JP2008546640A5 - - Google Patents
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- JP2008546640A5 JP2008546640A5 JP2008511051A JP2008511051A JP2008546640A5 JP 2008546640 A5 JP2008546640 A5 JP 2008546640A5 JP 2008511051 A JP2008511051 A JP 2008511051A JP 2008511051 A JP2008511051 A JP 2008511051A JP 2008546640 A5 JP2008546640 A5 JP 2008546640A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- meta arsenite
- treatment
- sodium
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 210000004072 Lung Anatomy 0.000 claims description 3
- 206010061289 Metastatic neoplasm Diseases 0.000 claims description 3
- 230000001394 metastastic Effects 0.000 claims description 3
- PTLRDCMBXHILCL-UHFFFAOYSA-M Sodium arsenite Chemical compound [Na+].[O-][As]=O PTLRDCMBXHILCL-UHFFFAOYSA-M 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 230000001613 neoplastic Effects 0.000 claims 2
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 102000008072 Lymphokines Human genes 0.000 claims 1
- 108010074338 Lymphokines Proteins 0.000 claims 1
- 206010027452 Metastases to bone Diseases 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 1
- 229960001603 Tamoxifen Drugs 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 229960000074 biopharmaceuticals Drugs 0.000 claims 1
- 239000003102 growth factor Substances 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
- 208000009956 Adenocarcinoma Diseases 0.000 description 6
- 210000004027 cells Anatomy 0.000 description 5
- 206010025323 Lymphomas Diseases 0.000 description 3
- 206010025310 Other lymphomas Diseases 0.000 description 3
- 206010041823 Squamous cell carcinoma Diseases 0.000 description 3
- 210000003932 Urinary Bladder Anatomy 0.000 description 3
- 230000001154 acute Effects 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 206010008958 Chronic lymphocytic leukaemia Diseases 0.000 description 2
- 206010020243 Hodgkin's disease Diseases 0.000 description 2
- 210000003734 Kidney Anatomy 0.000 description 2
- 206010024324 Leukaemias Diseases 0.000 description 2
- 208000000429 Leukemia, Lymphocytic, Chronic, B-Cell Diseases 0.000 description 2
- 210000004185 Liver Anatomy 0.000 description 2
- 206010029592 Non-Hodgkin's lymphomas Diseases 0.000 description 2
- 210000002307 Prostate Anatomy 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 2
- 206010044412 Transitional cell carcinoma Diseases 0.000 description 2
- 208000008383 Wilms Tumor Diseases 0.000 description 2
- 201000009030 carcinoma Diseases 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 201000008026 nephroblastoma Diseases 0.000 description 2
- 201000008968 osteosarcoma Diseases 0.000 description 2
- 206010001019 Acute promyelocytic leukaemia Diseases 0.000 description 1
- 206010059512 Apoptosis Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 210000004369 Blood Anatomy 0.000 description 1
- 210000001185 Bone Marrow Anatomy 0.000 description 1
- 210000000988 Bone and Bones Anatomy 0.000 description 1
- 210000000481 Breast Anatomy 0.000 description 1
- 210000003123 Bronchioles Anatomy 0.000 description 1
- 210000000845 Cartilage Anatomy 0.000 description 1
- 210000003169 Central Nervous System Anatomy 0.000 description 1
- 206010008263 Cervical dysplasia Diseases 0.000 description 1
- 210000003679 Cervix Uteri Anatomy 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 210000003238 Esophagus Anatomy 0.000 description 1
- 206010017758 Gastric cancer Diseases 0.000 description 1
- 210000004907 Glands Anatomy 0.000 description 1
- 208000005017 Glioblastoma Diseases 0.000 description 1
- 208000002927 Hamartoma Diseases 0.000 description 1
- 210000003128 Head Anatomy 0.000 description 1
- 208000002250 Hematologic Neoplasms Diseases 0.000 description 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 description 1
- 206010062904 Hormone-refractory prostate cancer Diseases 0.000 description 1
- 208000007766 Kaposi Sarcoma Diseases 0.000 description 1
- 208000008456 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Diseases 0.000 description 1
- 208000005749 Leukemia, Promyelocytic, Acute Diseases 0.000 description 1
- 206010025650 Malignant melanoma Diseases 0.000 description 1
- 206010027406 Mesothelioma Diseases 0.000 description 1
- 206010028549 Myeloid leukaemia Diseases 0.000 description 1
- 210000003739 Neck Anatomy 0.000 description 1
- 206010029260 Neuroblastoma Diseases 0.000 description 1
- 210000001672 Ovary Anatomy 0.000 description 1
- 208000004019 Papillary Adenocarcinoma Diseases 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
- 208000006265 Renal Cell Carcinoma Diseases 0.000 description 1
- 210000003491 Skin Anatomy 0.000 description 1
- 210000001550 Testis Anatomy 0.000 description 1
- GCPXMJHSNVMWNM-UHFFFAOYSA-N Trihydroxyarsenite(Iii) Chemical compound O[As](O)O GCPXMJHSNVMWNM-UHFFFAOYSA-N 0.000 description 1
- 210000003708 Urethra Anatomy 0.000 description 1
- 201000005510 acute lymphocytic leukemia Diseases 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 229960002594 arsenic trioxide Drugs 0.000 description 1
- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 201000002143 bronchus adenoma Diseases 0.000 description 1
- 230000001684 chronic Effects 0.000 description 1
- 201000006934 chronic myeloid leukemia Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002496 gastric Effects 0.000 description 1
- 230000002489 hematologic Effects 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 201000009251 multiple myeloma Diseases 0.000 description 1
- 201000003793 myelodysplastic syndrome Diseases 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 201000010133 oligodendroglioma Diseases 0.000 description 1
- 201000010198 papillary carcinoma Diseases 0.000 description 1
- 230000001855 preneoplastic Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 201000000582 retinoblastoma Diseases 0.000 description 1
- 230000001568 sexual Effects 0.000 description 1
- 210000004085 squamous epithelial cell Anatomy 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
Description
1991年に国立ガン研究所は、三酸化ヒ素が、多様な癌細胞株において増殖を阻害し、且つアポトーシスを促進することを報告し、血液性悪性疾患、例えば急性前骨髄球性白血病、急性骨髄性白血病、急性リンパ球性白血病、慢性骨髄性白血病、非ホジキンリンパ腫、ホジキン病、慢性リンパ球性白血病、骨髄異形成症候群、及び多発性骨髄腫等における、その臨床的活性を評価するための研究プログラムを開始した。それはまた、固形腫瘍、例えば進行したホルモン抵抗性前立腺癌及び腎細胞癌等についての、並びに子宮頸癌及び膀胱の抵抗性移行上皮細胞癌についての研究も支援している。
本明細書で提供される組成物及び方法は、特に、例えば乳房、中枢神経系、大腸、卵巣、腎臓、肺、肝臓、膀胱、前立腺、頭頸部等の固形腫瘍を含む初期及び転移性新生腫瘍の治療に有用であると考えられる。とりわけ、本発明の組成物及び方法によって治療され得る腫瘍は、上皮由来の腫瘍、例えば、肺：気管支原性癌（扁平上皮細胞、未分化小細胞、未分化大細胞、腺癌）、肺胞（細気管支）癌、気管支腺腫、肉腫、リンパ腫、軟骨性過誤腫、中皮腫；胃腸系：食道（扁平上皮細胞癌、腺癌）、胃癌、大腸癌；泌尿生殖器系：腎臓（腺癌、ウィルムス腫瘍［腎芽細胞腫］、リンパ腫、白血病）、膀胱及び尿道（扁平上皮細胞癌、移行上皮細胞癌、腺癌）、前立腺（腺癌、肉腫）、精巣（精上皮腫）；肝臓：肝癌（肝細胞癌）；骨：骨原性肉腫（骨肉腫）；神経系：神経芽細胞腫、網膜芽細胞腫、グリア芽腫、乏突起膠腫；婦人科系：頸部（子宮頸癌、前腫瘍子宮頸部形成異常）；血液系：血液（骨髄性白血病［急性及び慢性］、急性リンパ芽球性白血病、慢性リンパ球性白血病）、ホジキン病、非ホジキンリンパ腫［悪性リンパ腫］；皮膚：悪性黒色腫、基底細胞癌、扁平上皮細胞癌、カポジ肉腫；並びに腺及び管：腺癌、乳頭状癌及び乳頭状腺癌を含むが、これに制限されない。従って、本明細書で提供される用語「癌性細胞」は、前記に特定された症状のいずれか1つに罹患した細胞を含む。
Claims (7)
- 転移性新生物疾患の治療用の、メタ亜ヒ酸ナトリウムを含む組成物。
- 骨転移の治療用の、メタ亜ヒ酸ナトリウムを含む請求項１に記載の組成物。
- 転移性肺腫瘍の治療用の、メタ亜ヒ酸ナトリウムを含む請求項１に記載の組成物。
- 経口投与に適した、メタ亜ヒ酸ナトリウムを含む請求項１から３のいずれか一項に記載の組成物。
- 他の治療と併用して転移性新生物疾患を治療するための、請求項１から４のいずれか一項に記載の組成物。
- 前記他の治療が化学療法剤である、請求項５に記載の組成物。
- 前記化学療法剤が、タモキシフェン、タキソール、メトトレキサート、生物製剤、抗体、成長因子、および、リンフォカインからなる群から選択される、請求項６に記載の組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05076071A EP1721615A1 (en) | 2005-05-09 | 2005-05-09 | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| EP05076071.9 | 2005-05-09 | ||
| PCT/KR2006/001731 WO2006121280A1 (en) | 2005-05-09 | 2006-05-09 | Pharmaceutical compositions comprising of arsenous acid, its sodium salt and its derivatives intended for the treatment of urogenital cancer and its metastasis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008546640A JP2008546640A (ja) | 2008-12-25 |
| JP2008546640A5 true JP2008546640A5 (ja) | 2012-06-14 |
| JP5026408B2 JP5026408B2 (ja) | 2012-09-12 |
Family
ID=35197739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008511051A Active JP5026408B2 (ja) | 2005-05-09 | 2006-05-09 | 泌尿生殖器癌及びその転移の治療を意図した、亜ヒ酸、そのナトリウム塩、及びその誘導体を含む製薬組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20090011047A1 (ja) |
| EP (5) | EP1721615A1 (ja) |
| JP (1) | JP5026408B2 (ja) |
| KR (3) | KR20160035101A (ja) |
| CN (2) | CN104758312A (ja) |
| AR (1) | AR054448A1 (ja) |
| AU (1) | AU2006244767B2 (ja) |
| BR (1) | BRPI0608716A2 (ja) |
| CA (3) | CA2926846C (ja) |
| CY (2) | CY1113475T1 (ja) |
| DK (2) | DK1885380T3 (ja) |
| ES (2) | ES2394264T3 (ja) |
| HK (1) | HK1109736A1 (ja) |
| HU (1) | HUE046029T2 (ja) |
| IL (3) | IL187220A (ja) |
| LT (1) | LT3067068T (ja) |
| PL (2) | PL3067068T3 (ja) |
| PT (1) | PT1885380E (ja) |
| RU (1) | RU2401662C2 (ja) |
| SG (5) | SG175633A1 (ja) |
| SI (2) | SI1885380T1 (ja) |
| TW (5) | TWI574692B (ja) |
| WO (1) | WO2006121280A1 (ja) |
| ZA (1) | ZA200710559B (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1721615A1 (en) | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US8945505B2 (en) * | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
| US20090246291A1 (en) | 2008-03-27 | 2009-10-01 | Angelika Burger | Method and compositions for treatment of cancer |
| US20120045520A1 (en) * | 2008-08-21 | 2012-02-23 | Sang Bong Lee | Pharmaceutical composition comprising arsenite for the treatment of malignancy |
| EP2475362B1 (en) * | 2009-09-10 | 2019-03-27 | Kominox, Inc. | Cancer stem cell-targeted and drug resistant cancer therapy |
| SG179192A1 (en) * | 2009-09-18 | 2012-05-30 | Kominox Inc | Methods for treating brain tumors |
| US8735171B2 (en) | 2010-01-13 | 2014-05-27 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Promyelocytic leukemia protein as a redox sensor |
| AU2012206649A1 (en) * | 2011-01-11 | 2013-07-04 | Universitat Basel | Combination of syrosingopine and mitochondrial inhibitors for the treatment of cancer and immunosuppression |
| US20120251628A1 (en) * | 2011-03-30 | 2012-10-04 | Young Joo Min | Compositions and methods for treatment of cancer |
| KR101309844B1 (ko) * | 2013-03-15 | 2013-09-23 | 박상채 | 항암 활성 증진용 한약재 및 이의 제조방법 |
| RU2618405C1 (ru) * | 2015-12-31 | 2017-05-03 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ определения продолжительности адъювантной химиотерапии при местно-распространенном колоректальном раке с метастазами в регионарные лимфоузлы после радикальных оперативных вмешательств |
| US10806768B2 (en) * | 2016-05-26 | 2020-10-20 | Stephen N. Pitcher | Composition for promoting metallothionein production |
| DK3548044T3 (en) | 2016-12-01 | 2023-12-11 | Eupharma Pty Ltd | Arsenic compositions |
| AR114596A1 (es) * | 2018-03-22 | 2020-09-23 | Komipharm Int Australia Pty Ltd | Composición farmacéutica y método de fabricación |
| WO2019234112A1 (en) * | 2018-06-05 | 2019-12-12 | Katholieke Universiteit Leuven | Combination treatment of arsenic oxide and antiandrogens |
| JOP20220192A1 (ar) * | 2020-02-16 | 2023-01-30 | Panaphix Inc | طريقة علاج باستخدام ميتا-الزرنيخ |
| KR20220020637A (ko) * | 2020-08-12 | 2022-02-21 | 이상봉 | 항암화학요법이나 방사선요법으로 인한 암 환자의 탈모증을 포함한 탈모증 환자에 대하여 탈모를 방지하고 발모를 촉진하는 메타아르세나이트의 염을 함유하는 경구 투여용 약학적 조성물 |
| KR20220020635A (ko) * | 2020-08-12 | 2022-02-21 | 이상봉 | 탈모방지 또는 발모촉진용 외용제 조성물 |
| KR20220020633A (ko) * | 2020-08-12 | 2022-02-21 | 이상봉 | 탈모방지 또는 발모촉진용 주사제 조성물 |
| CN112336746A (zh) * | 2020-10-23 | 2021-02-09 | 内蒙古科技大学包头医学院 | 一种膀胱癌灌注化疗药物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| FR2431686A1 (fr) | 1978-07-20 | 1980-02-15 | Nestle Sa Soc Ass Tech Prod | Mecanisme de dosage et d'equilibrage et machine de remplissage comprenant un tel mecanisme |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| KR930001917A (ko) * | 1991-07-26 | 1993-02-22 | 김두석 | 악성 종양 치료제의 제조방법 |
| WO1995022336A1 (fr) | 1994-02-18 | 1995-08-24 | Tamara Vasilievna Vorobieva | Agent immunomodulateur et reducteur du dysfonctionnement du systeme de regulation de la propagation de cellules tissulaires |
| EP1419778A1 (en) * | 1997-10-15 | 2004-05-19 | Polarx Biopharmaceuticals, Inc. | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds |
| DK2255800T3 (da) | 1997-11-10 | 2013-02-04 | Sloan Kettering Inst Cancer | Arsentrioxid til anvendelse ved behandling af leukæmi |
| CN1233476A (zh) * | 1998-04-24 | 1999-11-03 | 陆道培 | 治疗急性白血病的药物及其制备方法 |
| KR20020083678A (ko) * | 2001-04-28 | 2002-11-04 | 주식회사 한국미생물연구소 | 아르세닉산나트륨 염, 소디움 메타아르세나이트 또는 이의혼합물을 함유한 항암제 조성물 |
| TW200408407A (en) | 2001-11-30 | 2004-06-01 | Dana Farber Cancer Inst Inc | Methods and compositions for modulating the immune system and uses thereof |
| RO123269B1 (ro) * | 2002-04-10 | 2011-05-30 | Komipharm International Co., Ltd. | Utilizarea meta-arsenitului de sodiu pentru tratamentul tumorilor solide |
| KR100632250B1 (ko) * | 2004-02-16 | 2006-10-11 | 정태호 | 비소 화합물을 유효성분으로 하는 항암제 |
| US20060104292A1 (en) | 2004-11-15 | 2006-05-18 | Gupta Vivek G | System and methods for supporting multiple communications interfaces with single client interface |
| EP1721615A1 (en) | 2005-05-09 | 2006-11-15 | Komipharm International Co., Ltd. | Pharmaceutical compositions comprising sodium or potassium arsenite for the treatment of urogenital cancer and its metastasis |
| US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
| US20090246291A1 (en) | 2008-03-27 | 2009-10-01 | Angelika Burger | Method and compositions for treatment of cancer |
| EP2475362B1 (en) | 2009-09-10 | 2019-03-27 | Kominox, Inc. | Cancer stem cell-targeted and drug resistant cancer therapy |
-
2005
- 2005-05-09 EP EP05076071A patent/EP1721615A1/en not_active Withdrawn
-
2006
- 2006-05-09 EP EP14166070.4A patent/EP2762145A1/en not_active Ceased
- 2006-05-09 SG SG2011075330A patent/SG175633A1/en unknown
- 2006-05-09 US US11/631,962 patent/US20090011047A1/en not_active Abandoned
- 2006-05-09 EP EP06732912A patent/EP1885380B1/en active Active
- 2006-05-09 TW TW104124162A patent/TWI574692B/zh active
- 2006-05-09 SI SI200631444T patent/SI1885380T1/sl unknown
- 2006-05-09 CN CN201510064962.8A patent/CN104758312A/zh active Pending
- 2006-05-09 BR BRPI0608716-7A patent/BRPI0608716A2/pt not_active Application Discontinuation
- 2006-05-09 KR KR1020167007395A patent/KR20160035101A/ko not_active Application Discontinuation
- 2006-05-09 AR ARP060101851A patent/AR054448A1/es unknown
- 2006-05-09 TW TW095116432A patent/TWI386214B/zh active
- 2006-05-09 SG SG10201602555WA patent/SG10201602555WA/en unknown
- 2006-05-09 TW TW105102103A patent/TW201615200A/zh unknown
- 2006-05-09 ES ES06732912T patent/ES2394264T3/es active Active
- 2006-05-09 EP EP16162414.3A patent/EP3067068B1/en active Active
- 2006-05-09 TW TW101132058A patent/TWI539957B/zh active
- 2006-05-09 ES ES16162414T patent/ES2754372T3/es active Active
- 2006-05-09 CA CA2926846A patent/CA2926846C/en active Active
- 2006-05-09 LT LT16162414T patent/LT3067068T/lt unknown
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