JP2008543902A - 皮膚潰瘍を処置するための方法および組成物 - Google Patents
皮膚潰瘍を処置するための方法および組成物 Download PDFInfo
- Publication number
- JP2008543902A JP2008543902A JP2008517423A JP2008517423A JP2008543902A JP 2008543902 A JP2008543902 A JP 2008543902A JP 2008517423 A JP2008517423 A JP 2008517423A JP 2008517423 A JP2008517423 A JP 2008517423A JP 2008543902 A JP2008543902 A JP 2008543902A
- Authority
- JP
- Japan
- Prior art keywords
- proanthocyanidins
- patient
- days
- composition
- ulcers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 206010040943 Skin Ulcer Diseases 0.000 title claims description 9
- 231100000019 skin ulcer Toxicity 0.000 title description 2
- 229920002770 condensed tannin Polymers 0.000 claims abstract description 78
- 208000025865 Ulcer Diseases 0.000 claims abstract description 50
- 231100000397 ulcer Toxicity 0.000 claims abstract description 42
- 230000000699 topical effect Effects 0.000 claims abstract description 16
- 208000005230 Leg Ulcer Diseases 0.000 claims abstract description 13
- 210000003141 lower extremity Anatomy 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims description 34
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 claims description 13
- 229920001991 Proanthocyanidin Polymers 0.000 claims description 13
- 206010052428 Wound Diseases 0.000 claims description 12
- 208000027418 Wounds and injury Diseases 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 7
- 241000196324 Embryophyta Species 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 235000010204 pine bark Nutrition 0.000 claims description 6
- 235000005105 Pinus pinaster Nutrition 0.000 claims description 4
- 241001236212 Pinus pinaster Species 0.000 claims description 4
- 239000000419 plant extract Substances 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- -1 drinks Substances 0.000 claims description 2
- 235000013373 food additive Nutrition 0.000 claims description 2
- 239000002778 food additive Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 230000000737 periodic effect Effects 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- 235000018192 pine bark supplement Nutrition 0.000 description 25
- 229940106796 pycnogenol Drugs 0.000 description 25
- 230000035876 healing Effects 0.000 description 18
- 230000000694 effects Effects 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 201000002816 chronic venous insufficiency Diseases 0.000 description 9
- 238000007906 compression Methods 0.000 description 9
- 230000006835 compression Effects 0.000 description 9
- 201000002282 venous insufficiency Diseases 0.000 description 9
- 206010012601 diabetes mellitus Diseases 0.000 description 8
- 230000036269 ulceration Effects 0.000 description 8
- 101100243025 Arabidopsis thaliana PCO2 gene Proteins 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 230000004089 microcirculation Effects 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 206010030113 Oedema Diseases 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 6
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 description 6
- 206010020772 Hypertension Diseases 0.000 description 5
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 5
- 230000004087 circulation Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229920002414 procyanidin Polymers 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 238000011200 topical administration Methods 0.000 description 5
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 4
- CXQWRCVTCMQVQX-LSDHHAIUSA-N (+)-taxifolin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-LSDHHAIUSA-N 0.000 description 4
- 244000105624 Arachis hypogaea Species 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- 208000000558 Varicose Ulcer Diseases 0.000 description 4
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 4
- 235000005487 catechin Nutrition 0.000 description 4
- 229950001002 cianidanol Drugs 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 235000020232 peanut Nutrition 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- QAIPRVGONGVQAS-DUXPYHPUSA-N trans-caffeic acid Chemical compound OC(=O)\C=C\C1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-DUXPYHPUSA-N 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 3
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 3
- YQUVCSBJEUQKSH-UHFFFAOYSA-N 3,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C(O)=C1 YQUVCSBJEUQKSH-UHFFFAOYSA-N 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 244000070406 Malus silvestris Species 0.000 description 3
- 244000299461 Theobroma cacao Species 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 235000009754 Vitis X bourquina Nutrition 0.000 description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 description 3
- 240000006365 Vitis vinifera Species 0.000 description 3
- 235000014787 Vitis vinifera Nutrition 0.000 description 3
- 235000021016 apples Nutrition 0.000 description 3
- 235000001671 coumarin Nutrition 0.000 description 3
- 229960000956 coumarin Drugs 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 3
- 235000012734 epicatechin Nutrition 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 238000007632 sclerotherapy Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- ACEAELOMUCBPJP-UHFFFAOYSA-N (E)-3,4,5-trihydroxycinnamic acid Natural products OC(=O)C=CC1=CC(O)=C(O)C(O)=C1 ACEAELOMUCBPJP-UHFFFAOYSA-N 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 2
- 206010056340 Diabetic ulcer Diseases 0.000 description 2
- 244000194101 Ginkgo biloba Species 0.000 description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 208000008589 Obesity Diseases 0.000 description 2
- 244000046052 Phaseolus vulgaris Species 0.000 description 2
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
- 240000003768 Solanum lycopersicum Species 0.000 description 2
- 240000004584 Tamarindus indica Species 0.000 description 2
- 235000004298 Tamarindus indica Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 235000009470 Theobroma cacao Nutrition 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- 241000893966 Trichophyton verrucosum Species 0.000 description 2
- 241001106462 Ulmus Species 0.000 description 2
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
- 240000000851 Vaccinium corymbosum Species 0.000 description 2
- 240000001717 Vaccinium macrocarpon Species 0.000 description 2
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 2
- 235000020224 almond Nutrition 0.000 description 2
- 210000003423 ankle Anatomy 0.000 description 2
- 235000021014 blueberries Nutrition 0.000 description 2
- 235000004883 caffeic acid Nutrition 0.000 description 2
- 229940074360 caffeic acid Drugs 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- QAIPRVGONGVQAS-UHFFFAOYSA-N cis-caffeic acid Natural products OC(=O)C=CC1=CC=C(O)C(O)=C1 QAIPRVGONGVQAS-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 208000027744 congestion Diseases 0.000 description 2
- 235000021019 cranberries Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- KQNGHARGJDXHKF-UHFFFAOYSA-N dihydrotamarixetin Natural products C1=C(O)C(OC)=CC=C1C1C(O)C(=O)C2=C(O)C=C(O)C=C2O1 KQNGHARGJDXHKF-UHFFFAOYSA-N 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 2
- 235000001785 ferulic acid Nutrition 0.000 description 2
- 229940114124 ferulic acid Drugs 0.000 description 2
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 206010062198 microangiopathy Diseases 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000020824 obesity Nutrition 0.000 description 2
- 150000007965 phenolic acids Chemical class 0.000 description 2
- 235000009048 phenolic acids Nutrition 0.000 description 2
- 208000001297 phlebitis Diseases 0.000 description 2
- 235000020741 pine bark extract Nutrition 0.000 description 2
- 229940106587 pine bark extract Drugs 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 1
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 description 1
- 201000006082 Chickenpox Diseases 0.000 description 1
- 235000016795 Cola Nutrition 0.000 description 1
- 241001634499 Cola Species 0.000 description 1
- 235000011824 Cola pachycarpa Nutrition 0.000 description 1
- 208000007163 Dermatomycoses Diseases 0.000 description 1
- 206010063547 Diabetic macroangiopathy Diseases 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 208000001034 Frostbite Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 1
- 229930182448 Prodelphinidin Natural products 0.000 description 1
- 229920000124 Prodelphinidin Polymers 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040844 Skin exfoliation Diseases 0.000 description 1
- 206010040954 Skin wrinkling Diseases 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
- 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
- 206010046980 Varicella Diseases 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940093797 bioflavonoids Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000001046 cacaotero Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000011284 combination treatment Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 201000003929 dermatomycosis Diseases 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 230000002857 effect on ulcer Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 125000002791 glucosyl group Chemical class C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000010187 selection method Methods 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 206010040872 skin infection Diseases 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 235000021012 strawberries Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- WKOLLVMJNQIZCI-UHFFFAOYSA-N vanillic acid Chemical compound COC1=CC(C(O)=O)=CC=C1O WKOLLVMJNQIZCI-UHFFFAOYSA-N 0.000 description 1
- TUUBOHWZSQXCSW-UHFFFAOYSA-N vanillic acid Natural products COC1=CC(O)=CC(C(O)=O)=C1 TUUBOHWZSQXCSW-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/166,510 US20060293258A1 (en) | 2005-06-23 | 2005-06-23 | Method and composition to treat skin ulcers |
| PCT/EP2006/006048 WO2006136428A2 (en) | 2005-06-23 | 2006-06-23 | Method and composition to treat skin ulcers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008543902A true JP2008543902A (ja) | 2008-12-04 |
| JP2008543902A5 JP2008543902A5 (https=) | 2009-08-06 |
Family
ID=37568333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517423A Pending JP2008543902A (ja) | 2005-06-23 | 2006-06-23 | 皮膚潰瘍を処置するための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060293258A1 (https=) |
| EP (1) | EP1896010A2 (https=) |
| JP (1) | JP2008543902A (https=) |
| AU (1) | AU2006261108A1 (https=) |
| CA (1) | CA2612750A1 (https=) |
| WO (1) | WO2006136428A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014104064A1 (ja) * | 2012-12-26 | 2014-07-03 | 株式会社エーゼット | 創傷治癒促進剤 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2657915A1 (en) * | 2006-07-21 | 2008-01-24 | Mars, Incorporated | Improvement of arginase levels/activity |
| BR112012012476A2 (pt) * | 2009-11-25 | 2015-09-15 | Nestec Sa | "composições nutritivas incluindo um componente de alta proteína e nucleotídeos exôgenos" |
| CN104582699B (zh) * | 2012-08-07 | 2019-10-22 | 英德斯生物技术私营有限公司 | 控制糖尿病足溃疡、压迫性溃疡、静脉性下肢溃疡和相关并发症的方法 |
| US10398664B2 (en) | 2013-05-01 | 2019-09-03 | Lanny Leo Johnson | Methods of diagnosing and treating infected implants |
| US9498413B2 (en) * | 2013-05-01 | 2016-11-22 | Lanny Leo Johnson | Antimicrobials and methods of use thereof for wound healing |
| US10016380B2 (en) | 2013-05-01 | 2018-07-10 | Lanny Leo Johnson | Antimicrobials and methods of use thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6377390A (ja) * | 1986-09-20 | 1988-04-07 | Sanyo Electric Co Ltd | キヤプスタンモ−タサ−ボ回路 |
| JP2003504402A (ja) * | 1999-07-16 | 2003-02-04 | エルジー ハウスホールド アンド ヘルス ケア エルティーディー． | マトリックスメタロプロテアーゼを阻害するプロシアニジンオリゴマー及びこれを有効成分とする薬剤 |
| JP2003504385A (ja) * | 1999-07-16 | 2003-02-04 | インダストリア エ コメルシオ デ コスメティコス ナチュラ リミタダ | 化粧及び医薬の用途のための組成物 |
| JP2003511476A (ja) * | 1999-10-20 | 2003-03-25 | ベーリンガー インゲルハイム インターナシヨナル ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク | 赤色ブドウ樹葉の抽出物を用いる慢性静脈不全の治療方法 |
| JP2005047818A (ja) * | 2002-07-29 | 2005-02-24 | Toyo Shinyaku:Kk | 健康食品および健康飲料 |
| JP2005047839A (ja) * | 2003-07-31 | 2005-02-24 | Toyo Shinyaku:Kk | プロアントシアニジン含有組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518289D0 (en) * | 1985-07-19 | 1985-08-29 | Inverni Della Beffa Spa | Obtaining proanthocyanidine a2 |
| IT1270999B (it) * | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5470874A (en) * | 1994-10-14 | 1995-11-28 | Lerner; Sheldon | Ascorbic acid and proanthocyanidine composition for topical application to human skin |
| US5804594A (en) * | 1997-01-22 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for improving wrinkles and other skin conditions |
| JP2001511153A (ja) * | 1997-02-04 | 2001-08-07 | ブイ． コスバブ，ジョン | 血管変性性疾患の予防および処置のための組成物および方法 |
-
2005
- 2005-06-23 US US11/166,510 patent/US20060293258A1/en not_active Abandoned
-
2006
- 2006-06-23 WO PCT/EP2006/006048 patent/WO2006136428A2/en not_active Ceased
- 2006-06-23 JP JP2008517423A patent/JP2008543902A/ja active Pending
- 2006-06-23 AU AU2006261108A patent/AU2006261108A1/en not_active Abandoned
- 2006-06-23 EP EP06762149A patent/EP1896010A2/en not_active Withdrawn
- 2006-06-23 CA CA002612750A patent/CA2612750A1/en not_active Abandoned
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6377390A (ja) * | 1986-09-20 | 1988-04-07 | Sanyo Electric Co Ltd | キヤプスタンモ−タサ−ボ回路 |
| JP2003504402A (ja) * | 1999-07-16 | 2003-02-04 | エルジー ハウスホールド アンド ヘルス ケア エルティーディー． | マトリックスメタロプロテアーゼを阻害するプロシアニジンオリゴマー及びこれを有効成分とする薬剤 |
| JP2003504385A (ja) * | 1999-07-16 | 2003-02-04 | インダストリア エ コメルシオ デ コスメティコス ナチュラ リミタダ | 化粧及び医薬の用途のための組成物 |
| JP2003511476A (ja) * | 1999-10-20 | 2003-03-25 | ベーリンガー インゲルハイム インターナシヨナル ゲゼルシヤフト ミツト ベシユレンクテル ハフツンク | 赤色ブドウ樹葉の抽出物を用いる慢性静脈不全の治療方法 |
| JP2005047818A (ja) * | 2002-07-29 | 2005-02-24 | Toyo Shinyaku:Kk | 健康食品および健康飲料 |
| JP2005047839A (ja) * | 2003-07-31 | 2005-02-24 | Toyo Shinyaku:Kk | プロアントシアニジン含有組成物 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014104064A1 (ja) * | 2012-12-26 | 2014-07-03 | 株式会社エーゼット | 創傷治癒促進剤 |
| JPWO2014104064A1 (ja) * | 2012-12-26 | 2017-01-12 | 株式会社エーゼット | 創傷治癒促進剤 |
| US9962364B2 (en) | 2012-12-26 | 2018-05-08 | A-Z Ltd. | Wound healing accelerator |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006136428A3 (en) | 2007-04-12 |
| WO2006136428A2 (en) | 2006-12-28 |
| US20060293258A1 (en) | 2006-12-28 |
| EP1896010A2 (en) | 2008-03-12 |
| CA2612750A1 (en) | 2006-12-28 |
| AU2006261108A1 (en) | 2006-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6495183B2 (ja) | 表面の創傷を処置するための組成物および方法 | |
| HK1048580B (zh) | 用红藤叶萃取物治疗慢性静脉机能不全的方法 | |
| KR20130120375A (ko) | 피부 궤양을 치료 및/또는 예방하기 위한 성분의 키트 | |
| JP2008543902A (ja) | 皮膚潰瘍を処置するための方法および組成物 | |
| KR101451816B1 (ko) | 당뇨병성 창상의 예방 또는 치료용 약학 조성물 | |
| AU2012307406B2 (en) | Compositions for the treatment of peripheral ulcers of various origins | |
| US20250090598A1 (en) | Systems and methods for thrombosis prevention | |
| ES2335729B1 (es) | Composicion cosmetica para pieles sensibles. | |
| RS55672B1 (sr) | Supstance oleuropeina za lečenje rana i čireva kod starijih ljudi i/ili dijabetičara | |
| RU2416425C1 (ru) | Масло противопролежневое | |
| AU2013301215B2 (en) | A method of managing diabetic foot ulcers, pressure ulcers, venous leg ulcers and associated complication | |
| CN109432117B (zh) | 一种促进术后皮肤伤口愈合的外用药物及其用途 | |
| Abascal et al. | Botanicals for chronic venous insufficiency | |
| US20190365735A1 (en) | Compositions and methods for treating varicose veins | |
| JP2024065091A (ja) | 傷害および／または皮膚症状を処置するための組成物および方法 | |
| Belcaro et al. | Treatment of chronic venous insufficiency and prevention of economy class syndrome. | |
| Daley | Chronic venous insufficiency | |
| Shojaii | 22 Myrtus communis L. | |
| WO2019038766A1 (en) | MEDICINAL PRODUCT FOR THE TREATMENT OF TROPHIC ULCERS AND WOUNDS AND BURNS OF VARIOUS ORIGIN |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090618 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090618 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120127 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120622 |