JP2008533152A5 - - Google Patents
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- Publication number
- JP2008533152A5 JP2008533152A5 JP2008501950A JP2008501950A JP2008533152A5 JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5 JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- nitrogen mustard
- alkynyl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66135605P | 2005-03-14 | 2005-03-14 | |
| US60/661,356 | 2005-03-14 | ||
| US75112805P | 2005-12-16 | 2005-12-16 | |
| US60/751,128 | 2005-12-16 | ||
| US11/369,305 US7872050B2 (en) | 2005-03-14 | 2006-03-07 | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US11/369,305 | 2006-03-07 | ||
| PCT/US2006/009060 WO2006099385A2 (en) | 2005-03-14 | 2006-03-14 | Stabilized compositions of volatile alkylating agents and methods of using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012253174A Division JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008533152A JP2008533152A (ja) | 2008-08-21 |
| JP2008533152A5 true JP2008533152A5 (enExample) | 2009-05-07 |
| JP5236457B2 JP5236457B2 (ja) | 2013-07-17 |
Family
ID=36971840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501950A Expired - Lifetime JP5236457B2 (ja) | 2005-03-14 | 2006-03-14 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
| JP2012253174A Expired - Lifetime JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012253174A Expired - Lifetime JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US7872050B2 (enExample) |
| EP (1) | EP1858864B1 (enExample) |
| JP (2) | JP5236457B2 (enExample) |
| KR (1) | KR101168252B1 (enExample) |
| CN (1) | CN101175735B (enExample) |
| AU (1) | AU2006223076B2 (enExample) |
| CA (1) | CA2600468C (enExample) |
| CY (2) | CY1113305T1 (enExample) |
| DK (1) | DK1858864T3 (enExample) |
| ES (1) | ES2388744T3 (enExample) |
| FR (1) | FR17C1029I2 (enExample) |
| HU (1) | HUS1700033I1 (enExample) |
| LT (1) | LTC1858864I2 (enExample) |
| LU (1) | LUC00033I2 (enExample) |
| NZ (3) | NZ561268A (enExample) |
| PL (1) | PL1858864T3 (enExample) |
| PT (1) | PT1858864E (enExample) |
| SI (1) | SI1858864T1 (enExample) |
| WO (1) | WO2006099385A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US8501818B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US7872050B2 (en) * | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US8501817B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| BRPI0906473A8 (pt) | 2008-01-04 | 2016-02-10 | Intellikine Inc | Certas entidades químicas, composições e métodos |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| CN104224703A (zh) * | 2008-09-25 | 2014-12-24 | 赛福伦公司 | 苯达莫司汀的液体配制品 |
| WO2010036380A1 (en) | 2008-09-26 | 2010-04-01 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
| JP5789252B2 (ja) | 2009-05-07 | 2015-10-07 | インテリカイン, エルエルシー | 複素環式化合物およびその使用 |
| US8545892B2 (en) * | 2009-06-26 | 2013-10-01 | Nano Pharmaceutical Laboratories, Llc | Sustained release beads and suspensions including the same for sustained delivery of active ingredients |
| WO2011094565A1 (en) | 2010-01-28 | 2011-08-04 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| EP2542058B1 (en) | 2010-03-02 | 2018-10-10 | RXi Pharmaceuticals Corporation | Effective sensitizing dose of a gelled immunomodulating topical composition |
| JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3238722B1 (en) | 2011-01-10 | 2019-03-13 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones |
| WO2013009800A2 (en) * | 2011-07-11 | 2013-01-17 | Ceptaris Therapeutics, Inc. | Compositions of alkylating agents and methods of treating skin disorders therewith |
| US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP2734520B1 (en) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PE20141371A1 (es) | 2011-08-29 | 2014-10-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US8828998B2 (en) | 2012-06-25 | 2014-09-09 | Infinity Pharmaceuticals, Inc. | Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors |
| US20140005148A1 (en) * | 2012-06-29 | 2014-01-02 | Coldstream Laboratories Inc. | Stable liquid formulations of nitrogen mustards |
| RU2702908C2 (ru) | 2012-11-01 | 2019-10-14 | Инфинити Фармасьютикалз, Инк. | Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3964507A1 (en) | 2013-10-04 | 2022-03-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| CN106456628A (zh) | 2014-03-19 | 2017-02-22 | 无限药品股份有限公司 | 用于治疗PI3K‑γ介导的障碍的杂环化合物 |
| WO2015160975A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| US20150320774A1 (en) | 2014-05-09 | 2015-11-12 | AuroMedics Pharma LLC | Formulations of cyclophosphamide liquid concentrate |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| JP6758325B2 (ja) | 2015-06-04 | 2020-09-23 | クリティテック・インコーポレイテッド | タキサン粒子およびその使用 |
| CN114230571B (zh) | 2015-09-14 | 2025-07-08 | 无限药品股份有限公司 | 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法 |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| CN114767860A (zh) | 2016-04-04 | 2022-07-22 | 克里蒂泰克公司 | 实体肿瘤治疗方法 |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3474856B1 (en) | 2016-06-24 | 2022-09-14 | Infinity Pharmaceuticals, Inc. | Combination therapies |
| CA3063420A1 (en) | 2017-06-09 | 2018-12-13 | Crititech, Inc. | Treatment of epithelial cysts by intracystic injection of antineoplastic particles |
| AU2018284247B2 (en) | 2017-06-14 | 2020-04-30 | Crititech Inc. | Methods for treating lung disorders |
| CA3076919A1 (en) | 2017-10-03 | 2019-04-11 | Crititech, Inc. | Local delivery of antineoplastic particles in combination with systemic delivery of immunotherapeutic agents for the treatment of cancer |
| JP6584588B2 (ja) | 2017-12-22 | 2019-10-02 | レオキシン・エルエルシー | セルライトの治療のための組成物及び方法 |
| US20190365698A1 (en) * | 2018-05-31 | 2019-12-05 | Crititech, Inc. | Use of Antineoplastic Agents to Stimulate the Immune System for Treatment of Cancer |
| WO2023059148A1 (ko) | 2021-10-08 | 2023-04-13 | 기초과학연구원 | 항암 치료 개선을 위한 2-클로로-n,n-디에틸에틸아민 염산염의 용도 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US157545A (en) * | 1874-12-08 | Improvement in car-couplings | ||
| US79492A (en) * | 1868-06-30 | Improvement in weae-plates foe, boots and shoes | ||
| US312290A (en) * | 1885-02-17 | James g | ||
| US4083692A (en) * | 1970-06-04 | 1978-04-11 | The United States Of America As Represented By The Secretary Of The Army | Detection and estimation of microquantities of alkylating agents |
| US3767792A (en) * | 1971-07-02 | 1973-10-23 | Stanley Drug Products Inc | Method for controlling the toxicity of drug products |
| US3904766A (en) * | 1973-06-19 | 1975-09-09 | Scott Eugene J Van | Treatment of psoriasis |
| US4206222A (en) * | 1977-06-23 | 1980-06-03 | Societe Civile Particuliere De Brevets Suffren | Method for preparing a substance having properties against collagen diseases and products obtained |
| AU605132B2 (en) | 1986-01-03 | 1991-01-10 | Consolidated Pharmaceuticals Limited | Melphalan derivatives |
| US4863910A (en) * | 1986-05-20 | 1989-09-05 | Takeo Takayanagi | Complexes of AZO compounds and/or their salts and an antitumor agent and a method for reducing the growth of tumors |
| US4725438A (en) * | 1986-05-29 | 1988-02-16 | Leazer Billie S | Aloe vera ointment |
| IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
| US5326790A (en) * | 1986-11-19 | 1994-07-05 | Dermatologic Research Corporation | Administration of skin medications by use of dicarboxylic acids and derivatives |
| US4853388A (en) * | 1987-05-15 | 1989-08-01 | Pearlman Dale L | Method for treating psoriasis with cytotoxic agents |
| US5051363A (en) * | 1987-06-26 | 1991-09-24 | University Of Pennsylvania | Method for modifying the toxicity of DNA reactive cross-linking agents to cells |
| US5229422A (en) * | 1987-09-07 | 1993-07-20 | Teijin Limited | Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion |
| GB8727157D0 (en) | 1987-11-19 | 1987-12-23 | Wellcome Found | Pharmaceutical formulations |
| US5098717A (en) | 1987-12-09 | 1992-03-24 | Thames Pharmacal Co., Inc. | Method of treatment for pruritus |
| US4888354A (en) * | 1987-12-21 | 1989-12-19 | Theratech, Inc. | Skin penetration enhancement using free base and acid addition salt combinations of active agents |
| US5719197A (en) * | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| DE4005911C1 (enExample) * | 1990-02-24 | 1991-04-25 | Gmn Georg Mueller Nuernberg Ag, 8500 Nuernberg, De | |
| US4949641A (en) * | 1990-03-05 | 1990-08-21 | The United States Of America As Represented By The Secretary Of The Army | Method of safely detoxifying mustard gases |
| US6764681B2 (en) * | 1991-10-07 | 2004-07-20 | Biogen, Inc. | Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction |
| US5820872A (en) * | 1992-11-18 | 1998-10-13 | Yale University | Methods and compositions for improving the effectiveness of X-irradiation therapy for the treatment of an internal solid tumor |
| EP0716589A4 (en) * | 1993-07-23 | 1997-06-11 | Morris Herstein | COSMETIC COMPOSITION STIMULATING THE RENEWAL OF THE SKIN WITH A PROLONGED IRRITATION ELIMINATION EFFECT |
| FR2728166A1 (fr) * | 1994-12-19 | 1996-06-21 | Oreal | Composition topique contenant un antagoniste de substance p |
| GB9501052D0 (en) * | 1995-01-19 | 1995-03-08 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6551611B2 (en) * | 1995-09-28 | 2003-04-22 | Schering Aktiengesellschaft | Hormone replacement therapy method |
| US5744460A (en) * | 1996-03-07 | 1998-04-28 | Novartis Corporation | Combination for treatment of proliferative diseases |
| US6124108A (en) * | 1996-05-15 | 2000-09-26 | The United States Of America As Represented By The Secretary Of The Army | Protein biomarker for mustard chemical injury |
| US5948437A (en) * | 1996-05-23 | 1999-09-07 | Zeneca Limited | Pharmaceutical compositions using thiazepine |
| DK0923941T3 (da) * | 1996-06-27 | 2006-09-18 | Chugai Pharmaceutical Co Ltd | Midler mod myelom der skal anvendes sammen med nitrogensennepantitumormidler |
| US6255502B1 (en) * | 1996-07-11 | 2001-07-03 | Farmarc Nederland B.V. | Pharmaceutical composition containing acid addition salt of basic drug |
| US6753155B1 (en) * | 1997-05-13 | 2004-06-22 | The United States Of America As Represented By The Secretary Of The Army | Protein biomarker for mustard chemical injury |
| KR20010020611A (ko) * | 1997-07-01 | 2001-03-15 | 아테로제닉스, 인코포레이티드 | 항산화제에 의한 과증식질병 치료의 향상 |
| JP2003518359A (ja) | 1998-01-30 | 2003-06-10 | コールド スプリング ハーバー ラボラトリー | 細胞増殖の調節、方法および試薬 |
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| US20060079492A1 (en) * | 1999-10-25 | 2006-04-13 | Ahlem Clarence N | Compositions and treatment methods |
| US6329148B1 (en) * | 1999-02-16 | 2001-12-11 | The Board Of Trustees Of The Leland Stanford University | Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells |
| US6017902A (en) * | 1999-02-25 | 2000-01-25 | Brookhaven Science Associates | Boron containing amino acid compounds and methods for their use |
| US6395721B1 (en) | 2000-01-05 | 2002-05-28 | Leonard Bloom | Low potency unpreserved sterile topical corticosteroid compositions for dermatitis |
| US20020146692A1 (en) * | 2000-01-21 | 2002-10-10 | Victoria Yamazaki | Methods and materials relating to G protein-coupled receptor-like polypeptides and polynucleotides |
| US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
| US20030215471A1 (en) * | 2001-01-31 | 2003-11-20 | Wilmott James M. | Surfactant free topical compositions and method for rapid preparation thereof |
| US7547673B2 (en) * | 2001-09-13 | 2009-06-16 | The Johns Hopkins University | Therapeutics for cancer using 3-bromopyruvate and other selective inhibitors of ATP production |
| WO2003094954A1 (en) * | 2001-09-25 | 2003-11-20 | Quick Med Technologies, Inc. | Composition and method for minimizing or avoiding adverse effects of vesicants |
| US20030082229A1 (en) | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| US6885492B2 (en) * | 2001-11-08 | 2005-04-26 | Imaginative Optics, Inc. | Spatial light modulator apparatus |
| ATE468855T1 (de) * | 2002-11-12 | 2010-06-15 | Jewish General Hospital | Kombination von stickstoff-senf analogen und imatinib für die behandlung von chronischer lymphatischer leukämie |
| CA2506442A1 (en) | 2002-11-18 | 2004-07-01 | Celgene Corporation | Methods of using and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide |
| US8088605B2 (en) | 2002-12-04 | 2012-01-03 | Technologies Biolactics Inc. | Exopolysaccharides delivery system for active molecules |
| WO2004113573A2 (en) * | 2003-06-19 | 2004-12-29 | The Samuel Roberts Noble Foundation, Inc. | Methods and compositions for analysis of plant gene function |
| WO2005007129A2 (en) | 2003-07-17 | 2005-01-27 | Angiotech International Ag | Topical formulations with bioactive components |
| US20070287719A1 (en) * | 2005-03-11 | 2007-12-13 | Pfizer Inc | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea |
| US8501817B2 (en) | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US8501818B2 (en) | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US20120157545A1 (en) * | 2005-03-14 | 2012-06-21 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US7872050B2 (en) | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US20060281720A1 (en) * | 2005-06-08 | 2006-12-14 | Loria Roger M | 5-Androstenediol As An Inhibitor of Gliomas |
| WO2013009800A2 (en) | 2011-07-11 | 2013-01-17 | Ceptaris Therapeutics, Inc. | Compositions of alkylating agents and methods of treating skin disorders therewith |
-
2006
- 2006-03-07 US US11/369,305 patent/US7872050B2/en active Active
- 2006-03-14 PL PL06738150T patent/PL1858864T3/pl unknown
- 2006-03-14 NZ NZ561268A patent/NZ561268A/en not_active IP Right Cessation
- 2006-03-14 KR KR1020077023666A patent/KR101168252B1/ko not_active Expired - Lifetime
- 2006-03-14 EP EP06738150A patent/EP1858864B1/en not_active Expired - Lifetime
- 2006-03-14 SI SI200631397T patent/SI1858864T1/sl unknown
- 2006-03-14 NZ NZ589188A patent/NZ589188A/en not_active IP Right Cessation
- 2006-03-14 AU AU2006223076A patent/AU2006223076B2/en active Active
- 2006-03-14 CN CN200680016627.XA patent/CN101175735B/zh not_active Expired - Lifetime
- 2006-03-14 PT PT06738150T patent/PT1858864E/pt unknown
- 2006-03-14 CA CA2600468A patent/CA2600468C/en not_active Expired - Lifetime
- 2006-03-14 NZ NZ599001A patent/NZ599001A/xx not_active IP Right Cessation
- 2006-03-14 WO PCT/US2006/009060 patent/WO2006099385A2/en not_active Ceased
- 2006-03-14 JP JP2008501950A patent/JP5236457B2/ja not_active Expired - Lifetime
- 2006-03-14 DK DK06738150.9T patent/DK1858864T3/da active
- 2006-03-14 US US11/908,531 patent/US8450375B2/en active Active
- 2006-03-14 ES ES06738150T patent/ES2388744T3/es not_active Expired - Lifetime
-
2009
- 2009-08-27 US US12/549,258 patent/US7838564B2/en not_active Expired - Lifetime
-
2010
- 2010-11-17 US US12/948,593 patent/US8501819B2/en not_active Expired - Lifetime
-
2012
- 2012-09-19 CY CY20121100855T patent/CY1113305T1/el unknown
- 2012-11-19 JP JP2012253174A patent/JP5671514B2/ja not_active Expired - Lifetime
-
2013
- 2013-01-07 US US13/735,710 patent/US8664278B2/en not_active Expired - Lifetime
- 2013-06-06 US US13/911,282 patent/US20140155491A1/en not_active Abandoned
-
2014
- 2014-01-13 US US14/153,914 patent/US9382191B2/en not_active Expired - Lifetime
-
2017
- 2017-08-09 LU LU00033C patent/LUC00033I2/fr unknown
- 2017-08-10 FR FR17C1029C patent/FR17C1029I2/fr active Active
- 2017-08-10 CY CY2017027C patent/CY2017027I1/el unknown
- 2017-08-11 HU HUS1700033C patent/HUS1700033I1/hu unknown
- 2017-08-14 LT LTPA2017026C patent/LTC1858864I2/lt unknown
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