JP2008527375A - 赤外線透過基板、半導体基板、珪素基板、流体サンプル分析装置、流体サンプル分析方法、及び計算機読み取り可能な記録媒体 - Google Patents
赤外線透過基板、半導体基板、珪素基板、流体サンプル分析装置、流体サンプル分析方法、及び計算機読み取り可能な記録媒体 Download PDFInfo
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- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3577—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing liquids, e.g. polluted water
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- G—PHYSICS
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/038,550 US20050211555A1 (en) | 2002-02-14 | 2005-01-18 | Method for multiple sample screening using IR spectroscopy |
| US11/038,435 US20050170521A1 (en) | 2002-02-14 | 2005-01-18 | Multiple sample screening using IR spectroscopy |
| US11/039,276 US20050153435A1 (en) | 2002-02-14 | 2005-01-18 | Multiple sample screening using a silicon substrate |
| PCT/US2005/044550 WO2006078366A2 (en) | 2005-01-18 | 2005-12-09 | Multiple sample screening using ir spectroscopy with capillary isoelectric focusing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008527375A true JP2008527375A (ja) | 2008-07-24 |
| JP2008527375A5 JP2008527375A5 (enExample) | 2009-01-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551259A Pending JP2008527375A (ja) | 2005-01-18 | 2005-12-09 | 赤外線透過基板、半導体基板、珪素基板、流体サンプル分析装置、流体サンプル分析方法、及び計算機読み取り可能な記録媒体 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080074646A1 (enExample) |
| EP (1) | EP1842045A4 (enExample) |
| JP (1) | JP2008527375A (enExample) |
| WO (1) | WO2006078366A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509634A (ja) * | 2015-01-14 | 2018-04-05 | フランク・トーマス・ハートレイ | 体液を抜き取る装置及びその方法 |
| JP2019515269A (ja) * | 2016-04-22 | 2019-06-06 | プロテイン ダイナミック ソリューションズ インコーポレイテッドProtein Dynamic Solutions,Inc. | スペクトル解析の試料採取アレイ装置及びシステム |
| WO2020153337A1 (ja) * | 2019-01-25 | 2020-07-30 | 横河電機株式会社 | フーリエ分光分析装置 |
Families Citing this family (9)
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|---|---|---|---|---|
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| US9947827B2 (en) | 2014-02-21 | 2018-04-17 | Terahertz Device Corporation | Front-side emitting mid-infrared light emitting diode |
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| US10712310B2 (en) | 2016-01-22 | 2020-07-14 | Temple University—Of the Commonwealth System of Higher Education | Protein quantification by near infrared spectral imaging |
| CN109552043A (zh) * | 2018-12-26 | 2019-04-02 | 华北理工大学 | 采用近红外光酒精检测的汽车防酒驾装置以及防酒驾方法 |
| US20230061881A1 (en) * | 2021-08-25 | 2023-03-02 | The United States Of America, As Represented By The Secretary Of The Navy | Measurement Device with Tunable Two-Dimensional Material for Environment Characterization |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10505410A (ja) * | 1994-06-08 | 1998-05-26 | アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ | バイオアレーチップ反応装置およびその製造方法 |
| JP2002284545A (ja) * | 2001-03-27 | 2002-10-03 | Ulvac Japan Ltd | ドライエッチング法 |
| JP2002357616A (ja) * | 2001-05-31 | 2002-12-13 | Inst Of Physical & Chemical Res | 微量液体制御機構 |
| JP2003527580A (ja) * | 1999-12-17 | 2003-09-16 | ツェプトゼンス アクチエンゲゼルシャフト | フローセル配列及び多重分析対象物測定のためのその利用 |
| WO2004017061A1 (en) * | 2002-08-17 | 2004-02-26 | Paraytec Ltd | Optical assembly and method for detection of light transmission |
| WO2004048929A2 (en) * | 2002-11-22 | 2004-06-10 | Solus Biosystems, Inc. | High throughput screening with parallel vibrational spectroscopy |
| JP2004340702A (ja) * | 2003-05-15 | 2004-12-02 | Aida Eng Ltd | マイクロチップ及び液体検出方法 |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4240692A (en) * | 1975-12-17 | 1980-12-23 | The University Of Chicago | Energy transmission |
| GB1562015A (en) * | 1976-03-03 | 1980-03-05 | Us Energy | Solar concentrator with the angle of incidence of energy on the energy absorber restricted |
| US4382656A (en) * | 1980-11-12 | 1983-05-10 | The Foxboro Company | Non-imaging optical energy transfer system |
| GB2191110B (en) * | 1986-06-06 | 1989-12-06 | Plessey Co Plc | Chromatographic separation device |
| US5153675A (en) * | 1990-02-22 | 1992-10-06 | Nicolet Instrument Corporation | Modular optical system for Fourier transform infrared spectrometer |
| US6176962B1 (en) * | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
| US5750015A (en) * | 1990-02-28 | 1998-05-12 | Soane Biosciences | Method and device for moving molecules by the application of a plurality of electrical fields |
| GB2244135B (en) * | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
| JPH0678978B2 (ja) * | 1990-05-25 | 1994-10-05 | スズキ株式会社 | 凝集パターン検出装置 |
| IL99367A (en) * | 1991-09-02 | 1995-12-31 | Israel Atomic Energy Comm | System for performing ir transmission spectroscopy |
| US5361160A (en) * | 1992-03-20 | 1994-11-01 | National Research Council Of Canada | Large angle broadband multilayer deflectors |
| US5744366A (en) * | 1992-05-01 | 1998-04-28 | Trustees Of The University Of Pennsylvania | Mesoscale devices and methods for analysis of motile cells |
| US5312535A (en) * | 1992-07-17 | 1994-05-17 | Beckman Instruments, Inc. | Capillary electrophoresis detection |
| US5348633A (en) * | 1993-01-22 | 1994-09-20 | Northeastern University | Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis |
| US5416325A (en) * | 1993-04-29 | 1995-05-16 | Arch Development Corporation | Fourier transform infrared spectrometer |
| US5580435A (en) * | 1994-06-10 | 1996-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | System for detecting components of a sample in electrophoretic separation |
| US5658413A (en) * | 1994-10-19 | 1997-08-19 | Hewlett-Packard Company | Miniaturized planar columns in novel support media for liquid phase analysis |
| US5585069A (en) * | 1994-11-10 | 1996-12-17 | David Sarnoff Research Center, Inc. | Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis |
| US5603351A (en) * | 1995-06-07 | 1997-02-18 | David Sarnoff Research Center, Inc. | Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device |
| US5644395A (en) * | 1995-07-14 | 1997-07-01 | Regents Of The University Of California | Miniaturized flow injection analysis system |
| US5872010A (en) * | 1995-07-21 | 1999-02-16 | Northeastern University | Microscale fluid handling system |
| AU2275097A (en) * | 1996-02-20 | 1997-09-02 | Waters Investments Limited | Capillary chromatography detector apparatus |
| US5777736A (en) * | 1996-07-19 | 1998-07-07 | Science Applications International Corporation | High etendue imaging fourier transform spectrometer |
| US5745243A (en) * | 1996-11-15 | 1998-04-28 | Optical Solutions, Inc. | Photometer apparatus |
| US6093330A (en) * | 1997-06-02 | 2000-07-25 | Cornell Research Foundation, Inc. | Microfabrication process for enclosed microstructures |
| US5900130A (en) * | 1997-06-18 | 1999-05-04 | Alcara Biosciences, Inc. | Method for sample injection in microchannel device |
| US6180536B1 (en) * | 1998-06-04 | 2001-01-30 | Cornell Research Foundation, Inc. | Suspended moving channels and channel actuators for microfluidic applications and method for making |
| US6245227B1 (en) * | 1998-09-17 | 2001-06-12 | Kionix, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
| US6158712A (en) * | 1998-10-16 | 2000-12-12 | Agilent Technologies, Inc. | Multilayer integrated assembly having an integral microminiature valve |
| EP1006355A3 (en) * | 1998-11-30 | 2000-11-08 | The Institute of Physical and Chemical Research | Capillary electrophoretic apparatus |
| US6156178A (en) * | 1999-07-13 | 2000-12-05 | Molecular Dynamics, Inc. | Increased throughput analysis of small compounds using multiple temporally spaced injections |
| US6210986B1 (en) * | 1999-09-23 | 2001-04-03 | Sandia Corporation | Microfluidic channel fabrication method |
| WO2002061858A2 (en) * | 2000-11-17 | 2002-08-08 | Thermogenic Imaging, Inc. | Apparatus and methods for infrared calorimetric measurements |
| US6570158B2 (en) * | 2001-06-02 | 2003-05-27 | Hya Feygin | Method and apparatus for infrared-spectrum imaging |
| US7033542B2 (en) * | 2002-02-14 | 2006-04-25 | Archibald William B | High throughput screening with parallel vibrational spectroscopy |
| AU2003297214A1 (en) * | 2002-12-16 | 2004-07-22 | Cytodiscovery, Inc. | Microfluidic system with integrated permeable membrane |
| WO2005052644A2 (en) * | 2003-11-21 | 2005-06-09 | Perkinelmer Las, Inc. | Optical device integrated with well |
| US6976782B1 (en) * | 2003-11-24 | 2005-12-20 | Lam Research Corporation | Methods and apparatus for in situ substrate temperature monitoring |
| JP4646035B2 (ja) * | 2006-04-07 | 2011-03-09 | 株式会社 日立ディスプレイズ | ラビング角度測定装置、及び液晶表示装置並びに光学フィルムの製造方法 |
-
2005
- 2005-12-09 JP JP2007551259A patent/JP2008527375A/ja active Pending
- 2005-12-09 EP EP05853462A patent/EP1842045A4/en not_active Withdrawn
- 2005-12-09 WO PCT/US2005/044550 patent/WO2006078366A2/en not_active Ceased
- 2005-12-09 US US11/795,379 patent/US20080074646A1/en not_active Abandoned
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10505410A (ja) * | 1994-06-08 | 1998-05-26 | アフィマックス テクノロジーズ ナムローゼ フェンノートシャップ | バイオアレーチップ反応装置およびその製造方法 |
| JP2003527580A (ja) * | 1999-12-17 | 2003-09-16 | ツェプトゼンス アクチエンゲゼルシャフト | フローセル配列及び多重分析対象物測定のためのその利用 |
| JP2002284545A (ja) * | 2001-03-27 | 2002-10-03 | Ulvac Japan Ltd | ドライエッチング法 |
| JP2002357616A (ja) * | 2001-05-31 | 2002-12-13 | Inst Of Physical & Chemical Res | 微量液体制御機構 |
| WO2004017061A1 (en) * | 2002-08-17 | 2004-02-26 | Paraytec Ltd | Optical assembly and method for detection of light transmission |
| WO2004048929A2 (en) * | 2002-11-22 | 2004-06-10 | Solus Biosystems, Inc. | High throughput screening with parallel vibrational spectroscopy |
| JP2006507504A (ja) * | 2002-11-22 | 2006-03-02 | ソルス バイオシステムズ インコーポレーテッド | 並列振動分光法による高スループットのスクリーニング |
| JP2004340702A (ja) * | 2003-05-15 | 2004-12-02 | Aida Eng Ltd | マイクロチップ及び液体検出方法 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018509634A (ja) * | 2015-01-14 | 2018-04-05 | フランク・トーマス・ハートレイ | 体液を抜き取る装置及びその方法 |
| JP2019515269A (ja) * | 2016-04-22 | 2019-06-06 | プロテイン ダイナミック ソリューションズ インコーポレイテッドProtein Dynamic Solutions,Inc. | スペクトル解析の試料採取アレイ装置及びシステム |
| JP2021185392A (ja) * | 2016-04-22 | 2021-12-09 | プロテイン ダイナミック ソリューションズ インコーポレイテッドProtein Dynamic Solutions, Inc. | スペクトル解析の試料採取アレイ装置及びシステム |
| JP7209790B2 (ja) | 2016-04-22 | 2023-01-20 | プロテイン ダイナミック ソリューションズ インコーポレイテッド | スペクトル解析の試料採取アレイ装置及びシステム |
| WO2020153337A1 (ja) * | 2019-01-25 | 2020-07-30 | 横河電機株式会社 | フーリエ分光分析装置 |
| JP2020118617A (ja) * | 2019-01-25 | 2020-08-06 | 横河電機株式会社 | フーリエ分光分析装置 |
| JP7014192B2 (ja) | 2019-01-25 | 2022-02-01 | 横河電機株式会社 | フーリエ分光分析装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006078366A3 (en) | 2007-02-22 |
| WO2006078366A2 (en) | 2006-07-27 |
| US20080074646A1 (en) | 2008-03-27 |
| EP1842045A2 (en) | 2007-10-10 |
| EP1842045A4 (en) | 2009-04-15 |
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