JP2009142259A5 - - Google Patents
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- Publication number
- JP2009142259A5 JP2009142259A5 JP2008186385A JP2008186385A JP2009142259A5 JP 2009142259 A5 JP2009142259 A5 JP 2009142259A5 JP 2008186385 A JP2008186385 A JP 2008186385A JP 2008186385 A JP2008186385 A JP 2008186385A JP 2009142259 A5 JP2009142259 A5 JP 2009142259A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- mrna
- base sequence
- rna
- control system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004999 messenger RNA Proteins 0.000 claims 20
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 14
- 230000014616 translation Effects 0.000 claims 10
- 230000003993 interaction Effects 0.000 claims 9
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 108700026244 Open Reading Frames Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 239000013600 plasmid vector Substances 0.000 claims 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- 108010029287 Threonine-tRNA ligase Proteins 0.000 claims 2
- 102100028196 Threonine-tRNA ligase 2, cytoplasmic Human genes 0.000 claims 2
- 230000003834 intracellular effect Effects 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000009752 translational inhibition Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008186385A JP5538691B2 (ja) | 2007-11-22 | 2008-07-17 | Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム |
| US12/743,853 US9255274B2 (en) | 2007-11-22 | 2008-11-21 | Protein-responsive translational regulatory system using RNA-protein interacting motif |
| PCT/JP2008/071213 WO2009066757A1 (ja) | 2007-11-22 | 2008-11-21 | Ｒｎａ－蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム |
| EP08851746.1A EP2221367B1 (en) | 2007-11-22 | 2008-11-21 | Protein-responsive translation control system utilizing rna-protein interaction motif |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007303662 | 2007-11-22 | ||
| JP2007303662 | 2007-11-22 | ||
| JP2008186385A JP5538691B2 (ja) | 2007-11-22 | 2008-07-17 | Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009142259A JP2009142259A (ja) | 2009-07-02 |
| JP2009142259A5 true JP2009142259A5 (https=) | 2011-09-01 |
| JP5538691B2 JP5538691B2 (ja) | 2014-07-02 |
Family
ID=40667579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008186385A Active JP5538691B2 (ja) | 2007-11-22 | 2008-07-17 | Ｒｎａ−蛋白質相互作用モチーフを利用した蛋白質応答翻訳制御システム |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9255274B2 (https=) |
| EP (1) | EP2221367B1 (https=) |
| JP (1) | JP5538691B2 (https=) |
| WO (1) | WO2009066757A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5308787B2 (ja) * | 2007-11-22 | 2013-10-09 | 独立行政法人科学技術振興機構 | 機能性ｒｎａ−蛋白質複合体の分子デザイン |
| US10227596B2 (en) | 2012-07-16 | 2019-03-12 | Kyoto University | Translational control system using RNA-protein interaction motif |
| US9458466B2 (en) | 2012-07-16 | 2016-10-04 | Kyoto University | Translational control system using RNA-protein interaction motif |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| WO2015105172A1 (ja) | 2014-01-10 | 2015-07-16 | 国立大学法人京都大学 | ｍｉＲＮＡの発現を指標として所望の細胞種を判別する方法 |
| US11351271B2 (en) | 2014-09-08 | 2022-06-07 | Massachusetts Institute Of Technology | RNA-based logic circuits with RNA binding proteins, aptamers and small molecules |
| WO2017094878A1 (ja) * | 2015-12-02 | 2017-06-08 | 国立大学法人京都大学 | 細胞内在性タンパク質の識別方法 |
| JP7318931B2 (ja) | 2017-07-12 | 2023-08-01 | 国立大学法人京都大学 | 高発現性ｍＲＮＡスイッチ |
| WO2020215092A1 (en) * | 2019-04-18 | 2020-10-22 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for designing rna nanostructures and uses thereof |
| US20250109397A1 (en) * | 2021-11-30 | 2025-04-03 | Kyoto University | Rna molecule |
| WO2023201631A1 (en) * | 2022-04-21 | 2023-10-26 | Tsinghua University | Methods for manipulating quantitative gene expression and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000509605A (ja) | 1996-05-07 | 2000-08-02 | ファルマシア・アンド・アップジョン・カンパニー | テイコ酸酵素および検定法 |
| US20020169306A1 (en) | 1999-05-18 | 2002-11-14 | Kaio Kitazato | Envelope gene-deficient paramyxovirus vector |
| WO2004046321A2 (en) | 2002-11-15 | 2004-06-03 | Trustees Of Boston University | Cis/trans riboregulators |
| JP2005341865A (ja) | 2004-06-02 | 2005-12-15 | Kyoto Univ | 核酸プローブ、核酸検出方法、核酸分析用デバイス、および反応速度を制御する方法 |
| TWI311152B (en) | 2004-09-17 | 2009-06-21 | Boehringer Ingelheim Rcv Gmbh & Co K | Host-vector system for antibiotic-free cole1 plasmid propagation |
-
2008
- 2008-07-17 JP JP2008186385A patent/JP5538691B2/ja active Active
- 2008-11-21 US US12/743,853 patent/US9255274B2/en active Active
- 2008-11-21 EP EP08851746.1A patent/EP2221367B1/en active Active
- 2008-11-21 WO PCT/JP2008/071213 patent/WO2009066757A1/ja not_active Ceased
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