JP2008535529A - 多相インプラントへ生物活性剤を選択的に添加するための方法及び装置 - Google Patents
多相インプラントへ生物活性剤を選択的に添加するための方法及び装置 Download PDFInfo
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- JP2008535529A JP2008535529A JP2007553374A JP2007553374A JP2008535529A JP 2008535529 A JP2008535529 A JP 2008535529A JP 2007553374 A JP2007553374 A JP 2007553374A JP 2007553374 A JP2007553374 A JP 2007553374A JP 2008535529 A JP2008535529 A JP 2008535529A
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Landscapes
- Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Prostheses (AREA)
Abstract
Description
本出願は、本明細書と矛盾しない限りにおいて、参照により本明細書に組み込まれる2005年2月1日に出願された米国仮特許出願番号第60/649,418号の利益を主張するものである。
2 頂部
3 下方インプラント区画
4、22 窪み
5 切り下げ
6 下方部
7 下方収容区画
8 上方部
9 上方インプラント区画
10 張り出し
11 スロット
12 送達装置
13 ポスト
14 プラットフォーム
15 中間下方部
16 中間上方部
17 中間インプラント区画
18 中間収容区画
19 中間区画張り出し
20 ベース
21 中間円周上切り下げ
22 中間窪み
23 上方中間分離膜
25 針ポート
26、45 ホルダー
27 膜すなわち薄膜
28 解放ポート
29 中間下方分離膜
30 カバー
40 中間部
50 インプラント装填組立体
52、54 オーリング
56 表示窓
60 多相インプラント
Claims (39)
- a.i.底部、
ii.頂部、
iii.前記頂部及び前記底部を通って延在し、断面形状を有する下方インプラント区画、
を備えたベースと、
b.i.断面形状が前記下方インプラント区画の断面形状と等しい上方インプラント区画を有する上方部、及び、
ii.前記ベースの前記頂部を収容するように大きさを決められた下方収容区画を有する下方部、
を備えた前記ベースに固定されるカバーと、
を含んでなることを特徴とする2相インプラントを構築するためのインプラント組立体。 - 膜を収容するために前記下方インプラント区画の前記頂部に形成される窪みを更に含んでなることを特徴とする請求項1に記載のインプラント組立体。
- 前記カバーと前記ベースとの間に配置される膜と接触するために、前記ベースの前記頂部の表面にオーリングを更に含んでなることを特徴とする請求項1又は2に記載のインプラント組立体。
- 前記カバーと前記ベースとの間に配置される膜と接触するために、前記カバーの前記下方部の表面にオーリングを更に備えることを特徴とする請求項3に記載のインプラント組立体。
- 前記カバーが、1つ又は複数の溶接、接着、及び前記カバー上の固定手段と取り外し可能に係合する前記ベース上の固定手段によって固定されていることを特徴とする請求項4に記載のインプラント組立体。
- 前記固定手段が、
a.前記ベース底部と前記ベース頂部との間に配置されている円周上切り下げ、
b.前記カバー下方部を前記円周上切り下げに係合させるために前記カバー下方部の前記底部に配置される区画張り出し、
c.前記カバー下方部の前記円周上切り下げへの係合を促進させるために、前記カバー下方部に沿って配置されている複数のスロット、
を備えたスナップビードを含んでなることを特徴とする請求項5に記載のインプラント組立体。 - 前記下方及び上方インプラント区画の断面形状が円形となっていることを特徴とする請求項1から6のいずれか一項に記載のインプラント組立体。
- 下方面及び上方面を有し、前記ベースと前記カバーとの間に配置されている膜を更に含んでなることを特徴とする請求項7に記載のインプラント組立体。
- 前記膜が不浸透性であることを特徴とする請求項8に記載のインプラント組立体。
- 前記膜が浸透性、或いは、選択的に浸透性となっていることを特徴とする請求項8に記載のインプラント組立体。
- a.前記下方区画に配置され前記膜の前記下方面に装着されるインプラントの第1の相と、
b.前記上方区画に配置され前記膜の前記上方面に装着されるインプラントの第2の相と、
を更に含んでなることを特徴とする請求項7から10のいずれか一項に記載のインプラント組立体。 - 前記第1の相及び前記第2の相が、それぞれ異なる物質を含んでなることを特徴とする請求項11に記載のインプラント組立体。
- 前記第1の相が骨移植に適合され、前記第2の相が軟骨移植に適合されることを特徴とする請求項11に記載のインプラント組立体。
- 前記第1の相及び/又は前記第2の相が、1つ又は複数の生物活性剤を包含することを特徴とする請求項11に記載のインプラント組立体。
- 前記1つ又は複数の生物活性剤が、成長因子、細胞外マトリクス、薬剤及び細胞懸濁液からなる群から選択されることを特徴とする請求項14に記載のインプラント組立体。
- 3相以上のインプラントが請求項1から6のいずれか一項に記載された装置を含み、更に前記カバーと前記ベースの間に配置される1つ又は複数の中間ユニットを含んでなり、前記中間ユニットが、
a.前記カバーに固定され、
i.前記下方インプラント区画の断面形状と等しい断面形状を有する中間インプラント区画、
ii.前記カバーの前記下方収容区画と係合するように大きさを決められる上方中間部、
iii.前記中間インプラント区画に1つ又は複数の生物活性剤を添加するためのポート、
を備えた中間上方部と、
b.前記ベースに固定され、前記ベース頂部を収容するように大きさを決められる中間収容区画を有する中間下方部と、
を含んでなることを特徴とするインプラント組立体。 - 前記カバーと前記ベースとの間に配置されている前記中間ユニットと同一である1つ又は複数の付加的中間ユニットを更に含んでなることを特徴とする請求項16に記載のインプラント組立体。
- 前記隣接するインプラント区画のそれぞれの間に形成される膜を更に含んでなることを特徴とする請求項16から17のいずれか一項に記載のインプラント組立体。
- 膜を収容するために前記上方中間区画の前記頂部に形成される窪みを更に含んでなることを特徴とする請求項18に記載のインプラント組立体。
- 前記中間部と前記カバーとの間に配置される膜に接触するために前記中間上方部の上面にオーリングを更に含んでなり、前記中間部と前記ベースとの間に配置される膜と接触するために前記中間下方部の底面にオーリングを含んでなることを特徴とする請求項19に記載のインプラント組立体。
- 前記インプラント組立体が装填装置に配置されていることを特徴とする請求項1から20のいずれか一項に記載のインプラント組立体。
- a.i.底部
ii.頂部
iii.前記頂部及び前記底部を通って延在し、断面形状を有する下方インプラント区画
を備えたベースと、
b.i.断面形状が前記下方インプラント区画の断面形状と等しい上方インプラント区画を有する上方部、
ii.前記ベースの前記頂部を収容するように大きさを決められた下方収容区画を有する下方部
を備えたカバーと、
c.前記ベースと前記カバー部の間に膜を配置する手段と、
d.前記ベースを前記カバーと密封係合させる手段と、
を含んでなることを特徴とする多相インプラントを構築するためのインプラント組立体。 - 前記ベースとカバーとの間に配置され、
a.i.前記下方インプラント区画の断面形状と等しい断面形状を有する中間インプラント区画、
ii.前記カバーの前記下方収容区画と係合するように大きさを決められる上方中間部、
iii.前記中間インプラント区画と隣接する区画の間に膜を配置する手段、
iv.前記中間上方部を前記カバー下方部と密封係合させる手段、
を備えた中間上方部と、
b.i.前記ベース頂部と係合するように大きさを決められる中間収容区画、
ii.前記中間下方部を前記ベースと密封係合させる手段、
を備えた中間下方部と、
を含む1つ又は複数の中間ユニットを更に含んでなることを特徴とする請求項22に記載のインプラント組立体。 - 隣接する相が、膜によって分離されている請求項1から23のいずれか一項に記載のインプラント組立体を使用して形成されていることを特徴とする多相インプラント。
- 前記隣接する相が、125μmから250μmまでの厚さを有する膜によって分離されていることを特徴とする請求項24に記載のインプラント。
- a.上面及び底面を有する膜、
b.前記膜の上面に装着される第1のインプラント相、
c.前記膜の底面に装着される第2のインプラント相、
を含んでなることを特徴とする組織損傷部に挿入されるインプラント。 - 前記第1のインプラント相が、前記第2のインプラント相の成分と異なる成分を有することを特徴とする請求項26に記載のインプラント。
- 前記第1のインプラント相及び/又は前記第2のインプラント相が、1つ又は複数の生物活性剤を包含することを特徴とする請求項26から27のいずれか一項に記載のインプラント。
- 前記第1のインプラント相が骨移植に適合され、前記第2のインプラント相が軟骨移植に適合されることを特徴とする請求項28に記載のインプラント。
- 膜によって分離される2つの相を備えた2相インプラントを構築するための方法であって、
a.第1のインプラント相に第1のホルダーを提供し、且つ、前記第1のホルダーの第1端部に膜用のホルダーを備えること、
b.第2のインプラント相に第2のホルダーを提供すること、
c.前記第1のホルダーに第1のインプラント相を挿入すること、
d.前記第1のホルダーの前記第1の端部に膜を挿入し、前記第1の相に前記膜を装着させること、
e.前記第2のホルダーに第2のインプラント相を挿入し、前記膜にこれを装着させること、
を含んでなることを特徴とする方法。 - 前記第1及び第2のホルダーに密封係合させることを更に含んでなることを特徴とする請求項30に記載の方法。
- 前記膜を非浸透性、或いは、選択的に浸透性とすることを特徴とする請求項31に記載の方法。
- 1つ又は複数の生物活性剤を前記第1のインプラント相に挿入すること、及び、1つ又は複数の生物活性剤を前記第2のインプラント相に挿入することを、更に含んでなることを特徴とする請求項32に記載の方法。
- 前記第1の相の1つ又は複数の生物活性剤が、前記第1のインプラント相の前記生物活性剤を第1の組織に選択的に送達することによって第1の組織修復を促進させ、前記第2のインプラント相の前記生物活性剤を第2の組織に選択的に送達することによって、第2の組織修復を促進させることを特徴とする請求項33に記載の方法。
- 前記第1の組織が軟骨であって、前記第2の組織が骨であることを特徴とする請求項34に記載の方法。
- 軟骨修復を促進させるための前記相の前記1つ又は複数の生物活性剤が、軟骨細胞の懸濁液を含んでなることを特徴とする請求項35に記載の方法。
- 前記2相インプラントを送達装置に挿入することを更に含んでなることを特徴とする請求項30から36のいずれか一項に記載の方法。
- 前記インプラントを患者の損傷部に挿入することを更に含んでなることを特徴とする請求項37に記載の方法。
- 患者の前記損傷部が骨組織及び軟骨組織におよぶことを特徴とする請求項38に記載の方法。
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US60/649,418 | 2005-02-01 | ||
PCT/US2006/003516 WO2006083946A2 (en) | 2005-02-01 | 2006-02-01 | Method and device for selective addition of a bioactive agent to a multi-phase implant |
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EP (1) | EP1883398A4 (ja) |
JP (1) | JP4796079B2 (ja) |
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