JP2008538099A5 - - Google Patents
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- Publication number
- JP2008538099A5 JP2008538099A5 JP2007554173A JP2007554173A JP2008538099A5 JP 2008538099 A5 JP2008538099 A5 JP 2008538099A5 JP 2007554173 A JP2007554173 A JP 2007554173A JP 2007554173 A JP2007554173 A JP 2007554173A JP 2008538099 A5 JP2008538099 A5 JP 2008538099A5
- Authority
- JP
- Japan
- Prior art keywords
- dione
- cancer
- propyl
- substituted
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims description 28
- 201000010099 disease Diseases 0.000 claims description 19
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 19
- 239000008194 pharmaceutical composition Substances 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 201000011510 cancer Diseases 0.000 claims description 13
- 102000005962 receptors Human genes 0.000 claims 18
- 108020003175 receptors Proteins 0.000 claims 18
- 125000003710 aryl alkyl group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 230000001404 mediated effect Effects 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 12
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 201000006474 Brain Ischemia Diseases 0.000 claims 9
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 9
- 206010061218 Inflammation Diseases 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 208000006673 asthma Diseases 0.000 claims 9
- 206010008118 cerebral infarction Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 230000004054 inflammatory process Effects 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 7
- 208000031225 myocardial ischemia Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 3
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 3
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 3
- 230000000747 cardiac effect Effects 0.000 claims 3
- 208000029742 colonic neoplasm Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 3
- 230000002530 ischemic preconditioning effect Effects 0.000 claims 3
- 201000005202 lung cancer Diseases 0.000 claims 3
- 208000020816 lung neoplasm Diseases 0.000 claims 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 201000002528 pancreatic cancer Diseases 0.000 claims 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- -1 n- propyl Chemical group 0.000 claims 2
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 2
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- DUBPHADYOBNKNU-UHFFFAOYSA-N 9-benzyl-1-(2-hydroxyethyl)-3-phenyl-7-propyl-4h-purino[8,7-c][1,2,4]triazine-6,8-dione Chemical compound C1=2N=C3N(CCO)N=C(C=4C=CC=CC=4)CN3C=2C(=O)N(CCC)C(=O)N1CC1=CC=CC=C1 DUBPHADYOBNKNU-UHFFFAOYSA-N 0.000 claims 1
- CMRVBWMIWIXVOZ-UHFFFAOYSA-N 9-benzyl-1-methyl-3-phenyl-7-propyl-4h-purino[8,7-c][1,2,4]triazine-6,8-dione Chemical compound C1=2N=C3N(C)N=C(C=4C=CC=CC=4)CN3C=2C(=O)N(CCC)C(=O)N1CC1=CC=CC=C1 CMRVBWMIWIXVOZ-UHFFFAOYSA-N 0.000 claims 1
- 125000000319 biphenyl-4-yl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 0 *C1=NN(*)c2nc(N(*)C(N(*)C3=O)=O)c3[n]2C1 Chemical compound *C1=NN(*)c2nc(N(*)C(N(*)C3=O)=O)c3[n]2C1 0.000 description 3
- WUZJIVYHLCHJGG-UHFFFAOYSA-N 1-benzyl-6-(dimethylamino)-5-(methylideneamino)-3-propylpyrimidine-2,4-dione Chemical compound O=C1N(CCC)C(=O)C(N=C)=C(N(C)C)N1CC1=CC=CC=C1 WUZJIVYHLCHJGG-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64972605P | 2005-02-02 | 2005-02-02 | |
| US11/344,295 US7435740B2 (en) | 2005-02-02 | 2006-01-31 | Adenosine A3 receptor modulators |
| PCT/US2006/003477 WO2006083916A2 (en) | 2005-02-02 | 2006-02-01 | Novel adenosine a3 receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008538099A JP2008538099A (ja) | 2008-10-09 |
| JP2008538099A5 true JP2008538099A5 (enExample) | 2008-12-18 |
Family
ID=36777854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007554173A Withdrawn JP2008538099A (ja) | 2005-02-02 | 2006-02-01 | 新規なアデノシンａ３受容体調節剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7435740B2 (enExample) |
| EP (1) | EP1845993A4 (enExample) |
| JP (1) | JP2008538099A (enExample) |
| KR (1) | KR20070100331A (enExample) |
| AU (1) | AU2006210817B2 (enExample) |
| BR (1) | BRPI0606750A2 (enExample) |
| CA (1) | CA2596612A1 (enExample) |
| IL (1) | IL184532A0 (enExample) |
| MX (1) | MX2007008501A (enExample) |
| NZ (1) | NZ556649A (enExample) |
| WO (1) | WO2006083916A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088403A1 (en) * | 2007-05-07 | 2009-04-02 | Randy Blakely | A3 adenosine receptors as targets for the modulation of central serotonergic signaling |
| WO2009092602A2 (en) * | 2008-01-24 | 2009-07-30 | Universität Zürich | Anti-angiogenic compounds |
| US20110190324A1 (en) * | 2008-07-16 | 2011-08-04 | Edward Leung | Methods of treating atherosclerosis |
| EP2456419B1 (en) | 2009-07-21 | 2016-11-23 | Oradin Pharmaceutical Ltd. | A3 adenosine receptor ligands for modulation of pigmentation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586429B2 (en) * | 2000-11-29 | 2003-07-01 | Cell Therapeutics, Inc. | Tricyclic fused xanthine compounds and their uses |
-
2006
- 2006-01-31 US US11/344,295 patent/US7435740B2/en not_active Expired - Fee Related
- 2006-02-01 AU AU2006210817A patent/AU2006210817B2/en not_active Ceased
- 2006-02-01 EP EP06734138A patent/EP1845993A4/en not_active Withdrawn
- 2006-02-01 KR KR1020077017126A patent/KR20070100331A/ko not_active Ceased
- 2006-02-01 BR BRPI0606750-6A patent/BRPI0606750A2/pt not_active IP Right Cessation
- 2006-02-01 JP JP2007554173A patent/JP2008538099A/ja not_active Withdrawn
- 2006-02-01 CA CA002596612A patent/CA2596612A1/en not_active Abandoned
- 2006-02-01 MX MX2007008501A patent/MX2007008501A/es active IP Right Grant
- 2006-02-01 NZ NZ556649A patent/NZ556649A/en not_active IP Right Cessation
- 2006-02-01 WO PCT/US2006/003477 patent/WO2006083916A2/en not_active Ceased
-
2007
- 2007-07-10 IL IL184532A patent/IL184532A0/en unknown
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