JP2008535790A5 - - Google Patents
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- JP2008535790A5 JP2008535790A5 JP2007558290A JP2007558290A JP2008535790A5 JP 2008535790 A5 JP2008535790 A5 JP 2008535790A5 JP 2007558290 A JP2007558290 A JP 2007558290A JP 2007558290 A JP2007558290 A JP 2007558290A JP 2008535790 A5 JP2008535790 A5 JP 2008535790A5
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- 239000000203 mixture Substances 0.000 claims 60
- 150000001875 compounds Chemical class 0.000 claims 39
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 23
- 229940002612 prodrug Drugs 0.000 claims 20
- 239000000651 prodrug Substances 0.000 claims 20
- -1 oxazolopyridyl Chemical group 0.000 claims 18
- 201000010099 disease Diseases 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
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- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 206010022489 Insulin Resistance Diseases 0.000 claims 4
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
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- 208000014767 Myeloproliferative disease Diseases 0.000 claims 1
- 201000009623 Myopathy Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000003435 Optic Neuritis Diseases 0.000 claims 1
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- 208000032319 Primary lateral sclerosis Diseases 0.000 claims 1
- 201000005660 Protein C Deficiency Diseases 0.000 claims 1
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- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
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- 230000037147 athletic performance Effects 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
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- 239000003085 diluting agent Substances 0.000 claims 1
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- 229940079593 drug Drugs 0.000 claims 1
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- 229910052736 halogen Inorganic materials 0.000 claims 1
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- 208000033666 hereditary antithrombin deficiency Diseases 0.000 claims 1
- 208000013746 hereditary thrombophilia due to congenital protein C deficiency Diseases 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- 201000010901 lateral sclerosis Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 208000015994 miscarriage Diseases 0.000 claims 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 201000006938 muscular dystrophy Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 201000008383 nephritis Diseases 0.000 claims 1
- 208000018360 neuromuscular disease Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 235000021049 nutrient content Nutrition 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000008723 osmotic stress Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 230000035935 pregnancy Effects 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000002510 pyrogen Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
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- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
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- 208000029257 vision disease Diseases 0.000 claims 1
- 230000004393 visual impairment Effects 0.000 claims 1
- CTXHOLCMGDAANM-UHFFFAOYSA-N Cc1nc2ncccc2[o]1 Chemical compound Cc1nc2ncccc2[o]1 CTXHOLCMGDAANM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65851605P | 2005-03-03 | 2005-03-03 | |
| US70561205P | 2005-08-04 | 2005-08-04 | |
| US74178305P | 2005-12-02 | 2005-12-02 | |
| PCT/US2006/007745 WO2006094236A1 (en) | 2005-03-03 | 2006-03-03 | N-phenyl benzamide derivatives as sirtuin modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008535790A JP2008535790A (ja) | 2008-09-04 |
| JP2008535790A5 true JP2008535790A5 (https=) | 2009-04-16 |
Family
ID=36499236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558290A Pending JP2008535790A (ja) | 2005-03-03 | 2006-03-03 | サーチュインモジュレーターであるｎ−フェニルベンズアミド誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090163476A1 (https=) |
| EP (1) | EP1853610A1 (https=) |
| JP (1) | JP2008535790A (https=) |
| AU (1) | AU2006218404A1 (https=) |
| CA (1) | CA2599989A1 (https=) |
| WO (1) | WO2006094236A1 (https=) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| EP1708689A2 (en) | 2003-12-29 | 2006-10-11 | The President and Fellows of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| US20090215681A1 (en) * | 2005-02-15 | 2009-08-27 | Joslin Diabetes Center | Methods of Diagnosis and Treatment of Metabolic Disorders |
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| US20080293081A1 (en) * | 2005-03-03 | 2008-11-27 | Sirtris Pharmaceuticals, Inc. | Fluorescence Polarization Assays for Acetyltransferase/Deacetylase Activity |
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| US8093401B2 (en) * | 2005-08-04 | 2012-01-10 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| EP1910385B1 (en) * | 2005-08-04 | 2013-07-24 | Sirtris Pharmaceuticals, Inc. | Benzothiazoles and thiazolopyridines as sirtuin modulators |
| US8088928B2 (en) * | 2005-08-04 | 2012-01-03 | Sirtris Pharmaceuticals, Inc. | Sirtuin modulating compounds |
| US20070092577A1 (en) * | 2005-10-03 | 2007-04-26 | University Of Tennessee Research Foundation | Dietary calcium for reducing the production of reactive oxygen species |
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| MX2008010187A (es) * | 2006-02-10 | 2008-10-31 | Summit Corp Plc | Tratamiento de distrofia muscular de duchenne. |
| US8969622B2 (en) * | 2006-08-23 | 2015-03-03 | Vanderbilt University | Dendritic molecular intracellular transporters and methods of making and using same |
| WO2008029152A2 (en) * | 2006-09-08 | 2008-03-13 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
| JP2010508288A (ja) | 2006-10-27 | 2010-03-18 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なヘテロサイクリックアミド化合物 |
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| US9326986B2 (en) | 2008-09-29 | 2016-05-03 | Glaxosmithkline Llc | Quinazolinone, quinolone and related analogs as sirtuin modulators |
| EP2179984A1 (en) * | 2008-10-27 | 2010-04-28 | Congenia S.r.l. | Acrylamido derivatives useful as inhibitors of the mitochondrial permeability transition |
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| EP2376502B1 (en) | 2008-12-19 | 2015-06-17 | GlaxoSmithKline LLC | Thiazolopyridine sirtuin modulating compounds |
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| EP2332528A1 (de) * | 2009-12-14 | 2011-06-15 | Grünenthal GmbH | Substituierte aromatische Dicarbonsäureamide als Arzneimittel |
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| RU2018110642A (ru) | 2010-05-03 | 2019-02-27 | Курна, Инк. | Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt) |
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| CN119744838B (zh) * | 2024-12-05 | 2025-12-26 | 中国农业科学院北京畜牧兽医研究所 | 蛋白质去乙酰化酶抑制剂nrd167在家禽精液超低温冷冻保存中的应用 |
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