JP2008526786A5 - - Google Patents
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- Publication number
- JP2008526786A5 JP2008526786A5 JP2007549782A JP2007549782A JP2008526786A5 JP 2008526786 A5 JP2008526786 A5 JP 2008526786A5 JP 2007549782 A JP2007549782 A JP 2007549782A JP 2007549782 A JP2007549782 A JP 2007549782A JP 2008526786 A5 JP2008526786 A5 JP 2008526786A5
- Authority
- JP
- Japan
- Prior art keywords
- fluorinated hydrocarbon
- use according
- amount
- nigozai
- milk
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000004215 Carbon black (E152) Substances 0.000 claims description 16
- 229930195733 hydrocarbon Natural products 0.000 claims description 16
- 150000002430 hydrocarbons Chemical class 0.000 claims description 16
- 239000000839 emulsion Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 10
- 239000011824 nuclear material Substances 0.000 claims description 9
- 239000012736 aqueous medium Substances 0.000 claims description 6
- 239000003623 enhancer Substances 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 8
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 6
- 239000000194 fatty acid Substances 0.000 claims 5
- 235000013336 milk Nutrition 0.000 claims 5
- 239000008267 milk Substances 0.000 claims 5
- 210000004080 milk Anatomy 0.000 claims 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- -1 sorbitan fatty acid ester Chemical class 0.000 claims 3
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 1
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 229930186217 Glycolipid Natural products 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 229920006197 POE laurate Polymers 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 239000002961 echo contrast media Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 150000008106 phosphatidylserines Chemical class 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200510000343A CN100574809C (zh) | 2005-01-10 | 2005-01-10 | 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用 |
| PCT/CN2005/001391 WO2006072200A1 (fr) | 2005-01-10 | 2005-09-02 | Adjuvant d’emulsions au fluorocarbure pour un traitement hifu et utilisation de celui-ci |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526786A JP2008526786A (ja) | 2008-07-24 |
| JP2008526786A5 true JP2008526786A5 (enExample) | 2009-03-19 |
Family
ID=36647408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549782A Pending JP2008526786A (ja) | 2005-01-10 | 2005-09-02 | 高密度焦点式超音波療法のためのフッ化炭化水素乳濁液増強剤およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20080138290A1 (enExample) |
| EP (1) | EP1839677B1 (enExample) |
| JP (1) | JP2008526786A (enExample) |
| KR (1) | KR20070094621A (enExample) |
| CN (1) | CN100574809C (enExample) |
| AT (1) | ATE491476T1 (enExample) |
| AU (1) | AU2005324273B2 (enExample) |
| BR (1) | BRPI0518494A2 (enExample) |
| CA (1) | CA2593644C (enExample) |
| DE (1) | DE602005025408D1 (enExample) |
| ES (1) | ES2355038T3 (enExample) |
| RU (1) | RU2388492C2 (enExample) |
| WO (1) | WO2006072200A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2948024B1 (fr) * | 2009-07-17 | 2020-01-10 | Centre National De La Recherche Scientifique - Cnrs - | Emulsion activable par ultrasons et son procede de fabrication. |
| US8852103B2 (en) | 2011-10-17 | 2014-10-07 | Butterfly Network, Inc. | Transmissive imaging and related apparatus and methods |
| US9667889B2 (en) | 2013-04-03 | 2017-05-30 | Butterfly Network, Inc. | Portable electronic devices with integrated imaging capabilities |
| CN103877598B (zh) * | 2014-03-18 | 2016-04-27 | 苏晓婷 | 一种超声造影剂及其制备方法 |
| CN105330786B (zh) * | 2014-07-03 | 2017-07-14 | 重庆海扶医疗科技股份有限公司 | 一种治疗用超声耦合介质材料及其制备方法 |
| CN105169420B (zh) * | 2015-09-02 | 2018-01-05 | 上海市第十人民医院 | 一种新型射频诊疗剂及其制备方法 |
| FR3082422B1 (fr) * | 2018-06-14 | 2021-01-22 | Univ D'avignon Et Des Pays De Vaucluse | Emulsion pour la chirurgie d'ablation ultrasonore |
| CN117919402A (zh) * | 2023-12-19 | 2024-04-26 | 中国科学院宁波材料技术与工程研究所 | 一种高强度聚焦超声用敏化剂及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5832829A (ja) * | 1981-08-22 | 1983-02-25 | Green Cross Corp:The | 血管造影剤 |
| US4767610A (en) * | 1984-10-19 | 1988-08-30 | The Regents Of The University Of California | Method for detecting abnormal cell masses in animals |
| US4987154A (en) * | 1986-01-14 | 1991-01-22 | Alliance Pharmaceutical Corp. | Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use |
| US6551576B1 (en) * | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| US6613306B1 (en) * | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| DE4127442C2 (de) * | 1991-08-17 | 1996-08-22 | Udo Dr Gros | Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung |
| US5196183A (en) * | 1991-12-04 | 1993-03-23 | Sterling Winthrop Inc. | Contrast agents for ultrasound imaging |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| AU2076895A (en) * | 1994-03-28 | 1995-10-17 | Daiichi Pharmaceutical Co., Ltd. | Liposomes |
| US5605934A (en) * | 1995-03-23 | 1997-02-25 | Baxter International Inc. | Method of manufacturing and storing solutions |
| US6165442A (en) * | 1996-02-19 | 2000-12-26 | Nycomed Imaging As | Thermally stabilized ultrasound contrast agent |
| EA001135B1 (ru) * | 1996-02-19 | 2000-10-30 | Нюкомед Имагинг А/С | Усовершенствования в области контрастных агентов |
| US5846517A (en) * | 1996-09-11 | 1998-12-08 | Imarx Pharmaceutical Corp. | Methods for diagnostic imaging using a renal contrast agent and a vasodilator |
| US6548047B1 (en) * | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
| CN1194763C (zh) * | 2002-09-06 | 2005-03-30 | 中国人民解放军第三军医大学 | 新型脂质体超声造影剂及其制备方法 |
-
2005
- 2005-01-10 CN CN200510000343A patent/CN100574809C/zh not_active Expired - Lifetime
- 2005-09-02 RU RU2007127668/15A patent/RU2388492C2/ru not_active IP Right Cessation
- 2005-09-02 AU AU2005324273A patent/AU2005324273B2/en not_active Ceased
- 2005-09-02 JP JP2007549782A patent/JP2008526786A/ja active Pending
- 2005-09-02 US US11/794,932 patent/US20080138290A1/en not_active Abandoned
- 2005-09-02 BR BRPI0518494-0A patent/BRPI0518494A2/pt not_active IP Right Cessation
- 2005-09-02 EP EP05781799A patent/EP1839677B1/en not_active Expired - Lifetime
- 2005-09-02 KR KR1020077015586A patent/KR20070094621A/ko not_active Ceased
- 2005-09-02 DE DE602005025408T patent/DE602005025408D1/de not_active Expired - Lifetime
- 2005-09-02 ES ES05781799T patent/ES2355038T3/es not_active Expired - Lifetime
- 2005-09-02 WO PCT/CN2005/001391 patent/WO2006072200A1/zh not_active Ceased
- 2005-09-02 AT AT05781799T patent/ATE491476T1/de not_active IP Right Cessation
- 2005-09-02 CA CA2593644A patent/CA2593644C/en not_active Expired - Lifetime
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