ATE474853T1 - Unterdrückung der b-zell apoptose in transgenen tieren die humanisierte immunglobulingene exprimieren - Google Patents
Unterdrückung der b-zell apoptose in transgenen tieren die humanisierte immunglobulingene exprimierenInfo
- Publication number
- ATE474853T1 ATE474853T1 AT06789294T AT06789294T ATE474853T1 AT E474853 T1 ATE474853 T1 AT E474853T1 AT 06789294 T AT06789294 T AT 06789294T AT 06789294 T AT06789294 T AT 06789294T AT E474853 T1 ATE474853 T1 AT E474853T1
- Authority
- AT
- Austria
- Prior art keywords
- immunoglobulin
- cells
- expression
- apoptosis
- inhibitor
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title abstract 5
- 230000009261 transgenic effect Effects 0.000 title abstract 3
- 230000024704 B cell apoptotic process Effects 0.000 title 1
- 230000001629 suppression Effects 0.000 title 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 7
- 108060003951 Immunoglobulin Proteins 0.000 abstract 5
- 102000018358 immunoglobulin Human genes 0.000 abstract 5
- 229940088872 Apoptosis inhibitor Drugs 0.000 abstract 4
- 239000000158 apoptosis inhibitor Substances 0.000 abstract 4
- 108700019146 Transgenes Proteins 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000004083 survival effect Effects 0.000 abstract 3
- 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 abstract 2
- 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 abstract 2
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 2
- 230000002708 enhancing effect Effects 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70530505P | 2005-08-03 | 2005-08-03 | |
| PCT/US2006/030250 WO2007019223A1 (en) | 2005-08-03 | 2006-08-02 | Suppression of b-cell apoptosis in transgenic animals expressing humanized immunoglobulin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE474853T1 true ATE474853T1 (de) | 2010-08-15 |
Family
ID=37309396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06789294T ATE474853T1 (de) | 2005-08-03 | 2006-08-02 | Unterdrückung der b-zell apoptose in transgenen tieren die humanisierte immunglobulingene exprimieren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7919672B2 (enExample) |
| EP (1) | EP1910418B1 (enExample) |
| JP (1) | JP5188969B2 (enExample) |
| CN (3) | CN102443058A (enExample) |
| AT (1) | ATE474853T1 (enExample) |
| CA (1) | CA2616069C (enExample) |
| DE (1) | DE602006015653D1 (enExample) |
| ES (1) | ES2347979T3 (enExample) |
| WO (1) | WO2007019223A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008027986A2 (en) | 2006-09-01 | 2008-03-06 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| HU0700534D0 (en) | 2006-11-24 | 2007-10-29 | Mezoegazdasagi Biotechnologiai | Transgenic animal with enhanced immune response and method for the preparation thereof |
| US20080227688A1 (en) * | 2007-03-13 | 2008-09-18 | Johnston Randal N | Inhibition of viral replication |
| CN112690250B (zh) * | 2008-12-18 | 2024-03-08 | 伊拉兹马斯大学鹿特丹医学中心 | 表达人源化抗体的非人转基因动物及其用途 |
| CA3133545C (en) * | 2012-05-25 | 2023-08-08 | Cellectis | Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells |
| EP4141108A1 (en) | 2013-12-24 | 2023-03-01 | Kling Biotherapeutics B.V. | Ex vivo antibody production |
| WO2015143284A1 (en) * | 2014-03-21 | 2015-09-24 | The General Hospital Corporation | Essential fatty acid-producing nonhuman transgenic animals and uses thereof |
| IL297997A (en) * | 2015-03-04 | 2023-01-01 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| EP4335918A3 (en) * | 2015-04-03 | 2024-04-17 | Dana-Farber Cancer Institute, Inc. | Composition and methods of genome editing of b-cells |
| CN105274116B (zh) * | 2015-10-21 | 2020-09-29 | 重庆金迈博生物科技有限公司 | 一种制备人源化抗体的核酸分子及其应用 |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| IL263160B2 (en) * | 2016-06-03 | 2024-01-01 | Regeneron Pharma | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
| CN110373428A (zh) * | 2016-10-08 | 2019-10-25 | 杭州电子科技大学 | 一种促进细胞移植和基因表达的转基因载体系统及其应用 |
| GB201704417D0 (en) | 2017-03-20 | 2017-05-03 | Univ Copenhagen | Improved li vaccine adjuvant |
| JP2021508471A (ja) | 2017-12-29 | 2021-03-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗ｖｅｇｆ抗体のｖｅｇｆ受容体遮断選択性を改善する方法 |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| JP7354306B2 (ja) | 2019-06-27 | 2023-10-02 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 新規ｉｃｏｓ抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| AR119393A1 (es) | 2019-07-15 | 2021-12-15 | Hoffmann La Roche | Anticuerpos que se unen a nkg2d |
| CR20240246A (es) | 2021-12-20 | 2024-07-19 | Hoffmann La Roche | Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden |
| WO2024261013A1 (en) | 2023-06-21 | 2024-12-26 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted lymphotoxin beta receptor agonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2509700A (en) * | 1999-01-25 | 2000-08-07 | E.I. Du Pont De Nemours And Company | Polysaccharide fibers |
| CA2634294A1 (en) * | 2000-08-03 | 2002-02-14 | Therapeutic Human Polyclonals, Inc. | Production of humanized antibodies in transgenic animals |
| WO2004037849A2 (en) * | 2002-10-21 | 2004-05-06 | Regents Of The University Of Minnesota | Transgenic non-human animals with expanded mature b cell and plasma cell populations |
-
2006
- 2006-08-02 CN CN2011103336928A patent/CN102443058A/zh active Pending
- 2006-08-02 ES ES06789294T patent/ES2347979T3/es active Active
- 2006-08-02 WO PCT/US2006/030250 patent/WO2007019223A1/en not_active Ceased
- 2006-08-02 AT AT06789294T patent/ATE474853T1/de not_active IP Right Cessation
- 2006-08-02 US US11/498,571 patent/US7919672B2/en active Active
- 2006-08-02 CN CN2006800333215A patent/CN101263158B/zh active Active
- 2006-08-02 DE DE602006015653T patent/DE602006015653D1/de active Active
- 2006-08-02 CA CA2616069A patent/CA2616069C/en active Active
- 2006-08-02 EP EP06789294A patent/EP1910418B1/en active Active
- 2006-08-02 JP JP2008525183A patent/JP5188969B2/ja active Active
- 2006-08-02 CN CN201310739364.7A patent/CN103710371B/zh active Active
-
2011
- 2011-03-17 US US13/050,792 patent/US8354568B2/en active Active
-
2012
- 2012-12-13 US US13/714,286 patent/US20130102072A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1910418A1 (en) | 2008-04-16 |
| CN102443058A (zh) | 2012-05-09 |
| JP5188969B2 (ja) | 2013-04-24 |
| US20070033661A1 (en) | 2007-02-08 |
| US20110219465A1 (en) | 2011-09-08 |
| CN103710371A (zh) | 2014-04-09 |
| US20130102072A1 (en) | 2013-04-25 |
| CN101263158B (zh) | 2011-12-28 |
| US7919672B2 (en) | 2011-04-05 |
| CN103710371B (zh) | 2017-03-01 |
| WO2007019223A1 (en) | 2007-02-15 |
| EP1910418B1 (en) | 2010-07-21 |
| ES2347979T3 (es) | 2010-11-26 |
| CN101263158A (zh) | 2008-09-10 |
| CA2616069C (en) | 2018-07-31 |
| DE602006015653D1 (de) | 2010-09-02 |
| CA2616069A1 (en) | 2007-02-15 |
| US8354568B2 (en) | 2013-01-15 |
| JP2009502203A (ja) | 2009-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |