JP2008538117A5 - - Google Patents

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Publication number
JP2008538117A5
JP2008538117A5 JP2008504239A JP2008504239A JP2008538117A5 JP 2008538117 A5 JP2008538117 A5 JP 2008538117A5 JP 2008504239 A JP2008504239 A JP 2008504239A JP 2008504239 A JP2008504239 A JP 2008504239A JP 2008538117 A5 JP2008538117 A5 JP 2008538117A5
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JP
Japan
Prior art keywords
aryl
alkyl
heteroaryl
perfluoroalkyl
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008504239A
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English (en)
Japanese (ja)
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JP2008538117A (ja
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Publication date
Priority claimed from US11/093,757 external-priority patent/US7582785B2/en
Application filed filed Critical
Publication of JP2008538117A publication Critical patent/JP2008538117A/ja
Publication of JP2008538117A5 publication Critical patent/JP2008538117A5/ja
Pending legal-status Critical Current

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JP2008504239A 2005-03-29 2006-03-28 トリヒドロキシポリ不飽和エイコサノイド誘導体 Pending JP2008538117A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/093,757 US7582785B2 (en) 2002-04-01 2005-03-29 Trihydroxy polyunsaturated eicosanoid derivatives
PCT/US2006/011222 WO2006105058A2 (en) 2005-03-29 2006-03-28 Trihydroxy polyunsaturated eicosanoid derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012128022A Division JP2012162576A (ja) 2005-03-29 2012-06-05 トリヒドロキシポリ不飽和エイコサノイド誘導体

Publications (2)

Publication Number Publication Date
JP2008538117A JP2008538117A (ja) 2008-10-09
JP2008538117A5 true JP2008538117A5 (https=) 2010-04-02

Family

ID=36645579

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008504239A Pending JP2008538117A (ja) 2005-03-29 2006-03-28 トリヒドロキシポリ不飽和エイコサノイド誘導体
JP2012128022A Pending JP2012162576A (ja) 2005-03-29 2012-06-05 トリヒドロキシポリ不飽和エイコサノイド誘導体
JP2014061270A Pending JP2014122240A (ja) 2005-03-29 2014-03-25 トリヒドロキシポリ不飽和エイコサノイド誘導体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012128022A Pending JP2012162576A (ja) 2005-03-29 2012-06-05 トリヒドロキシポリ不飽和エイコサノイド誘導体
JP2014061270A Pending JP2014122240A (ja) 2005-03-29 2014-03-25 トリヒドロキシポリ不飽和エイコサノイド誘導体

Country Status (9)

Country Link
US (1) US7582785B2 (https=)
EP (1) EP1863753B1 (https=)
JP (3) JP2008538117A (https=)
CN (1) CN101203481A (https=)
AU (1) AU2006230136B2 (https=)
BR (1) BRPI0609767A2 (https=)
CA (1) CA2603371C (https=)
MX (2) MX2007012022A (https=)
WO (1) WO2006105058A2 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1762557B1 (en) 2000-02-16 2011-04-06 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
WO2003053423A2 (en) * 2001-12-18 2003-07-03 The Brigham And Women's Hospital Inhibition or prevention of infection by bacteria with epa, dha or analogs
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7902257B2 (en) 2002-04-01 2011-03-08 University Of Southern California Trihydroxy polyunsaturated eicosanoid
US8481772B2 (en) 2002-04-01 2013-07-09 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
US7759395B2 (en) * 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
DE60330154D1 (de) * 2002-08-12 2009-12-31 Brigham & Womens Hospital Resolvine: biotemplate zur durchführung therapeutischer anwendungen
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
EP1755537A4 (en) * 2004-04-14 2009-12-09 Univ Boston METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA
US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
BRPI0516803A (pt) * 2004-11-19 2008-09-23 Martek Biosciences Corp oxilipinas de ácidos graxos polinsaturados de cadeia longa e métodos de produção e uso dos mesmos
US20090318394A1 (en) * 2004-11-19 2009-12-24 Julie Nauroth Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
US20060293288A1 (en) * 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases
WO2007041440A2 (en) 2005-10-03 2007-04-12 The Brigham And Women's Hospital, Inc. Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers
US8636986B2 (en) * 2005-11-18 2014-01-28 The Forsyth Institute Treatment and prevention of bone loss using resolvins
US20090320148A1 (en) * 2006-01-31 2009-12-24 Martek Biosciences Corporation Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same
CA2650607A1 (en) * 2006-04-28 2007-11-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of cardiovascular disease
MX2009000657A (es) * 2006-07-19 2009-05-28 Resolvyx Pharmaceuticals Inc Composiciones y metodos para el tratamiento de mucositis.
WO2008057283A2 (en) * 2006-10-26 2008-05-15 Resolvyx Pharmaceuticals, Inc. Use of resolvins for inhibition of bone loss
WO2008070129A2 (en) * 2006-12-05 2008-06-12 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of inflammatory disease
WO2008103753A2 (en) * 2007-02-20 2008-08-28 Martek Biosciences Corporation Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
CA2699483A1 (en) * 2007-09-14 2009-03-26 Resolvyx Pharmaceuticals, Inc. Compositions and methods for modulating immune function
JP5421272B2 (ja) * 2007-10-12 2014-02-19 リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド 眼病治療のための組成物及び方法
WO2009086281A1 (en) * 2007-12-21 2009-07-09 Martek Biosciences Corporation Method for preparation of oxylipins
WO2010039529A2 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treament of inflammatory disease
WO2010095706A1 (ja) 2009-02-20 2010-08-26 国立大学法人東京大学 新規抗炎症性化合物
TW201039815A (en) * 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
JP5184565B2 (ja) * 2010-03-10 2013-04-17 独立行政法人科学技術振興機構 水系溶媒中での含窒素化合物の製造方法
CN103396350B (zh) * 2012-01-09 2014-11-05 浙江师范大学 一种利用顺式-1-卤-2-氯代烯烃合成维生素a的方法
HK1211867A1 (en) 2012-08-24 2016-06-03 Sun Pharma Global Fze Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and treatment of ocular conditions
WO2014110261A1 (en) 2013-01-11 2014-07-17 Massachusetts Eye And Ear Infirmary Cyp450 lipid metabolites reduce inflammation and angiogenesis
WO2014115098A1 (en) * 2013-01-26 2014-07-31 Mahesh Kandula Compositions and methods for the treatment of neurological diseases and inflammation
WO2016144569A1 (en) 2015-03-10 2016-09-15 Elc Management Llc Methods and compositions for treating skin to resolve inflammation and screening for actives that stimulate pro-resolution pathways
CN114377138A (zh) 2015-03-18 2022-04-22 福塞斯儿童牙科医院 使用脂氧素、消退素及其类似物稳定动脉粥状硬化斑块的方法
WO2017083167A1 (en) 2015-11-10 2017-05-18 Ocular Technologies Sarl Topical formulations and uses thereof
EP3950649A1 (en) * 2015-11-23 2022-02-09 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
US11903998B2 (en) 2016-05-27 2024-02-20 Forsyth Dental Infirmary For Children Compositions and methods of treating cancer using lipid agonists and receptors thereof
IL295783B2 (en) 2020-02-21 2026-03-01 Retrotope Inc Processes for isotopic alteration of polyunsaturated fatty acids and their derivatives

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3023A (en) * 1843-03-30 peters
GB2033745B (en) 1978-05-26 1983-08-17 Wellcome Found Fatty acid and derivatives thereof for use in treatment or prophylaxis of thromboembolic conditions
US4567290A (en) * 1981-11-27 1986-01-28 Research Corporation Leukotriene analogues
US4442099A (en) * 1981-11-27 1984-04-10 Research Corporation Leukotriene analogues
US4576758A (en) * 1984-06-01 1986-03-18 The Upjohn Company Anti-inflammatory lipoxin B analogs
US4759880A (en) * 1984-09-27 1988-07-26 Research Corporation Alkanoarachidonic acids
US4710521A (en) * 1986-07-25 1987-12-01 The Celotex Corporation Catalyst mixtures for polyisocyanurate foam
US5136501A (en) * 1989-05-26 1992-08-04 Reuters Limited Anonymous matching system
JPH06505959A (ja) 1990-05-07 1994-07-07 ボッコー　バリー　アイ 安定な脱臭油及びその医薬組成物の方法及び製剤
US5087790A (en) * 1991-06-12 1992-02-11 University Of Southern California Method for olefination of carbonyl compounds using titanocene derivatives
US5177046A (en) * 1991-09-20 1993-01-05 Air Products And Chemicals, Inc. Amine-boron adducts as reduced odor catalyst compositions for the production of polyurethanes
US5409955A (en) * 1993-05-13 1995-04-25 Bockow; Barry I. Compositions and methods for inhibiting uterine contractility
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
WO1998019259A1 (en) 1996-10-25 1998-05-07 Ipf, Inc. System and method for managing and serving consumer product related information over the internet
US6030917A (en) * 1996-07-23 2000-02-29 Symyx Technologies, Inc. Combinatorial synthesis and analysis of organometallic compounds and catalysts
US5752238A (en) * 1994-11-03 1998-05-12 Intel Corporation Consumer-driven electronic information pricing mechanism
US5594732A (en) * 1995-03-03 1997-01-14 Intecom, Incorporated Bridging and signalling subsystems and methods for private and hybrid communications systems including multimedia systems
US5801280A (en) 1995-04-07 1998-09-01 Sumitomo Chemical Company, Limited Processes for preparing optically active alcohols and optically active amines
US5845265A (en) * 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5756789A (en) * 1995-06-08 1998-05-26 Texaco, Inc. Synthesis of metal--containing aluminophosphates with layered structure
WO1997019415A2 (en) 1995-11-07 1997-05-29 Cadis, Inc. Search engine for remote object oriented database management system
US5870717A (en) * 1995-11-13 1999-02-09 International Business Machines Corporation System for ordering items over computer network using an electronic catalog
US5995943A (en) 1996-04-01 1999-11-30 Sabre Inc. Information aggregation and synthesization system
US5878400A (en) * 1996-06-17 1999-03-02 Trilogy Development Group, Inc. Method and apparatus for pricing products in multi-level product and organizational groups
US5842040A (en) * 1996-06-18 1998-11-24 Storage Technology Corporation Policy caching method and apparatus for use in a communication device based on contents of one data unit in a subset of related data units
AU3718397A (en) * 1996-06-28 1998-01-21 University Of Southern California Method for the synthesis of amines and amino acids with organoboron derivatives
US5890138A (en) * 1996-08-26 1999-03-30 Bid.Com International Inc. Computer auction system
US5861399A (en) * 1996-07-17 1999-01-19 Heart Care Partners Methods and compositions for the rapid and enduring relief of inadequate myocardial function
US5896379A (en) * 1996-08-26 1999-04-20 Motorola, Inc. Network node for packet switching with selective data processing and method therefor
US5912006A (en) * 1996-08-28 1999-06-15 Eboc, Inc. Compositions and methods for alleviating discomforting menstrual pain
US5946467A (en) * 1996-09-20 1999-08-31 Novell, Inc. Application-level, persistent packeting apparatus and method
US20020055539A1 (en) * 1996-10-02 2002-05-09 Bockow Barry I. Compositions and methods for treating cardiovascular conditions
JPH10152448A (ja) * 1996-11-20 1998-06-09 Fuji Photo Film Co Ltd 不飽和化合物の水素化方法および重水素化方法
US6117911A (en) 1997-04-11 2000-09-12 Neorx Corporation Compounds and therapies for the prevention of vascular and non-vascular pathologies
US5878423A (en) * 1997-04-21 1999-03-02 Bellsouth Corporation Dynamically processing an index to create an ordered set of questions
US6006264A (en) 1997-08-01 1999-12-21 Arrowpoint Communications, Inc. Method and system for directing a flow between a client and a server
US6038668A (en) 1997-09-08 2000-03-14 Science Applications International Corporation System, method, and medium for retrieving, organizing, and utilizing networked data
US6030715A (en) * 1997-10-09 2000-02-29 The University Of Southern California Azlactone-related dopants in the emissive layer of an OLED
US6259699B1 (en) * 1997-12-30 2001-07-10 Nexabit Networks, Llc System architecture for and method of processing packets and/or cells in a common switch
CA2331640A1 (en) 1998-05-07 1999-11-11 Elan Corporation Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
US6377937B1 (en) * 1998-05-28 2002-04-23 Paskowitz Associates Method and system for more effective communication of characteristics data for products and services
US6069109A (en) * 1998-07-01 2000-05-30 Union Carbide Chemicals & Plastics Technology Corporation Process for the production of half-sandwich transition metal based catalyst precursors
US6336138B1 (en) * 1998-08-25 2002-01-01 Hewlett-Packard Company Template-driven approach for generating models on network services
WO2000024510A1 (en) * 1998-10-23 2000-05-04 University Of Southern California Combinatorial approach to chiral reagents or catalysts having amine or amino alcohol ligands
US6336105B1 (en) * 1998-11-16 2002-01-01 Trade Access Inc. System and method for representing data and providing electronic non-repudiation in a negotiations system
DE19855426A1 (de) 1998-12-02 2000-06-08 Wolfgang Langhoff Mittel zur Therapie und Prophylaxe von rheumatisch-arthritischen Erkrankungen und zur Prophylaxe von cardiovaskulären Erkrankungen
US6272474B1 (en) * 1999-02-08 2001-08-07 Crisostomo B. Garcia Method for monitoring and trading stocks via the internet displaying bid/ask trade bars
US6397212B1 (en) * 1999-03-04 2002-05-28 Peter Biffar Self-learning and self-personalizing knowledge search engine that delivers holistic results
US6427132B1 (en) * 1999-08-31 2002-07-30 Accenture Llp System, method and article of manufacture for demonstrating E-commerce capabilities via a simulation on a network
US6415270B1 (en) * 1999-09-03 2002-07-02 Omnihub, Inc. Multiple auction coordination method and system
EP1762557B1 (en) * 2000-02-16 2011-04-06 The Brigham And Women's Hospital, Inc. Aspirin-triggered lipid mediators
DE10049271A1 (de) * 2000-09-28 2002-04-11 Basf Ag Verfahren zur katalytischen Reduktion von Alkinverbindungen
WO2003053423A2 (en) * 2001-12-18 2003-07-03 The Brigham And Women's Hospital Inhibition or prevention of infection by bacteria with epa, dha or analogs
US7582785B2 (en) * 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
AU2003260687A1 (en) 2002-04-01 2003-10-20 University Of Southern California Trihydroxy polyunsaturated eicosanoids
JP2005529945A (ja) * 2002-06-17 2005-10-06 リソルヴィックス ファーマシューティカルズ オメガ−３ｐｕｆａ由来の脂質メディエーターの類似体及び使用方法
US7759395B2 (en) 2002-08-12 2010-07-20 The Brigham And Women's Hospital, Inc. Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma
DE60330154D1 (de) * 2002-08-12 2009-12-31 Brigham & Womens Hospital Resolvine: biotemplate zur durchführung therapeutischer anwendungen
WO2004078143A2 (en) * 2003-03-05 2004-09-16 The Brigham And Women's Hospital Inc. Methods for identification and uses of anti-inflammatory receptors for eicosapentaenoic acid analogs
US20060293288A1 (en) * 2005-01-07 2006-12-28 Serhan Charles N Use of resolvins to treat gastrointestinal diseases
JP5421272B2 (ja) * 2007-10-12 2014-02-19 リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド 眼病治療のための組成物及び方法
WO2010039531A1 (en) * 2008-09-23 2010-04-08 Resolvyx Pharmaceuticals, Inc. Therapeutic compounds
EP2393353A4 (en) * 2009-02-05 2013-12-25 Resolvyx Pharmaceuticals Inc COMPOSITIONS AND METHODS OF ORGAN CONSERVATION
TW201039815A (en) * 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation

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