CA2596612A1 - Novel adenosine a3 receptor modulators - Google Patents
Novel adenosine a3 receptor modulators Download PDFInfo
- Publication number
- CA2596612A1 CA2596612A1 CA002596612A CA2596612A CA2596612A1 CA 2596612 A1 CA2596612 A1 CA 2596612A1 CA 002596612 A CA002596612 A CA 002596612A CA 2596612 A CA2596612 A CA 2596612A CA 2596612 A1 CA2596612 A1 CA 2596612A1
- Authority
- CA
- Canada
- Prior art keywords
- dione
- purine
- substituted
- imidazo
- benzyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 238000003653 radioligand binding assay Methods 0.000 description 1
- 239000000018 receptor agonist Substances 0.000 description 1
- 229940044601 receptor agonist Drugs 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000005338 substituted cycloalkoxy group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000013269 sustained drug release Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64972605P | 2005-02-02 | 2005-02-02 | |
| US60/649,726 | 2005-02-02 | ||
| US11/344,295 | 2006-01-31 | ||
| US11/344,295 US7435740B2 (en) | 2005-02-02 | 2006-01-31 | Adenosine A3 receptor modulators |
| PCT/US2006/003477 WO2006083916A2 (en) | 2005-02-02 | 2006-02-01 | Novel adenosine a3 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2596612A1 true CA2596612A1 (en) | 2006-08-10 |
Family
ID=36777854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002596612A Abandoned CA2596612A1 (en) | 2005-02-02 | 2006-02-01 | Novel adenosine a3 receptor modulators |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7435740B2 (enExample) |
| EP (1) | EP1845993A4 (enExample) |
| JP (1) | JP2008538099A (enExample) |
| KR (1) | KR20070100331A (enExample) |
| AU (1) | AU2006210817B2 (enExample) |
| BR (1) | BRPI0606750A2 (enExample) |
| CA (1) | CA2596612A1 (enExample) |
| IL (1) | IL184532A0 (enExample) |
| MX (1) | MX2007008501A (enExample) |
| NZ (1) | NZ556649A (enExample) |
| WO (1) | WO2006083916A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090088403A1 (en) * | 2007-05-07 | 2009-04-02 | Randy Blakely | A3 adenosine receptors as targets for the modulation of central serotonergic signaling |
| WO2009092602A2 (en) * | 2008-01-24 | 2009-07-30 | Universität Zürich | Anti-angiogenic compounds |
| US20110190324A1 (en) * | 2008-07-16 | 2011-08-04 | Edward Leung | Methods of treating atherosclerosis |
| EP2456419B1 (en) | 2009-07-21 | 2016-11-23 | Oradin Pharmaceutical Ltd. | A3 adenosine receptor ligands for modulation of pigmentation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6586429B2 (en) * | 2000-11-29 | 2003-07-01 | Cell Therapeutics, Inc. | Tricyclic fused xanthine compounds and their uses |
-
2006
- 2006-01-31 US US11/344,295 patent/US7435740B2/en not_active Expired - Fee Related
- 2006-02-01 AU AU2006210817A patent/AU2006210817B2/en not_active Ceased
- 2006-02-01 EP EP06734138A patent/EP1845993A4/en not_active Withdrawn
- 2006-02-01 KR KR1020077017126A patent/KR20070100331A/ko not_active Ceased
- 2006-02-01 BR BRPI0606750-6A patent/BRPI0606750A2/pt not_active IP Right Cessation
- 2006-02-01 JP JP2007554173A patent/JP2008538099A/ja not_active Withdrawn
- 2006-02-01 CA CA002596612A patent/CA2596612A1/en not_active Abandoned
- 2006-02-01 MX MX2007008501A patent/MX2007008501A/es active IP Right Grant
- 2006-02-01 NZ NZ556649A patent/NZ556649A/en not_active IP Right Cessation
- 2006-02-01 WO PCT/US2006/003477 patent/WO2006083916A2/en not_active Ceased
-
2007
- 2007-07-10 IL IL184532A patent/IL184532A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7435740B2 (en) | 2008-10-14 |
| NZ556649A (en) | 2010-03-26 |
| AU2006210817A2 (en) | 2006-08-10 |
| KR20070100331A (ko) | 2007-10-10 |
| IL184532A0 (en) | 2007-10-31 |
| WO2006083916A2 (en) | 2006-08-10 |
| AU2006210817A1 (en) | 2006-08-10 |
| AU2006210817B2 (en) | 2010-12-23 |
| JP2008538099A (ja) | 2008-10-09 |
| WO2006083916A3 (en) | 2007-12-21 |
| EP1845993A4 (en) | 2009-03-11 |
| BRPI0606750A2 (pt) | 2009-07-14 |
| US20060178385A1 (en) | 2006-08-10 |
| EP1845993A2 (en) | 2007-10-24 |
| MX2007008501A (es) | 2007-09-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130201 |