Serine Proteases Proteins 0.000 claims 3
- 102000035100 Threonine proteases Human genes 0.000 claims 3
- 108091005501 Threonine proteases Proteins 0.000 claims 3
- 235000003704 aspartic acid Nutrition 0.000 claims 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 3
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 238000012250 transgenic expression Methods 0.000 claims 3
- 241000271566 Aves Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241000283707 Capra Species 0.000 claims 2
- 241000283086 Equidae Species 0.000 claims 2
- 241000283074 Equus asinus Species 0.000 claims 2
- 241000287828 Gallus gallus Species 0.000 claims 2
- 241001494479 Pecora Species 0.000 claims 2
- 241000282887 Suidae Species 0.000 claims 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 235000013330 chicken meat Nutrition 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 230000035899 viability Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70530505P | 2005-08-03 | 2005-08-03 | |
| US60/705,305 | 2005-08-03 | ||
| PCT/US2006/030250 WO2007019223A1 (en) | 2005-08-03 | 2006-08-02 | Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502203A JP2009502203A (ja) | 2009-01-29 |
| JP2009502203A5 true JP2009502203A5 (enExample) | 2009-07-23 |
| JP5188969B2 JP5188969B2 (ja) | 2013-04-24 |
Family
ID=37309396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525183A Active JP5188969B2 (ja) | 2005-08-03 | 2006-08-02 | ヒト化免疫グロブリンを発現するトランスジェニック動物におけるｂ細胞アポトーシスの抑制 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7919672B2 (enExample) |
| EP (1) | EP1910418B1 (enExample) |
| JP (1) | JP5188969B2 (enExample) |
| CN (3) | CN102443058A (enExample) |
| AT (1) | ATE474853T1 (enExample) |
| CA (1) | CA2616069C (enExample) |
| DE (1) | DE602006015653D1 (enExample) |
| ES (1) | ES2347979T3 (enExample) |
| WO (1) | WO2007019223A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027986A2 (en) | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| US20080227688A1 (en) * | 2007-03-13 | 2008-09-18 | Johnston Randal N | Inhibition of viral replication |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| EP4141108A1 (en) | 2013-12-24 | 2023-03-01 | Kling Biotherapeutics B.V. | Ex vivo antibody production |
| WO2015143284A1 (en) * | 2014-03-21 | 2015-09-24 | The General Hospital Corporation | Essential fatty acid-producing nonhuman transgenic animals and uses thereof |
| IL297997A (en) * | 2015-03-04 | 2023-01-01 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| EP4335918A3 (en) * | 2015-04-03 | 2024-04-17 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| IL263160B2 (en) * | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| CN110373428A (zh) * | 2016-10-08 | 2019-10-25 | 杭州电子科技大学 | 一种促进细胞移植和基因表达的转基因载体系统及其应用 |
| GB201704417D0 (en) | 2017-03-20 | 2017-05-03 | Univ Copenhagen | Improved li vaccine adjuvant |
| JP2021508471A (ja) | 2017-12-29 | 2021-03-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ｖｅｇｆ抗体のｖｅｇｆ受容体遮断選択性を改善する方法 |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| JP7354306B2 (ja) | 2019-06-27 | 2023-10-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規ｉｃｏｓ抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2509700A (en) * | 1999-01-25 | 2000-08-07 | E.I. Du Pont De Nemours And Company | Polysaccharide fibers |
| CA2634294A1 (en) * | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| WO2004037849A2 (en) * | 2002-10-21 | 2004-05-06 | Regents Of The University Of Minnesota | Transgenic non-human animals with expanded mature b cell and plasma cell populations |
-
2006
- 2006-08-02 CN CN2011103336928A patent/CN102443058A/zh active Pending
- 2006-08-02 ES ES06789294T patent/ES2347979T3/es active Active
- 2006-08-02 WO PCT/US2006/030250 patent/WO2007019223A1/en not_active Ceased
- 2006-08-02 AT AT06789294T patent/ATE474853T1/de not_active IP Right Cessation
- 2006-08-02 US US11/498,571 patent/US7919672B2/en active Active
- 2006-08-02 CN CN2006800333215A patent/CN101263158B/zh active Active
- 2006-08-02 DE DE602006015653T patent/DE602006015653D1/de active Active
- 2006-08-02 CA CA2616069A patent/CA2616069C/en active Active
- 2006-08-02 EP EP06789294A patent/EP1910418B1/en active Active
- 2006-08-02 JP JP2008525183A patent/JP5188969B2/ja active Active
- 2006-08-02 CN CN201310739364.7A patent/CN103710371B/zh active Active
-
2011
- 2011-03-17 US US13/050,792 patent/US8354568B2/en active Active
-
2012
- 2012-12-13 US US13/714,286 patent/US20130102072A1/en not_active Abandoned
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