JP2008531594A5 - - Google Patents
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- Publication number
- JP2008531594A5 JP2008531594A5 JP2007557195A JP2007557195A JP2008531594A5 JP 2008531594 A5 JP2008531594 A5 JP 2008531594A5 JP 2007557195 A JP2007557195 A JP 2007557195A JP 2007557195 A JP2007557195 A JP 2007557195A JP 2008531594 A5 JP2008531594 A5 JP 2008531594A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- weight
- amount
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 43
- -1 N-ethyl-carbamoyloxy Chemical group 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 11
- 230000036470 plasma concentration Effects 0.000 claims 10
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 8
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 7
- 235000021355 Stearic acid Nutrition 0.000 claims 7
- 239000000945 filler Substances 0.000 claims 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 7
- 239000008117 stearic acid Substances 0.000 claims 7
- 208000024827 Alzheimer disease Diseases 0.000 claims 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 5
- 229930195725 Mannitol Natural products 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims 5
- 239000000314 lubricant Substances 0.000 claims 5
- 239000000594 mannitol Substances 0.000 claims 5
- 235000010355 mannitol Nutrition 0.000 claims 5
- 229940045902 sodium stearyl fumarate Drugs 0.000 claims 5
- 239000000454 talc Substances 0.000 claims 5
- 229910052623 talc Inorganic materials 0.000 claims 5
- MTVWFVDWRVYDOR-UHFFFAOYSA-N 3,4-Dihydroxyphenylglycol Chemical compound OCC(O)C1=CC=C(O)C(O)=C1 MTVWFVDWRVYDOR-UHFFFAOYSA-N 0.000 claims 4
- 206010012289 Dementia Diseases 0.000 claims 4
- 239000011230 binding agent Substances 0.000 claims 4
- 239000007884 disintegrant Substances 0.000 claims 4
- 238000005567 liquid scintillation counting Methods 0.000 claims 4
- 235000019359 magnesium stearate Nutrition 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 3
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 238000005550 wet granulation Methods 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 2
- 108010062431 Monoamine oxidase Proteins 0.000 claims 2
- 208000012902 Nervous system disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims 1
- 206010036631 Presenile dementia Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 201000004810 Vascular dementia Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 230000019771 cognition Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 210000004558 lewy body Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000003068 static effect Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65647705P | 2005-02-24 | 2005-02-24 | |
| PCT/US2006/006636 WO2006091836A1 (en) | 2005-02-24 | 2006-02-24 | Formulations of ladostigil tartrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531594A JP2008531594A (ja) | 2008-08-14 |
| JP2008531594A5 true JP2008531594A5 (enExample) | 2009-03-05 |
Family
ID=36927766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007557195A Withdrawn JP2008531594A (ja) | 2005-02-24 | 2006-02-24 | 酒石酸ラドスチジルの製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8022104B2 (enExample) |
| EP (1) | EP1848417A1 (enExample) |
| JP (1) | JP2008531594A (enExample) |
| AU (1) | AU2006216509B8 (enExample) |
| CA (1) | CA2600603A1 (enExample) |
| IL (1) | IL185420A0 (enExample) |
| WO (1) | WO2006091836A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006091836A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Formulations of ladostigil tartrate |
| US20070093549A1 (en) * | 2005-09-28 | 2007-04-26 | Judith Aronhime | Methods for preparation of ladostigil tartrate crystalline form A1 |
| US7491847B2 (en) * | 2005-11-17 | 2009-02-17 | Teva Pharmaceutical Industries, Ltd. | Methods for isolating propargylated aminoindans |
| JP2009518433A (ja) * | 2005-12-09 | 2009-05-07 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 神経保護用の低用量ラドスチギルの使用 |
| US20070135518A1 (en) * | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| WO2007126898A2 (en) * | 2006-03-31 | 2007-11-08 | Teva Pharmaceutical Industries, Ltd. | Use of ladostigil for the treatment of schizophrenia |
| WO2012059920A1 (en) * | 2010-11-02 | 2012-05-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Ladostigil dosage regime |
| WO2013118126A1 (en) | 2012-02-12 | 2013-08-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Ladostigil therapy for immunomodulation |
| WO2013182625A1 (en) * | 2012-06-08 | 2013-12-12 | Actavis Group Ptc Ehf | Pharmaceutical formulation with propargylamine compound |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1534864A (en) * | 1919-12-19 | 1925-04-21 | Hazel Atlas Glass Co | Apparatus for tempering glassware |
| US2026165A (en) * | 1934-08-01 | 1935-12-31 | Libbey Owens Ford Glass Co | Process and apparatus for producing case hardened glass |
| US3903297A (en) | 1973-11-01 | 1975-09-02 | Upjohn Co | Method of treatment and prophylaxis of gastric hypersecretion and gastric and duodenal ulcers using prostaglandin analogs |
| US4086263A (en) * | 1976-11-17 | 1978-04-25 | Ppg Industries, Inc. | Shipping rack having spacer strips attached thereto |
| US4488192A (en) * | 1982-05-28 | 1984-12-11 | International Business Machines Corporation | Cooling arrangement for hermetically sealed disk files |
| US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
| IL92952A (en) | 1990-01-03 | 1994-06-24 | Teva Pharma | R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them |
| EP0738149B1 (en) | 1994-01-10 | 2006-11-29 | Teva Pharmaceutical Industries, Ltd. | 1-aminoindan derivatives and compositions thereof |
| FI100397B (fi) * | 1995-10-24 | 1997-11-28 | Glassrobots Oy | Lämmönsiirtomenetelmä lasilevyjen taivutusuunissa ja taivutusuuni |
| CN1183090A (zh) * | 1996-03-21 | 1998-05-27 | 彼得·利瑟 | 玻璃钢化方法及系统 |
| FR2747112B1 (fr) * | 1996-04-03 | 1998-05-07 | Commissariat Energie Atomique | Dispositif de transport d'objets plats et procede de transfert de ces objets entre ledit dispositif et une machine de traitement |
| CA2275425C (en) | 1996-12-18 | 2009-08-04 | Michael Chorev | Aminoindan derivatives |
| AU5620998A (en) | 1996-12-18 | 1998-07-15 | Technion Research & Development Foundation Ltd. | Phenylethylamine derivatives |
| US6251938B1 (en) | 1996-12-18 | 2001-06-26 | Teva Pharmaceutical Industries, Ltd., | Phenylethylamine derivatives |
| CA2276150A1 (en) | 1996-12-30 | 1998-07-09 | Steven D. Young | Inhibitors of farnesyl-protein transferase |
| JPH1179389A (ja) * | 1997-09-16 | 1999-03-23 | Mitsui Eng & Shipbuild Co Ltd | 基板ガラス検査加工システム |
| JPH1179388A (ja) * | 1997-09-16 | 1999-03-23 | Mitsui Eng & Shipbuild Co Ltd | ガラス類枚葉処理装置 |
| TW444275B (en) * | 1998-01-13 | 2001-07-01 | Toshiba Corp | Processing device, laser annealing device, laser annealing method, manufacturing device and substrate manufacturing device for panel display |
| AU2003219913A1 (en) | 2002-02-27 | 2003-09-09 | Teva Pharmaceutical Industries, Ltd. | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective mao inhibitors |
| US20040010038A1 (en) | 2002-02-27 | 2004-01-15 | Eran Blaugrund | Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| EP2433626B1 (en) | 2003-11-25 | 2015-11-04 | Technion Research & Development Foundation Ltd. | Compositions and methods for treatment of cardiovascular disorders and diseases |
| CA2566204A1 (en) | 2004-05-14 | 2005-12-01 | The Johns Hopkins University | Method for improving cognitive function by co-administration of a gabab receptor antagonist and an acetylcholinesterase inhibitor |
| US7335685B2 (en) | 2005-02-24 | 2008-02-26 | Teva Pharmaceutical Industries, Ltd. | Crystals of ladostigil tartrate, methods of production and pharmaceutical compositions thereof |
| WO2006091836A1 (en) | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Formulations of ladostigil tartrate |
| WO2006130726A2 (en) | 2005-06-01 | 2006-12-07 | Teva Pharmaceutical Industries, Ltd. | Use of ladostigil for the treatment of multiple sclerosis |
| US20070135518A1 (en) | 2005-12-09 | 2007-06-14 | Marta Weinstock-Rosin | Use of low-dose ladostigil for neuroprotection |
| JP2009518433A (ja) | 2005-12-09 | 2009-05-07 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブライ ユニバーシティー オブ エルサレム | 神経保護用の低用量ラドスチギルの使用 |
| TW200744576A (en) | 2006-02-24 | 2007-12-16 | Teva Pharma | Propargylated aminoindans, processes for preparation, and uses thereof |
| WO2007126898A2 (en) | 2006-03-31 | 2007-11-08 | Teva Pharmaceutical Industries, Ltd. | Use of ladostigil for the treatment of schizophrenia |
-
2006
- 2006-02-24 WO PCT/US2006/006636 patent/WO2006091836A1/en not_active Ceased
- 2006-02-24 JP JP2007557195A patent/JP2008531594A/ja not_active Withdrawn
- 2006-02-24 CA CA002600603A patent/CA2600603A1/en not_active Abandoned
- 2006-02-24 AU AU2006216509A patent/AU2006216509B8/en not_active Ceased
- 2006-02-24 EP EP06721040A patent/EP1848417A1/en not_active Withdrawn
- 2006-02-24 US US11/361,379 patent/US8022104B2/en not_active Expired - Fee Related
-
2007
- 2007-08-21 IL IL185420A patent/IL185420A0/en unknown
-
2011
- 2011-08-17 US US13/211,721 patent/US20110301234A1/en not_active Abandoned
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