JP2009035530A5 - - Google Patents
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- Publication number
- JP2009035530A5 JP2009035530A5 JP2008129762A JP2008129762A JP2009035530A5 JP 2009035530 A5 JP2009035530 A5 JP 2009035530A5 JP 2008129762 A JP2008129762 A JP 2008129762A JP 2008129762 A JP2008129762 A JP 2008129762A JP 2009035530 A5 JP2009035530 A5 JP 2009035530A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide
- oligonucleotide
- immunostimulatory oligonucleotide
- deaza
- thio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 229920000272 Oligonucleotide Polymers 0.000 claims 3
- 230000003308 immunostimulating Effects 0.000 claims 2
Claims (1)
- 以下の式：
５’−（Ｚ１）ＫＸ１Ｙ１Ｒ１Ｘ２Ｙ２Ｒ２Ｘ３Ｙ３Ｒ３（Ｚ２）Ｌ（Ｇ）Ｎ（Ｚ３）Ｍ−３’（配列番号７０）
で示される免疫刺激性オリゴヌクレオチドであって、
式中、Ｘ１は、あらゆるヌクレオチド（ただしｄＧを除く）であり、Ｘ２およびＸ３は、あらゆるヌクレオチドであり、Ｙ１、Ｙ２およびＹ３は、ｄＣ、５−メチル−ｄＣ、５−ヒドロキシ−ｄＣ、または、５−フルオロ−ｄＣであり、Ｒ１、Ｒ２およびＲ３は、ｄＧ、ｄＩ、６−チオ−ｄＧ、または、７−デアザ−ｄＧであり、Ｚ１、Ｚ２およびＺ３は、あらゆるヌクレオチドであり、ここで、Ｋ、ＬおよびＭは、それぞれ独立して０〜１０を示し、Ｎは、４〜１０であり、ここで、該免疫刺激性オリゴヌクレオチドは、長さが１６個未満のヌクレオチドである、上記オリゴヌクレオチド。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93058007P | 2007-05-17 | 2007-05-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009035530A JP2009035530A (ja) | 2009-02-19 |
| JP2009035530A5 true JP2009035530A5 (ja) | 2011-06-30 |
Family
ID=39720158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008129762A Pending JP2009035530A (ja) | 2007-05-17 | 2008-05-16 | 免疫刺激能を有するクラスａオリゴヌクレオチド |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20100285041A1 (ja) |
| EP (1) | EP2160199A2 (ja) |
| JP (1) | JP2009035530A (ja) |
| KR (1) | KR20100010509A (ja) |
| CN (1) | CN101678098A (ja) |
| AR (1) | AR066626A1 (ja) |
| AU (1) | AU2008252577A1 (ja) |
| BR (1) | BRPI0811621A2 (ja) |
| CA (1) | CA2687441A1 (ja) |
| IL (1) | IL202096A0 (ja) |
| MX (1) | MX2009012482A (ja) |
| RU (1) | RU2009142211A (ja) |
| TW (1) | TW200916115A (ja) |
| WO (1) | WO2008142509A2 (ja) |
| ZA (1) | ZA200908062B (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| US7276489B2 (en) * | 2002-10-24 | 2007-10-02 | Idera Pharmaceuticals, Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends |
| NZ573064A (en) | 2002-04-04 | 2011-02-25 | Coley Pharm Gmbh | Immunostimulatory G,U-containing oligoribonucleotides |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| AR040996A1 (es) | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
| ZA200503511B (en) | 2002-10-29 | 2006-10-25 | Coley Pharmaceutical Group Ltd | Use of CPG oligonucleotides in the treatment of hepatitis C virus infection |
| GEP20094767B (en) | 2003-10-30 | 2009-09-10 | Coley Pharm Group Inc | C-class oligonucleotide analogs with enhanced immunostimulatory potency |
| KR101251707B1 (ko) | 2006-09-27 | 2013-04-11 | 콜리 파마슈티칼 게엠베하 | 면역 자극 활성이 증강된 소수성 Ｔ 유사체를 함유하는 ＣｐＧ 올리고뉴클레오티드 유사체 |
| JP2011251963A (ja) * | 2010-05-28 | 2011-12-15 | Coley Pharmaceutical Group Inc | 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用 |
| EP2471926A3 (en) * | 2010-12-30 | 2012-07-11 | Intervet International BV | Immunostimulatory oligodeoxynucleotides |
| SG11201500232UA (en) * | 2012-07-13 | 2015-04-29 | Wave Life Sciences Pte Ltd | Chiral control |
| EP3238727B1 (en) * | 2014-12-25 | 2023-01-18 | National Institutes of Biomedical Innovation, Health and Nutrition | Non-aggregating immunostimulatory oligonucleotides |
| WO2016152767A1 (ja) * | 2015-03-20 | 2016-09-29 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途 |
| JP7511478B2 (ja) | 2018-04-09 | 2024-07-05 | チェックメイト ファーマシューティカルズ | ウイルス様粒子中へのオリゴヌクレオチドのパッケージ化 |
| WO2019240504A1 (en) * | 2018-06-12 | 2019-12-19 | Am Sciences Co., Ltd. | Modified oligonucleotides for inhibition of target gene expression |
| KR102273071B1 (ko) * | 2018-06-12 | 2021-07-05 | 주식회사 에이엠사이언스 | B형 간염 예방 또는 치료용 조성물 |
| WO2023034853A2 (en) * | 2021-08-31 | 2023-03-09 | City Of Hope | Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof |
| CN113517062B (zh) * | 2021-09-14 | 2021-12-10 | 青岛未来移动医疗科技有限公司 | 一种智能疫苗雾化系统及使用方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US4469863A (en) * | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5023243A (en) * | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DE4321946A1 (de) * | 1993-07-01 | 1995-01-12 | Hoechst Ag | Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung |
| US5658738A (en) * | 1994-05-31 | 1997-08-19 | Becton Dickinson And Company | Bi-directional oligonucleotides that bind thrombin |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| DK0772619T4 (da) * | 1994-07-15 | 2011-02-21 | Univ Iowa Res Found | Immunmodulatoriske oligonukleotider |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| US6214806B1 (en) | 1997-02-28 | 2001-04-10 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CPC dinucleotide in the treatment of LPS-associated disorders |
| US6339068B1 (en) * | 1997-05-20 | 2002-01-15 | University Of Iowa Research Foundation | Vectors and methods for immunization or therapeutic protocols |
| CA2323929C (en) * | 1998-04-03 | 2004-03-09 | University Of Iowa Research Foundation | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
| TR200103018T2 (tr) * | 1999-04-19 | 2002-02-21 | Beecham Biologicals S.A. Smithkline | İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri. |
| US6949520B1 (en) * | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| ES2265980T5 (es) | 1999-09-27 | 2010-12-28 | Coley Pharmaceutical Group, Inc. | Metodos relacionados con interferón inducido por ácidos nucleicos inmunoestimuladores. |
| JP4383534B2 (ja) | 2001-08-17 | 2009-12-16 | コーリー ファーマシューティカル ゲーエムベーハー | 改善した活性を有する組み合わせモチーフ免疫刺激オリゴヌクレオチド |
| AU2006216493A1 (en) * | 2005-02-24 | 2006-08-31 | Coley Pharmaceutical Gmbh | Immunostimulatory oligonucleotides |
| MX2007012488A (es) * | 2005-04-08 | 2008-03-11 | Coley Pharm Group Inc | Metodos para el tratamiento de asma exacerbado por enfermedad infecciosa. |
-
2008
- 2008-05-15 US US12/600,364 patent/US20100285041A1/en not_active Abandoned
- 2008-05-15 RU RU2009142211/15A patent/RU2009142211A/ru not_active Application Discontinuation
- 2008-05-15 CA CA002687441A patent/CA2687441A1/en not_active Abandoned
- 2008-05-15 BR BRPI0811621-0A2A patent/BRPI0811621A2/pt not_active IP Right Cessation
- 2008-05-15 KR KR1020097026396A patent/KR20100010509A/ko not_active Application Discontinuation
- 2008-05-15 MX MX2009012482A patent/MX2009012482A/es unknown
- 2008-05-15 EP EP08750940A patent/EP2160199A2/en not_active Withdrawn
- 2008-05-15 WO PCT/IB2008/001199 patent/WO2008142509A2/en active Application Filing
- 2008-05-15 CN CN200880016477A patent/CN101678098A/zh active Pending
- 2008-05-15 AU AU2008252577A patent/AU2008252577A1/en not_active Abandoned
- 2008-05-16 AR ARP080102108A patent/AR066626A1/es unknown
- 2008-05-16 TW TW097118306A patent/TW200916115A/zh unknown
- 2008-05-16 JP JP2008129762A patent/JP2009035530A/ja active Pending
-
2009
- 2009-11-12 IL IL202096A patent/IL202096A0/en unknown
- 2009-11-16 ZA ZA200908062A patent/ZA200908062B/xx unknown
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