JP2009035530A - 免疫刺激能を有するクラスａオリゴヌクレオチド - Google Patents

免疫刺激能を有するクラスａオリゴヌクレオチド Download PDF

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Publication number
JP2009035530A
JP2009035530A JP2008129762A JP2008129762A JP2009035530A JP 2009035530 A JP2009035530 A JP 2009035530A JP 2008129762 A JP2008129762 A JP 2008129762A JP 2008129762 A JP2008129762 A JP 2008129762A JP 2009035530 A JP2009035530 A JP 2009035530A
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JP
Japan
Prior art keywords
seq
oligonucleotide
subject
nucleotides
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008129762A
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English (en)
Japanese (ja)
Other versions
JP2009035530A5 (cg-RX-API-DMAC7.html
Inventor
Arthur M Krieg
アーサー・エム・クリーグ
Eugen Dr Uhlmann
オイゲン・ウールマン
Joerg Vollmer
イェルク・フォルマー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coley Pharmaceutical GmbH
Coley Pharmaceutical Group Inc
Original Assignee
Coley Pharmaceutical GmbH
Coley Pharmaceutical Group Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coley Pharmaceutical GmbH, Coley Pharmaceutical Group Inc filed Critical Coley Pharmaceutical GmbH
Publication of JP2009035530A publication Critical patent/JP2009035530A/ja
Publication of JP2009035530A5 publication Critical patent/JP2009035530A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008129762A 2007-05-17 2008-05-16 免疫刺激能を有するクラスａオリゴヌクレオチド Pending JP2009035530A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93058007P 2007-05-17 2007-05-17

Publications (2)

Publication Number Publication Date
JP2009035530A true JP2009035530A (ja) 2009-02-19
JP2009035530A5 JP2009035530A5 (cg-RX-API-DMAC7.html) 2011-06-30

Family

ID=39720158

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008129762A Pending JP2009035530A (ja) 2007-05-17 2008-05-16 免疫刺激能を有するクラスａオリゴヌクレオチド

Country Status (15)

Country Link
US (1) US20100285041A1 (cg-RX-API-DMAC7.html)
EP (1) EP2160199A2 (cg-RX-API-DMAC7.html)
JP (1) JP2009035530A (cg-RX-API-DMAC7.html)
KR (1) KR20100010509A (cg-RX-API-DMAC7.html)
CN (1) CN101678098A (cg-RX-API-DMAC7.html)
AR (1) AR066626A1 (cg-RX-API-DMAC7.html)
AU (1) AU2008252577A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0811621A2 (cg-RX-API-DMAC7.html)
CA (1) CA2687441A1 (cg-RX-API-DMAC7.html)
IL (1) IL202096A0 (cg-RX-API-DMAC7.html)
MX (1) MX2009012482A (cg-RX-API-DMAC7.html)
RU (1) RU2009142211A (cg-RX-API-DMAC7.html)
TW (1) TW200916115A (cg-RX-API-DMAC7.html)
WO (1) WO2008142509A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200908062B (cg-RX-API-DMAC7.html)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013532140A (ja) * 2010-05-28 2013-08-15 ゾエティス・ベルジャム・エス・アー 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用
WO2016103703A1 (ja) * 2014-12-25 2016-06-30 国立研究開発法人医薬基盤・健康・栄養研究所 非凝集性免疫賦活化オリゴヌクレオチド
WO2016152767A1 (ja) * 2015-03-20 2016-09-29 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途

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US20030026782A1 (en) * 1995-02-07 2003-02-06 Arthur M. Krieg Immunomodulatory oligonucleotides
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6406705B1 (en) 1997-03-10 2002-06-18 University Of Iowa Research Foundation Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
US7276489B2 (en) * 2002-10-24 2007-10-02 Idera Pharmaceuticals, Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
EP1499187B1 (en) 2002-04-04 2015-06-17 Zoetis Belgium S.A. Immunostimulatory g,u-containing oligoribonucleotides
US20040053880A1 (en) 2002-07-03 2004-03-18 Coley Pharmaceutical Group, Inc. Nucleic acid compositions for stimulating immune responses
AR040996A1 (es) 2002-08-19 2005-04-27 Coley Pharm Group Inc Acidos nucleicos inmunoestimuladores
PT2241325E (pt) 2002-10-29 2012-04-12 Coley Pharm Gmbh Utilização de oligonucleótidos cpg no tratamento de infecção com vírus da hepatite c
NZ546275A (en) 2003-10-30 2009-05-31 Coley Pharm Gmbh C-class oligonucleotides analogs with enhanced immunostimulatory potency
PT2078080E (pt) 2006-09-27 2015-09-18 Coley Pharm Gmbh Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
EP2471926A3 (en) 2010-12-30 2012-07-11 Intervet International BV Immunostimulatory oligodeoxynucleotides
SG10201912895PA (en) * 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
AU2019251421B2 (en) 2018-04-09 2025-05-01 Checkmate Pharmaceuticals Packaging oligonucleotides into virus-like particles
WO2019240504A1 (en) * 2018-06-12 2019-12-19 Am Sciences Co., Ltd. Modified oligonucleotides for inhibition of target gene expression
WO2019240503A1 (ko) * 2018-06-12 2019-12-19 주식회사 에이엠사이언스 B형 간염 예방 또는 치료용 조성물
US20250376689A1 (en) * 2021-08-31 2025-12-11 City Of Hope Oligonucleotides having 6-thio-2'-deoxyguanosine residues and uses thereof
CN113517062B (zh) * 2021-09-14 2021-12-10 青岛未来移动医疗科技有限公司 一种智能疫苗雾化系统及使用方法

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US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US5023243A (en) * 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4452775A (en) * 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
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DE4321946A1 (de) * 1993-07-01 1995-01-12 Hoechst Ag Methylphosphonsäureester, Verfahren zu deren Herstellung und deren Verwendung
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US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
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EP1167378B1 (en) * 1994-07-15 2011-05-11 University of Iowa Research Foundation Immunomodulatory oligonucleotides
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
EP1039935A4 (en) * 1997-02-28 2005-04-27 Univ Iowa Res Found USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE IN THE TREATMENT OF LPS-ASSOCIATED DISORDERS
US6339068B1 (en) * 1997-05-20 2002-01-15 University Of Iowa Research Foundation Vectors and methods for immunization or therapeutic protocols
CA2323929C (en) * 1998-04-03 2004-03-09 University Of Iowa Research Foundation Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines
WO2000062800A2 (en) * 1999-04-19 2000-10-26 Smithkline Beecham Biologicals Sa Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide
US6949520B1 (en) * 1999-09-27 2005-09-27 Coley Pharmaceutical Group, Inc. Methods related to immunostimulatory nucleic acid-induced interferon
IL148844A0 (en) 1999-09-27 2002-09-12 Coley Pharm Group Inc Methods related to immunostimulatory nucleic acid-induced interferon
NZ552377A (en) 2001-08-17 2008-08-29 Coley Pharm Gmbh Combination motif immune stimulatory oligonucleotides with improved activity
US20080009455A9 (en) * 2005-02-24 2008-01-10 Coley Pharmaceutical Group, Inc. Immunostimulatory oligonucleotides
BRPI0610449A2 (pt) * 2005-04-08 2012-01-10 Coley Pharm Group Inc métodos para tratar asma exarcebada por doença infecciosa

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013532140A (ja) * 2010-05-28 2013-08-15 ゾエティス・ベルジャム・エス・アー 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用
JP2017048187A (ja) * 2010-05-28 2017-03-09 ゾエティス・ベルジャム・エス・アー 抗原および免疫調節ワクチンおよびコレステロール、ならびにその使用
WO2016103703A1 (ja) * 2014-12-25 2016-06-30 国立研究開発法人医薬基盤・健康・栄養研究所 非凝集性免疫賦活化オリゴヌクレオチド
US11268098B2 (en) 2014-12-25 2022-03-08 National Institutes Of Biomedical Innovation, Health And Nutrition Non-aggregating immunostimulatory oligonucleotides
WO2016152767A1 (ja) * 2015-03-20 2016-09-29 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途
JPWO2016152767A1 (ja) * 2015-03-20 2018-03-15 国立研究開発法人医薬基盤・健康・栄養研究所 免疫賦活活性を有するＣｐＧスペーサーオリゴヌクレオチド含有複合体及びその用途

Also Published As

Publication number Publication date
RU2009142211A (ru) 2011-05-27
AR066626A1 (es) 2009-09-02
IL202096A0 (en) 2010-06-16
ZA200908062B (en) 2010-06-30
WO2008142509A2 (en) 2008-11-27
MX2009012482A (es) 2009-12-02
CN101678098A (zh) 2010-03-24
KR20100010509A (ko) 2010-02-01
AU2008252577A1 (en) 2008-11-27
US20100285041A1 (en) 2010-11-11
WO2008142509A3 (en) 2009-03-05
CA2687441A1 (en) 2008-11-27
EP2160199A2 (en) 2010-03-10
BRPI0811621A2 (pt) 2014-10-21
TW200916115A (en) 2009-04-16

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