JP2009138000A5 - - Google Patents
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- Publication number
- JP2009138000A5 JP2009138000A5 JP2009018865A JP2009018865A JP2009138000A5 JP 2009138000 A5 JP2009138000 A5 JP 2009138000A5 JP 2009018865 A JP2009018865 A JP 2009018865A JP 2009018865 A JP2009018865 A JP 2009018865A JP 2009138000 A5 JP2009138000 A5 JP 2009138000A5
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- JP
- Japan
- Prior art keywords
- formula
- compound according
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- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 33
- UIRKNQLZZXALBI-MSVGPLKSSA-N Squalamine Chemical compound C([C@@H]1C[C@H]2O)[C@@H](NCCCNCCCCN)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](C)CC[C@H](C(C)C)OS(O)(=O)=O)[C@@]2(C)CC1 UIRKNQLZZXALBI-MSVGPLKSSA-N 0.000 claims 4
- UIRKNQLZZXALBI-UHFFFAOYSA-N Squalamine Natural products OC1CC2CC(NCCCNCCCCN)CCC2(C)C2C1C1CCC(C(C)CCC(C(C)C)OS(O)(=O)=O)C1(C)CC2 UIRKNQLZZXALBI-UHFFFAOYSA-N 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229950001248 squalamine Drugs 0.000 claims 4
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 2
- IUSARDYWEPUTPN-OZBXUNDUSA-N (2r)-n-[(2s,3r)-4-[[(4s)-6-(2,2-dimethylpropyl)spiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-3-hydroxy-1-[3-(1,3-thiazol-2-yl)phenyl]butan-2-yl]-2-methoxypropanamide Chemical compound C([C@H](NC(=O)[C@@H](C)OC)[C@H](O)CN[C@@H]1C2=CC(CC(C)(C)C)=CN=C2OC2(CCC2)C1)C(C=1)=CC=CC=1C1=NC=CS1 IUSARDYWEPUTPN-OZBXUNDUSA-N 0.000 claims 1
- 229940125807 compound 37 Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3237896P | 1996-12-06 | 1996-12-06 | |
| US60/032,378 | 1996-12-06 | ||
| US08/985,876 US6262283B1 (en) | 1996-12-06 | 1997-12-05 | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds |
| US08/985,876 | 1997-12-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52401298A Division JP4441769B2 (ja) | 1996-12-06 | 1997-12-08 | アミノステロール、ビタミンｄ類似体および他の化合物の製造に有用な２４−ヒドロキシル化された化合物の立体選択的合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009138000A JP2009138000A (ja) | 2009-06-25 |
| JP2009138000A5 true JP2009138000A5 (cg-RX-API-DMAC7.html) | 2009-11-12 |
| JP5097724B2 JP5097724B2 (ja) | 2012-12-12 |
Family
ID=26708341
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52401298A Expired - Lifetime JP4441769B2 (ja) | 1996-12-06 | 1997-12-08 | アミノステロール、ビタミンｄ類似体および他の化合物の製造に有用な２４−ヒドロキシル化された化合物の立体選択的合成 |
| JP2009018865A Expired - Lifetime JP5097724B2 (ja) | 1996-12-06 | 2009-01-29 | アミノステロール、ビタミンｄ類似体および他の化合物の製造に有用な２４−ヒドロキシル化された化合物の立体選択的合成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52401298A Expired - Lifetime JP4441769B2 (ja) | 1996-12-06 | 1997-12-08 | アミノステロール、ビタミンｄ類似体および他の化合物の製造に有用な２４−ヒドロキシル化された化合物の立体選択的合成 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6262283B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0942918A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP4441769B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU746559B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2272721C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2486840T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1998024800A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7410959B1 (en) | 2000-07-13 | 2008-08-12 | Genaera Corporation | Therapeutic uses for aminosterol compounds |
| AU773038B2 (en) * | 1998-08-12 | 2004-05-13 | Genaera Corporation | Aminosterol compounds and uses thereof |
| US6359012B1 (en) * | 1999-12-22 | 2002-03-19 | Bone Care International, Inc. | Method for making 24(S)-hydroxyvitamin D2 |
| DK1274718T3 (da) * | 2000-04-12 | 2007-02-12 | Genaera Corp | En fremgangsmåde til forberedelse af 7.alpha.-hydroxy 3-aminosubstituerede steroler vee en ubeskyttet 7.alpha.-hydroxy gruppe |
| US7319112B2 (en) | 2000-07-14 | 2008-01-15 | The Procter & Gamble Co. | Non-halogenated antibacterial agents and processes for making same |
| US20030181742A1 (en) * | 2000-09-08 | 2003-09-25 | Makoto Nakazawa | Process for the preparation of pregnane derivatives |
| ATE417122T1 (de) | 2001-09-04 | 2008-12-15 | Kuraray Co | 7alpha-hydroxypregn-4-en-3-on,20-carbaldehyd und verfahren zur herstellung davon sowie verfahren zur herstellung von 7alpha,21-dihydroxy-20- methylpregn-4-en-3-on daraus |
| JP2005514929A (ja) * | 2002-01-10 | 2005-05-26 | テバ ファーマシューティカル インダストリーズ リミティド | エピマービタミンｄ類似物の酵素による選択的なエステル化及び加溶媒分解及びエピマーの分離 |
| KR100859277B1 (ko) * | 2004-03-18 | 2008-09-19 | 레오 파마 에이/에스 | 비타민 ｄ 유사체의 입체선택적 합성 |
| MY139521A (en) | 2004-03-18 | 2009-10-30 | Leo Pharma As | Stereoselective synthesis of vitamin d analogues |
| US20060052350A1 (en) * | 2004-07-01 | 2006-03-09 | Alexei Ploutno | Crystalline forms of 1,24(S)-dihydroxy vitamin D2 |
| US7557097B2 (en) * | 2004-11-20 | 2009-07-07 | Regents Of The University Of Minnesota | Structural, behavioral characterization, and synthesis of attractants for migratory lamprey |
| EP1837343A4 (en) * | 2004-12-08 | 2009-07-29 | Kuraray Co | METHOD OF PREPARING BENZOIC ACID (5 ', 7') - 3-SPIRO-2 '- (1', 3'-DIOXILANE) -24-OXOCHOLEST-22-EN-7-YLESTER |
| AU2006239811B2 (en) | 2005-04-25 | 2012-02-02 | Enterin, Inc. | Polymorphic and amorphous salt forms of squalamine dilactate |
| CA2656717A1 (en) * | 2006-07-06 | 2008-01-10 | Ciba Holding Inc. | Encapsulated dispersions comprising electrophoretically mobile organic colorants |
| WO2008038965A1 (en) * | 2006-09-26 | 2008-04-03 | Kyungpook National University Industry-Academic Cooperation Foundation | 7alpha-aminosteroid derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and composition for anticancer or antibiotics containing the same as an active ingredient |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| JOP20180077A1 (ar) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | تركيبات وطرق لحمض صفراوي تخليقي |
| CA2985271A1 (en) * | 2007-09-06 | 2009-03-12 | Ohr Pharmaceutical, Inc. | A method for treating diabetes |
| KR100876857B1 (ko) * | 2008-02-15 | 2008-12-31 | 경북대학교 산학협력단 | 7-플루오로-3-아미노스테로이드 유도체 또는 이의약학적으로 허용가능한 염, 이의 제조방법 및 이를유효성분으로 함유하는 항균용 약학적 조성물 |
| US9127036B2 (en) | 2010-08-12 | 2015-09-08 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| CA2808628A1 (en) | 2010-08-17 | 2012-02-23 | Ohr Pharmaceutical, Inc. | Ophthalmic formulations of squalamine |
| WO2012047495A2 (en) * | 2010-09-27 | 2012-04-12 | Kythera Biopharmaceuticals, Inc. | Methods for preparing synthetic bile acids and compositions comprising the same |
| CA3249322A1 (en) * | 2022-01-25 | 2023-08-03 | Enterin, Inc. | R and S C25 Isomeres of Aminosterols and Methods of Manufacture and Use |
| CN116836214B (zh) * | 2022-03-25 | 2024-07-09 | 苏州恩泰新材料科技有限公司 | 一种7-酮石胆酸中间体的合成方法和应用 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3016390A (en) | 1960-06-30 | 1962-01-09 | Searle & Co | N-(substituted alkyl) amino-5alpha-androstan-17beta-ols |
| US3370070A (en) | 1965-06-16 | 1968-02-20 | Searle & Co | [n-alkyl-17-(dialkylaminoalkyl)amino] androst-4-en-3-ones |
| GB1565351A (en) | 1975-06-02 | 1980-04-16 | Theramex | Steroid aminoethers |
| US4220598A (en) | 1977-11-14 | 1980-09-02 | Abbott Laboratories | Method and reagents for measuring the level of conjugated bile acids |
| US4550163A (en) | 1979-02-05 | 1985-10-29 | Abbott Laboratories | Ligand analog-irreversible enzyme inhibitor conjugates |
| US4372888A (en) | 1980-08-26 | 1983-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Nondenaturing zwitterionic detergents |
| JPS5842878B2 (ja) | 1981-12-02 | 1983-09-22 | 名糖産業株式会社 | １２−オキソコラン酸トシルヒドラゾン化合物、その製法ならびに利用 |
| FR2523745B1 (fr) * | 1982-03-18 | 1987-06-26 | Bull Sa | Procede et dispositif de protection d'un logiciel livre par un fournisseur a un utilisateur |
| EP0101554B1 (en) | 1982-07-29 | 1986-10-15 | Lehner A.G. | New derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same |
| US5001116A (en) | 1982-12-20 | 1991-03-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| US4994443A (en) | 1982-12-20 | 1991-02-19 | The Children's Medical Center Corporation | Inhibition of angiogenesis |
| IT1221734B (it) | 1983-02-24 | 1990-07-12 | Schiena Michele Giuseppe Di | Ursodesossicolico solfato acido sale sodico |
| US4545938A (en) | 1983-11-02 | 1985-10-08 | Beth Israel Medical Center | Chemical synthesis |
| WO1987002367A2 (en) | 1985-10-18 | 1987-04-23 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
| US4771042A (en) | 1985-11-25 | 1988-09-13 | The Upjohn Company | Inhibition of angiogenesis involving the coadministration of steroids with heparin or heparin fragments |
| JPS62175497A (ja) | 1986-01-28 | 1987-08-01 | Wakunaga Pharmaceut Co Ltd | 胆汁酸誘導体およびその製造法 |
| US5075464A (en) | 1987-04-22 | 1991-12-24 | Merrell Dow Pharmaceuticals Inc. | 17β-(cyclopropylamino)androstene derivatives |
| SE8702254D0 (sv) | 1987-05-29 | 1987-05-29 | Kabivitrum Ab | Novel heparin derivatives |
| US4943635A (en) * | 1987-08-27 | 1990-07-24 | President & Fellows Of Harvard College | Enantioselective reduction of ketones |
| US5135919A (en) | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| IT1229569B (it) | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| IT1229570B (it) | 1989-04-17 | 1991-09-04 | Giuliani Spa | Derivati fluorurati di acidi biliari, loro preparazione e composizioni farmaceutiche che li contengono. |
| JPH07116215B2 (ja) | 1989-04-19 | 1995-12-13 | エスエス製薬株式会社 | 新規なステロイド化合物 |
| PT93847A (pt) | 1989-04-24 | 1990-11-20 | Harvard College | Processo para a preparacao de oligossacaridos de baixo peso molecular derivados de heparina ou de sulfato de heparano despolimerizados e de composicoes farmaceuticas que os contem |
| US4966897A (en) | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5004737A (en) | 1989-09-22 | 1991-04-02 | Pacific Chemical Co., Ltd. | Quaternary ammonium-substituted sterol derivatives |
| EP0466315A3 (en) | 1990-05-30 | 1992-07-01 | Larrian Gillespie | Compositions containing xylan sulphates for affecting growth factor function and for inhibiting fibroblast proliferation |
| ATE190623T1 (de) | 1990-06-11 | 2000-04-15 | Alcon Lab Inc | Verwendung von steroiden zur inhibierung von angiogenesis |
| DE59108326D1 (de) | 1990-12-06 | 1996-12-12 | Hoechst Ag | Gallensäurederivate, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindung als Arzneimittel |
| US5192756A (en) | 1992-03-18 | 1993-03-09 | The Children's Hospital Of Pennsylvania | Aminosterol antibiotic |
| AU4534593A (en) | 1992-06-12 | 1994-01-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| US5247104A (en) | 1992-11-04 | 1993-09-21 | Wisconsin Alumni Research Foundation | Preparation of 1α, 24-dihydroxyvitamin D analogs |
| JPH06329679A (ja) | 1993-01-20 | 1994-11-29 | Nissan Chem Ind Ltd | 光学活性β−アミノアルコキシボラン錯体 |
| WO1994019366A1 (en) | 1993-02-26 | 1994-09-01 | Magainin Pharmaceuticals Inc. | Chemical synthesis of squalamine |
| WO1994020520A1 (en) | 1993-03-10 | 1994-09-15 | Magainin Pharmaceuticals Inc. | Steroid derivatives, pharmaceutical compositions containing them, and their use as antibiotics or disinfectants |
| DK0749437T3 (da) | 1994-03-10 | 2002-03-04 | Magainin Pharma | Farmaceutisk anvendelse af steroidderivater |
| EP1420027A3 (en) | 1995-06-07 | 2012-01-04 | Genaera Corporation | Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE), pharmaceutical methods and compositions employing such inhibitors, and processes for evaluating the NHE-inhibitory efficacy of compounds |
| US5792635A (en) | 1995-06-07 | 1998-08-11 | Magainin Pharmaceuticals, Inc. | Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine |
| US5623546A (en) * | 1995-06-23 | 1997-04-22 | Motorola, Inc. | Encryption method and system for portable data |
| DE69715123T2 (de) | 1996-04-29 | 2003-05-15 | Koninklijke Philips Electronics N.V., Eindhoven | Brotröster mit sicherheitseinrichtung zum anzeigen des spannungszustandes |
-
1997
- 1997-12-05 US US08/985,876 patent/US6262283B1/en not_active Expired - Lifetime
- 1997-12-08 WO PCT/US1997/022031 patent/WO1998024800A2/en not_active Ceased
- 1997-12-08 JP JP52401298A patent/JP4441769B2/ja not_active Expired - Lifetime
- 1997-12-08 CA CA002272721A patent/CA2272721C/en not_active Expired - Lifetime
- 1997-12-08 AU AU55914/98A patent/AU746559B2/en not_active Ceased
- 1997-12-08 EP EP97952256A patent/EP0942918A2/en not_active Ceased
- 1997-12-08 ES ES03011093.6T patent/ES2486840T3/es not_active Expired - Lifetime
-
2001
- 2001-04-12 US US09/833,055 patent/US6610866B2/en not_active Expired - Lifetime
-
2009
- 2009-01-29 JP JP2009018865A patent/JP5097724B2/ja not_active Expired - Lifetime
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