JP2008531734A5 - - Google Patents

Download PDF

Info

Publication number
JP2008531734A5
JP2008531734A5 JP2007558320A JP2007558320A JP2008531734A5 JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5 JP 2007558320 A JP2007558320 A JP 2007558320A JP 2007558320 A JP2007558320 A JP 2007558320A JP 2008531734 A5 JP2008531734 A5 JP 2008531734A5
Authority
JP
Japan
Prior art keywords
compound
formula
compound according
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007558320A
Other languages
English (en)
Japanese (ja)
Other versions
JP5167473B2 (ja
JP2008531734A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/007865 external-priority patent/WO2006094269A2/en
Publication of JP2008531734A publication Critical patent/JP2008531734A/ja
Publication of JP2008531734A5 publication Critical patent/JP2008531734A5/ja
Application granted granted Critical
Publication of JP5167473B2 publication Critical patent/JP5167473B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2007558320A 2005-03-03 2006-03-03 抗血管新生化合物 Expired - Fee Related JP5167473B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US65865405P 2005-03-03 2005-03-03
US60/658,654 2005-03-03
US67708905P 2005-05-02 2005-05-02
US60/677,089 2005-05-02
PCT/US2006/007865 WO2006094269A2 (en) 2005-03-03 2006-03-03 Anti-angiogenic compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012228959A Division JP2013056895A (ja) 2005-03-03 2012-10-16 抗血管新生化合物

Publications (3)

Publication Number Publication Date
JP2008531734A JP2008531734A (ja) 2008-08-14
JP2008531734A5 true JP2008531734A5 (OSRAM) 2011-03-03
JP5167473B2 JP5167473B2 (ja) 2013-03-21

Family

ID=36941895

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007558320A Expired - Fee Related JP5167473B2 (ja) 2005-03-03 2006-03-03 抗血管新生化合物
JP2012228959A Pending JP2013056895A (ja) 2005-03-03 2012-10-16 抗血管新生化合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012228959A Pending JP2013056895A (ja) 2005-03-03 2012-10-16 抗血管新生化合物

Country Status (6)

Country Link
US (3) US20080152660A1 (OSRAM)
EP (2) EP1853294A4 (OSRAM)
JP (2) JP5167473B2 (OSRAM)
KR (1) KR101373140B1 (OSRAM)
CA (1) CA2598833A1 (OSRAM)
WO (1) WO2006094269A2 (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101159061B1 (ko) * 2001-10-22 2012-06-22 더 스크립스 리서치 인스티튜트 항체 표적화 화합물
WO2006094269A2 (en) * 2005-03-03 2006-09-08 Covx Technologies Ireland Limited Anti-angiogenic compounds
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
AU2011254001B2 (en) * 2007-01-05 2012-08-02 Covx Technologies Ireland Limited Glucagon-like protein-1 receptor (GLP-1R) agonist compounds
US8293714B2 (en) * 2008-05-05 2012-10-23 Covx Technology Ireland, Ltd. Anti-angiogenic compounds
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
EP2395992A2 (en) 2009-02-10 2011-12-21 The Scripps Research Institute Chemically programmed vaccination
US20120189635A1 (en) 2009-07-29 2012-07-26 Regeneron Pharmaceuticals, Inc. Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
US8980268B2 (en) 2009-07-29 2015-03-17 Regeneron Pharamceuticals, Inc. Methods for treating cancer by administering an anti-Ang-2 antibody
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
WO2011094671A2 (en) * 2010-01-29 2011-08-04 The Uab Research Foundation N-terminally conjugated polypeptides for targeted therapy and diagnosis
EP2569336A1 (en) 2010-05-14 2013-03-20 Amgen Inc. Enhanced death receptor agonists
PH12013500070A1 (en) 2010-07-12 2017-08-23 Covx Tech Ireland Ltd Multifunctional antibody conjugates
KR20130086623A (ko) 2010-11-05 2013-08-02 씨오브이엑스 테크놀로지스 아일랜드 리미티드 항-당뇨병 화합물
EP2661282A1 (en) 2011-01-03 2013-11-13 F.Hoffmann-La Roche Ag A pharmaceutical composition of a complex of an anti-dig antibody and digoxigenin that is conjugated to a peptide
EP2780039B9 (en) 2011-11-17 2018-04-18 Pfizer Inc Cytotoxic peptides and antibody drug conjugates thereof
MX2014007500A (es) 2011-12-20 2014-07-28 Pfizer Procesos mejorados para preparar conjugados y enlazadores de peptido.
KR101640697B1 (ko) 2011-12-22 2016-07-18 화이자 인코포레이티드 항당뇨병 화합물
CA2859755C (en) 2011-12-23 2021-04-20 Pfizer Inc. Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
AR090410A1 (es) 2012-01-09 2014-11-12 Covx Technologies Ireland Ltd Anticuerpos mutantes y conjugacion de los mismos
HK1206760A1 (en) 2012-03-28 2016-01-15 Amgen Inc. Dr5 receptor agonist combinations
KR101762047B1 (ko) 2012-11-05 2017-07-27 화이자 인코포레이티드 스플라이세오스타틴 유사체
TWI589590B (zh) 2012-11-07 2017-07-01 輝瑞股份有限公司 抗切口３（ａｎｔｉ-ｎｏｔｃｈ３）抗體及抗體-藥物共軛體
BR112016016490B1 (pt) 2014-01-27 2022-11-29 Pfizer Inc Compostos de agentes citotóxicos bifuncionais, composição farmacêutica compreendendo os referidos compostos e usos dos mesmos
DK3242884T3 (da) * 2015-01-09 2021-04-19 Ipsen Bioinnovation Ltd Kationiske neurotoksiner
TWI712605B (zh) 2015-03-20 2020-12-11 美商輝瑞股份有限公司 含有ｃｔｉ藥效基團之雙功能性細胞毒性劑
JP6990650B2 (ja) * 2015-09-17 2022-03-04 ザ スクリプス リサーチ インスティテュート 二重可変ドメインイムノコンジュゲートおよびその用途
TWI726942B (zh) 2015-11-30 2021-05-11 美商輝瑞股份有限公司 位點專一性ｈｅｒ２抗體藥物共軛體
WO2017134547A1 (en) 2016-02-01 2017-08-10 Pfizer Inc. Tubulysin analogs and methods for their preparation
CA3061467A1 (en) 2017-04-28 2019-10-24 Ajinomoto Co., Inc. Compound having affinity substance to soluble protein, cleavable portionand reactive group, or salt thereof
US11364303B2 (en) 2017-09-29 2022-06-21 Pfizer Inc. Cysteine engineered antibody drug conjugates
CN108066285B (zh) * 2017-11-30 2019-06-07 江南大学 一种肝靶向共输送基因/药物的整合纳米系统及制备方法
US20250312472A1 (en) * 2022-04-29 2025-10-09 University Of Florida Research Foundation, Incorporated Antibody compounds with reactive cysteine and related antibody drug conjugates

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719667A (en) * 1970-08-24 1973-03-06 Lilly Co Eli Epimerization of 6-acylamido and 6-imido penicillin sulfoxide esters
US3840556A (en) * 1971-05-28 1974-10-08 Lilly Co Eli Penicillin conversion by halogen electrophiles and anti-bacterials derived thereby
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
US5216132A (en) * 1990-01-12 1993-06-01 Protein Design Labs, Inc. Soluble t-cell antigen receptor chimeric antigens
WO1991015515A1 (en) * 1990-04-06 1991-10-17 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5229275A (en) * 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US6080840A (en) * 1992-01-17 2000-06-27 Slanetz; Alfred E. Soluble T cell receptors
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
US5733757A (en) * 1995-12-15 1998-03-31 The Scripps Research Institute Aldolase catalytic antibody
US5739277A (en) * 1995-04-14 1998-04-14 Genentech Inc. Altered polypeptides with increased half-life
EP0852624A2 (en) * 1995-09-26 1998-07-15 University Of Washington Glycoprotein b of the rfhv/kshv subfamily of herpes viruses
DE19544393A1 (de) 1995-11-15 1997-05-22 Hoechst Schering Agrevo Gmbh Synergistische herbizide Mischungen
US5932545A (en) * 1997-03-17 1999-08-03 Abbott Laboratories Antiangiogenic drug to treat cancer, arthritis and retinopathy
GB9722131D0 (en) * 1997-10-20 1997-12-17 Medical Res Council Method
US6326176B1 (en) 1997-12-18 2001-12-04 The Scripps Research Institute Aldol condensations by catalytic antibodies
US6774211B1 (en) 1998-05-22 2004-08-10 Abbott Laboratories Peptide antiangiogenic drugs
US6716963B1 (en) * 1998-05-22 2004-04-06 Abbott Laboratories Peptide antiangiogenic drugs
PT1078002E (pt) 1998-05-22 2008-09-02 Abbott Lab Fármacos de péptidos antiangiogénicos
WO2001022922A2 (en) 1999-09-27 2001-04-05 The Regents Of The University Of California Engineering antibodies that bind irreversibly
US6294374B1 (en) * 1999-10-08 2001-09-25 The Scripps Research Institute Use of catalytic antibodies for synthesizing epothilone
US6753408B1 (en) 1999-11-22 2004-06-22 Fortuna Haviv Peptides having antiangiogenic activity
CO5261544A1 (es) 1999-11-22 2003-03-31 Abbott Lab Peptidos n-alquilados que tienen actividad antiangiogenica
CA2391386A1 (en) 1999-11-22 2001-05-31 Abbott Laboratories Peptides having antiangiogenic activity
WO2001037807A1 (en) * 1999-11-24 2001-05-31 The Liposome Company, Inc. Modular targeted liposomal delivery system
US20020183242A1 (en) 2001-04-11 2002-12-05 Jack Henkin Peptide antiangiogenic drugs
WO2003002609A2 (en) 2001-06-28 2003-01-09 Domantis Limited Dual-specific ligand and its use
US20030045477A1 (en) 2001-07-26 2003-03-06 Fortuna Haviv Peptides having antiangiogenic activity
KR101159061B1 (ko) * 2001-10-22 2012-06-22 더 스크립스 리서치 인스티튜트 항체 표적화 화합물
AU2003244817B2 (en) 2002-06-28 2010-08-26 Domantis Limited Antigen-binding immunoglobulin single variable domains and dual-specific constructs
AU2003290330A1 (en) 2002-12-27 2004-07-22 Domantis Limited Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
WO2004091484A2 (en) * 2003-04-07 2004-10-28 Board Of Regents, The University Of Texas System Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en­22-one 16-0-(2-0-4-methoxybenzoyl-beta-d-xylopyranosyl)-(1->3)-(2-0­acetyl-alpha-l-arabinopyranoside)] or osw-1 and its derivatives for cancer therapeutics
WO2004091542A2 (en) * 2003-04-15 2004-10-28 Covx Pharmaceuticals, Inc. Nitrogen containing integrin targeting compounds
WO2006094269A2 (en) * 2005-03-03 2006-09-08 Covx Technologies Ireland Limited Anti-angiogenic compounds

Similar Documents

Publication Publication Date Title
JP2008531734A5 (OSRAM)
JP2011500769A5 (OSRAM)
JP2009004351A5 (OSRAM)
JP2006520339A5 (OSRAM)
DE602006006200D1 (de) Antikörper gegen 25-hydroxyvitamin d
JP2010536766A5 (OSRAM)
JP2009541403A5 (OSRAM)
EP2586842A3 (fr) Fluide de transfert de chaleur
JP2016537478A5 (OSRAM)
WO2005016115A3 (en) Biosensors utilizing dendrimer-immobilized ligands and their use thereof
JP2011526313A5 (OSRAM)
WO2009052400A8 (en) Antibodies that bind to mammalian ngal and uses thereof
WO2012041837A3 (de) Verfahren zur herstellung höherer hydridosilanverbindungen
JP2010519270A5 (OSRAM)
JP2010520851A5 (OSRAM)
JP2006527780A5 (OSRAM)
JP2004535412A5 (OSRAM)
JP2007191765A5 (OSRAM)
WO2005119323A3 (en) Buffer tubes with improved flexibility
JP2010500432A5 (OSRAM)
JP2007186562A5 (ja) ポリ乳酸含有樹脂組成物
JP2009523791A5 (OSRAM)
JP2008506698A5 (OSRAM)
JP2007217514A5 (OSRAM)
RU2012137206A (ru) Лигнангидроксилаза