JP2008541729A5 - - Google Patents

Info

Publication number

JP2008541729A5

JP2008541729A5 JP2008513714A JP2008513714A JP2008541729A5 JP 2008541729 A5 JP2008541729 A5 JP 2008541729A5 JP 2008513714 A JP2008513714 A JP 2008513714A JP 2008513714 A JP2008513714 A JP 2008513714A JP 2008541729 A5 JP2008541729 A5 JP 2008541729A5

Authority

JP

Japan

Prior art keywords

region

composition

compound

modified

compound according

Prior art date

2006-05-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 29
• 239000000203 mixture Substances 0.000 claims 23
• 238000000034 method Methods 0.000 claims 11
• 208000024891 symptom Diseases 0.000 claims 10
• 241001465754 Metazoa Species 0.000 claims 8
• 230000000692 anti-sense effect Effects 0.000 claims 7
• 206010022489 Insulin Resistance Diseases 0.000 claims 6
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
• 238000007385 chemical modification Methods 0.000 claims 5
• 239000002773 nucleotide Substances 0.000 claims 5
• 125000003729 nucleotide group Chemical group 0.000 claims 5
• UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 5
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 4
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 4
• 208000008589 Obesity Diseases 0.000 claims 3
• 235000012000 cholesterol Nutrition 0.000 claims 3
• 235000020824 obesity Nutrition 0.000 claims 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
• 102000004877 Insulin Human genes 0.000 claims 2
• 108090001061 Insulin Proteins 0.000 claims 2
• 102100040323 Low molecular weight phosphotyrosine protein phosphatase Human genes 0.000 claims 2
• 101710186835 Low molecular weight phosphotyrosine protein phosphatase Proteins 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
• RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 206010012601 diabetes mellitus Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 239000008103 glucose Substances 0.000 claims 2
• 229940125396 insulin Drugs 0.000 claims 2
• 238000012986 modification Methods 0.000 claims 2
• 230000004048 modification Effects 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 230000002194 synthesizing effect Effects 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
• 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
• 238000008214 LDL Cholesterol Methods 0.000 claims 1
• 108010069201 VLDL Cholesterol Proteins 0.000 claims 1
• 210000000577 adipose tissue Anatomy 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 230000000295 complement effect Effects 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 230000007812 deficiency Effects 0.000 claims 1
• 235000005911 diet Nutrition 0.000 claims 1
• 230000037213 diet Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 238000005259 measurement Methods 0.000 claims 1
• 239000003961 penetration enhancing agent Substances 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1