JP2008530110A5 - - Google Patents
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- JP2008530110A5 JP2008530110A5 JP2007555236A JP2007555236A JP2008530110A5 JP 2008530110 A5 JP2008530110 A5 JP 2008530110A5 JP 2007555236 A JP2007555236 A JP 2007555236A JP 2007555236 A JP2007555236 A JP 2007555236A JP 2008530110 A5 JP2008530110 A5 JP 2008530110A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutical composition
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- effective amount
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 201000004681 Psoriasis Diseases 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 206010025135 lupus erythematosus Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 210000002374 sebum Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 230000037393 skin firmness Effects 0.000 claims 2
- 230000037067 skin hydration Effects 0.000 claims 2
- 230000037303 wrinkles Effects 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 206010031240 Osteodystrophy Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- -1 t-butyldimethylsilyl groups Chemical group 0.000 claims 1
- XPJAYNDSNNJWDA-AWCUZLSVSA-N C[C@H]([C@@H](CC1)[C@@](C)(CCC2)[C@@H]1/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O)/C=C/[C@@H](C(C)(C)O)C=[IH] Chemical compound C[C@H]([C@@H](CC1)[C@@](C)(CCC2)[C@@H]1/C2=C/C=C(C[C@H](C1=C)O)C[C@H]1O)/C=C/[C@@H](C(C)(C)O)C=[IH] XPJAYNDSNNJWDA-AWCUZLSVSA-N 0.000 description 2
- 0 C[C@](C(CC1)[C@@](C)(CCC2)[C@@]1C2=CC=C(C[C@@](*)C1=C)C[C@]1*#C)C=C[C@](*)C(C)(C)* Chemical compound C[C@](C(CC1)[C@@](C)(CCC2)[C@@]1C2=CC=C(C[C@@](*)C1=C)C[C@]1*#C)C=C[C@](*)C(C)(C)* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65247305P | 2005-02-11 | 2005-02-11 | |
| US60/652,473 | 2005-02-11 | ||
| PCT/US2006/004699 WO2006086613A2 (en) | 2005-02-11 | 2006-02-10 | 2-METHYLENE-19-NOR- (20S-24S) - 1α, 25-D IHYDROXYVITAMIN-D2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008530110A JP2008530110A (ja) | 2008-08-07 |
| JP2008530110A5 true JP2008530110A5 (cg-RX-API-DMAC7.html) | 2009-03-05 |
| JP5036566B2 JP5036566B2 (ja) | 2012-09-26 |
Family
ID=36793746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555236A Expired - Fee Related JP5036566B2 (ja) | 2005-02-11 | 2006-02-10 | ２−メチレン−１９−ノル−（２０Ｓ−２４Ｓ）−１α，２５−ジヒドロキシビタミン−Ｄ２ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7563783B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1853274B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5036566B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006213727B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2597624C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2404061T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007009726A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006086613A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060079490A1 (en) * | 2001-01-25 | 2006-04-13 | Deluca Hector F | Method of treatment of type I diabetes |
| EP1656157B1 (en) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| CA2662992A1 (en) * | 2006-09-28 | 2008-04-03 | Wisconsin Alumni Research Foundation | 2-methylene-(20r,25s)-19,27-dinor-(22e)-vitamin d analogs |
| WO2011017165A1 (en) * | 2009-08-03 | 2011-02-10 | Wisconsin Alumni Research Foundation | Method of preventing renal disease and treating symptoms thereof |
| MX2012003883A (es) * | 2009-10-02 | 2012-06-27 | Wisconsin Alumni Res Found | Analogos de (20s,22e)-2-metileno-19-nor-22-ene-1a,25-dihidroxovita mina d3. |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| WO2011119622A1 (en) * | 2010-03-23 | 2011-09-29 | Wisconsin Alumni Research Foundation | DIASTEREOMERS OF 2-METHYLENE-19-NOR-22-METHYL-1α,25- DIHYDROXYVITAMIN D3 |
| ES2545403T3 (es) * | 2010-03-23 | 2015-09-10 | Wisconsin Alumni Research Foundation | (20S)-2-metilen-19-nor-22-dimetil-1alfa,25-dihidroxivitamina D3 y (20R)-2-metilen-19-nor-22-dimetil-1alfa,25-hidroxivitamina D3 |
| CA2824870C (en) * | 2011-06-14 | 2018-08-14 | Wisconsin Alumni Research Foundation | 3-desoxy-2-methylene-19-nor-vitamin d analogs and their uses |
| RU2666995C2 (ru) | 2012-06-29 | 2018-09-13 | Висконсин Алюмни Рисерч Фаундейшн | ПРИМЕНЕНИЕ 2-МЕТИЛЕН-19-НОР-(20S)-1α,25-ДИГИДРОКСИВИТАМИНА D3 ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗА |
| US10369161B2 (en) | 2014-12-30 | 2019-08-06 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-NOR-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat primary hyperparathyroidism |
| US9539264B2 (en) | 2014-12-30 | 2017-01-10 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-(20S)-1-alpha,25-dihydroxyvitamin D3 to treat secondary hyperparathyroidism in patients previously treated with calcimimetics |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588716A (en) * | 1984-05-04 | 1986-05-13 | Wisconsin Alumni Research Foundation | Method for treating metabolic bone disease in mammals |
| US4666634A (en) * | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5552392A (en) * | 1993-11-03 | 1996-09-03 | Wisconsin Alumni Research Foundation | Method of treating hypoparathyroidism with (20S) vitamin D compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6673782B2 (en) * | 1999-04-29 | 2004-01-06 | Wisconsin Alumni Research Foundation | Treatment of systemic lupus erythematosis |
| US6479474B2 (en) * | 1999-07-08 | 2002-11-12 | Wisconsin Alumni Research Foundation | Dietary calcium as a supplement to vitamin D compound treatment of multiple sclerosis |
| US7704979B2 (en) * | 2000-09-01 | 2010-04-27 | The University Of Tennessee Research Foundation | Materials and methods for the treatment or prevention of obesity |
| US6384087B1 (en) * | 2000-09-01 | 2002-05-07 | University Of Tennesseee Research Corporation, Inc. | Materials and methods for the treatment or prevention of obesity |
| BR0113703A (pt) * | 2000-09-08 | 2003-07-22 | Wisconsin Alumni Researcg Foun | Compostos e métodos de tratamento de psorìase, leucemia, câncer do cólon, do seio ou da próstata, osteodistrofia renal, de doenças auto-imune, inflamatória e de condição de pele |
| US6627622B2 (en) * | 2002-02-18 | 2003-09-30 | Wisconsin Alumni Research Foundation | (20S)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol and its uses |
| US6566352B1 (en) * | 2002-02-18 | 2003-05-20 | Wisconsin Alumni Research Foudation | 1 α-hydroxy-2-methylene-19-nor-pregnacalciferol and its uses |
| DE60310050T2 (de) * | 2002-03-29 | 2007-07-05 | Wisconsin Alumni Research Foundation, Madison | Ein verfahren zur herstellung von 1-alpha-hydroxy-2-methylen-19-nor-homopregnacalciferol |
| US7259143B2 (en) * | 2002-09-05 | 2007-08-21 | Wisconsin Alumni Research Foundation | Method of extending the dose range of vitamin D compounds |
| US7241747B2 (en) * | 2003-04-10 | 2007-07-10 | Wisconsin Alumni Research Foundation | 2-propylidene-19-nor-vitamin D compounds |
| EP1656157B1 (en) * | 2003-08-20 | 2011-12-21 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin d2 compounds |
| CA2539357A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and parathyroid hormone |
| WO2005027931A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an ep2 or ep4 selective agonist |
| WO2005027913A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue |
| CA2539361A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and an estrogen agonist/antagonist |
| US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
-
2006
- 2006-02-10 WO PCT/US2006/004699 patent/WO2006086613A2/en not_active Ceased
- 2006-02-10 ES ES06720601T patent/ES2404061T3/es active Active
- 2006-02-10 US US11/352,454 patent/US7563783B2/en not_active Expired - Fee Related
- 2006-02-10 MX MX2007009726A patent/MX2007009726A/es active IP Right Grant
- 2006-02-10 CA CA2597624A patent/CA2597624C/en not_active Expired - Fee Related
- 2006-02-10 AU AU2006213727A patent/AU2006213727B2/en not_active Ceased
- 2006-02-10 JP JP2007555236A patent/JP5036566B2/ja not_active Expired - Fee Related
- 2006-02-10 EP EP06720601A patent/EP1853274B1/en not_active Not-in-force