JP2008533161A - PPAR−γアンタゴニストを使用するがんの治療方法 - Google Patents

PPAR−γアンタゴニストを使用するがんの治療方法 Download PDF

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Publication number
JP2008533161A
JP2008533161A JP2008501998A JP2008501998A JP2008533161A JP 2008533161 A JP2008533161 A JP 2008533161A JP 2008501998 A JP2008501998 A JP 2008501998A JP 2008501998 A JP2008501998 A JP 2008501998A JP 2008533161 A JP2008533161 A JP 2008533161A
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JP
Japan
Prior art keywords
cancer
pparγ
antagonist
subject
anticancer agent
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Pending
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JP2008501998A
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English (en)
Japanese (ja)
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JP2008533161A5 (enExample
Inventor
バートン,ジャック
ブルメンタール,ロザリン
Original Assignee
イムノメディクス, インコーポレイテッド
センター・フォー・モレキュラー・メディシン・アンド・イムノロジー
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Publication of JP2008533161A publication Critical patent/JP2008533161A/ja
Publication of JP2008533161A5 publication Critical patent/JP2008533161A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
JP2008501998A 2005-03-14 2006-03-14 PPAR−γアンタゴニストを使用するがんの治療方法 Pending JP2008533161A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66102405P 2005-03-14 2005-03-14
PCT/US2006/009309 WO2006099479A2 (en) 2005-03-14 2006-03-14 Methods of treating cancer using ppar-gamma antagonists

Publications (2)

Publication Number Publication Date
JP2008533161A true JP2008533161A (ja) 2008-08-21
JP2008533161A5 JP2008533161A5 (enExample) 2009-05-07

Family

ID=36992402

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008501998A Pending JP2008533161A (ja) 2005-03-14 2006-03-14 PPAR−γアンタゴニストを使用するがんの治療方法

Country Status (6)

Country Link
US (1) US20060217425A1 (enExample)
EP (1) EP1858512A4 (enExample)
JP (1) JP2008533161A (enExample)
AU (1) AU2006223000B2 (enExample)
CA (1) CA2600712A1 (enExample)
WO (1) WO2006099479A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012526079A (ja) * 2009-05-06 2012-10-25 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008094860A2 (en) 2007-01-30 2008-08-07 Allergan, Inc. Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists
US20080206194A1 (en) * 2007-02-16 2008-08-28 Glazer Robert I Method for the treatment of breast cancer
CA3254026A1 (en) * 2022-03-08 2023-09-14 Flare Therapeutics Inc. Inverse PPARG agonists and their uses
AU2023231613A1 (en) * 2022-03-08 2024-09-05 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510462A (ja) * 1996-12-11 2001-07-31 ダナ・フアーバー・キヤンサー・インスチチユート 腫瘍細胞の成長を阻害するための方法および製薬学的組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7585512B1 (en) * 1990-05-08 2009-09-08 Thomas Jefferson University Composition and method of using tumor cells
PL357678A1 (en) * 2000-04-28 2004-07-26 Sankyo Company, Limited Ppargamma modulators
AU2002303156A1 (en) * 2001-03-23 2002-10-08 Bethesda Pharmaceuticals, Inc. Design and synthesis of optimized ligands for ppar
US6972175B2 (en) * 2002-11-27 2005-12-06 David Pinsky Inhibition of Egr-1 expression by ppar-gamma agonists and related compositions and methods
KR100576575B1 (ko) * 2003-09-16 2006-05-04 한국생명공학연구원 피피에이알감마에 대한 단일클론 항체, 특이 항체분비 융합세포주 및 항체를 이용한 염증, 암, 대사성 질환과 같은 질병 관련 조절인자를 검색하는 방법
WO2005077126A2 (en) * 2004-02-10 2005-08-25 Boston Medical Center Corporation Use of ppargamma specific inhibitors as anti-cancer therapeutics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001510462A (ja) * 1996-12-11 2001-07-31 ダナ・フアーバー・キヤンサー・インスチチユート 腫瘍細胞の成長を阻害するための方法および製薬学的組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012526079A (ja) * 2009-05-06 2012-10-25 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用
US9289509B2 (en) 2009-05-06 2016-03-22 Biotest Ag Uses of immunoconjugates targeting CD138
JP2016053053A (ja) * 2009-05-06 2016-04-14 バイオテスト・アクチエンゲゼルシヤフト Cd138を標的とする免疫複合体の使用

Also Published As

Publication number Publication date
EP1858512A4 (en) 2009-08-05
US20060217425A1 (en) 2006-09-28
AU2006223000A1 (en) 2006-09-21
WO2006099479A2 (en) 2006-09-21
EP1858512A2 (en) 2007-11-28
CA2600712A1 (en) 2006-09-21
WO2006099479A3 (en) 2006-11-16
AU2006223000B2 (en) 2011-06-30

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