JP2008535790A - サーチュインモジュレーターであるn−フェニルベンズアミド誘導体 - Google Patents

サーチュインモジュレーターであるn−フェニルベンズアミド誘導体 Download PDF

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JP2008535790A
JP2008535790A JP2007558290A JP2007558290A JP2008535790A JP 2008535790 A JP2008535790 A JP 2008535790A JP 2007558290 A JP2007558290 A JP 2007558290A JP 2007558290 A JP2007558290 A JP 2007558290A JP 2008535790 A JP2008535790 A JP 2008535790A
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JP2008535790A5 (enExample
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マイケル ミルバーン,
ジル ミルン,
ジーン ビーミス,
ジョセフ ジェイ. ヌーネス,
ロジャー シエ,
カール ディー. ノーミングトン,
チー ビー. ブ,
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サートリス ファーマシューティカルズ, インコーポレイテッド
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    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62Benzothiazoles
    • C07D277/64Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
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    • C07D241/38Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
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    • C07D265/201,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
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JP2007558290A 2005-03-03 2006-03-03 サーチュインモジュレーターであるn−フェニルベンズアミド誘導体 Pending JP2008535790A (ja)

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US65851605P 2005-03-03 2005-03-03
US70561205P 2005-08-04 2005-08-04
US74178305P 2005-12-02 2005-12-02
PCT/US2006/007745 WO2006094236A1 (en) 2005-03-03 2006-03-03 N-phenyl benzamide derivatives as sirtuin modulators

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JP2008535790A true JP2008535790A (ja) 2008-09-04
JP2008535790A5 JP2008535790A5 (enExample) 2009-04-16

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US (1) US20090163476A1 (enExample)
EP (1) EP1853610A1 (enExample)
JP (1) JP2008535790A (enExample)
AU (1) AU2006218404A1 (enExample)
CA (1) CA2599989A1 (enExample)
WO (1) WO2006094236A1 (enExample)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009526034A (ja) * 2006-02-10 2009-07-16 スムミト コーポレーション ピーエルシー デュシェンヌ型筋ジストロフィーの治療
JP2012506852A (ja) * 2008-10-27 2012-03-22 コンジェニア・エッセエッレエッレ ミトコンドリアの膜透過性遷移の阻害剤として有用なアクリルアミド誘導体
JP2012512907A (ja) * 2008-12-19 2012-06-07 サートリス ファーマシューティカルズ, インコーポレイテッド チアゾロピリジンサーチュイン調節化合物
JP2012530750A (ja) * 2009-06-22 2012-12-06 エフ.ホフマン−ラ ロシュ アーゲー 新規なビフェニルピリジンアミドおよびフェニルピリジンアミド
JP2013538223A (ja) * 2010-09-15 2013-10-10 エフ.ホフマン−ラ ロシュ アーゲー アザベンゾチアゾール化合物、組成物及び使用方法
WO2016148114A1 (ja) * 2015-03-13 2016-09-22 国立大学法人北海道大学 酸化ストレス誘導神経細胞死抑制化合物
JP2018515080A (ja) * 2015-04-29 2018-06-14 中国科学院上海生命科学研究院 筋萎縮関連タンパク質分子マーカーDkk−3のスクリーニング及びその使用
JP2023504162A (ja) * 2019-12-02 2023-02-01 アカデミア シニカ PDIA4阻害剤及びβ細胞発症機序を阻害し、糖尿病を治療するためのこのPDIA4阻害剤の使用
JP2023511076A (ja) * 2020-01-15 2023-03-16 プレートフューズ、インコーポレイテッド 血小板貯蔵方法及び組成物

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US8017634B2 (en) * 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US20050171027A1 (en) 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
US20090215681A1 (en) * 2005-02-15 2009-08-27 Joslin Diabetes Center Methods of Diagnosis and Treatment of Metabolic Disorders
US20090142335A1 (en) * 2005-02-15 2009-06-04 Joslin Diabetes Center Methods of diagnosis and treatment of metabolic disorders
ATE544071T1 (de) * 2005-03-03 2012-02-15 Sirtris Pharmaceuticals Inc Fluoreszenzpolarisationstests für die acetyltransferase-deacetylase-aktivität
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8093401B2 (en) * 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
AU2006278504B2 (en) 2005-08-04 2013-01-17 Sirtris Pharmaceuticals, Inc. Imidazopyridine derivatives as sirtuin modulating agents
US7855289B2 (en) * 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US20070077310A1 (en) * 2005-10-03 2007-04-05 University Of Tennessee Research Foundation Methods of reducing the production of reactive oxygen species and methods of screening or identifying compounds and compositions that reduce the production of reactive oxygen species
ES2389111T3 (es) * 2005-12-02 2012-10-23 Sirtris Pharmaceuticals, Inc. Ensayos de espectrometría de masas para la actividad acetiltransferasa/desacetilasa
US8969622B2 (en) * 2006-08-23 2015-03-03 Vanderbilt University Dendritic molecular intracellular transporters and methods of making and using same
WO2008029152A2 (en) * 2006-09-08 2008-03-13 Summit Corporation Plc Treatment of duchenne muscular dystrophy
US7935696B2 (en) 2006-10-27 2011-05-03 Bristol-Myers Squibb Company Heterocyclic amide compounds useful as kinase inhibitors
TW200918542A (en) 2007-06-20 2009-05-01 Sirtris Pharmaceuticals Inc Sirtuin modulating compounds
CL2008001822A1 (es) * 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
LT2170396T (lt) 2007-08-03 2017-03-10 Summit (Oxford) Limited Vaistų deriniai, skirti diušeno raumenų distrofijos gydymui
EP2214698A2 (en) * 2007-10-23 2010-08-11 President and Fellows of Harvard College Use of compounds activating sirt-3 for mimicking exercise
US20090239868A1 (en) * 2007-10-23 2009-09-24 Institute Of Medical Molecular Design, Inc. Inhibitor of pai-1 production
AU2008319267A1 (en) * 2007-11-01 2009-05-07 Sirtris Pharmaceuticals, Inc. Amide derivatives as sirtuin modulators
US7868001B2 (en) * 2007-11-02 2011-01-11 Hutchison Medipharma Enterprises Limited Cytokine inhibitors
US20110274620A1 (en) * 2007-11-05 2011-11-10 Harth Eva M Multifunctional degradable nanoparticles with control over size and functionalities
ES2744834T3 (es) 2007-11-05 2020-02-26 Univ Vanderbilt Nanopartículas degradables multifuncionales con control sobre el tamaño y las funcionalidades
US11254786B2 (en) 2007-11-05 2022-02-22 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
US20130142733A1 (en) 2007-11-05 2013-06-06 Vanderbilt University Multifunctional degradable nanoparticles with control over size and functionalities
EP2217606A1 (en) * 2007-11-08 2010-08-18 Sirtris Pharmaceuticals, Inc. Solubilized thiazolopyridines
US8067409B2 (en) 2007-11-27 2011-11-29 Abbott Laboratories Protein kinase inhibitors
RU2364597C1 (ru) * 2007-12-14 2009-08-20 Андрей Александрович Иващенко ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ Hh-СИГНАЛЬНОГО КАСКАДА, ЛЕКАРСТВЕННЫЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АББЕРАНТНОЙ АКТИВНОСТЬЮ Hh СИГНАЛЬНОЙ СИСТЕМЫ
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