JP2008531638A - 抗マラリアピリジノン誘導体 - Google Patents

抗マラリアピリジノン誘導体 Download PDF

Info

Publication number
JP2008531638A
JP2008531638A JP2007557451A JP2007557451A JP2008531638A JP 2008531638 A JP2008531638 A JP 2008531638A JP 2007557451 A JP2007557451 A JP 2007557451A JP 2007557451 A JP2007557451 A JP 2007557451A JP 2008531638 A JP2008531638 A JP 2008531638A
Authority
JP
Japan
Prior art keywords
dimethyl
bipyridin
chloro
phenyl
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007557451A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008531638A5 (https=
Inventor
ホセ・マリア・フィアンドル・ロマン
ホセ・マリア・ブエノ・カルデロン
アラセリ・マッリョ・ルビオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2008531638A publication Critical patent/JP2008531638A/ja
Publication of JP2008531638A5 publication Critical patent/JP2008531638A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2007557451A 2005-03-04 2006-03-02 抗マラリアピリジノン誘導体 Pending JP2008531638A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05381011 2005-03-04
PCT/EP2006/002160 WO2006094799A2 (en) 2005-03-04 2006-03-02 Pyridinone derivatives against malaria

Publications (2)

Publication Number Publication Date
JP2008531638A true JP2008531638A (ja) 2008-08-14
JP2008531638A5 JP2008531638A5 (https=) 2009-04-16

Family

ID=36593784

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007557451A Pending JP2008531638A (ja) 2005-03-04 2006-03-02 抗マラリアピリジノン誘導体

Country Status (4)

Country Link
US (1) US7579353B2 (https=)
EP (1) EP1858876A2 (https=)
JP (1) JP2008531638A (https=)
WO (1) WO2006094799A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011504914A (ja) * 2007-11-30 2011-02-17 グラクソ グループ リミテッド 抗マラリア化合物の結晶形態
US8598354B2 (en) 2008-12-05 2013-12-03 University Of South Florida Compounds having antiparasitic or anti-infectious activity
WO2010081904A1 (en) 2009-01-19 2010-07-22 Glaxo Group Limited 4 ( 1h) -pyridinone derivatives and their use as antimalaria agents
EP2246329A1 (en) 2009-01-19 2010-11-03 Glaxo Group Limited 4(1H)-pyridinone derivatives and their use as antimalaria agents
WO2010142741A1 (en) * 2009-06-12 2010-12-16 Glaxo Group Limited Phenylpyridylpyridones for use as antimalarial agents
WO2011072064A1 (en) 2009-12-08 2011-06-16 Array Biopharma Inc. S piro [chroman - 4, 4 ' - imidazol] ones as beta - secretase inhibitors
CN103209975B (zh) 2010-09-16 2016-01-13 日东电工株式会社 用于有机发光装置的取代的联吡啶
US8585926B2 (en) 2011-03-03 2013-11-19 Nitto Denko Corporation Substituted bipyridines for use in light-emitting devices
US9328094B2 (en) 2011-09-19 2016-05-03 Nitto Denko Corporation Substituted biaryl compounds for light-emitting devices
CN105237483B (zh) * 2015-11-10 2018-04-20 东华大学 一种对称型嘧啶基碘鎓盐及其制备方法
US11766435B2 (en) 2016-02-18 2023-09-26 Merck Sharp & Dohme Llc N3-substituted iminopyrimidinones as antimalarial agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05140107A (ja) * 1991-02-11 1993-06-08 Imperial Chem Ind Plc <Ici> ピリジン化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9005518D0 (en) * 1990-03-12 1990-05-09 Wellcome Found Heterocyclic compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05140107A (ja) * 1991-02-11 1993-06-08 Imperial Chem Ind Plc <Ici> ピリジン化合物

Also Published As

Publication number Publication date
EP1858876A2 (en) 2007-11-28
US7579353B2 (en) 2009-08-25
WO2006094799A3 (en) 2007-03-29
WO2006094799A2 (en) 2006-09-14
US20080287461A1 (en) 2008-11-20

Similar Documents

Publication Publication Date Title
US10774070B2 (en) 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors
JP6807385B2 (ja) Ｒｅｔの阻害剤
JP2009538873A (ja) 新規複素環化合物
CN1960977B (zh) 喹唑啉衍生物
TWI722004B (zh) 1,3,5-三嗪衍生物及其使用方法
JPWO2007029847A1 (ja) 二環性芳香族置換ピリドン誘導体
GB2432834A (en) Selective Kinase Inhibitors
JP2005521698A (ja) 新規な三環式化合物
TW200825090A (en) Nitrogen-containing heterocyclic compounds and methods of use thereof
CN117599049A (zh) 色氨酸双加氧酶(ido1和tdo)的抑制剂和其在治疗中的用途
JP2008531638A (ja) 抗マラリアピリジノン誘導体
CN107501169A (zh) 一类反式二芳基乙烯类lsd1抑制剂、其制备方法及应用
CN114981256B (zh) 干扰素基因刺激物sting的单环激动剂
ES2236288T3 (es) 6-heteroarilfenantridinas.
US20060111368A1 (en) Phosphodiesterase inhibitor
WO2014012467A1 (zh) 间二芳基苯胺类或吡啶胺类化合物、其制备方法及医药用途
WO2010081904A1 (en) 4 ( 1h) -pyridinone derivatives and their use as antimalaria agents
CN107635991A (zh) 作为tdp2的抑制剂的呋喃并喹啉二酮
CN107573336B (zh) 苯并杂环-甲酰胺-吡啶酮衍生物及其制备方法和用途
CN103804390B (zh) 多取代芳香二酮类化合物及其制备方法和应用
WO2022166990A1 (zh) 用于抗肿瘤的药物组合
JPH10310576A (ja) イソキノリンスルフォンアミド誘導体及びこれを有効成分とする医薬
CN104230834B (zh) 一种基于芳香五元环分子骨架能够稳定rna g-四联体的新型抗肿瘤化合物
WO2014203044A1 (en) Dihydropyrimidin-2(1h)-ones and dihydropyrimidin-2(1h)-thiones as inhibitors of sodium iodide symporter
M'ddl et al. Fiandor Roman et a].(45) Date of Patent: Aug. 25, 2009

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090226

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120124

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20120309

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120703