JP2008531573A5 - - Google Patents
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- Publication number
- JP2008531573A5 JP2008531573A5 JP2007557124A JP2007557124A JP2008531573A5 JP 2008531573 A5 JP2008531573 A5 JP 2008531573A5 JP 2007557124 A JP2007557124 A JP 2007557124A JP 2007557124 A JP2007557124 A JP 2007557124A JP 2008531573 A5 JP2008531573 A5 JP 2008531573A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- cycloalkyl
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 41
- -1 amino, aminocarbonyl Chemical group 0.000 claims 40
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000003118 aryl group Chemical group 0.000 claims 22
- 229910052739 hydrogen Inorganic materials 0.000 claims 21
- 239000001257 hydrogen Substances 0.000 claims 21
- 125000003342 alkenyl group Chemical group 0.000 claims 20
- 125000000304 alkynyl group Chemical group 0.000 claims 20
- 150000002431 hydrogen Chemical class 0.000 claims 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims 18
- 239000000651 prodrug Substances 0.000 claims 18
- 229940002612 prodrug Drugs 0.000 claims 18
- 150000003839 salts Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 16
- 125000002252 acyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000004423 acyloxy group Chemical group 0.000 claims 13
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 13
- 125000004414 alkyl thio group Chemical group 0.000 claims 13
- 150000001408 amides Chemical class 0.000 claims 13
- 125000005110 aryl thio group Chemical group 0.000 claims 13
- 125000005200 aryloxy carbonyloxy group Chemical group 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 13
- 125000004093 cyano group Chemical group *C#N 0.000 claims 13
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 13
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 13
- 150000002148 esters Chemical class 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 13
- DYMRYCZRMAHYKE-UHFFFAOYSA-N n-diazonitramide Chemical compound [O-][N+](=O)N=[N+]=[N-] DYMRYCZRMAHYKE-UHFFFAOYSA-N 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 12
- 150000001350 alkyl halides Chemical class 0.000 claims 11
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 4
- 125000004103 aminoalkyl group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000001475 halogen functional group Chemical group 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229930182555 Penicillin Natural products 0.000 claims 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 2
- 108010059993 Vancomycin Proteins 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 229960003085 meticillin Drugs 0.000 claims 2
- 229940049954 penicillin Drugs 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 2
- 229960003165 vancomycin Drugs 0.000 claims 2
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 2
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 2
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 241000194031 Enterococcus faecium Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 125000005099 aryl alkyl carbonyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 229940032049 enterococcus faecalis Drugs 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- MQTVTRVMHTUJGJ-UHFFFAOYSA-N C=[N]=C(C1)C1N Chemical compound C=[N]=C(C1)C1N MQTVTRVMHTUJGJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65560505P | 2005-02-22 | 2005-02-22 | |
| PCT/US2006/006278 WO2006091669A1 (en) | 2005-02-22 | 2006-02-22 | Anti-cancer and anti-microbial oxazolidinones and analogues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531573A JP2008531573A (ja) | 2008-08-14 |
| JP2008531573A5 true JP2008531573A5 (https=) | 2009-03-12 |
Family
ID=36580024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007557124A Withdrawn JP2008531573A (ja) | 2005-02-22 | 2006-02-22 | 抗癌性及び抗微生物性オキサゾリジノン並びに類似体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7378530B2 (https=) |
| EP (1) | EP1856066B1 (https=) |
| JP (1) | JP2008531573A (https=) |
| KR (1) | KR20070106578A (https=) |
| CN (1) | CN101160294A (https=) |
| AT (1) | ATE503748T1 (https=) |
| AU (1) | AU2006216708A1 (https=) |
| BR (1) | BRPI0607974A2 (https=) |
| CA (1) | CA2597667A1 (https=) |
| DE (1) | DE602006020992D1 (https=) |
| IL (1) | IL185266A0 (https=) |
| MX (1) | MX2007009990A (https=) |
| WO (1) | WO2006091669A1 (https=) |
| ZA (1) | ZA200707855B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7378530B2 (en) * | 2005-02-22 | 2008-05-27 | Nereus Pharmaceuticals, Inc. | Anti-cancer and anti-microbial 5-membered heterocyclic compounds |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| FR2948940B1 (fr) * | 2009-08-04 | 2011-07-22 | Servier Lab | Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| MX2015002399A (es) * | 2012-10-29 | 2015-06-10 | Hoffmann La Roche | Derivados de oxazolidinona 3,4-disustituidos y su uso como inhibidores del canal de potasio activado con calcio. |
| US10556874B2 (en) * | 2015-07-03 | 2020-02-11 | Bayer Cropscience Aktiengesellschaft | N-(1,3,4-oxadiazol-2-yl)aryl carboxamide derivatives with herbicidal action |
| AU2016290425A1 (en) * | 2015-07-03 | 2018-01-18 | Bayer Cropscience Aktiengesellschaft | N-(tetrazole-5-yl)- and N-(triazole-5-yl)aryl carboxamide derivatives with herbicidal action |
| US10822315B2 (en) | 2016-08-22 | 2020-11-03 | North Carolina State University | 5-benzylidene-4-oxazolidinones |
| WO2018039242A1 (en) | 2016-08-22 | 2018-03-01 | North Carolina State University | 4-oxazolidinone antimicrobial agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2915527A (en) * | 1959-12-01 | Oxazolidone compounds and means for | ||
| US2971958A (en) * | 1959-03-17 | 1961-02-14 | Union Carbide Corp | Cyanoethylated oxalactams |
| US3129222A (en) * | 1960-12-01 | 1964-04-14 | Merck & Co Inc | 2, 2, 5-trisubstituted-4-oxazolidinone compounds |
| US3182063A (en) * | 1961-03-06 | 1965-05-04 | Warner Lambert Pharmaceutical | Substituted 4-thiazolidinones and process therefor |
| DE1917615U (de) | 1963-02-15 | 1965-06-10 | Kloeckner Humboldt Deutz Ag | Rotationskolbenmaschine. |
| DE1916715A1 (de) | 1969-04-01 | 1970-10-08 | Goedecke Ag | Verfahren zur Herstellung von Oxazolidon-(4)-Derivaten |
| US4049816A (en) * | 1975-03-24 | 1977-09-20 | Beecham Group Limited | Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones |
| US4584385A (en) * | 1984-03-22 | 1986-04-22 | Pfizer Inc. | Antibacterial 2-amino-oxazolinones and process therefor |
| US4769232A (en) * | 1984-03-22 | 1988-09-06 | Pfizer Inc. | Parenteral formulations of indolmycin |
| US4650512A (en) * | 1984-09-27 | 1987-03-17 | Stauffer Chemical Company | Oxazolidone herbicides and methods of use |
| US4629794A (en) * | 1985-02-04 | 1986-12-16 | Pfizer Inc. | Antibacterial 2-amino-oxazolinones and process therefor |
| US5677463A (en) | 1996-11-20 | 1997-10-14 | Abbott Laboratories | Process for the preparation of 2-imino-5-phenyl-4 oxazolidinone and its intermediates |
| EP1103600A4 (en) * | 1998-07-30 | 2002-11-06 | Takeda Chemical Industries Ltd | PROCESS FOR PRODUCING INDOLEMYCIN |
| US7378530B2 (en) * | 2005-02-22 | 2008-05-27 | Nereus Pharmaceuticals, Inc. | Anti-cancer and anti-microbial 5-membered heterocyclic compounds |
-
2006
- 2006-02-21 US US11/358,961 patent/US7378530B2/en not_active Expired - Fee Related
- 2006-02-22 EP EP06735789A patent/EP1856066B1/en not_active Expired - Lifetime
- 2006-02-22 DE DE602006020992T patent/DE602006020992D1/de not_active Expired - Lifetime
- 2006-02-22 WO PCT/US2006/006278 patent/WO2006091669A1/en not_active Ceased
- 2006-02-22 BR BRPI0607974-1A patent/BRPI0607974A2/pt not_active IP Right Cessation
- 2006-02-22 MX MX2007009990A patent/MX2007009990A/es active IP Right Grant
- 2006-02-22 CN CNA2006800120083A patent/CN101160294A/zh active Pending
- 2006-02-22 JP JP2007557124A patent/JP2008531573A/ja not_active Withdrawn
- 2006-02-22 AT AT06735789T patent/ATE503748T1/de not_active IP Right Cessation
- 2006-02-22 AU AU2006216708A patent/AU2006216708A1/en not_active Abandoned
- 2006-02-22 CA CA002597667A patent/CA2597667A1/en not_active Abandoned
- 2006-02-22 KR KR1020077021734A patent/KR20070106578A/ko not_active Ceased
-
2007
- 2007-08-14 IL IL185266A patent/IL185266A0/en unknown
- 2007-09-14 ZA ZA200707855A patent/ZA200707855B/xx unknown
-
2008
- 2008-05-21 US US12/124,896 patent/US20080221182A1/en not_active Abandoned
- 2008-05-21 US US12/124,909 patent/US7879892B2/en not_active Expired - Fee Related
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