JP2008533150A5 - - Google Patents
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- Publication number
- JP2008533150A5 JP2008533150A5 JP2008501942A JP2008501942A JP2008533150A5 JP 2008533150 A5 JP2008533150 A5 JP 2008533150A5 JP 2008501942 A JP2008501942 A JP 2008501942A JP 2008501942 A JP2008501942 A JP 2008501942A JP 2008533150 A5 JP2008533150 A5 JP 2008533150A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- independently
- phenyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003342 alkenyl group Chemical group 0.000 description 58
- 229910052736 halogen Inorganic materials 0.000 description 34
- 150000002367 halogens Chemical class 0.000 description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 12
- 229910052799 carbon Inorganic materials 0.000 description 12
- 229910052757 nitrogen Inorganic materials 0.000 description 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 6
- 125000005037 alkyl phenyl group Chemical group 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 239000011737 fluorine Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- 150000002431 hydrogen Chemical class 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 3
- -1 di-substituted phenyl Chemical group 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66268605P | 2005-03-17 | 2005-03-17 | |
| US60/662,686 | 2005-03-17 | ||
| PCT/US2006/008943 WO2006101808A1 (en) | 2005-03-17 | 2006-03-13 | Pyrrolidine derivatives as histamine h3 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008533150A JP2008533150A (ja) | 2008-08-21 |
| JP2008533150A5 true JP2008533150A5 (https=) | 2012-07-26 |
| JP5052497B2 JP5052497B2 (ja) | 2012-10-17 |
Family
ID=36642817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501942A Expired - Fee Related JP5052497B2 (ja) | 2005-03-17 | 2006-03-13 | ヒスタミンｈ３受容体アンタゴニストとしてのピロリジン誘導体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7951826B2 (https=) |
| EP (1) | EP1861360B1 (https=) |
| JP (1) | JP5052497B2 (https=) |
| CN (1) | CN101142180B (https=) |
| AT (1) | ATE450503T1 (https=) |
| AU (1) | AU2006227815B2 (https=) |
| BR (1) | BRPI0608523A2 (https=) |
| CA (1) | CA2600757C (https=) |
| CY (1) | CY1109694T1 (https=) |
| DE (1) | DE602006010833D1 (https=) |
| DK (1) | DK1861360T3 (https=) |
| ES (1) | ES2335305T3 (https=) |
| MX (1) | MX2007011374A (https=) |
| PL (1) | PL1861360T3 (https=) |
| PT (1) | PT1861360E (https=) |
| SI (1) | SI1861360T1 (https=) |
| WO (1) | WO2006101808A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008301B2 (en) * | 2004-04-01 | 2011-08-30 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| JP2010529157A (ja) * | 2007-06-11 | 2010-08-26 | エフ．ホフマン−ラ ロシュ アーゲー | シクロヘキシル誘導体 |
| CN101903340B (zh) | 2007-10-17 | 2013-03-27 | 赛诺菲-安万特 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
| EP2212282B1 (en) | 2007-10-17 | 2011-09-21 | Sanofi | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| WO2009052068A1 (en) | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
| CN101903342B (zh) * | 2007-10-17 | 2012-11-21 | 赛诺菲-安万特 | 取代的n-苯基-吡咯烷基甲基吡咯烷酰胺及其作为组胺h3受体调节剂的治疗用途 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| CN103242212B (zh) * | 2013-05-13 | 2015-11-04 | 南京理工大学 | 一种脑组胺h3受体放射性配体的前体及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671083B1 (fr) * | 1990-12-31 | 1994-12-23 | Inst Nat Sante Rech Med | Nouvelles 4-(4-imidazolyl) piperidines substituees en 1, leur preparation ainsi que leurs applications therapeutiques. |
| US5652258A (en) | 1995-05-30 | 1997-07-29 | Gliatech, Inc. | 2-(4-imidazoyl) cyclopropyl derivatives |
| DK0841922T3 (da) * | 1995-05-30 | 2002-06-03 | Gliatech Inc | 1H-4(5)-substituerede imidazolderivater |
| JP2004532834A (ja) * | 2001-03-23 | 2004-10-28 | イーライ・リリー・アンド・カンパニー | ヒスタミンｈ３受容体アンタゴニストである非イミダゾール系アリールアルキルアミン化合物、その製造および治療的使用 |
| EP1421071B1 (en) * | 2001-07-02 | 2009-11-18 | High Point Pharmaceuticals, LLC | Substituted piperazine and diazepane derivaives as histamine h3 receptor modulators |
| GB0224084D0 (en) * | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| AU2005252178B2 (en) * | 2004-06-02 | 2011-04-21 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| US7846950B2 (en) * | 2004-10-18 | 2010-12-07 | Eli Lilly And Company | Histamine H3 receptor inhibitors, preparation and therapeutic uses |
-
2006
- 2006-03-13 AU AU2006227815A patent/AU2006227815B2/en not_active Ceased
- 2006-03-13 MX MX2007011374A patent/MX2007011374A/es active IP Right Grant
- 2006-03-13 DE DE602006010833T patent/DE602006010833D1/de not_active Expired - Lifetime
- 2006-03-13 PL PL06738050T patent/PL1861360T3/pl unknown
- 2006-03-13 DK DK06738050.1T patent/DK1861360T3/da active
- 2006-03-13 BR BRPI0608523-7A patent/BRPI0608523A2/pt not_active IP Right Cessation
- 2006-03-13 CN CN2006800085959A patent/CN101142180B/zh not_active Expired - Fee Related
- 2006-03-13 AT AT06738050T patent/ATE450503T1/de active
- 2006-03-13 US US11/908,501 patent/US7951826B2/en not_active Expired - Fee Related
- 2006-03-13 EP EP06738050A patent/EP1861360B1/en not_active Expired - Lifetime
- 2006-03-13 JP JP2008501942A patent/JP5052497B2/ja not_active Expired - Fee Related
- 2006-03-13 CA CA2600757A patent/CA2600757C/en not_active Expired - Fee Related
- 2006-03-13 WO PCT/US2006/008943 patent/WO2006101808A1/en not_active Ceased
- 2006-03-13 SI SI200630576T patent/SI1861360T1/sl unknown
- 2006-03-13 PT PT06738050T patent/PT1861360E/pt unknown
- 2006-03-13 ES ES06738050T patent/ES2335305T3/es not_active Expired - Lifetime
-
2009
- 2009-12-30 CY CY20091101350T patent/CY1109694T1/el unknown
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