JP2008529541A5 - - Google Patents
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- Publication number
- JP2008529541A5 JP2008529541A5 JP2007555539A JP2007555539A JP2008529541A5 JP 2008529541 A5 JP2008529541 A5 JP 2008529541A5 JP 2007555539 A JP2007555539 A JP 2007555539A JP 2007555539 A JP2007555539 A JP 2007555539A JP 2008529541 A5 JP2008529541 A5 JP 2008529541A5
- Authority
- JP
- Japan
- Prior art keywords
- container
- tumor cells
- lower limit
- intrinsic density
- separation medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000926 separation method Methods 0.000 claims 17
- 210000004881 tumor cell Anatomy 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 230000009974 thixotropic effect Effects 0.000 claims 14
- 239000000126 substance Substances 0.000 claims 12
- 239000012472 biological sample Substances 0.000 claims 11
- 230000004888 barrier function Effects 0.000 claims 10
- 239000000463 material Substances 0.000 claims 6
- 150000001720 carbohydrates Chemical class 0.000 claims 5
- 238000005119 centrifugation Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 238000003745 diagnosis Methods 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 238000010240 RT-PCR analysis Methods 0.000 claims 2
- 230000002776 aggregation Effects 0.000 claims 2
- 238000004220 aggregation Methods 0.000 claims 2
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 229960005423 diatrizoate Drugs 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 238000003752 polymerase chain reaction Methods 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 239000005995 Aluminium silicate Substances 0.000 claims 1
- 229920001917 Ficoll Polymers 0.000 claims 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000012211 aluminium silicate Nutrition 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 239000003130 blood coagulation factor inhibitor Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 229920001971 elastomer Polymers 0.000 claims 1
- 239000000806 elastomer Substances 0.000 claims 1
- 210000003743 erythrocyte Anatomy 0.000 claims 1
- 210000000416 exudates and transudate Anatomy 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims 1
- 229910000271 hectorite Inorganic materials 0.000 claims 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000012760 immunocytochemical staining Methods 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 230000000405 serological effect Effects 0.000 claims 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 239000011534 wash buffer Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05003640A EP1693109A1 (de) | 2005-02-21 | 2005-02-21 | Behältnis zur Separation von Tumorzellen |
| PCT/EP2006/001496 WO2006087220A2 (de) | 2005-02-21 | 2006-02-20 | Behältnis zur separation von tumorzellen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008529541A JP2008529541A (ja) | 2008-08-07 |
| JP2008529541A5 true JP2008529541A5 (enExample) | 2009-04-09 |
Family
ID=34933847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555539A Pending JP2008529541A (ja) | 2005-02-21 | 2006-02-20 | 腫瘍細胞の分離用容器 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090186341A1 (enExample) |
| EP (1) | EP1693109A1 (enExample) |
| JP (1) | JP2008529541A (enExample) |
| AU (1) | AU2006215776A1 (enExample) |
| CA (1) | CA2642274A1 (enExample) |
| WO (1) | WO2006087220A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008022651A1 (en) | 2006-08-21 | 2008-02-28 | Antoine Turzi | Process and device for the preparation of platelet rich plasma for extemporaneous use and combination thereof with skin and bone cells |
| EP2067855A1 (de) | 2007-12-07 | 2009-06-10 | Michael W. Dahm | Anreicherung und Nachweis von fetalen Zellen aus maternalem Blut |
| ES2390171T3 (es) | 2008-07-21 | 2012-11-07 | Becton, Dickinson And Company | Dispositivo de separación de fases de densidad |
| JP5607621B2 (ja) | 2008-07-21 | 2014-10-15 | ベクトン・ディキンソン・アンド・カンパニー | 密度相分離デバイス |
| CN104588140B (zh) | 2008-07-21 | 2016-06-29 | 贝克顿·迪金森公司 | 密度相分离装置 |
| EP2918344B1 (en) | 2009-05-15 | 2021-06-30 | Becton, Dickinson and Company | Density phase separation device |
| WO2011069145A2 (en) * | 2009-12-04 | 2011-06-09 | Becton, Dickinson And Company | Blood collection tube with separation barrier |
| EP2500095A1 (de) * | 2011-03-15 | 2012-09-19 | Siemens Healthcare Diagnostics Products GmbH | Vorrichtungen und Verfahren zur Bestimmung der Plättchenfunktion in einem Zentrifugalanalyzer |
| EP2848935A4 (en) | 2012-05-10 | 2015-12-09 | Konica Minolta Inc | PROCESS FOR REMOVING RED BLOOD BODIES AND CENTRIFUGAL TUBES FOR BLOOD TREATMENT |
| EP2810717B1 (en) * | 2013-06-06 | 2018-10-17 | F. Hoffmann-La Roche AG | Acceleration sensitive indicator |
| WO2014202957A1 (en) | 2013-06-19 | 2014-12-24 | Brightwake Limited | Cell collecting device |
| US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
| CN105368706A (zh) * | 2015-12-11 | 2016-03-02 | 何守贵 | 大容量单个核细胞分离瓶 |
| JP6779483B2 (ja) | 2016-09-29 | 2020-11-04 | 住友ゴム工業株式会社 | 医療用検査装置及び細胞検査方法 |
| JP2018157812A (ja) * | 2017-03-23 | 2018-10-11 | 東ソー株式会社 | 試料中に含まれる細胞の検出方法 |
| US20210146352A1 (en) * | 2017-07-24 | 2021-05-20 | Epitope Diagnostics, Inc. | Fecal sample collection and analyte extraction device and method |
| JP7109719B2 (ja) | 2018-02-14 | 2022-08-01 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
| JP7170254B2 (ja) * | 2018-02-14 | 2022-11-14 | 住友ゴム工業株式会社 | 特定細胞捕捉方法 |
| US11614440B2 (en) * | 2019-01-24 | 2023-03-28 | Sumitomo Rubber Industries, Ltd. | Specific cell fractionating and capturing methods |
| KR20240005874A (ko) * | 2021-05-05 | 2024-01-12 | 살루스 디스커버리 엘엘씨 | 안정적인 계면 시스템 및 조성물 |
| CN114832471A (zh) * | 2022-05-20 | 2022-08-02 | 深圳华大医学检验实验室 | 一种滤芯及其过滤装置与方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4844818A (en) * | 1987-10-23 | 1989-07-04 | Becton Dickinson & Company | Method for separating the cellular components of blood samples |
| US4867887A (en) * | 1988-07-12 | 1989-09-19 | Becton Dickinson And Company | Method and apparatus for separating mononuclear cells from blood |
| US5494590A (en) * | 1992-06-11 | 1996-02-27 | Becton Dickinson | Method of using anticoagulant solution in blood separation |
| US5840502A (en) * | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
| CA2239729C (en) * | 1995-12-11 | 2006-10-31 | Dendreon Corporation | Cell separation composition, kit and method |
| DE19904267A1 (de) * | 1999-02-03 | 2000-08-10 | Michael W Dahm | Verfahren zur Anreicherung von Tumorzellen aus einer Körperflüssigkeit und dazu geeigneter Kit |
| DE50309796D1 (de) * | 2002-08-14 | 2008-06-19 | Hexal Gentech Forschungsgmbh | Verfahren zum immunzytologischen oder molekularen nachweis von disseminierten tumorzellen aus einer körperflüssigkeit und dazu geeigneter kit |
-
2005
- 2005-02-21 EP EP05003640A patent/EP1693109A1/de not_active Withdrawn
-
2006
- 2006-02-20 US US11/816,742 patent/US20090186341A1/en not_active Abandoned
- 2006-02-20 JP JP2007555539A patent/JP2008529541A/ja active Pending
- 2006-02-20 CA CA002642274A patent/CA2642274A1/en not_active Abandoned
- 2006-02-20 WO PCT/EP2006/001496 patent/WO2006087220A2/de not_active Ceased
- 2006-02-20 AU AU2006215776A patent/AU2006215776A1/en not_active Abandoned
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