JP2008539271A5 - - Google Patents
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- Publication number
- JP2008539271A5 JP2008539271A5 JP2008509143A JP2008509143A JP2008539271A5 JP 2008539271 A5 JP2008539271 A5 JP 2008539271A5 JP 2008509143 A JP2008509143 A JP 2008509143A JP 2008509143 A JP2008509143 A JP 2008509143A JP 2008539271 A5 JP2008539271 A5 JP 2008539271A5
- Authority
- JP
- Japan
- Prior art keywords
- cspcna
- antibody
- seq
- isoform
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000001708 Protein Isoforms Human genes 0.000 claims 34
- 108010029485 Protein Isoforms Proteins 0.000 claims 34
- 238000000034 method Methods 0.000 claims 32
- 206010028980 Neoplasm Diseases 0.000 claims 22
- 201000011510 cancer Diseases 0.000 claims 21
- 108050006400 Cyclin Proteins 0.000 claims 18
- 102000009339 Proliferating Cell Nuclear Antigen Human genes 0.000 claims 18
- 239000012472 biological sample Substances 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 4
- 238000003018 immunoassay Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 201000008558 xeroderma pigmentosum group G Diseases 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 3
- 239000010839 body fluid Substances 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010003445 Ascites Diseases 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 238000002965 ELISA Methods 0.000 claims 2
- 206010036790 Productive cough Diseases 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000004910 pleural fluid Anatomy 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000001179 synovial fluid Anatomy 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003238 esophagus Anatomy 0.000 claims 1
- 239000000284 extract Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000016784 immunoglobulin production Effects 0.000 claims 1
- 238000012151 immunohistochemical method Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 201000008968 osteosarcoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000001819 pancreatic juice Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 210000003932 urinary bladder Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67527505P | 2005-04-27 | 2005-04-27 | |
| US68961405P | 2005-06-09 | 2005-06-09 | |
| PCT/US2006/016096 WO2006116631A2 (en) | 2005-04-27 | 2006-04-27 | Cancer specific pcna isoform binding antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539271A JP2008539271A (ja) | 2008-11-13 |
| JP2008539271A5 true JP2008539271A5 (enExample) | 2009-06-18 |
Family
ID=37215524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008509143A Pending JP2008539271A (ja) | 2005-04-27 | 2006-04-27 | csPCNAイソ型抗体およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20080206140A1 (enExample) |
| EP (1) | EP1874823B1 (enExample) |
| JP (1) | JP2008539271A (enExample) |
| AU (1) | AU2006239318A1 (enExample) |
| CA (1) | CA2605745A1 (enExample) |
| EA (1) | EA200702361A1 (enExample) |
| MX (1) | MX2007013584A (enExample) |
| WO (1) | WO2006116631A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7294471B2 (en) * | 2002-02-27 | 2007-11-13 | Cskeys, Llc | Method for purifying cancer-specific proliferating cell nuclear antigen |
| WO2007098415A2 (en) * | 2006-02-17 | 2007-08-30 | Indiana University Research And Technology Corporation | Peptide based inhibition of capcna protein-protein interactions in cancer |
| JP2011529079A (ja) * | 2008-07-24 | 2011-12-01 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | 癌のペプチド治療剤 |
| US20120195978A1 (en) * | 2009-10-07 | 2012-08-02 | Indiana University Research And Technology Corpora | Capcna peptide therapeutics for cancer |
| US8455200B2 (en) | 2009-10-15 | 2013-06-04 | Traxxsson, Llc | Measurement of PKA for cancer detection |
| EP2688566A4 (en) * | 2011-03-23 | 2014-09-10 | Univ Indiana Res & Tech Corp | THERAPEUTIC AGENTS AGAINST CANCER |
| CN112964883A (zh) | 2014-03-24 | 2021-06-15 | 艾摩科诊断公司 | 用于全身性和非全身性自身免疫紊乱的改进的抗核抗体检测和诊断 |
| US10420840B2 (en) | 2015-04-10 | 2019-09-24 | Rll, Llc | Anticancer therapeutic agents |
| EP3555128B1 (en) | 2016-12-15 | 2023-12-27 | The National Institute for Biotechnology in the Negev Ltd. | Anti-pcna monoclonal antibodies and use thereof |
| CN112638375A (zh) | 2018-06-15 | 2021-04-09 | 旗舰创业创新五公司 | 通过后细胞信号传导因子的调节来增加免疫活性 |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| WO2021127217A1 (en) | 2019-12-17 | 2021-06-24 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| EP4172323A1 (en) | 2020-06-29 | 2023-05-03 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| KR20230165276A (ko) | 2021-03-31 | 2023-12-05 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션 폴리펩티드 및 암의 치료에서의 이의 용도 |
| AU2022303363A1 (en) | 2021-06-29 | 2024-01-18 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
| US20240269251A1 (en) | 2023-01-09 | 2024-08-15 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2305625A1 (en) * | 1997-09-29 | 1999-04-08 | University Of Maryland, Baltimore | Altered dna synthesome components as biomarkers for malignancy |
| US7294471B2 (en) * | 2002-02-27 | 2007-11-13 | Cskeys, Llc | Method for purifying cancer-specific proliferating cell nuclear antigen |
| EP1998177A3 (en) * | 2003-01-06 | 2009-02-18 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
| CN101632020B (zh) * | 2006-09-13 | 2013-11-27 | 昂西免疫有限公司 | 改进的免疫测定方法 |
-
2006
- 2006-04-27 JP JP2008509143A patent/JP2008539271A/ja active Pending
- 2006-04-27 CA CA002605745A patent/CA2605745A1/en not_active Abandoned
- 2006-04-27 AU AU2006239318A patent/AU2006239318A1/en not_active Abandoned
- 2006-04-27 US US11/912,704 patent/US20080206140A1/en not_active Abandoned
- 2006-04-27 EP EP06751685.6A patent/EP1874823B1/en active Active
- 2006-04-27 EA EA200702361A patent/EA200702361A1/ru unknown
- 2006-04-27 WO PCT/US2006/016096 patent/WO2006116631A2/en not_active Ceased
- 2006-04-27 MX MX2007013584A patent/MX2007013584A/es not_active Application Discontinuation
-
2012
- 2012-05-22 US US13/477,419 patent/US9006396B2/en active Active
-
2015
- 2015-03-12 US US14/645,498 patent/US20150259407A1/en not_active Abandoned
-
2018
- 2018-03-05 US US15/911,870 patent/US20180362626A1/en not_active Abandoned
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