JP2008545712A5 - - Google Patents
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- JP2008545712A5 JP2008545712A5 JP2008513797A JP2008513797A JP2008545712A5 JP 2008545712 A5 JP2008545712 A5 JP 2008545712A5 JP 2008513797 A JP2008513797 A JP 2008513797A JP 2008513797 A JP2008513797 A JP 2008513797A JP 2008545712 A5 JP2008545712 A5 JP 2008545712A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- derivative
- peptide
- analog
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 27
- 239000008194 pharmaceutical composition Substances 0.000 claims description 23
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- JUFFVKRROAPVBI-PVOYSMBESA-N chembl1210015 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N[C@H]1[C@@H]([C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@]3(O[C@@H](C[C@H](O)[C@H](O)CO)[C@H](NC(C)=O)[C@@H](O)C3)C(O)=O)O2)O)[C@@H](CO)O1)NC(C)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 JUFFVKRROAPVBI-PVOYSMBESA-N 0.000 claims description 4
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- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims description 3
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- JWUBBDSIWDLEOM-XHQRYOPUSA-N (3e)-3-[(2e)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical compound C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2\C1=C\C=C1/CC(O)CCC1=C JWUBBDSIWDLEOM-XHQRYOPUSA-N 0.000 claims 1
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| EP2941250A4 (en) * | 2013-01-04 | 2016-07-27 | Claresa Levetan | INSULIN INDEPENDENCE IN PATIENTS WITH DIABETES USING A PPI IN COMBINATION WITH AN IMMUNO-TOLERANT |
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| FR3004354A1 (fr) * | 2013-04-10 | 2014-10-17 | Alfact Innovation | Composition comprenant la proteine hip/pap ou l'un de ses derives pour le traitement de la resistance a l'insuline |
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| US9321812B2 (en) * | 2014-03-28 | 2016-04-26 | Perle Bioscience | Insulin independence among patients with diabetes utilizing an optimized hamster REG3 gamma peptide |
| JP6672175B2 (ja) | 2014-05-07 | 2020-03-25 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１及び抗ｉｌ−２１を使用した１型糖尿病の治療 |
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2006
- 2006-05-25 JP JP2008513797A patent/JP2008545712A/ja active Pending
- 2006-05-25 EA EA200702625A patent/EA013821B1/ru not_active IP Right Cessation
- 2006-05-25 EP EP10181798.9A patent/EP2295066B1/en not_active Expired - Lifetime
- 2006-05-25 CA CA2726759A patent/CA2726759C/en not_active Expired - Fee Related
- 2006-05-25 WO PCT/US2006/020644 patent/WO2006128083A2/en not_active Ceased
- 2006-05-25 EP EP06771419A patent/EP1883417A2/en not_active Withdrawn
- 2006-05-25 US US11/441,491 patent/US7393919B2/en not_active Expired - Fee Related
- 2006-05-25 CA CA2609667A patent/CA2609667C/en not_active Expired - Fee Related
-
2008
- 2008-05-15 US US12/121,123 patent/US7714103B2/en not_active Expired - Fee Related
-
2009
- 2009-12-10 US US12/635,053 patent/US7989415B2/en not_active Expired - Fee Related
-
2011
- 2011-06-24 US US13/168,461 patent/US8383578B2/en not_active Expired - Fee Related
-
2013
- 2013-01-18 US US13/745,706 patent/US8829158B2/en not_active Expired - Fee Related
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2014
- 2014-09-04 US US14/477,484 patent/US20150056167A1/en not_active Abandoned
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