JP2008533152A5 - - Google Patents

Download PDF

Info

Publication number
JP2008533152A5
JP2008533152A5 JP2008501950A JP2008501950A JP2008533152A5 JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5 JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5
Authority
JP
Japan
Prior art keywords
group
carbon atoms
nitrogen mustard
alkynyl
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008501950A
Other languages
English (en)
Japanese (ja)
Other versions
JP5236457B2 (ja
JP2008533152A (ja
Filing date
Publication date
Priority claimed from US11/369,305 external-priority patent/US7872050B2/en
Application filed filed Critical
Publication of JP2008533152A publication Critical patent/JP2008533152A/ja
Publication of JP2008533152A5 publication Critical patent/JP2008533152A5/ja
Application granted granted Critical
Publication of JP5236457B2 publication Critical patent/JP5236457B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP2008501950A 2005-03-14 2006-03-14 発揮性アルキル化剤の安定化組成物およびその使用方法 Expired - Lifetime JP5236457B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66135605P 2005-03-14 2005-03-14
US60/661,356 2005-03-14
US75112805P 2005-12-16 2005-12-16
US60/751,128 2005-12-16
US11/369,305 US7872050B2 (en) 2005-03-14 2006-03-07 Stabilized compositions of volatile alkylating agents and methods of using thereof
US11/369,305 2006-03-07
PCT/US2006/009060 WO2006099385A2 (en) 2005-03-14 2006-03-14 Stabilized compositions of volatile alkylating agents and methods of using thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012253174A Division JP5671514B2 (ja) 2005-03-14 2012-11-19 発揮性アルキル化剤の安定化組成物およびその使用方法

Publications (3)

Publication Number Publication Date
JP2008533152A JP2008533152A (ja) 2008-08-21
JP2008533152A5 true JP2008533152A5 (enExample) 2009-05-07
JP5236457B2 JP5236457B2 (ja) 2013-07-17

Family

ID=36971840

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008501950A Expired - Lifetime JP5236457B2 (ja) 2005-03-14 2006-03-14 発揮性アルキル化剤の安定化組成物およびその使用方法
JP2012253174A Expired - Lifetime JP5671514B2 (ja) 2005-03-14 2012-11-19 発揮性アルキル化剤の安定化組成物およびその使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012253174A Expired - Lifetime JP5671514B2 (ja) 2005-03-14 2012-11-19 発揮性アルキル化剤の安定化組成物およびその使用方法

Country Status (19)

Country Link
US (7) US7872050B2 (enExample)
EP (1) EP1858864B1 (enExample)
JP (2) JP5236457B2 (enExample)
KR (1) KR101168252B1 (enExample)
CN (1) CN101175735B (enExample)
AU (1) AU2006223076B2 (enExample)
CA (1) CA2600468C (enExample)
CY (2) CY1113305T1 (enExample)
DK (1) DK1858864T3 (enExample)
ES (1) ES2388744T3 (enExample)
FR (1) FR17C1029I2 (enExample)
HU (1) HUS1700033I1 (enExample)
LT (1) LTC1858864I2 (enExample)
LU (1) LUC00033I2 (enExample)
NZ (3) NZ561268A (enExample)
PL (1) PL1858864T3 (enExample)
PT (1) PT1858864E (enExample)
SI (1) SI1858864T1 (enExample)
WO (1) WO2006099385A2 (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US8501818B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US7872050B2 (en) * 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US8501817B2 (en) * 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
BRPI0906473A8 (pt) 2008-01-04 2016-02-10 Intellikine Inc Certas entidades químicas, composições e métodos
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
CN104224703A (zh) * 2008-09-25 2014-12-24 赛福伦公司 苯达莫司汀的液体配制品
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン, エルエルシー 複素環式化合物およびその使用
US8545892B2 (en) * 2009-06-26 2013-10-01 Nano Pharmaceutical Laboratories, Llc Sustained release beads and suspensions including the same for sustained delivery of active ingredients
WO2011094565A1 (en) 2010-01-28 2011-08-04 Eagle Pharmaceuticals, Inc. Formulations of bendamustine
EP2542058B1 (en) 2010-03-02 2018-10-10 RXi Pharmaceuticals Corporation Effective sensitizing dose of a gelled immunomodulating topical composition
JP5951600B2 (ja) 2010-05-21 2016-07-13 インフィニティー ファーマシューティカルズ, インコーポレイテッド キナーゼ調節のための、化合物、組成物および方法
WO2012064973A2 (en) 2010-11-10 2012-05-18 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3238722B1 (en) 2011-01-10 2019-03-13 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinones
WO2013009800A2 (en) * 2011-07-11 2013-01-17 Ceptaris Therapeutics, Inc. Compositions of alkylating agents and methods of treating skin disorders therewith
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
PE20141371A1 (es) 2011-08-29 2014-10-13 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
US20140005148A1 (en) * 2012-06-29 2014-01-02 Coldstream Laboratories Inc. Stable liquid formulations of nitrogen mustards
RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
WO2015051241A1 (en) 2013-10-04 2015-04-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3964507A1 (en) 2013-10-04 2022-03-09 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN106456628A (zh) 2014-03-19 2017-02-22 无限药品股份有限公司 用于治疗PI3K‑γ介导的障碍的杂环化合物
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
US20150320774A1 (en) 2014-05-09 2015-11-12 AuroMedics Pharma LLC Formulations of cyclophosphamide liquid concentrate
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
JP6758325B2 (ja) 2015-06-04 2020-09-23 クリティテック・インコーポレイテッド タキサン粒子およびその使用
CN114230571B (zh) 2015-09-14 2025-07-08 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CN114767860A (zh) 2016-04-04 2022-07-22 克里蒂泰克公司 实体肿瘤治疗方法
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3474856B1 (en) 2016-06-24 2022-09-14 Infinity Pharmaceuticals, Inc. Combination therapies
CA3063420A1 (en) 2017-06-09 2018-12-13 Crititech, Inc. Treatment of epithelial cysts by intracystic injection of antineoplastic particles
AU2018284247B2 (en) 2017-06-14 2020-04-30 Crititech Inc. Methods for treating lung disorders
CA3076919A1 (en) 2017-10-03 2019-04-11 Crititech, Inc. Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer
JP6584588B2 (ja) 2017-12-22 2019-10-02 レオキシン・エルエルシー セルライトの治療のための組成物及び方法
US20190365698A1 (en) * 2018-05-31 2019-12-05 Crititech, Inc. Use of Antineoplastic Agents to Stimulate the Immune System for Treatment of Cancer
WO2023059148A1 (ko) 2021-10-08 2023-04-13 기초과학연구원 항암 치료 개선을 위한 2-클로로-n,n-디에틸에틸아민 염산염의 용도

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US157545A (en) * 1874-12-08 Improvement in car-couplings
US79492A (en) * 1868-06-30 Improvement in weae-plates foe, boots and shoes
US312290A (en) * 1885-02-17 James g
US4083692A (en) * 1970-06-04 1978-04-11 The United States Of America As Represented By The Secretary Of The Army Detection and estimation of microquantities of alkylating agents
US3767792A (en) * 1971-07-02 1973-10-23 Stanley Drug Products Inc Method for controlling the toxicity of drug products
US3904766A (en) * 1973-06-19 1975-09-09 Scott Eugene J Van Treatment of psoriasis
US4206222A (en) * 1977-06-23 1980-06-03 Societe Civile Particuliere De Brevets Suffren Method for preparing a substance having properties against collagen diseases and products obtained
AU605132B2 (en) 1986-01-03 1991-01-10 Consolidated Pharmaceuticals Limited Melphalan derivatives
US4863910A (en) * 1986-05-20 1989-09-05 Takeo Takayanagi Complexes of AZO compounds and/or their salts and an antitumor agent and a method for reducing the growth of tumors
US4725438A (en) * 1986-05-29 1988-02-16 Leazer Billie S Aloe vera ointment
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
US5326790A (en) * 1986-11-19 1994-07-05 Dermatologic Research Corporation Administration of skin medications by use of dicarboxylic acids and derivatives
US4853388A (en) * 1987-05-15 1989-08-01 Pearlman Dale L Method for treating psoriasis with cytotoxic agents
US5051363A (en) * 1987-06-26 1991-09-24 University Of Pennsylvania Method for modifying the toxicity of DNA reactive cross-linking agents to cells
US5229422A (en) * 1987-09-07 1993-07-20 Teijin Limited Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion
GB8727157D0 (en) 1987-11-19 1987-12-23 Wellcome Found Pharmaceutical formulations
US5098717A (en) 1987-12-09 1992-03-24 Thames Pharmacal Co., Inc. Method of treatment for pruritus
US4888354A (en) * 1987-12-21 1989-12-19 Theratech, Inc. Skin penetration enhancement using free base and acid addition salt combinations of active agents
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
DE4005911C1 (enExample) * 1990-02-24 1991-04-25 Gmn Georg Mueller Nuernberg Ag, 8500 Nuernberg, De
US4949641A (en) * 1990-03-05 1990-08-21 The United States Of America As Represented By The Secretary Of The Army Method of safely detoxifying mustard gases
US6764681B2 (en) * 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US5820872A (en) * 1992-11-18 1998-10-13 Yale University Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor
EP0716589A4 (en) * 1993-07-23 1997-06-11 Morris Herstein COSMETIC COMPOSITION STIMULATING THE RENEWAL OF THE SKIN WITH A PROLONGED IRRITATION ELIMINATION EFFECT
FR2728166A1 (fr) * 1994-12-19 1996-06-21 Oreal Composition topique contenant un antagoniste de substance p
GB9501052D0 (en) * 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
US6551611B2 (en) * 1995-09-28 2003-04-22 Schering Aktiengesellschaft Hormone replacement therapy method
US5744460A (en) * 1996-03-07 1998-04-28 Novartis Corporation Combination for treatment of proliferative diseases
US6124108A (en) * 1996-05-15 2000-09-26 The United States Of America As Represented By The Secretary Of The Army Protein biomarker for mustard chemical injury
US5948437A (en) * 1996-05-23 1999-09-07 Zeneca Limited Pharmaceutical compositions using thiazepine
DK0923941T3 (da) * 1996-06-27 2006-09-18 Chugai Pharmaceutical Co Ltd Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler
US6255502B1 (en) * 1996-07-11 2001-07-03 Farmarc Nederland B.V. Pharmaceutical composition containing acid addition salt of basic drug
US6753155B1 (en) * 1997-05-13 2004-06-22 The United States Of America As Represented By The Secretary Of The Army Protein biomarker for mustard chemical injury
KR20010020611A (ko) * 1997-07-01 2001-03-15 아테로제닉스, 인코포레이티드 항산화제에 의한 과증식질병 치료의 향상
JP2003518359A (ja) 1998-01-30 2003-06-10 コールド スプリング ハーバー ラボラトリー 細胞増殖の調節、方法および試薬
GB9805868D0 (en) * 1998-03-20 1998-05-13 Zeneca Ltd Anti-tumour agents
US20060079492A1 (en) * 1999-10-25 2006-04-13 Ahlem Clarence N Compositions and treatment methods
US6329148B1 (en) * 1999-02-16 2001-12-11 The Board Of Trustees Of The Leland Stanford University Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells
US6017902A (en) * 1999-02-25 2000-01-25 Brookhaven Science Associates Boron containing amino acid compounds and methods for their use
US6395721B1 (en) 2000-01-05 2002-05-28 Leonard Bloom Low potency unpreserved sterile topical corticosteroid compositions for dermatitis
US20020146692A1 (en) * 2000-01-21 2002-10-10 Victoria Yamazaki Methods and materials relating to G protein-coupled receptor-like polypeptides and polynucleotides
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20030215471A1 (en) * 2001-01-31 2003-11-20 Wilmott James M. Surfactant free topical compositions and method for rapid preparation thereof
US7547673B2 (en) * 2001-09-13 2009-06-16 The Johns Hopkins University Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production
WO2003094954A1 (en) * 2001-09-25 2003-11-20 Quick Med Technologies, Inc. Composition and method for minimizing or avoiding adverse effects of vesicants
US20030082229A1 (en) 2001-11-01 2003-05-01 Board Of Regents, The University Of Texas Systems Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use
US6885492B2 (en) * 2001-11-08 2005-04-26 Imaginative Optics, Inc. Spatial light modulator apparatus
ATE468855T1 (de) * 2002-11-12 2010-06-15 Jewish General Hospital Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie
CA2506442A1 (en) 2002-11-18 2004-07-01 Celgene Corporation Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
US8088605B2 (en) 2002-12-04 2012-01-03 Technologies Biolactics Inc. Exopolysaccharides delivery system for active molecules
WO2004113573A2 (en) * 2003-06-19 2004-12-29 The Samuel Roberts Noble Foundation, Inc. Methods and compositions for analysis of plant gene function
WO2005007129A2 (en) 2003-07-17 2005-01-27 Angiotech International Ag Topical formulations with bioactive components
US20070287719A1 (en) * 2005-03-11 2007-12-13 Pfizer Inc Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea
US8501817B2 (en) 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US8501818B2 (en) 2005-03-14 2013-08-06 Ceptaris Therapeutics, Inc. Stabilized compositions of alkylating agents and methods of using same
US20110039943A1 (en) * 2005-03-14 2011-02-17 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US20120157545A1 (en) * 2005-03-14 2012-06-21 Robert Alonso Methods for treating skin disorders with topical nitrogen mustard compositions
US7872050B2 (en) 2005-03-14 2011-01-18 Yaupon Therapeutics Inc. Stabilized compositions of volatile alkylating agents and methods of using thereof
US20060281720A1 (en) * 2005-06-08 2006-12-14 Loria Roger M 5-Androstenediol As An Inhibitor of Gliomas
WO2013009800A2 (en) 2011-07-11 2013-01-17 Ceptaris Therapeutics, Inc. Compositions of alkylating agents and methods of treating skin disorders therewith

Similar Documents

Publication Publication Date Title
KR850001896A (ko) 방향족 살균성 화합물의 제조방법과 이를 함유한 제약학적 제형
JP2013091643A5 (enExample)
RU2010133903A (ru) Способ и промежуточные соединения для получения производных 5-бифенил-4-ил-2-метилпентановой кислоты
AR068756A1 (es) Compuestos peptidicos, formulacion farmaceutica y sus usos como moduladores del virus de la hepatitis c
JP2015062072A5 (enExample)
KR950000728A (ko) 포스포네이트 뉴클레오티드 에스테르 유도체
JP2005532287A5 (enExample)
JP2010514786A5 (enExample)
CO5631432A2 (es) Derivados de n-[fenil(piepidin-2-il)metil]benzamida, su preparacion y su aplicacion en terapeutica
CO5130007A1 (es) Derivados glicol de xantinas y composiciones farmaceuticas que contienen dichos compuestos
JP2009536221A5 (enExample)
JPWO2020004649A5 (enExample)
JP2008512408A5 (enExample)
JP2005533013A5 (enExample)
JP2021515755A5 (enExample)
JP2022552159A5 (enExample)
JP2008266635A5 (ja) 活性エネルギー線硬化型液体組成物、水性インク及び液体カートリッジ
RU2008130887A (ru) Водорастворимое соединение бензоазепина и содержащая его фармацевтическая композиция
RU2004119056A (ru) Составленные на основе воды фармацевтические композиции водорастворимых пролекарств пропофола
RU2002124767A (ru) Косметическая композиция для карандашей с низкой липкостью
JP2013545728A5 (enExample)
JP2006517932A5 (enExample)
KR900001675A (ko) 기관지확장 작용을 갖는 화합물
JP2005533141A5 (enExample)
RU2007132737A (ru) Новый пиримидиновый нуклеозид или его соль