JP2009225702A - 健康機能成分を吸着・濃縮した乾燥脱脂穀類糠、該糠から調製した健康機能成分の濃縮物、及びそれらの製造方法 - Google Patents
健康機能成分を吸着・濃縮した乾燥脱脂穀類糠、該糠から調製した健康機能成分の濃縮物、及びそれらの製造方法 Download PDFInfo
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Abstract
【解決手段】本発明は、γオリザノール、トコフェロール、及びポリフェノール類等の極性のある健康機能成分を含有する原料から、有機溶媒によって抽出された抽出物を、乾燥脱脂穀類糠を吸着担体として吸着処理することにより、γオリザノール、トコフェロール、ポリフェノール等の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠を製造する。本発明の方法によって製造された健康機能成分が吸着・濃縮された乾燥脱脂穀類糠、又は、該健康機能成分の濃縮物は、素材的に利用上の制約なく、広い範囲の用途に利用することが可能である。
【選択図】なし
Description
本発明において用いられる乾燥脱脂穀類糠は、穀類糠を低極性有機溶媒及び高極性有機溶媒で洗浄し、極性の高い化学物質を吸着する吸着担体であるように改質した脱脂穀類糠を乾燥したものであることが好ましい。該処理は、穀類糠をヘキサン又はクロロホルムからなる低極性有機溶媒及びアセトン、メタノール又はエタノールからなる高極性有機溶媒で洗浄処理することにより行われる。乾燥脱脂穀類糠の調製は、脱脂穀類糠を50〜100℃で、12〜24時間乾燥処理することにより調製される。
米糠を順次n−ヘキサン、n−ヘキサンエタノール混合液、エタノール、水にて十分に洗浄し、極性の低いトリグリセリドや極性の高いフェルラ酸までほぼ全ての脂溶性成分を除去した。得られた完全脱脂米糠を100℃で24時間乾燥し、乾燥米糠を得た。
γオリザノールを含む市販米糠油を、ヘキサンにて抽出し、n−ヘキサン飽和溶液を作成した。
調製された乾燥米糠に対して体積換算で5倍量のγオリザノールn−ヘキサン飽和溶液を加え、30分間振とう攪拌した。これをn−ヘキサンで十分に洗浄し、過剰のγオリザノールを除去した。次いで、クロロホルムメタノールにて乾燥米糠に吸着したγオリザノールを完全に採取した。得られたγオリザノール抽出液をロータリーエバポレーター及び真空乾燥機にて完全に乾固し、その重量を測定した。その結果、乾燥米糠1g当たり1.67±0.18mgのγオリザノールが吸着していた(図1:γオリザノールを付加した脱脂米糠から再回収したγオリザノール)。乾重量1gあたりの脱脂米糠のγオリザノール含量が最大で80μg程度であることから、20倍もの強化が可能であることが明らかとなった。このように、脱脂米糠はγオリザノール強化担体としての利用が可能であることが確認された。
米糠をn−ヘキサン、ジエチルエーテル、エタノールにて順次10回以上洗浄した後、図2(脱脂米糠充填カラム)のようにガラスカラム内に充填した。クロロホルムメタノールによって乾燥利尻昆布から抽出した全脂質を重層し、10カラム容のジエチルエーテルを流した。その後、ジエチルエーテル・エタノール混液(98:2)にて溶出される画分をTLCにて検出した。
脱脂穀類糠によるγオリザノール吸着に及ぼすpHの影響について検討した。種々のpH に調整した100mM 3,3-dimethylglutaric acid(GTA)緩衝液を作製し,γオリザノール吸着済み米糠(1g)を緩衝液中(50ml)中に分散して1時間室温で攪拌した.吸引濾過にて米糠を回収し,クロロホルムメタノール混液にて全脂質を抽出した.得られた抽出液を,クロロホルムを展開溶媒としたSi60シリカゲルにて分離し,302nmにおける蛍光強度から定量し,吸着残増量を算出した。
上記実施例1の乾燥脱脂米糠と同様の処理によって調製した完全脱脂小麦フスマ及び小麦フスマからデンプン並びにセルロースを糖化処理によって除いたバイオマス残渣について、γオリザノールの結合量を測定した。
Claims (15)
- 極性のある健康機能成分を含有する原料から、有機溶媒によって抽出された抽出物を、乾燥脱脂穀類糠を吸着担体として吸着処理することを特徴とする極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 極性のある健康機能成分が、γオリザノール、トコフェロール、及びポリフェノール類から選択される1又は2以上の健康機能成分であることを特徴とする請求項1記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- γオリザノール、トコフェロール、及びポリフェノール類から選択される1又は2以上の健康機能成分を含有する原料から、有機溶媒によって抽出された抽出物が、米糠或いはコンブから抽出された抽出物であることを特徴とする請求項2記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠が、乾燥脱脂米糠又は乾燥脱脂小麦フスマであることを特徴とする請求項1〜3のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠が、穀類糠を低極性有機溶媒及び高極性有機溶媒で洗浄し、極性の高い化学物質を吸着する吸着担体であるように改質した脱脂穀類糠を乾燥したものであることを特徴とする請求項1〜4のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠が、穀類糠をn−ヘキサン又はクロロホルムからなる低極性有機溶媒及びアセトン、メタノール又はエタノールからなる高極性有機溶媒で洗浄し、極性の高い化学物質を吸着する吸着担体であるように改質した脱脂穀類糠を乾燥したものであることを特徴とする請求項5記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠が、脱脂穀類糠を50〜100℃で、12〜24時間乾燥したものであることを特徴とする請求項1〜6のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠を吸着担体として行う吸着処理を、非極性有機溶媒を用いて行なうことを特徴とする請求項1〜7のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 乾燥脱脂穀類糠を吸着担体として行う吸着処理を、n−ヘキサンを用いて行なうことを特徴とする請求項8記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 有機溶媒によって抽出された抽出物を、乾燥脱脂穀類糠を吸着担体として吸着する処理を、中性乃至酸性条件下で行なうことを特徴とする請求項1〜9のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠の製造方法。
- 請求項1〜10のいずれか記載の極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠から、極性のある健康機能成分を極性の溶出・分離溶媒を用いて溶出・分離することを特徴とする極性のある健康機能成分の濃縮物の製造方法。
- 極性のある健康機能成分が、γオリザノール、トコフェロール、及びポリフェノール類から選択される1又は2以上の健康機能成分であることを特徴とする請求項11記載の極性のある健康機能成分の濃縮物の製造方法。
- 極性溶出・分離溶媒として、n−ヘキサン・エタノール混合溶媒を用いることを特徴とする請求項11又は12記載の極性のある健康機能成分の濃縮物の製造方法。
- 極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠から、極性のある健康機能成分を溶出・分離溶媒を用いて溶出・分離する処理を、アルカリ条件下で行なうことを特徴とする請求項11〜13のいずれか記載の極性のある健康機能成分の濃縮物の製造方法。
- 請求項1〜10のいずれか記載の乾燥脱脂穀類糠の製造方法によって製造された極性のある健康機能成分が吸着・濃縮された乾燥脱脂穀類糠、又は、請求項11〜14のいずれか記載の濃縮物の製造方法によって製造された極性のある健康機能成分の濃縮物からなる、健康機能成分含有飲食品用、医薬品用、医薬部外品用、化粧品用、動物飼料用、又は水産飼料用素材。
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US20130066048A1 (en) * | 2010-03-15 | 2013-03-14 | Rutgers, The State University Of New Jersey | Methods of Obtaining Natural Products from the Comestible Fluids and Methods of Use |
JP2013158320A (ja) * | 2012-02-07 | 2013-08-19 | Nisshin Pet Food Kk | ペッドフード |
JP2015086153A (ja) * | 2013-10-29 | 2015-05-07 | 株式会社ファンケル | Vldl分泌抑制剤 |
WO2023204363A1 (ko) * | 2022-04-20 | 2023-10-26 | 한국 한의학 연구원 | 고량강 추출물을 유효성분으로 포함하는 아토피 피부염의 예방, 개선 또는 치료용 조성물 |
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