JP2008528514A - 4−アミノ−2−(3−メチル−2,6−ジオキソピペリジン−3−イル)−イソインドール−1,3−ジオンを使用する方法及び組成物 - Google Patents
4−アミノ−2−(3−メチル−2,6−ジオキソピペリジン−3−イル)−イソインドール−1,3−ジオンを使用する方法及び組成物 Download PDFInfo
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- JP2008528514A JP2008528514A JP2007552380A JP2007552380A JP2008528514A JP 2008528514 A JP2008528514 A JP 2008528514A JP 2007552380 A JP2007552380 A JP 2007552380A JP 2007552380 A JP2007552380 A JP 2007552380A JP 2008528514 A JP2008528514 A JP 2008528514A
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- disorder
- methyl
- amino
- isoindole
- dione
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- 0 CC(CCC(*1)=O)(*=*)C1=O Chemical compound CC(CCC(*1)=O)(*=*)C1=O 0.000 description 1
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64650505P | 2005-01-25 | 2005-01-25 | |
| PCT/US2006/002503 WO2006081251A2 (en) | 2005-01-25 | 2006-01-24 | Methods and compositions using 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1-3-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528514A true JP2008528514A (ja) | 2008-07-31 |
| JP2008528514A5 JP2008528514A5 (enExample) | 2009-07-16 |
Family
ID=36609267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552380A Abandoned JP2008528514A (ja) | 2005-01-25 | 2006-01-24 | 4−アミノ−2−(3−メチル−2,6−ジオキソピペリジン−3−イル)−イソインドール−1,3−ジオンを使用する方法及び組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060205787A1 (enExample) |
| EP (1) | EP1848433A2 (enExample) |
| JP (1) | JP2008528514A (enExample) |
| KR (1) | KR20070099031A (enExample) |
| CN (1) | CN101141960A (enExample) |
| AR (1) | AR052196A1 (enExample) |
| AU (1) | AU2006208201A1 (enExample) |
| BR (1) | BRPI0607239A2 (enExample) |
| CA (1) | CA2595711A1 (enExample) |
| IL (1) | IL184821A0 (enExample) |
| MX (1) | MX2007008903A (enExample) |
| WO (1) | WO2006081251A2 (enExample) |
| ZA (1) | ZA200707010B (enExample) |
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| US20070253960A1 (en) * | 2006-04-28 | 2007-11-01 | Josee Roy | Pharmaceutical removal of vascular extensions from a degenerating disc |
| US20080234243A1 (en) * | 2007-01-31 | 2008-09-25 | Lavallee Theresa M | Method of treating amyloidosis mediated diseases |
| US7579464B2 (en) * | 2007-05-25 | 2009-08-25 | Hoffmann-La Roche Inc. | Process for preparation of enantiomerically pure compounds |
| WO2009085234A2 (en) * | 2007-12-20 | 2009-07-09 | Signal Pharmaceuticals, Inc. | Use of micro-rna as a biomarker of immunomodulatory drug activity |
| US20090232796A1 (en) * | 2008-02-20 | 2009-09-17 | Corral Laura G | Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand |
| CN105168219B (zh) * | 2008-05-27 | 2018-11-20 | 细胞内治疗公司 | 用于睡眠障碍和其他疾病的方法和组合物 |
| ES2713524T3 (es) | 2009-03-25 | 2019-05-22 | Celularity Inc | Supresión tumoral usando linfocitos citolíticos naturales intermedios obtenidos a partir de placenta humana y compuestos inmunomoduladores |
| US20120134969A1 (en) | 2009-05-25 | 2012-05-31 | Hiroshi Handa | Pharmaceutical composition containing nuclear factor involved in proliferation and differentiation of central neuronal cells |
| WO2011069608A1 (en) * | 2009-12-09 | 2011-06-16 | Ratiopharm Gmbh | S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide |
| EP2521543B1 (en) | 2010-01-05 | 2016-04-13 | Celgene Corporation | A combination of an immunomodulatory compound and an artemisinin derivative for treating cancer |
| MX2013012083A (es) | 2011-04-18 | 2014-04-16 | Celgene Corp | Biomarcadores para el tratamiento de mieloma multiple. |
| CN103688176A (zh) | 2011-04-29 | 2014-03-26 | 细胞基因公司 | 利用cereblon作为预报因子治疗癌和炎性疾病的方法 |
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| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| EP2941423B1 (en) | 2013-01-07 | 2021-06-09 | University of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2014145192A1 (en) | 2013-03-15 | 2014-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US20150031697A1 (en) * | 2013-07-26 | 2015-01-29 | Wisconsin Alumni Research Foundation | Method for preventing ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas |
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| EP3076967B1 (en) | 2013-12-03 | 2021-07-28 | Intra-Cellular Therapies, Inc. | Methods for treating residual symptoms of schizophrenia |
| CN106061952B (zh) | 2014-01-03 | 2022-01-28 | 南加州大学 | 含有杂原子的脱氧尿苷三磷酸酶抑制剂 |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP6640126B2 (ja) | 2014-06-27 | 2020-02-05 | セルジーン コーポレイション | セレブロン及び他のe3ユビキチンリガーゼの立体構造の変化を誘導するための組成物及び方法 |
| US10302644B2 (en) | 2014-11-04 | 2019-05-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| US10570100B2 (en) | 2015-07-08 | 2020-02-25 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| DK3319939T3 (da) | 2015-07-08 | 2025-02-24 | Cv6 Therapeutics Ni Ltd | Hydantoin indeholdende deoxyuridintriphosphatase-inhibitorer |
| WO2017006270A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| US10830762B2 (en) | 2015-12-28 | 2020-11-10 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other E3 ubiquitin ligases |
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| IL272249B2 (en) | 2017-07-26 | 2023-11-01 | Intra Cellular Therapies Inc | Organic compounds |
| MX2020008718A (es) | 2018-02-21 | 2020-12-07 | Celgene Corp | Anticuerpos de union a bcma y usos de los mismos. |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| EP3628007B1 (en) | 2018-06-06 | 2023-05-03 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| CA3102948A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| WO2020047241A1 (en) | 2018-08-29 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| CA3108558A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| EP3843738A4 (en) | 2018-08-31 | 2022-06-01 | Intra-Cellular Therapies, Inc. | NEW METHODS |
| CN114072150A (zh) | 2019-07-07 | 2022-02-18 | 细胞内治疗公司 | 新方法 |
| CN114786665A (zh) | 2019-10-21 | 2022-07-22 | 新基公司 | 取代的4-氨基异二氢吲哚-1,3-二酮化合物和第二种活性剂的组合用途 |
| KR20220103952A (ko) | 2019-10-21 | 2022-07-25 | 셀진 코포레이션 | (s)-2-(2,6-디옥소피페리딘-3-일)-4-((2-플루오로-4-((3-모르폴리노아제티딘-1-일)메틸)벤질)아미노)이소인돌린-1,3-디온을 포함하는 제약 조성물 및 그의 사용 방법 |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281230B1 (en) * | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US7091353B2 (en) * | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
-
2006
- 2006-01-24 KR KR1020077019386A patent/KR20070099031A/ko not_active Withdrawn
- 2006-01-24 CA CA002595711A patent/CA2595711A1/en not_active Abandoned
- 2006-01-24 JP JP2007552380A patent/JP2008528514A/ja not_active Abandoned
- 2006-01-24 BR BRPI0607239-9A patent/BRPI0607239A2/pt not_active IP Right Cessation
- 2006-01-24 AR ARP060100261A patent/AR052196A1/es not_active Application Discontinuation
- 2006-01-24 WO PCT/US2006/002503 patent/WO2006081251A2/en not_active Ceased
- 2006-01-24 AU AU2006208201A patent/AU2006208201A1/en not_active Abandoned
- 2006-01-24 ZA ZA200707010A patent/ZA200707010B/xx unknown
- 2006-01-24 CN CNA2006800081712A patent/CN101141960A/zh active Pending
- 2006-01-24 EP EP06719389A patent/EP1848433A2/en not_active Withdrawn
- 2006-01-24 MX MX2007008903A patent/MX2007008903A/es not_active Application Discontinuation
- 2006-01-25 US US11/338,688 patent/US20060205787A1/en not_active Abandoned
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2007
- 2007-07-24 IL IL184821A patent/IL184821A0/en unknown
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|---|---|
| IL184821A0 (en) | 2007-12-03 |
| CN101141960A (zh) | 2008-03-12 |
| US20060205787A1 (en) | 2006-09-14 |
| ZA200707010B (en) | 2009-01-28 |
| BRPI0607239A2 (pt) | 2009-08-25 |
| CA2595711A1 (en) | 2006-08-03 |
| AU2006208201A1 (en) | 2006-08-03 |
| EP1848433A2 (en) | 2007-10-31 |
| WO2006081251A3 (en) | 2006-12-28 |
| AR052196A1 (es) | 2007-03-07 |
| WO2006081251A2 (en) | 2006-08-03 |
| MX2007008903A (es) | 2007-09-07 |
| KR20070099031A (ko) | 2007-10-08 |
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