JP2008530053A5 - - Google Patents

Info

Publication number

JP2008530053A5

JP2008530053A5 JP2007554570A JP2007554570A JP2008530053A5 JP 2008530053 A5 JP2008530053 A5 JP 2008530053A5 JP 2007554570 A JP2007554570 A JP 2007554570A JP 2007554570 A JP2007554570 A JP 2007554570A JP 2008530053 A5 JP2008530053 A5 JP 2008530053A5

Authority

JP

Japan

Prior art keywords

phenyl

pyridine

cyano

dihydro

thieno

Prior art date

2006-02-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• -1 cyano, hydroxyl Chemical group 0.000 claims 26
• 150000001875 compounds Chemical class 0.000 claims 20
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 19
• 125000004432 carbon atom Chemical group C* 0.000 claims 16
• 206010028980 Neoplasm Diseases 0.000 claims 14
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 14
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 13
• 125000000217 alkyl group Chemical group 0.000 claims 12
• 229910052739 hydrogen Inorganic materials 0.000 claims 12
• 239000001257 hydrogen Substances 0.000 claims 12
• 125000004076 pyridyl group Chemical group 0.000 claims 12
• 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
• 125000003545 alkoxy group Chemical group 0.000 claims 8
• 229910052799 carbon Inorganic materials 0.000 claims 8
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 8
• 229910052736 halogen Inorganic materials 0.000 claims 8
• 150000002367 halogens Chemical class 0.000 claims 8
• 150000002431 hydrogen Chemical group 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 7
• 229910052731 fluorine Inorganic materials 0.000 claims 7
• 239000011737 fluorine Substances 0.000 claims 7
• 229910052757 nitrogen Inorganic materials 0.000 claims 7
• AMSSJLMJTRPWOA-UHFFFAOYSA-N 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylic acid Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(O)=O)=C2S1 AMSSJLMJTRPWOA-UHFFFAOYSA-N 0.000 claims 6
• DDQJELXIYYFGNC-UHFFFAOYSA-N 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylic acid Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(O)=O)=C2S1 DDQJELXIYYFGNC-UHFFFAOYSA-N 0.000 claims 6
• UWSRUSYETIJRFM-UHFFFAOYSA-N 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylic acid Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(O)=O)C#N)=C1 UWSRUSYETIJRFM-UHFFFAOYSA-N 0.000 claims 6
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 6
• 239000002246 antineoplastic agent Substances 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 125000001153 fluoro group Chemical group F* 0.000 claims 5
• 125000001424 substituent group Chemical group 0.000 claims 5
• HBJYIPIVHUNXLW-UHFFFAOYSA-N 3-cyano-2-[3-(3-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylic acid Chemical compound CCOC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(O)=O)C#N)=C1 HBJYIPIVHUNXLW-UHFFFAOYSA-N 0.000 claims 4
• 208000017604 Hodgkin disease Diseases 0.000 claims 4
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 4
• 210000003734 kidney Anatomy 0.000 claims 4
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 4
• 230000009826 neoplastic cell growth Effects 0.000 claims 4
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
• 125000004204 2-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C(OC([H])([H])[H])C([H])=C1[H] 0.000 claims 3
• 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 3
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 3
• 239000000556 agonist Substances 0.000 claims 3
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 125000005842 heteroatom Chemical group 0.000 claims 3
• 230000003211 malignant effect Effects 0.000 claims 3
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims 3
• 125000002950 monocyclic group Chemical group 0.000 claims 3
• 229910052760 oxygen Inorganic materials 0.000 claims 3
• 239000001301 oxygen Substances 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 239000011593 sulfur Substances 0.000 claims 3
• AHUXKFICWDIMHZ-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC3OC(C)(C)OC3)=C2S1 AHUXKFICWDIMHZ-UHFFFAOYSA-N 0.000 claims 2
• QMTQJTZJWOFXGV-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 QMTQJTZJWOFXGV-UHFFFAOYSA-N 0.000 claims 2
• 208000030507 AIDS Diseases 0.000 claims 2
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
• 208000007860 Anus Neoplasms Diseases 0.000 claims 2
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 2
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 2
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 2
• 206010025323 Lymphomas Diseases 0.000 claims 2
• 206010027406 Mesothelioma Diseases 0.000 claims 2
• 208000034578 Multiple myelomas Diseases 0.000 claims 2
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 2
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
• 206010033128 Ovarian cancer Diseases 0.000 claims 2
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
• 206010060862 Prostate cancer Diseases 0.000 claims 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
• 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
• 206010038389 Renal cancer Diseases 0.000 claims 2
• 201000000582 Retinoblastoma Diseases 0.000 claims 2
• 206010039491 Sarcoma Diseases 0.000 claims 2
• 208000000453 Skin Neoplasms Diseases 0.000 claims 2
• 208000032383 Soft tissue cancer Diseases 0.000 claims 2
• 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
• 206010042971 T-cell lymphoma Diseases 0.000 claims 2
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
• 229940124613 TLR 7/8 agonist Drugs 0.000 claims 2
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 2
• 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
• 206010057644 Testis cancer Diseases 0.000 claims 2
• 208000023915 Ureteral Neoplasms Diseases 0.000 claims 2
• 206010046392 Ureteric cancer Diseases 0.000 claims 2
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
• 208000008383 Wilms tumor Diseases 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 2
• 201000011165 anus cancer Diseases 0.000 claims 2
• 229960000397 bevacizumab Drugs 0.000 claims 2
• 210000000988 bone and bone Anatomy 0.000 claims 2
• 210000001185 bone marrow Anatomy 0.000 claims 2
• 210000004556 brain Anatomy 0.000 claims 2
• 210000000481 breast Anatomy 0.000 claims 2
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
• 210000003169 central nervous system Anatomy 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 230000000973 chemotherapeutic effect Effects 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• 210000001072 colon Anatomy 0.000 claims 2
• NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
• 210000003372 endocrine gland Anatomy 0.000 claims 2
• 210000004696 endometrium Anatomy 0.000 claims 2
• 229930013356 epothilone Natural products 0.000 claims 2
• 229960001433 erlotinib Drugs 0.000 claims 2
• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
• 210000003238 esophagus Anatomy 0.000 claims 2
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
• 206010017758 gastric cancer Diseases 0.000 claims 2
• 229960002584 gefitinib Drugs 0.000 claims 2
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 2
• 210000004602 germ cell Anatomy 0.000 claims 2
• 210000003128 head Anatomy 0.000 claims 2
• 210000003026 hypopharynx Anatomy 0.000 claims 2
• 201000010982 kidney cancer Diseases 0.000 claims 2
• 206010023841 laryngeal neoplasm Diseases 0.000 claims 2
• 210000000867 larynx Anatomy 0.000 claims 2
• 208000032839 leukemia Diseases 0.000 claims 2
• 210000004185 liver Anatomy 0.000 claims 2
• 208000014018 liver neoplasm Diseases 0.000 claims 2
• 210000004072 lung Anatomy 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
• 230000036210 malignancy Effects 0.000 claims 2
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 2
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000001613 neoplastic effect Effects 0.000 claims 2
• 201000008026 nephroblastoma Diseases 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 210000001672 ovary Anatomy 0.000 claims 2
• 210000000496 pancreas Anatomy 0.000 claims 2
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
• 210000001428 peripheral nervous system Anatomy 0.000 claims 2
• 208000010626 plasma cell neoplasm Diseases 0.000 claims 2
• 230000002062 proliferating effect Effects 0.000 claims 2
• 210000002307 prostate Anatomy 0.000 claims 2
• 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims 2
• 206010038038 rectal cancer Diseases 0.000 claims 2
• 210000000664 rectum Anatomy 0.000 claims 2
• 201000001275 rectum cancer Diseases 0.000 claims 2
• 229930002330 retinoic acid Natural products 0.000 claims 2
• OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 claims 2
• 210000003491 skin Anatomy 0.000 claims 2
• 201000000849 skin cancer Diseases 0.000 claims 2
• 210000000813 small intestine Anatomy 0.000 claims 2
• 201000002314 small intestine cancer Diseases 0.000 claims 2
• 210000004872 soft tissue Anatomy 0.000 claims 2
• 229960003787 sorafenib Drugs 0.000 claims 2
• 210000002784 stomach Anatomy 0.000 claims 2
• 201000011549 stomach cancer Diseases 0.000 claims 2
• WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 claims 2
• AYUNIORJHRXIBJ-TXHRRWQRSA-N tanespimycin Chemical compound N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=C(NCC=C)C(=O)C=C1C2=O AYUNIORJHRXIBJ-TXHRRWQRSA-N 0.000 claims 2
• 201000003120 testicular cancer Diseases 0.000 claims 2
• 210000001550 testis Anatomy 0.000 claims 2
• 229940124597 therapeutic agent Drugs 0.000 claims 2
• 238000002560 therapeutic procedure Methods 0.000 claims 2
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 2
• 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 2
• 210000000626 ureter Anatomy 0.000 claims 2
• 201000011294 ureter cancer Diseases 0.000 claims 2
• 210000003932 urinary bladder Anatomy 0.000 claims 2
• 210000001215 vagina Anatomy 0.000 claims 2
• 206010046885 vaginal cancer Diseases 0.000 claims 2
• 208000013139 vaginal neoplasm Diseases 0.000 claims 2
• MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 claims 2
• 229960000604 valproic acid Drugs 0.000 claims 2
• 239000004066 vascular targeting agent Substances 0.000 claims 2
• VSTDWZNJQANEBO-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 VSTDWZNJQANEBO-UHFFFAOYSA-N 0.000 claims 1
• NWMZLSCTZGWIAA-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 NWMZLSCTZGWIAA-UHFFFAOYSA-N 0.000 claims 1
• IATLRCKVAHGIMH-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 IATLRCKVAHGIMH-UHFFFAOYSA-N 0.000 claims 1
• XMPNEZYNNAIXOM-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 XMPNEZYNNAIXOM-UHFFFAOYSA-N 0.000 claims 1
• CHXGNVHHUROWES-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 CHXGNVHHUROWES-UHFFFAOYSA-N 0.000 claims 1
• UPIAIJAJDRNQNO-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=CN=3)C)=C2S1 UPIAIJAJDRNQNO-UHFFFAOYSA-N 0.000 claims 1
• CVZAWTAKUYLECJ-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=CN=2)C)C#N)=C1 CVZAWTAKUYLECJ-UHFFFAOYSA-N 0.000 claims 1
• DGKUXLDGIJNFRD-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=CN=2)C)C#N)=C1 DGKUXLDGIJNFRD-UHFFFAOYSA-N 0.000 claims 1
• NVCDCHNJHGGRSF-UHFFFAOYSA-N (1-methylimidazol-2-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=CN=2)C)C#N)=C1 NVCDCHNJHGGRSF-UHFFFAOYSA-N 0.000 claims 1
• SKPHRKAFMRDPQT-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC3OC(C)(C)OC3)=C2S1 SKPHRKAFMRDPQT-UHFFFAOYSA-N 0.000 claims 1
• YGYKHFTUGWIPFN-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC3OC(C)(C)OC3)=C2S1 YGYKHFTUGWIPFN-UHFFFAOYSA-N 0.000 claims 1
• OCZSUYZZMWHIOQ-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC3OC(C)(C)OC3)=C2S1 OCZSUYZZMWHIOQ-UHFFFAOYSA-N 0.000 claims 1
• WYIYANBMIOSQKM-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC3OC(C)(C)OC3)=C2S1 WYIYANBMIOSQKM-UHFFFAOYSA-N 0.000 claims 1
• UPLBBMBHIPAXKY-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC2OC(C)(C)OC2)C#N)=C1 UPLBBMBHIPAXKY-UHFFFAOYSA-N 0.000 claims 1
• TUECZFZXIDXERC-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC2OC(C)(C)OC2)C#N)=C1 TUECZFZXIDXERC-UHFFFAOYSA-N 0.000 claims 1
• JZYQZJIQUVBWAR-UHFFFAOYSA-N (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC2OC(C)(C)OC2)C#N)=C1 JZYQZJIQUVBWAR-UHFFFAOYSA-N 0.000 claims 1
• VOKSPSNUZGXZDC-UHFFFAOYSA-N (2-methoxy-2-oxoethyl) 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(=O)OC)=C2S1 VOKSPSNUZGXZDC-UHFFFAOYSA-N 0.000 claims 1
• HOFYYKIYKZRNQQ-UHFFFAOYSA-N (2-methoxy-2-oxoethyl) 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound C1N(C(=O)OCC(=O)OC)CCC(C=2C#N)=C1SC=2NC(=O)CC(C)C1=CC(C)=CC=C1OC HOFYYKIYKZRNQQ-UHFFFAOYSA-N 0.000 claims 1
• RARPUJRJHBRMHH-UHFFFAOYSA-N (2-methoxy-2-oxoethyl) 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound C1N(C(=O)OCC(=O)OC)CCC(C=2C#N)=C1SC=2NC(=O)CCC1=CC=CC=C1OC RARPUJRJHBRMHH-UHFFFAOYSA-N 0.000 claims 1
• JWKWBUINXJLDLW-UHFFFAOYSA-N (2-methoxy-2-oxoethyl) 3-cyano-2-[3-(3-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(=O)OC)C#N)=C1 JWKWBUINXJLDLW-UHFFFAOYSA-N 0.000 claims 1
• FHZVCPLXTYNSHO-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 FHZVCPLXTYNSHO-UHFFFAOYSA-N 0.000 claims 1
• DJWQGKFVCZMCIM-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 DJWQGKFVCZMCIM-UHFFFAOYSA-N 0.000 claims 1
• JQQKNBIJKOGCAR-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 JQQKNBIJKOGCAR-UHFFFAOYSA-N 0.000 claims 1
• GMQZENTZEKWBEM-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 GMQZENTZEKWBEM-UHFFFAOYSA-N 0.000 claims 1
• ZUKCEJAKZXABGA-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 ZUKCEJAKZXABGA-UHFFFAOYSA-N 0.000 claims 1
• CDKZLFSSAHUMTA-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC=3N(C=NC=3)C)=C2S1 CDKZLFSSAHUMTA-UHFFFAOYSA-N 0.000 claims 1
• IMAOEOWQGAEXNY-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=NC=2)C)C#N)=C1 IMAOEOWQGAEXNY-UHFFFAOYSA-N 0.000 claims 1
• IPALXVNLHHFINO-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=NC=2)C)C#N)=C1 IPALXVNLHHFINO-UHFFFAOYSA-N 0.000 claims 1
• FCSIGPSPGNIQFY-UHFFFAOYSA-N (3-methylimidazol-4-yl)methyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC=2N(C=NC=2)C)C#N)=C1 FCSIGPSPGNIQFY-UHFFFAOYSA-N 0.000 claims 1
• AFMKRFIYXCKTPH-UHFFFAOYSA-N (4-methoxypyridin-3-yl)methyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=NC=C1COC(=O)N1CC(SC(NC(=O)CCC=2C(=CC=C(C)C=2)OC)=C2C#N)=C2CC1 AFMKRFIYXCKTPH-UHFFFAOYSA-N 0.000 claims 1
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
• ZGNLFUXWZJGETL-YUSKDDKASA-N (Z)-[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium Chemical compound N[C@@H](C\[N+]([O-])=N\O)C(O)=O ZGNLFUXWZJGETL-YUSKDDKASA-N 0.000 claims 1
• BWDQBBCUWLSASG-MDZDMXLPSA-N (e)-n-hydroxy-3-[4-[[2-hydroxyethyl-[2-(1h-indol-3-yl)ethyl]amino]methyl]phenyl]prop-2-enamide Chemical compound C=1NC2=CC=CC=C2C=1CCN(CCO)CC1=CC=C(\C=C\C(=O)NO)C=C1 BWDQBBCUWLSASG-MDZDMXLPSA-N 0.000 claims 1
• NVKGVBZZSJFQLM-UHFFFAOYSA-N 1-(2-chloroethyl)-1-nitrosourea Chemical compound NC(=O)N(N=O)CCCl NVKGVBZZSJFQLM-UHFFFAOYSA-N 0.000 claims 1
• CKTSBUTUHBMZGZ-SHYZEUOFSA-N 2'‐deoxycytidine Chemical class O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-SHYZEUOFSA-N 0.000 claims 1
• OCYQOWZMICUMMP-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 OCYQOWZMICUMMP-UHFFFAOYSA-N 0.000 claims 1
• IWIZYTYVBDVLSV-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 IWIZYTYVBDVLSV-UHFFFAOYSA-N 0.000 claims 1
• VULUFOZFVXMSOO-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 VULUFOZFVXMSOO-UHFFFAOYSA-N 0.000 claims 1
• JENGSCKFGVPXRW-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 JENGSCKFGVPXRW-UHFFFAOYSA-N 0.000 claims 1
• SBSJAKFYCHMUOT-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)CO)=C2S1 SBSJAKFYCHMUOT-UHFFFAOYSA-N 0.000 claims 1
• ROVDLIJTYCEJMA-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)CO)C#N)=C1 ROVDLIJTYCEJMA-UHFFFAOYSA-N 0.000 claims 1
• LAFWGJACWPBLHN-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)CO)C#N)=C1 LAFWGJACWPBLHN-UHFFFAOYSA-N 0.000 claims 1
• CELVEARRTYIWIE-UHFFFAOYSA-N 2,3-dihydroxypropyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)CO)C#N)=C1 CELVEARRTYIWIE-UHFFFAOYSA-N 0.000 claims 1
• BYWBGEPOWDYZCR-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 BYWBGEPOWDYZCR-UHFFFAOYSA-N 0.000 claims 1
• RBKOUPRHKZDMPS-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 RBKOUPRHKZDMPS-UHFFFAOYSA-N 0.000 claims 1
• BOLATEPXESBGIN-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 BOLATEPXESBGIN-UHFFFAOYSA-N 0.000 claims 1
• WNWCJGZOFSRSBI-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 WNWCJGZOFSRSBI-UHFFFAOYSA-N 0.000 claims 1
• QSRRBZUOIXQHPG-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 QSRRBZUOIXQHPG-UHFFFAOYSA-N 0.000 claims 1
• BSDABSLFAJUXHY-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC(C)=C3)C)=C2S1 BSDABSLFAJUXHY-UHFFFAOYSA-N 0.000 claims 1
• QNXHVUMKIHWLQG-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C(=NC(C)=C2)C)C#N)=C1 QNXHVUMKIHWLQG-UHFFFAOYSA-N 0.000 claims 1
• XZYFVNHOZXWLEZ-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C(=NC(C)=C2)C)C#N)=C1 XZYFVNHOZXWLEZ-UHFFFAOYSA-N 0.000 claims 1
• IGMCHIDODOPMNJ-UHFFFAOYSA-N 2-(2,4-dimethylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C(=NC(C)=C2)C)C#N)=C1 IGMCHIDODOPMNJ-UHFFFAOYSA-N 0.000 claims 1
• JCMPCXLQEBNCQH-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC=C3)C)=C2S1 JCMPCXLQEBNCQH-UHFFFAOYSA-N 0.000 claims 1
• VJUKSYHQFAEEAU-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC=C3)C)=C2S1 VJUKSYHQFAEEAU-UHFFFAOYSA-N 0.000 claims 1
• JPOKMGRFTRZOFW-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC=C3)C)=C2S1 JPOKMGRFTRZOFW-UHFFFAOYSA-N 0.000 claims 1
• LDZDHMTYOIXKLI-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C(=NC=C3)C)=C2S1 LDZDHMTYOIXKLI-UHFFFAOYSA-N 0.000 claims 1
• SZQVWVSEUWHRHP-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C(=NC=C2)C)C#N)=C1 SZQVWVSEUWHRHP-UHFFFAOYSA-N 0.000 claims 1
• SUFHHZNIZUCIAC-UHFFFAOYSA-N 2-(2-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C(=NC=C2)C)C#N)=C1 SUFHHZNIZUCIAC-UHFFFAOYSA-N 0.000 claims 1
• RXUDGXCDMSVRJG-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=C(C)N=C3)=C2S1 RXUDGXCDMSVRJG-UHFFFAOYSA-N 0.000 claims 1
• DSXFOHXIGYEFNG-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=C(C)N=C3)=C2S1 DSXFOHXIGYEFNG-UHFFFAOYSA-N 0.000 claims 1
• XEMSMTDONVIEPF-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=C(C)N=C3)=C2S1 XEMSMTDONVIEPF-UHFFFAOYSA-N 0.000 claims 1
• CAQKBQQKZUSTQC-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=C(C)N=C3)=C2S1 CAQKBQQKZUSTQC-UHFFFAOYSA-N 0.000 claims 1
• BIWLLOALRCTKRG-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C=C(C)N=C2)C#N)=C1 BIWLLOALRCTKRG-UHFFFAOYSA-N 0.000 claims 1
• XCZCFVWMKKZFAR-UHFFFAOYSA-N 2-(4-methylimidazol-1-yl)ethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C=C(C)N=C2)C#N)=C1 XCZCFVWMKKZFAR-UHFFFAOYSA-N 0.000 claims 1
• YJHZMUOJVRTDAB-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 YJHZMUOJVRTDAB-UHFFFAOYSA-N 0.000 claims 1
• IPDFVNSFJFSMAK-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 IPDFVNSFJFSMAK-UHFFFAOYSA-N 0.000 claims 1
• JMSDYDDGYCFCSV-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 JMSDYDDGYCFCSV-UHFFFAOYSA-N 0.000 claims 1
• XVQKRDWCFIRIET-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 XVQKRDWCFIRIET-UHFFFAOYSA-N 0.000 claims 1
• NZBDLLJRXMTLNJ-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 NZBDLLJRXMTLNJ-UHFFFAOYSA-N 0.000 claims 1
• PPWARDSKMLZSDL-UHFFFAOYSA-N 2-[3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCC(O)=O)=C2S1 PPWARDSKMLZSDL-UHFFFAOYSA-N 0.000 claims 1
• CIEWPFXTLNENGJ-UHFFFAOYSA-N 2-[3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)=O)C#N)=C1 CIEWPFXTLNENGJ-UHFFFAOYSA-N 0.000 claims 1
• PDLKDTDZJMGWHO-UHFFFAOYSA-N 2-[3-cyano-2-[3-(3-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound CCOC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)=O)C#N)=C1 PDLKDTDZJMGWHO-UHFFFAOYSA-N 0.000 claims 1
• VXDFONYMNNONOS-UHFFFAOYSA-N 2-[3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carbonyl]oxyacetic acid Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCC(O)=O)C#N)=C1 VXDFONYMNNONOS-UHFFFAOYSA-N 0.000 claims 1
• ANJBCVVJKSMUKF-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC(C)=O)=C2S1 ANJBCVVJKSMUKF-UHFFFAOYSA-N 0.000 claims 1
• QEDMZBZDJSVFND-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC(C)=O)=C2S1 QEDMZBZDJSVFND-UHFFFAOYSA-N 0.000 claims 1
• FXBFPQTUELCALG-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC(C)=O)=C2S1 FXBFPQTUELCALG-UHFFFAOYSA-N 0.000 claims 1
• SZJYZOPKRPFQLO-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC(C)=O)=C2S1 SZJYZOPKRPFQLO-UHFFFAOYSA-N 0.000 claims 1
• GTALHEYWPAWLQW-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC(C)=O)=C2S1 GTALHEYWPAWLQW-UHFFFAOYSA-N 0.000 claims 1
• MWMMVVWXEQUKPA-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCOC(C)=O)C#N)=C1 MWMMVVWXEQUKPA-UHFFFAOYSA-N 0.000 claims 1
• CJXHGQQTVNWFAG-UHFFFAOYSA-N 2-acetyloxyethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCOC(C)=O)C#N)=C1 CJXHGQQTVNWFAG-UHFFFAOYSA-N 0.000 claims 1
• BHKSJWUQDFCKRK-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2,5-dimethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(OC)C(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCO)C#N)=C1 BHKSJWUQDFCKRK-UHFFFAOYSA-N 0.000 claims 1
• QQCDILQEJDCMGV-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCO)=C2S1 QQCDILQEJDCMGV-UHFFFAOYSA-N 0.000 claims 1
• PYODLLNFYGSZIP-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCO)=C2S1 PYODLLNFYGSZIP-UHFFFAOYSA-N 0.000 claims 1
• OLFQLLWDXRGEGQ-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCO)=C2S1 OLFQLLWDXRGEGQ-UHFFFAOYSA-N 0.000 claims 1
• QHJVIRDFCKWRCX-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCO)=C2S1 QHJVIRDFCKWRCX-UHFFFAOYSA-N 0.000 claims 1
• YOTDFNHAMNTIDD-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCO)=C2S1 YOTDFNHAMNTIDD-UHFFFAOYSA-N 0.000 claims 1
• VANCUKBXLDIRDA-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCO)C#N)=C1 VANCUKBXLDIRDA-UHFFFAOYSA-N 0.000 claims 1
• HOLPCQLWKIDQAH-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCO)C#N)=C1 HOLPCQLWKIDQAH-UHFFFAOYSA-N 0.000 claims 1
• CQKBBPCOKXTRNS-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCO)C#N)=C1 CQKBBPCOKXTRNS-UHFFFAOYSA-N 0.000 claims 1
• RFWJDQUYPALQRP-UHFFFAOYSA-N 2-hydroxyethyl 3-cyano-2-[3-(5-methoxy-2-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCO)C#N)=C1 RFWJDQUYPALQRP-UHFFFAOYSA-N 0.000 claims 1
• UJAQYKAHKYSABU-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=NC=C3)=C2S1 UJAQYKAHKYSABU-UHFFFAOYSA-N 0.000 claims 1
• WONFYGIAXRGRNJ-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=NC=C3)=C2S1 WONFYGIAXRGRNJ-UHFFFAOYSA-N 0.000 claims 1
• ZWJIVJNDJFCIFT-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=NC=C3)=C2S1 ZWJIVJNDJFCIFT-UHFFFAOYSA-N 0.000 claims 1
• ZZDSMGWEUVXVOC-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3C=NC=C3)=C2S1 ZZDSMGWEUVXVOC-UHFFFAOYSA-N 0.000 claims 1
• MALUZLYISMPCJN-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C=NC=C2)C#N)=C1 MALUZLYISMPCJN-UHFFFAOYSA-N 0.000 claims 1
• SOXFNPRRMNCZQW-UHFFFAOYSA-N 2-imidazol-1-ylethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCN2C=NC=C2)C#N)=C1 SOXFNPRRMNCZQW-UHFFFAOYSA-N 0.000 claims 1
• YOZWOCYFKHLMGP-UHFFFAOYSA-N 2-methoxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOC)=C2S1 YOZWOCYFKHLMGP-UHFFFAOYSA-N 0.000 claims 1
• HUWJIKUHICFZLU-UHFFFAOYSA-N 2-methoxyethyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound C1N(C(=O)OCCOC)CCC(C=2C#N)=C1SC=2NC(=O)CCC1=CC=CC=C1OC HUWJIKUHICFZLU-UHFFFAOYSA-N 0.000 claims 1
• JCNIZLAWCJEIFD-UHFFFAOYSA-N 2-methoxyethyl 3-cyano-2-[3-(3-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound C1N(C(=O)OCCOC)CCC(C=2C#N)=C1SC=2NC(=O)CCC1=CC=CC(OC)=C1 JCNIZLAWCJEIFD-UHFFFAOYSA-N 0.000 claims 1
• WBQMNEIKWSVEIC-UHFFFAOYSA-N 2-morpholin-4-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCN3CCOCC3)=C2S1 WBQMNEIKWSVEIC-UHFFFAOYSA-N 0.000 claims 1
• HUXVIOZBSCFQME-UHFFFAOYSA-N 2-phenylmethoxyethyl 3-cyano-2-[3-(2-ethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOCC=3C=CC=CC=3)=C2S1 HUXVIOZBSCFQME-UHFFFAOYSA-N 0.000 claims 1
• FCCVPSKOAANCBM-UHFFFAOYSA-N 2-phenylmethoxyethyl 3-cyano-2-[3-(2-methoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCOCC=3C=CC=CC=3)=C2S1 FCCVPSKOAANCBM-UHFFFAOYSA-N 0.000 claims 1
• DZHDUFJBRZSYGU-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(2,5-dimethoxyphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(OC)C(CCC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCC=2N=CC=CC=2)C#N)=C1 DZHDUFJBRZSYGU-UHFFFAOYSA-N 0.000 claims 1
• AEMWJTPJUWAYBR-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3N=CC=CC=3)=C2S1 AEMWJTPJUWAYBR-UHFFFAOYSA-N 0.000 claims 1
• RLVAPTDMKRPVRO-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3N=CC=CC=3)=C2S1 RLVAPTDMKRPVRO-UHFFFAOYSA-N 0.000 claims 1
• MRAVFDXPWWRBCT-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3N=CC=CC=3)=C2S1 MRAVFDXPWWRBCT-UHFFFAOYSA-N 0.000 claims 1
• CBXYMEWTZXSKDU-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3N=CC=CC=3)=C2S1 CBXYMEWTZXSKDU-UHFFFAOYSA-N 0.000 claims 1
• DYBTVMOAWCKOKK-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(3-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCC=2N=CC=CC=2)C#N)=C1 DYBTVMOAWCKOKK-UHFFFAOYSA-N 0.000 claims 1
• GLPONYAXPUVEQP-UHFFFAOYSA-N 2-pyridin-2-ylethyl 3-cyano-2-[3-(3-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC(C(C)CC(=O)NC2=C(C=3CCN(CC=3S2)C(=O)OCCC=2N=CC=CC=2)C#N)=C1 GLPONYAXPUVEQP-UHFFFAOYSA-N 0.000 claims 1
• JQNZTRHVRBTUKQ-UHFFFAOYSA-N 2-pyridin-3-ylethyl 3-cyano-2-[3-(2-ethoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound CCOC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3C=NC=CC=3)=C2S1 JQNZTRHVRBTUKQ-UHFFFAOYSA-N 0.000 claims 1
• JIARIEOZXWCYPD-UHFFFAOYSA-N 2-pyridin-3-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3C=NC=CC=3)=C2S1 JIARIEOZXWCYPD-UHFFFAOYSA-N 0.000 claims 1
• IIOWTROLDWWQSK-UHFFFAOYSA-N 2-pyridin-3-ylethyl 3-cyano-2-[3-(2-methoxy-5-methylphenyl)propanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=C(C)C=C1CCC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3C=NC=CC=3)=C2S1 IIOWTROLDWWQSK-UHFFFAOYSA-N 0.000 claims 1
• QEYIADPRNMAEJB-UHFFFAOYSA-N 2-pyridin-3-ylethyl 3-cyano-2-[3-(2-methoxyphenyl)butanoylamino]-5,7-dihydro-4h-thieno[2,3-c]pyridine-6-carboxylate Chemical compound COC1=CC=CC=C1C(C)CC(=O)NC1=C(C#N)C(CCN(C2)C(=O)OCCC=3C=NC=CC=3)=C2S1 QEYIADPRNMAEJB-UHFFFAOYSA-N 0.000 claims 1
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