AU2006230136B2 - Trihydroxy polyunsaturated eicosanoid derivatives - Google Patents
Trihydroxy polyunsaturated eicosanoid derivatives Download PDFInfo
- Publication number
- AU2006230136B2 AU2006230136B2 AU2006230136A AU2006230136A AU2006230136B2 AU 2006230136 B2 AU2006230136 B2 AU 2006230136B2 AU 2006230136 A AU2006230136 A AU 2006230136A AU 2006230136 A AU2006230136 A AU 2006230136A AU 2006230136 B2 AU2006230136 B2 AU 2006230136B2
- Authority
- AU
- Australia
- Prior art keywords
- aryl
- alkyl
- heteroaryl
- perfluoroalkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 150000002066 eicosanoids Chemical class 0.000 title abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 60
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 206010061218 Inflammation Diseases 0.000 claims abstract description 17
- 230000004054 inflammatory process Effects 0.000 claims abstract description 17
- 201000010099 disease Diseases 0.000 claims abstract description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 16
- 230000002159 abnormal effect Effects 0.000 claims abstract description 15
- 230000004663 cell proliferation Effects 0.000 claims abstract description 15
- 230000028709 inflammatory response Effects 0.000 claims abstract description 15
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract description 13
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract description 13
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 13
- 201000011510 cancer Diseases 0.000 claims abstract description 13
- 206010039073 rheumatoid arthritis Diseases 0.000 claims abstract description 10
- 125000003118 aryl group Chemical group 0.000 claims description 114
- 125000000217 alkyl group Chemical group 0.000 claims description 96
- 125000001072 heteroaryl group Chemical group 0.000 claims description 87
- 150000001875 compounds Chemical class 0.000 claims description 86
- 229910052739 hydrogen Inorganic materials 0.000 claims description 72
- 239000001257 hydrogen Substances 0.000 claims description 71
- 125000003545 alkoxy group Chemical group 0.000 claims description 66
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims description 56
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 50
- 125000000623 heterocyclic group Chemical group 0.000 claims description 41
- 125000002837 carbocyclic group Chemical group 0.000 claims description 40
- 125000004104 aryloxy group Chemical group 0.000 claims description 33
- 125000001153 fluoro group Chemical group F* 0.000 claims description 33
- 125000003282 alkyl amino group Chemical group 0.000 claims description 31
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 31
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/303—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
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- Pain & Pain Management (AREA)
- Rheumatology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Priority Applications (1)
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| US11/093,757 | 2005-03-29 | ||
| PCT/US2006/011222 WO2006105058A2 (en) | 2005-03-29 | 2006-03-28 | Trihydroxy polyunsaturated eicosanoid derivatives |
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| US7582785B2 (en) * | 2002-04-01 | 2009-09-01 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
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| US8481772B2 (en) | 2002-04-01 | 2013-07-09 | University Of Southern California | Trihydroxy polyunsaturated eicosanoid derivatives |
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| DE60330154D1 (de) * | 2002-08-12 | 2009-12-31 | Brigham & Womens Hospital | Resolvine: biotemplate zur durchführung therapeutischer anwendungen |
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| EP1755537A4 (en) * | 2004-04-14 | 2009-12-09 | Univ Boston | METHOD AND COMPOSITIONS FOR PREVENTING OR TREATING PERIODONTOPATHIA |
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| US20090318394A1 (en) * | 2004-11-19 | 2009-12-24 | Julie Nauroth | Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same |
| US20060293288A1 (en) * | 2005-01-07 | 2006-12-28 | Serhan Charles N | Use of resolvins to treat gastrointestinal diseases |
| WO2007041440A2 (en) | 2005-10-03 | 2007-04-12 | The Brigham And Women's Hospital, Inc. | Anti-inflammatory actions of neuroprotectin d1/protectin d1 and its natural stereoisomers |
| US8636986B2 (en) * | 2005-11-18 | 2014-01-28 | The Forsyth Institute | Treatment and prevention of bone loss using resolvins |
| US20090320148A1 (en) * | 2006-01-31 | 2009-12-24 | Martek Biosciences Corporation | Oxylipins from stearidonic acid and gamma-linolenic acid and methods of making and using the same |
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| WO2008057283A2 (en) * | 2006-10-26 | 2008-05-15 | Resolvyx Pharmaceuticals, Inc. | Use of resolvins for inhibition of bone loss |
| WO2008070129A2 (en) * | 2006-12-05 | 2008-06-12 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treatment of inflammatory disease |
| WO2008103753A2 (en) * | 2007-02-20 | 2008-08-28 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
| CA2699483A1 (en) * | 2007-09-14 | 2009-03-26 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| JP5421272B2 (ja) * | 2007-10-12 | 2014-02-19 | リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド | 眼病治療のための組成物及び方法 |
| WO2009086281A1 (en) * | 2007-12-21 | 2009-07-09 | Martek Biosciences Corporation | Method for preparation of oxylipins |
| WO2010039529A2 (en) * | 2008-09-23 | 2010-04-08 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for the treament of inflammatory disease |
| WO2010095706A1 (ja) | 2009-02-20 | 2010-08-26 | 国立大学法人東京大学 | 新規抗炎症性化合物 |
| TW201039815A (en) * | 2009-04-13 | 2010-11-16 | Resolvyx Pharmaceuticals Inc | Compositions and methods for the treatment of inflammation |
| JP5184565B2 (ja) * | 2010-03-10 | 2013-04-17 | 独立行政法人科学技術振興機構 | 水系溶媒中での含窒素化合物の製造方法 |
| CN103396350B (zh) * | 2012-01-09 | 2014-11-05 | 浙江师范大学 | 一种利用顺式-1-卤-2-氯代烯烃合成维生素a的方法 |
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| WO2017083167A1 (en) | 2015-11-10 | 2017-05-18 | Ocular Technologies Sarl | Topical formulations and uses thereof |
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- 2006-03-28 WO PCT/US2006/011222 patent/WO2006105058A2/en not_active Ceased
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| EP1863753A2 (en) | 2007-12-12 |
| MX352197B (es) | 2017-11-13 |
| CA2603371A1 (en) | 2006-10-05 |
| US7582785B2 (en) | 2009-09-01 |
| MX2007012022A (es) | 2011-06-16 |
| JP2012162576A (ja) | 2012-08-30 |
| JP2014122240A (ja) | 2014-07-03 |
| US20050228047A1 (en) | 2005-10-13 |
| EP1863753B1 (en) | 2017-09-20 |
| WO2006105058A2 (en) | 2006-10-05 |
| BRPI0609767A2 (pt) | 2010-04-27 |
| CN101203481A (zh) | 2008-06-18 |
| AU2006230136A1 (en) | 2006-10-05 |
| WO2006105058A3 (en) | 2007-04-12 |
| CA2603371C (en) | 2013-05-28 |
| JP2008538117A (ja) | 2008-10-09 |
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