JP2008528621A - 腎細胞ガンを処置するための方法 - Google Patents

腎細胞ガンを処置するための方法 Download PDF

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JP2008528621A
JP2008528621A JP2007553304A JP2007553304A JP2008528621A JP 2008528621 A JP2008528621 A JP 2008528621A JP 2007553304 A JP2007553304 A JP 2007553304A JP 2007553304 A JP2007553304 A JP 2007553304A JP 2008528621 A JP2008528621 A JP 2008528621A
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amino acid
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JP2008528621A5 (https=
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ローレンス エリアス，
ゲイリー ウィザレル，
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ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド
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Publication of JP2008528621A publication Critical patent/JP2008528621A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP2007553304A 2005-01-27 2006-01-27 腎細胞ガンを処置するための方法 Pending JP2008528621A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64749605P 2005-01-27 2005-01-27
PCT/US2006/003116 WO2006081510A2 (en) 2005-01-27 2006-01-27 Methods for treating renal cell carcinoma

Related Child Applications (1)

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JP2011266809A Division JP2012046552A (ja) 2005-01-27 2011-12-06 腎細胞ガンを処置するための方法

Publications (2)

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JP2008528621A true JP2008528621A (ja) 2008-07-31
JP2008528621A5 JP2008528621A5 (https=) 2009-01-29

Family

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Family Applications (2)

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JP2007553304A Pending JP2008528621A (ja) 2005-01-27 2006-01-27 腎細胞ガンを処置するための方法
JP2011266809A Pending JP2012046552A (ja) 2005-01-27 2011-12-06 腎細胞ガンを処置するための方法

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JP2011266809A Pending JP2012046552A (ja) 2005-01-27 2011-12-06 腎細胞ガンを処置するための方法

Country Status (13)

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US (2) US20070014765A1 (https=)
EP (1) EP1846020B1 (https=)
JP (2) JP2008528621A (https=)
KR (1) KR20070102576A (https=)
CN (1) CN101132809A (https=)
AU (1) AU2006207987B2 (https=)
BR (1) BRPI0606774A2 (https=)
CA (1) CA2595959A1 (https=)
ES (1) ES2432141T3 (https=)
IL (1) IL184865A (https=)
MX (1) MX2007009012A (https=)
RU (1) RU2404795C2 (https=)
WO (1) WO2006081510A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018514558A (ja) * 2015-04-27 2018-06-07 スサヴィオン バイオサイエンシーズ インコーポレイテッド がんおよび持続性ウイルス感染を処置するための組成物および方法
JP2019014743A (ja) * 2011-03-11 2019-01-31 アシスタンス ピュブリク−オピトー ドゥ パリＡｓｓｉｓｔａｎｃｅ Ｐｕｂｌｉｑｕｅ − Ｈｏｐｉｔａｕｘ Ｄｅ Ｐａｒｉｓ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ−２の使用
JP2023029565A (ja) * 2011-03-11 2023-03-03 アシスタンス ピュブリク－オピトー ドゥ パリ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ－２の使用

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EP2370399A4 (en) * 2008-12-11 2013-05-22 Agency Science Tech & Res GLUCOSE-PEG CONJUGATES TO REDUCE GLUCOSE TRANSPORT INTO A CELL
US20150299255A1 (en) * 2010-11-01 2015-10-22 Susavion Biosciences, Inc. Compositions and methods for modulating innate and adaptive immune systems
US9428567B2 (en) 2010-12-22 2016-08-30 The Board Of Trustees Of The Leland Stanford Junior University Antagonists of interleukin-2 receptor
CN105722860A (zh) 2013-09-24 2016-06-29 梅迪塞纳医疗股份有限公司 白介素-2融合蛋白及其应用
WO2015164815A1 (en) 2014-04-24 2015-10-29 The Board Of Trustees Of The Leland Stanford Junior University Superagonists, partial agonists and antagonists of interleukin-2
WO2016025385A1 (en) 2014-08-11 2016-02-18 Delinia, Inc. Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
US10350260B2 (en) * 2015-04-27 2019-07-16 Susavion Biosciences, Inc. Compositions and methods for treating cancer and persistent viral infections
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
US11077172B2 (en) 2016-11-08 2021-08-03 Delinia, Inc. IL-2 variants for the treatment of psoriasis
CU24483B1 (es) * 2016-11-15 2020-04-02 Ct Inmunologia Molecular Método para incrementar los niveles de secreción de la interleucina-2
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
BR112019024556A2 (pt) 2017-05-24 2020-06-23 Novartis Ag Proteínas enxertadas com citocina de anticorpo e métodos para uso no tratamento de câncer
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
AU2018287317B2 (en) 2017-06-19 2024-06-20 Medicenna Therapeutics Inc. Uses and methods for IL-2 superagonists, agonists, and fusions thereof
AU2018300069C1 (en) 2017-07-11 2025-11-20 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
WO2019028419A1 (en) 2017-08-03 2019-02-07 Synthorx, Inc. CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
US20200299349A1 (en) 2017-11-21 2020-09-24 The Board Of Trustees Of The Leland Stanford Junior University Partial agonists of interleukin-2
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
EP3737692A4 (en) 2018-01-09 2021-09-29 Elstar Therapeutics, Inc. CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES
US12152073B2 (en) 2018-03-14 2024-11-26 Marengo Therapeutics, Inc. Multifunctional molecules that bind to calreticulin and uses thereof
EP3818083A2 (en) 2018-07-03 2021-05-12 Elstar Therapeutics, Inc. Anti-tcr antibody molecules and uses thereof
ES3059360T3 (en) 2018-11-08 2026-03-19 Synthorx Inc Interleukin 10 conjugates and uses thereof
KR20260039812A (ko) 2019-02-06 2026-03-20 신톡스, 인크. Il-2 콘쥬게이트 및 이의 사용 방법
JP7710373B2 (ja) 2019-02-21 2025-07-18 マレンゴ・セラピューティクス，インコーポレーテッド Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用
AU2020224681A1 (en) 2019-02-21 2021-09-16 Marengo Therapeutics, Inc. Antibody molecules that bind to NKp30 and uses thereof
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
CN114555632A (zh) 2019-08-23 2022-05-27 新索思股份有限公司 Il-15缀合物及其用途
MX2022002740A (es) 2019-09-10 2022-03-25 Synthorx Inc Conjugados de il-2 y metodos de uso para tratar enfermedades autoinmunes.
BR112022012112A2 (pt) 2019-12-20 2022-09-06 Regeneron Pharma Agonistas de il2 e métodos de uso dos mesmos
CN116234829A (zh) 2020-01-03 2023-06-06 马伦戈治疗公司 抗tcr抗体分子及其用途
US11633488B2 (en) 2020-01-10 2023-04-25 Bright Peak Therapeutics Ag Modified IL-2 polypeptides and uses thereof
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
TW202317623A (zh) 2021-06-14 2023-05-01 美商再生元醫藥公司 基於il2之治療劑及其使用方法

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WO2004002526A1 (en) * 2002-07-01 2004-01-08 Wilex Ag Co-administration of cg250 and il-2 or ifn-alpha for treating cancer such as renal cell carcinomas

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US4931543A (en) 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US5830452A (en) * 1990-11-20 1998-11-03 Chiron Corporation Method for enhancing the anti-tumor therapeutic index of interleukin-2
RU2174409C2 (ru) * 1995-11-30 2001-10-10 Борд оф Риджентс, ЗЭ Юниверсити оф Тексас Систем Способы и композиции для диагностики и лечения рака

Patent Citations (1)

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WO2004002526A1 (en) * 2002-07-01 2004-01-08 Wilex Ag Co-administration of cg250 and il-2 or ifn-alpha for treating cancer such as renal cell carcinomas

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019014743A (ja) * 2011-03-11 2019-01-31 アシスタンス ピュブリク−オピトー ドゥ パリＡｓｓｉｓｔａｎｃｅ Ｐｕｂｌｉｑｕｅ − Ｈｏｐｉｔａｕｘ Ｄｅ Ｐａｒｉｓ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ−２の使用
JP2021006591A (ja) * 2011-03-11 2021-01-21 アシスタンス ピュブリク−オピトー ドゥ パリＡｓｓｉｓｔａｎｃｅ Ｐｕｂｌｉｑｕｅ − Ｈｏｐｉｔａｕｘ Ｄｅ Ｐａｒｉｓ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ−２の使用
JP2023029565A (ja) * 2011-03-11 2023-03-03 アシスタンス ピュブリク－オピトー ドゥ パリ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ－２の使用
JP7561893B2 (ja) 2011-03-11 2024-10-04 アシスタンス ピュブリク－オピトー ドゥ パリ 自己免疫関連障害または炎症性障害の治療のための低用量ｉｌ－２の使用
JP2018514558A (ja) * 2015-04-27 2018-06-07 スサヴィオン バイオサイエンシーズ インコーポレイテッド がんおよび持続性ウイルス感染を処置するための組成物および方法

Also Published As

Publication number Publication date
MX2007009012A (es) 2007-09-14
WO2006081510A2 (en) 2006-08-03
AU2006207987B2 (en) 2011-09-15
EP1846020A2 (en) 2007-10-24
RU2007132125A (ru) 2009-03-10
US20100316595A1 (en) 2010-12-16
BRPI0606774A2 (pt) 2009-07-14
CA2595959A1 (en) 2006-08-03
WO2006081510A3 (en) 2007-01-18
IL184865A (en) 2011-04-28
IL184865A0 (en) 2007-12-03
JP2012046552A (ja) 2012-03-08
RU2404795C2 (ru) 2010-11-27
AU2006207987A1 (en) 2006-08-03
ES2432141T3 (es) 2013-11-29
CN101132809A (zh) 2008-02-27
EP1846020B1 (en) 2013-08-21
US20070014765A1 (en) 2007-01-18
US8012465B2 (en) 2011-09-06
KR20070102576A (ko) 2007-10-18

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