JP2009039210A - Medical container package bag and method of storing medical container using the same, medicament-coinjected medical container package body and method of manufacturing medicament uncoinjected medical container package body, and medicament uncoinjected medical container package body - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical container package bag easily discharging air inside, preventing inflow of air and preventing alteration of a solvent coinjected into a medical container without using an exclusive device or instrument such as a vacuum machine; a method of storing the medical container using the same; a medicament-coinjected medical container package body and a method of manufacturing a medicament uncoinjected medical container package body; and a medicament uncoinjected medical container package body. <P>SOLUTION: The medical container package bag 10 formed with a gas barrier film for wrapping the medical container comprises a sealing means 12 which can be reopened, and a check valve mechanism 13 which discharges air from inside the medical container package bag 10 to the outside and which prevents inflow of air from the outside to the inside. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a medical container packaging bag, a method for containing a medical container using the same, a medical container package with a medicine mixed, a method for manufacturing a medical container packaging with no medicine mixed, and a medicine with no medicine mixed The present invention relates to a container package.

As a medical container used in the medical field, for example, a bag-shaped infusion bag 70 formed by making a film as shown in FIG. 11, a medical container manufactured by blow molding, an ampule, a syringe with a medicine, There are bottles.
For example, infusion bags containing medicines prevent the transmission of oxygen and ultraviolet rays in the distribution stage until they are delivered to hospitals, etc., to suppress the deterioration of the contents (drugs) and maintain the quality, and to ensure hygiene. Or, for the purpose of preventing mechanical damage such as scratches on the container, it is usually packed and transported in a dedicated packaging bag.

  After the infusion bag transported to a hospital or the like is taken out of the packaging bag and before administration to the patient, another drug is put into the infusion bag according to the patient's pathology, or the infusion bag of the multi-chamber infusion bag is used. In many cases, so-called mixed injection operations such as mixing medicines in a room are performed. In order to perform mixed injection operation efficiently and quickly, or to prepare an infusion bag pre-mixed in the hospital for home medical care, the hospital mixes the drug at a stage before immediately before using the infusion bag, The infusion bag may be stored in a refrigerator or the like with the medicine mixed.

Usually, an infusion bag is made of a polyolefin resin having poor gas barrier properties, so oxygen and the like easily pass through the infusion bag. When oxygen or the like enters the container, the drug after mixed injection may be deteriorated.
In general, the above-described packaging bags (packaging bags for non-drug-infusion infusion bags) used in the distribution stage before being delivered to a hospital or the like often have no barrier property.
Therefore, as a method of storing the infusion bag with the drug mixed injection, prepare a new packaging bag with gas barrier properties, put the infusion bag with the drug mixed injection into this packaging bag, evacuate the air in the packaging bag and heat seal it. The method of sealing is common. Furthermore, in order to maintain a more stable storage state, the inside of the packaging bag may be deaerated using a vacuum packaging sealing machine and then sealed and stored by heat sealing.

Thus, in order to transport an infusion bag containing a medicine and store an infusion bag mixed with other medicines, it is necessary to prepare a packaging bag for each application.
In recent years, a packaging bag corresponding to the purpose of transporting and storing an infusion bag has been proposed. For example, in Patent Document 1, the end surface area on the side to be opened has a linear tearing property in a direction parallel to the opening direction, and the end edge portion of the opening having a straight cut is used as a sealing allowance. A package that can be stopped is disclosed. Since the package has improved resealability, it is used when transporting a drug-containing infusion bag, then opened once, and other drugs are mixed and infused into the infusion bag. Can be stored.
JP 2004-121649 A

Drugs mixed in medical containers are easily affected by oxygen in the air and easily deteriorated. Therefore, it is necessary to pay close attention to the storage of the medical container mixed with medicine so that the air in the packaging bag for packaging the medical container does not remain and the air does not flow into the packaging bag. .
However, in the conventional packaging bag as described in Patent Document 1, air tends to remain in the packaging bag, and it is not always sufficient to suppress the deterioration of the mixed medicine in particular. In order to reduce the amount of air remaining in the packaging bag and suppress the deterioration of the drug, it is necessary to deaerate the inside of the packaging bag using a vacuum machine, etc., and then reseal it by heat sealing etc. The workability was easy to decrease.

  The present invention has been made in view of such a situation, and without using a dedicated device or instrument such as a vacuum machine, the internal air can be easily discharged and the inflow of air can be prevented. Medical container packaging bag capable of suppressing deterioration of mixed solvent, method for containing medical container using the same, method for manufacturing medical container package with mixed drug, method for manufacturing medical container package without drug mixed, and It is an object of the present invention to realize a medical container package in which no medicine is mixed.

As a result of intensive studies, the present inventors have found that the above problems can be solved by using a packaging bag having the following configuration, and have completed the present invention.
That is, the medical container packaging bag of the present invention is a medical container packaging bag formed using a gas barrier film, and sealing means that can be re-sealed and air from the inside of the medical container packaging bag to the outside. And a check valve mechanism that discharges air and prevents inflow of air from the outside to the inside.
Moreover, it is preferable that a sealing allowance A for sealing the peripheral edge portion a on the side of the check valve mechanism that contacts the outside air is provided.
Furthermore, it is preferable that a sealing allowance B for sealing the peripheral edge b on the side of the sealing means that comes into contact with the outside air is provided.

In the medical container housing method of the present invention, the medical container packaging bag is used, the sealing means is opened, the medical container mixed with the medicine is accommodated, and then the sealing means is sealed. The air inside the medical container packaging bag is discharged from the check valve mechanism to the outside.
Furthermore, the medical-contained medical container package of the present invention is characterized in that a medical container mixed with a medicine is packaged by the method for housing medical containers.

  Further, the method for producing a medical non-mixed medical container package according to the present invention uses the medical container packaging bag, and cuts one side not having the sealing means and the check valve mechanism to provide an opening portion. In addition, after the medical unmixed medical container is accommodated from the opening portion, the opening portion is sealed.

  In addition, the medical unmixed medical container package of the present invention is a medical unmixed medical container in which a medical unmixed medical container is packaged in a medical container packaging bag formed using a gas barrier film. The medical container packaging bag includes a sealing means capable of re-sealing, and a reverse means for discharging air from the inside of the medical container packaging bag to the outside and preventing air from flowing from the outside to the inside. It has a valve stop mechanism, and the peripheral part on the side which contacts the outside air of the sealing means and the check valve mechanism is sealed.

According to the present invention, the internal air can be easily discharged and the inflow of air can be prevented without using a dedicated device or instrument such as a vacuum machine, and the alteration of the solvent mixed in the medical container can be suppressed. MEDICAL CONTAINER PACKAGING BAG, METHOD FOR Storing MEDICAL CONTAINER USING THE SAME, MEDICAL CONTAINED MEDICAL CONTAINER PACKAGE BODY, METHOD FOR MANUFACTURING MEDIUM CONTAINER MEDICAL CONTAINER, AND MEDICAL UNMIXED MEDICAL CONTAINER Can be realized.
In addition, according to the present invention, after being used for transporting a medical container with no medicine mixed, it can be opened once, and another medicine can be mixed into the medical container and reused for storing the medical container with the medicine mixed. It is not necessary to use two types of packaging bags for transporting and storing medical containers, the cost can be reduced, and the amount of packaging bags discarded can be reduced by half.

Hereinafter, the present invention will be described in detail with reference to the drawings.
FIG. 1 is a plan view showing an example of a medical container packaging bag (hereinafter referred to as “packaging bag”) 10 according to the present invention, and FIG. 2 is an exploded perspective view of the packaging bag 10. In addition, although the packaging bag 10 of this example has shown the rectangular shape, in this invention, it is not restricted to this, The packaging bag of another shape can also be implemented.
As shown in FIG. 2, the packaging bag 10 of the present invention is a bag in which two films 11 are heat-sealed at both side fused portions 11a, a first bottom fused portion 11b, and a second bottom fused portion 11c. It is formed in a shape. Each film 11 includes a gas barrier film, and has a structure in which the gas barrier film and another film are laminated.

The gas barrier film used in the present invention may be any film having an oxygen barrier property, for example, a film obtained by vapor-depositing silica, aluminum, alumina or the like on a film made of polyester or polyamide, an aluminum foil laminate film, Examples thereof include a film made of polyvinyl alcohol, a film made of ethylene / vinyl alcohol copolymer, a film made of polyvinylidene chloride, and the like.
Commercially available products can be used as the gas barrier film. For example, “GL film” manufactured by Toppan Printing Co., Ltd., “IB film” manufactured by Dai Nippon Printing Co., Ltd., “Tech Barrier” manufactured by Mitsubishi Plastics, Inc. “Eval film” manufactured by Kuraray Co., Ltd., “Saran UB” manufactured by Asahi Kasei Co., Ltd., “Hyttron BX” manufactured by Tamapoli Co., Ltd., and the like.
The thickness of the gas barrier film is preferably 7 to 30 μm.

  Examples of other films include sealant films. As the resin constituting the sealant film, polyolefins such as polyethylene and polypropylene are suitable. Polyethylene is particularly preferable, and among them, low density polyethylene and high-strength linear low density polyethylene are preferable. Although the thickness of these sealant films depends on the mass of the medical container to be accommodated, for example, 30 to 200 μm is preferable, and 40 to 100 μm is more preferable.

  In addition to the above-described sealant film, in addition to the oxygen barrier property, a film having a water vapor barrier property and a light shielding property may be used in combination. When using a light-shielding film (light-shielding film) in combination, a light-shielding film that blocks or suppresses the transmission of ultraviolet rays is preferable, especially when storing medical containers such as infusion bags mixed with vitamin B1 and the like. It is suitable for. As such a light-shielding film, for example, in addition to general aluminum foil and aluminum foil laminate film, commercially available products such as “Eagle Cut UV” manufactured by Krillon Kasei Co., Ltd. and “Rayparia” manufactured by Sumitomo Osaka Cement Co., Ltd. And “ZMF-110”. The thickness of the light shielding film is preferably 7 to 30 μm.

As shown in FIG. 1, the packaging bag 10 of the present invention includes a sealing means 12 that can be re-sealed and a check valve mechanism 13.
The sealing means 12 is disposed on the opening 14 side between the two films 11, and the sealing means 12 is opened to accommodate one or more medical containers in the packaging bag 10 from the opening 14. Then, the sealing means 12 is sealed and the packaging bag 10 is sealed.
Such a sealing means 12 is not particularly limited as long as it can be opened and sealed many times and the medical container can be taken in and out of the packaging bag 10, but has, for example, a chuck structure. For example, a case where a pressure-sensitive adhesive is applied to the inner surface of the packaging bag 10, a case where a pressure-sensitive adhesive tape is affixed, a case where a clamp is held, and the like. Among these, those having a chuck structure are preferable in terms of good operability and excellent sealing performance after sealing.

The check valve mechanism 13 discharges air from the inside of the packaging bag 10 to the outside and prevents air from flowing from the outside to the inside. Although the check valve mechanism 13 of this example is provided to face the sealing means 12, it is not limited to this and may be provided at other positions.
The check valve mechanism 13 is not particularly limited as long as it has the above-described function.

Here, an example of the check valve mechanism 13 will be described with reference to FIG.
The check valve mechanism 13 in this example arranges a valve strip 15 between two films 11, and heats the upper fusion portion 15 a and the lower fusion portion 15 b of the valve piece 15 to each film 11. It is configured by sealing. In addition, the upper side fusion | fusion part 15a and the lower side fusion | fusion part 15b of the valve strip 15 are the 1st bottom fusion | fusion part 11b and 2nd bottom fusion | fusion which the two films 11 shown in FIG. 1 adhere | attached Each overlaps with the part 11c.
Examples of the material of the valve strip 15 include polyethylene, polypropylene, and ethylene vinyl acetate copolymer.

The valve strip 15 has two communication passages formed by adhesion of the upper fusion portion 15a and the lower fusion portion 15b, and the upper communication passage is formed between one film 11 and the valve piece 15 and is A communication path is formed between the other film 11 and the valve strip 15.
The width W1 of each communication path is preferably 1 to 8 cm, although it depends on the size of the packaging bag 10. Further, the diameter Wc2 of the first passage port 15c of the communication passage and the diameter Wd2 of the second passage port 15d are preferably 1/30 to 1/10 times the width W of the packaging bag 10. The diameter Wc2 of the passage opening 15c and the diameter Wd2 of the passage opening 15d may be the same or different. In addition, the width W of the packaging bag 10 is not limited because it appropriately changes depending on the size and number of medical containers to be accommodated, but is preferably 10 to 50 cm, for example.

  When the medical container is not accommodated in the packaging bag 10, both surfaces of the valve strip 15 are in contact with the films 11. Then, when the medical container is accommodated and the sealing means 12 is sealed and the pressure inside the packaging bag 10 becomes higher than the surrounding air pressure due to the pressure outside the bag, etc., the air inside the packaging bag 10 is connected to the communication path. It passes through the first passage port 15c and is discharged from the second passage port 15d through the upper communication passage and the lower communication passage. Next, the pressure of the air around the packaging bag 10 presses each sheet 11 against the valve strip 15, whereby the upper communication path and the lower communication path are closed to prevent inflow of air from the outside.

As a method for discharging the air in the packaging bag 10, for example, as shown in FIGS. 10A and 10B, a method of compressing one side of the packaging bag 10 by pressing with one hand or the like, sealing means 12 And a method of compressing by bending toward the check valve mechanism 13 or performing an ironing operation. According to the present invention, the air in the space between the container and the packaging bag can be easily discharged from the inside of the packaging bag 10 by discharging the air inside the packaging bag 10 by such a simple method. In addition, since the inflow of air or the like from the outside is prevented, it is possible to suppress the deterioration of the medicine mixed especially in the medical container.
In the present invention, a medical container not mixed with a drug is referred to as a “medicine-unmixed medical container”, and a non-drug-mixed medical container is mixed with another drug as a “medicine-mixed medical container” It is called a “container”.

In the present invention, the check valve mechanism 13 is not limited to the above-described one, and for example, the one shown in FIGS.
Here, the check valve mechanism 13 shown in FIGS.

The packaging bag 100 shown in FIG. 3A is formed into a bag shape by heat-sealing two films 111 at both side fusion portions 111a and bottom fusion portions 111b. And a check valve mechanism 113 is provided at the bottom. The check valve mechanism 113 is attached so as to penetrate a part of the bottom fusion part 111b, and the bottom fusion part 111b of the part to which the check valve mechanism 113 is attached is not heat-sealed. Shall.
As shown in FIG. 3B, the check valve mechanism 113 includes an outer cylinder portion 113a having a flat cylindrical sheet so that the inside and the outside of the packaging bag 100 are continuous, and the outer cylinder portion 113a. And a valve seat 113b provided inside. By providing the valve sheet 113b, the air flow (air flow) from the inside to the outside of the packaging bag 100 can be promoted, and the air flow in the reverse direction can be blocked.

When the check valve mechanism 113 is provided at the bottom of the packaging bag 100, the film 111 and the outer cylinder portion 113a may be bonded by heat sealing at the fusion portion 113c. In order to prevent the valve sheet 113b from being heat-sealed at the time of bonding, an anti-melting paint is applied to the surface of the valve sheet 113b on the side facing the inner surface of the outer cylinder part 113a. May be.
As the material of the outer tube portion 113a and the valve sheet 113b, one or more types can be selected and used from the materials of the valve strip 15 exemplified above.

The packaging bag 200 shown in FIG. 4A is formed into a bag shape by heat-sealing two films 211 at both side fused portions 211a and bottom fused portions 211b. And a check valve mechanism 213 is provided at the bottom.
In addition, when heat-sealing the bottom fusion | bond part 211b, what is necessary is just to heat-seal using the metal mold | die like a shaded part shown to Fig.4 (a), (f).

As shown in FIG. 4F, the check valve mechanism 213 of this example is configured by arranging two valve sheets 213a and two pedestal sheets 213b between two films 211. Has been. When the air inside the packaging bag 200 is discharged, an air passage portion P is formed as shown in FIGS. 4B and 4D, and the air is discharged from the inside of the packaging bag 200 to the outside. Is possible. A portion of the valve sheet 213a is movable until the air passage portion P is closed, and one valve sheet 213a is attached to each film 211 adhered to the valve sheet 213a. The air passage part P can be blocked by the part rising and closely contacting the other valve sheet 213a (FIGS. 4C and 4E). Thereby, inflow of air from the outside to the inside of the packaging bag 200 can be suppressed.
As the material of the valve sheet 213a, one or more kinds can be selected and used from the materials of the valve piece 15 exemplified above.

A packaging bag 300 shown in FIG. 5A is formed into a bag shape by heat-sealing two films 311 at both side fused portions 311a and bottom fused portions 311b. And a check valve mechanism 313 is provided at the bottom.
As shown in FIG. 5A, the packaging bag 300 of this example is a compartment seal heat-sealed so as to be parallel to the bottom fused portion 311b at a position a predetermined distance from the bottom fused portion 311b. 311c is formed.

As shown in FIG. 5B, the check valve mechanism 313 is configured by arranging a single valve sheet 313 a between two films 311. One side of the valve sheet 313a is in close contact with one film 311 ′ of the peripheral sides, and the other side of the valve sheet 313a is all the peripheral sides with the other film 311 ″. The communication path 313b is formed by having such a structure. In addition, a part of the partition seal 311c is assumed to be interrupted in the middle, and the interrupted portion serves as a communication portion 311d, which communicates the inside of the packaging bag 300 and the communication path 313b. Further, the communication passage 313b of one film 311 is provided with a deaeration hole 313c, and the air inside the packaging bag 300 passes through the communication part 311d and the communication passage 313b and is discharged from the deaeration hole 313c.
The other surface of the valve sheet 313a can be separated from the other film 311 '' except for the portion that is in close contact with the other film 311 ''. Accordingly, the degassing hole 313c can be blocked by the valve sheet 313a being lifted with respect to the other film 311 ″ and being in close contact with the other sheet 311 ′. Thereby, the inflow of air from the outside to the inside of the packaging bag 300 can be suppressed. Further, a sealing member 313d that can be attached to and detached from one film 311 ′ is provided on one film 311 ′ so as to cover the deaeration hole 313c, and after the air in the packaging bag 300 is discharged, the sealing member 313d If the deaeration hole 313c is closed, the inflow of air can be suppressed more effectively.
As the material of the valve sheet 313a, one or more kinds can be selected and used from the materials of the valve piece 15 exemplified above.

  In the present invention, it is possible to use a check valve mechanism having a configuration other than that described above, but the check valve mechanism 13 shown in FIGS.

The packaging bag of the present invention has the sealing means and the check valve mechanism as described above, so that the medical container can be taken in and out, the air in the packaging bag can be discharged, and the inflow of air from the outside. This is particularly suitable for storing medically mixed medical containers.
In the case of storing and storing a medicine-mixed medical container into which a medicine is mixed using the packaging bag of the present invention, first, as shown in FIG. The container 71 is accommodated and the sealing means 12 is sealed. Next, as shown in FIG. 6 (b), by using a housing method in which the air inside the packaging bag 10 is discharged from the check valve mechanism 13 to the outside, a medically mixed medical container package 50 is obtained. The mixed medical container 71 can be stored in a sealed state. In storage, it is preferable to store in a cool and dark place such as a refrigerator in consideration of the stability of the medicine mixed in the medical container.

Moreover, the packaging bag of this invention can also be used when conveying the medical container with no medicine mixed injection to a hospital etc. In such a case, the sealing means is unsealed at the timing when other drugs are mixed and taken out, and the medical container not filled with the medicine is taken out.After other drugs are mixed and mixed, the sealing means is stored again in the same packaging bag. By sealing and discharging the air inside the packaging bag from the check valve mechanism to the outside, it is possible to store the medical container with the medicine mixed in a sealed state.
Thus, according to this invention, the packaging bag used for conveyance of a medical container can be reused for storage.

When the air in the packaging bag is discharged, a vacuum machine or the like may be installed in the second passage port 15d shown in FIG. 1, and the inside of the packaging bag may be deaerated with the vacuum machine.
However, in the present invention, since the air in the packaging bag can be discharged to the outside by a simple method such as compressing the packaging bag, the air inside the packaging bag can be used without using a dedicated device or instrument such as a vacuum machine. Can be easily degassed and the inflow of air from the outside is prevented, so that the alteration of the medicine mixed in the medical container can be particularly suppressed.

  In addition, when the inside of a medical container in which a medicine that is easily affected by a small amount of oxygen is mixed and contained in a packaging bag, it is preferable to store the oxygen scavenger in the packaging bag together with the medical container. Any oxygen scavenger can be used as long as it can remove oxygen. Examples thereof include an oxygen scavenger using amorphous copper. As commercial products, “AGELESS” manufactured by Mitsubishi Gas Chemical Co., Ltd. can be used.

As shown in FIG. 7, the packaging bag of the present invention preferably has a structure in which a sealing margin A is provided at the peripheral edge portion a on the side of the check valve mechanism 13 that contacts the outside air. With such a structure, since the peripheral edge a of the check valve mechanism 13 is sealed, it is possible to further suppress the flow of outside air from the outside of the packaging bag 10 to the inside, and for medical use that has been mixed with a medicine. The packaging bag can be kept more hygienic until just before being used for storage of the container.
When such a packaging bag is used for storing a medical container with mixed medicines, the check valve mechanism 13 can be cut by cutting along an arbitrary portion of the peripheral edge a, for example, along the cutting line 16 shown in FIG. The peripheral edge part a is exposed, and the air inside the packaging bag can be released to the outside.

Furthermore, it is preferable that a sealing margin B is provided at the peripheral edge b (that is, the opening) on the side of the sealing means 12 that contacts the outside air. By setting it as such a structure, since the peripheral part b of the sealing means 12 is sealed, the inside of a packaging bag can be hold | maintained more hygienically just before it is used for storage of the medical container by which medicine mixing was carried out.
When such a packaging bag is used for storing a medical container with mixed medicines, the peripheral edge of the sealing means 12 can be cut by cutting along an arbitrary portion of the peripheral edge b, for example, along the cutting line 17 shown in FIG. Since the part b is exposed, the sealing means 12 can be opened, and the medical container mixed with medicine can be accommodated in the packaging bag.

  In addition, when cutting the sealing allowances A and B along the cutting lines 16 and 17, it may be cut using a blade such as scissors, but a film having a straight cut property may be used or cut. By providing a notch at the start or roughening the surface, it will be easier to cut with a tool such as a blade, and it can also be cut by hand without using a tool. become.

As shown in FIG. 7, the packaging bag is a packaging bag 20 having a structure in which a sealing margin A is provided at the peripheral portion a of the check valve mechanism 13 and a sealing margin B is provided at the peripheral portion b of the sealing means 12. Thus, since the peripheral edge portion a and the peripheral edge portion b are sealed, the check valve mechanism 13 and the sealing means 12 are protected.
Therefore, when the packaging bag is used for transporting a medical container not mixed with medicine, the sealing means 12 and the check valve mechanism 13 are protected from the impact of transport and the like, and these damages can be effectively suppressed.
The packaging bag 20 may have a structure in which both a sealing allowance A and a sealing allowance B are provided, or may have a structure in which any one sealing allowance is provided, but a structure in which both sealing allowances are provided is more preferable.

  When the packaging bag 20 having such a structure is used for transporting a medical container, for example, after the medical container 72 with no medicine mixed therein is accommodated in the packaging bag 30 shown in FIG. By sealing the peripheral edge b, a medical container package 60 with no medicine mixed as shown in FIG. 8B may be produced, but the following method may be used.

The connected packaging bag 40 (FIG. 6) manufactured in a state where the peripheral edge b of the sealing means 12 and the peripheral edge a of the check valve mechanism 13 are sealed and the packaging bags are connected to each other by the double-side fused portions 11a. 9 (a)) is cut at a cutting line 18 parallel to the both side fusion parts 11a to provide an opening part 19, and a medical container 72 with no medicine mixed therein is accommodated from the opening part 19 (FIG. 9 ( b)) Further, the unsealed medical container package 60 as shown in FIG. 8B is manufactured by joining the opening 19 by heat sealing or the like. When cutting the connected packaging bag 40, the individual packaging bags after cutting have one double-side fused portion 11a (that is, one side serves as a fused portion and the other side serves as an unsealed portion). ) The cutting line 18 may be set. Specifically, it is preferable to set the cutting line 18 at a position where the distance d from the end of the both-side fused part 11a is 0 to 10 mm. In addition, when the cutting line 18 is set so that the distance d is 0 mm, the individual packaging bag after cutting has a structure as shown in FIG.
According to such a method, even if the sealing means 12 is not opened and sealed, the medical container 72 containing the unmixed medicine in a mass production can be obtained by a simple operation such as cutting and heat sealing. Furthermore, it can be transported to a hospital or the like while effectively suppressing damage to the sealing means 12 and the check valve mechanism 13.

In addition, although it does not restrict | limit especially about the manufacturing method of the packaging bag of this invention, For example, it can manufacture as follows.
First, a gas barrier film and a sealant film are laminated by an adhesive with a dry lamination method to produce two gas barrier laminated films.
Next, the sealing means and the check valve mechanism are sandwiched between two gas barrier laminated films so as to have the arrangement as shown in FIG. 1, so that the structure as shown in FIG. 1 or FIG. 7 is obtained. It can be manufactured by heat-sealing and welding necessary portions such as both-side fused portions and bottom fused portions.

As described above, according to the present invention, the sealing means capable of re-sealing and the check valve mechanism are provided, so that the medical container can be taken in and out and the air in the packaging bag can be discharged.
Therefore, when storing a mixed medicine medical container mixed with a medicine using the packaging bag of the present invention, the sealing means is opened to accommodate the mixed medicine medical container, and the sealing means is sealed, By discharging the air inside the packaging bag from the check valve mechanism to the outside, it is possible to store the medical container with the medicine mixed in a sealed state. Since the check valve mechanism can prevent the inflow of air from the outside to the inside of the packaging bag, the deterioration of the solvent can be suppressed even when a solvent unstable to air or the like is mixedly injected into the medical container.

  Furthermore, the packaging bag of the present invention can be reused for storage of a solvent-mixed medical container after it is used for transporting a solvent-unmixed medical container, thereby reducing the amount of packaging bag discarded. .

Examples of the present invention will be described below, but the present invention is not limited to these examples.
[Example 1]
<Manufacture of packaging bags>
Gas barrier film (made by Toppan Printing Co., Ltd., “GL film GL-AU”, thickness: 15 μm) and linear low density polyethylene sealant film (thickness: 60 μm) are used with urethane adhesive. Then, a gas barrier laminated film was prepared by laminating by dry lamination and further attaching a chuck (manufactured by Idemitsu Unitech Co., Ltd.) as a sealing means by heat sealing. This film was cut into 50 cm × 40 cm.
Using two cut films, the sealant film surfaces are overlapped so that the sealant film surfaces are in contact with each other, and a check valve mechanism 13 as shown in FIG. 2 is produced, and the opening 14 (the peripheral edge b of the sealing means) is excluded. The packaging bag 30 in which the peripheral edge a of the check valve mechanism 13 was also sealed with a sealing allowance A as shown in FIG.
Next, as an unmixed medical container 72, a 500 ml amino acid-containing preparation infusion bag and an oxygen scavenger (manufactured by Mitsubishi Gas Chemical Co., Ltd., “AGELESS”) are opened in the sealing bag 12 and the packaging bag 30 The sealing means is sealed, the sealing margin B provided at the opening (peripheral edge of the sealing means) is sealed, and the medical container packaging with no medicine mixed as shown in FIG. 8 (b) A body 60 was produced.

The sealing allowances A and B of the medical container package 60 are cut along the cutting lines 16 and 17, the sealing means 12 is opened, and the medical container 72 with no medicine mixed is taken out, and vitamins are used as other medicines. B1 formulation was mixed. After the medical mixed container 71 is returned to the previous packaging bag from which the sealing margins A and B have been cut and the sealing means 12 is sealed, one side of the packaging bag is attached as shown in FIG. After pressing by hand and compressing, the air in the packaging bag was discharged from the check valve mechanism 13 (FIG. 10B), and stored in a refrigerator at 4 ° C. for one week.
As a result of visual observation of the medical mixed container after one week storage, no change in appearance was observed.

[Example 2]
Using the same gas barrier laminate film as in Example 1, heat sealing is performed on the four sides, and the peripheral edge a of the check valve mechanism 13 and the peripheral edge b of the sealing means 12 as shown in FIG. A packaging bag 20 sealed with A and a sealing allowance B was manufactured.

A medical non-mixed medical container (500 ml amino acid-containing preparation infusion bag) stored in a conventional packaging bag was taken out from the packaging bag, and vitamin B1 preparation was mixed and injected as another drug.
The sealing allowances A and B of the packaging bag 20 produced earlier are cut along the cutting lines 16 and 17, the sealing means 12 is opened, the medicine mixed medical container is accommodated, and the sealing means 12 is Sealed. Subsequent operations were performed in the same manner as in Example 1.
As a result of visual observation of the medical mixed container after one week storage, no change in appearance was observed.

[Example 3]
As an unmixed medical container 72, an infusion bag (with an internal volume of 1200 mL) containing sugar and an electrolyte solution and an amino acid solution in two chambers separated by a removable partition wall, The same operation as in Example 1 was carried out except that the partition partitioning the two chambers was opened and mixed.
As a result of visually observing the medically mixed medical container after storage for 3 days in a refrigerator at 4 ° C., no change in appearance was observed.

[Comparative Example 1]
The same procedure as in Example 1 was carried out except that the medical container into which the medicine was mixed was not accommodated in the packaging bag.
As a result of visually observing the medical mixed container after one week storage, discoloration was observed in the solution inside the medical container, and a precipitate could be confirmed.

From the above results, with the packaging bag of the present invention, the internal air can be easily deaerated without using a dedicated device or instrument such as a vacuum machine, and the deterioration of the solvent mixed in the medical container can be suppressed. it can.
Further, after being used for transporting a medical container not mixed with solvent, it can be reused for storing a medical container mixed with solvent.

It is a top view which shows an example of the packaging bag of this invention. It is a disassembled perspective view of the packaging bag shown in FIG. It is a figure which shows the other example of the packaging bag of this invention, (a) is a top view, (b) is sectional drawing cut | disconnected by the AA of (a). It is a figure which shows the other example of the packaging bag of this invention, (a) is a top view, (b) And (c) is sectional drawing cut | disconnected by the BB line of (a), (d ) Corresponds to the state shown in (b) and is a cross-sectional view taken along line CC of (a), (e) corresponds to the state shown in (c), and C-- It is sectional drawing cut | disconnected by the C line. It is a figure which shows the other example of the packaging bag of this invention, (a) is a top view, (b) is a disassembled perspective view. It is a figure explaining an example of the manufacturing method of the accommodation method of a medical container, and the medical container packaging body by which medicine mixing was carried out. It is a top view which shows an example of the packaging bag provided with the sealing allowance. It is process drawing explaining an example of the manufacturing process of the medical container with no medicine mixed injection. It is process drawing explaining the other example of the manufacturing process of the medical container with no medicine mixed injection. It is explanatory drawing which shows an example of the discharge method of the air in a packaging bag, (a) is a figure before compression, (b) is a figure which shows after compression. It is a top view which shows an example of a medical container.

Explanation of symbols

10: Medical container packaging bag, 12: Sealing means, 13: Check valve mechanism, 20: Medical container packaging bag, 30: Medical container packaging bag, 50: Medical mixed container package filled with medicine, 60: Medical container packaging body with unmixed medicine, 100: medical container packaging bag, 200: medical container packaging bag, 300: medical container packaging bag.

Claims (7)

In a medical container packaging bag formed using a gas barrier film,
A medical device comprising: sealing means capable of re-sealing; and a check valve mechanism for discharging air from the inside to the outside of the medical container packaging bag and preventing air from flowing from the outside to the inside. Container packaging bag.   The medical container packaging bag according to claim 1, wherein a sealing margin A is provided for sealing the peripheral edge portion a on the side of the check valve mechanism that contacts the outside air.   The medical container packaging bag according to claim 1 or 2, wherein a sealing margin B for sealing the peripheral edge b on the side of the sealing means in contact with the outside air is provided.   After using the medical container packaging bag according to any one of claims 1 to 3, the sealing means is opened and the medical container mixed with the medicine is accommodated, and then the sealing means is sealed, and the medical A method for containing a medical container, wherein the air inside the container packaging bag is discharged from the check valve mechanism to the outside.   A medical container packaged with a medicine mixed-injected, wherein a medical container mixed with a medicine is packaged by the medical container housing method according to claim 4.   Using the medical container packaging bag according to any one of claims 1 to 3, a side not having the sealing means and the check valve mechanism is cut to provide an opening portion, and a drug unmixed injection from the opening portion A method for producing a medical container package containing unmixed medicines, wherein after opening the medical container, the opening is sealed. A medical container packaging body with unmixed medicine in which a medical container with unmixed medicine is packaged in a medical container packaging bag formed using a gas barrier film,
The medical container packaging bag has sealing means that can be re-sealed, and a check valve mechanism that discharges air from the inside of the medical container packaging bag to the outside and prevents air from flowing from the outside to the inside. And the peripheral part of the side in contact with the outside air of the sealing means and the check valve mechanism is sealed.

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