JP2008542386A5 - - Google Patents
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- Publication number
- JP2008542386A5 JP2008542386A5 JP2008514814A JP2008514814A JP2008542386A5 JP 2008542386 A5 JP2008542386 A5 JP 2008542386A5 JP 2008514814 A JP2008514814 A JP 2008514814A JP 2008514814 A JP2008514814 A JP 2008514814A JP 2008542386 A5 JP2008542386 A5 JP 2008542386A5
- Authority
- JP
- Japan
- Prior art keywords
- och
- conh
- aryl
- chco
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 24
- 150000001875 compounds Chemical class 0.000 claims 17
- 201000002674 obstructive nephropathy Diseases 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000004432 carbon atoms Chemical group C* 0.000 claims 3
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatoms Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000008466 Metabolic Disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 230000000271 cardiovascular Effects 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68658505P | 2005-06-02 | 2005-06-02 | |
| US60/686,585 | 2005-06-02 | ||
| PCT/US2006/021142 WO2006130707A2 (en) | 2005-06-02 | 2006-06-01 | Mao-b inhibitors useful for treating obesity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542386A JP2008542386A (ja) | 2008-11-27 |
| JP2008542386A5 true JP2008542386A5 (US20040106767A1-20040603-C00005.png) | 2012-07-12 |
| JP5253155B2 JP5253155B2 (ja) | 2013-07-31 |
Family
ID=37482280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008514814A Expired - Fee Related JP5253155B2 (ja) | 2005-06-02 | 2006-06-01 | 肥満治療に有用なｍａｏ−ｂ阻害剤 |
Country Status (10)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI361075B (en) * | 2007-03-16 | 2012-04-01 | Brion Res Inst Of Taiwan | Pharmaceutical composition for inhibiting the syndrome of snore |
| EP2053033A1 (en) * | 2007-10-26 | 2009-04-29 | Bayer Schering Pharma AG | Compounds for use in imaging, diagnosing and/or treatment of diseases of the central nervous system or of tumors |
| IT1392914B1 (it) * | 2009-01-22 | 2012-04-02 | Dipharma Francis Srl | Procedimento per la preparazione di (r)-n-propargil-1-amminoindano e suoi sali |
| KR102007633B1 (ko) * | 2016-12-15 | 2019-08-06 | 일동제약(주) | 신규 페닐 프로피온 산 유도체 및 이의 용도 |
| CN107056630B (zh) * | 2017-01-23 | 2020-01-17 | 合肥工业大学 | 一种茚满类衍生物及其合成方法和在医药上的用途 |
| BR112020005489A2 (pt) | 2017-09-22 | 2020-09-24 | Jubilant Epipad Llc, | composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer |
| PT3697785T (pt) | 2017-10-18 | 2023-04-03 | Jubilant Epipad LLC | Compostos de imidazopiridina como inibidores de pad |
| BR112020008851A2 (pt) | 2017-11-06 | 2020-10-20 | Jubilant Prodel LLC | composto da fórmula i, processo de preparação de compostos da fórmula i, composição farmacêutica, método para o tratamento e/ou prevenção de várias doenças, uso, método para o tratamento de câncer, método de tratamento de câncer e método para o tratamento e/ou prevenção de câncer e doenças infecciosas |
| JP7368369B2 (ja) | 2017-11-24 | 2023-10-24 | ジュビラント・エピスクライブ・エルエルシー | Ｐｒｍｔ５阻害剤としてのヘテロ環式化合物 |
| WO2019175897A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| US20220409598A1 (en) * | 2021-06-21 | 2022-12-29 | Ildong Pharmaceutical Co., Ltd. | Method of controlling blood sugar level and treatment of diabetes and related conditions |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3201470A (en) | 1965-08-17 | Chsx c cech | ||
| US3253037A (en) | 1962-06-19 | 1966-05-24 | Ciba Geigy Corp | N-2-alkynyl-amino-benzocylo-alkanes |
| GB1187017A (en) | 1966-07-16 | 1970-04-08 | Aspro Nicholas Ltd | Substituted 1-Amino Indanes and Tetrahydronaphthalens |
| IL92952A (en) * | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| IL112819A (en) * | 1991-10-16 | 2001-11-25 | Teva Pharma | Fluorinated 1-aminoindan compounds and a process for their preparation |
| US5877218A (en) | 1994-01-10 | 1999-03-02 | Teva Pharmaceutical Industries, Ltd. | Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| ZA96211B (en) | 1995-01-12 | 1996-07-26 | Teva Pharma | Compositions containing and methods of using 1- aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives |
| DE69732984T2 (de) * | 1996-12-18 | 2006-02-16 | Teva Pharmaceutical Industries Ltd. | Aminoindanderivate |
| EP1078632A1 (en) * | 1999-08-16 | 2001-02-28 | Sanofi-Synthelabo | Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity |
| DE10142667B4 (de) * | 2001-08-31 | 2004-06-09 | Aventis Pharma Deutschland Gmbh | C2-substituierte Indan-1-ole und ihre Derivate und ihre Verwendung als Arzneimittel |
| CN1606552A (zh) * | 2001-12-21 | 2005-04-13 | H.隆德贝克有限公司 | 氨基茚满衍生物作为5－羟色胺和去甲肾上腺素摄取抑制剂 |
| US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| JP2005523289A (ja) | 2002-02-27 | 2005-08-04 | テバ ファーマシューティカル インダストリーズ リミティド | 脳選択性ｍａｏ阻害剤としてのプロパルギルアミノインダン誘導体及びプロパルギルアミノテトラリン誘導体 |
| EP2433626B1 (en) * | 2003-11-25 | 2015-11-04 | Technion Research & Development Foundation Ltd. | Compositions and methods for treatment of cardiovascular disorders and diseases |
| WO2005084205A2 (en) * | 2004-02-27 | 2005-09-15 | Teva Pharmaceutical Industries, Ltd. | Diamino thiazoloindan derivatives and their use |
| US20050197365A1 (en) * | 2004-02-27 | 2005-09-08 | Jeffrey Sterling | Diamino thiazoloindan derivatives and their use |
| JP2008531546A (ja) | 2005-02-22 | 2008-08-14 | テバ ファーマシューティカル インダストリーズ リミティド | エナンチオマー性インダニルアミン誘導体の合成のための改良されたプロセス |
-
2006
- 2006-06-01 AU AU2006252540A patent/AU2006252540B2/en not_active Ceased
- 2006-06-01 CA CA002620476A patent/CA2620476A1/en not_active Abandoned
- 2006-06-01 US US11/445,044 patent/US7649115B2/en not_active Expired - Fee Related
- 2006-06-01 CN CN2006800273036A patent/CN101300006B/zh not_active Expired - Fee Related
- 2006-06-01 NZ NZ564130A patent/NZ564130A/en not_active IP Right Cessation
- 2006-06-01 WO PCT/US2006/021142 patent/WO2006130707A2/en active Application Filing
- 2006-06-01 EP EP06771748A patent/EP1890690A4/en not_active Withdrawn
- 2006-06-01 JP JP2008514814A patent/JP5253155B2/ja not_active Expired - Fee Related
-
2007
- 2007-12-02 IL IL187825A patent/IL187825A/en not_active IP Right Cessation
-
2008
- 2008-01-02 ZA ZA200800036A patent/ZA200800036B/xx unknown
-
2009
- 2009-12-31 US US12/650,642 patent/US8541475B2/en not_active Expired - Fee Related
