RU2388492C2 - Фторуглеродный эмульсионный активатор для высокоинтенсивной фокусированной ультразвуковой терапии и его применение - Google Patents

Фторуглеродный эмульсионный активатор для высокоинтенсивной фокусированной ультразвуковой терапии и его применение Download PDF

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Publication number
RU2388492C2
RU2388492C2 RU2007127668/15A RU2007127668A RU2388492C2 RU 2388492 C2 RU2388492 C2 RU 2388492C2 RU 2007127668/15 A RU2007127668/15 A RU 2007127668/15A RU 2007127668 A RU2007127668 A RU 2007127668A RU 2388492 C2 RU2388492 C2 RU 2388492C2
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RU
Russia
Prior art keywords
activator
therapy
vifuz
substance
amount
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RU2007127668/15A
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English (en)
Russian (ru)
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RU2007127668A (ru
Inventor
Чжибяо ВАН (CN)
Чжибяо ВАН
Фаци ЛИ (CN)
Фаци ЛИ
Цзывэнь СЯО (CN)
Цзывэнь СЯО
Яньбин СЯО (CN)
Яньбин СЯО
Липин ЛЮ (CN)
Липин ЛЮ
Чжилун ВАН (CN)
Чжилун ВАН
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Чунцин Хайфу(Хифу) Текнолоджи Ко., Лтд
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Publication of RU2007127668A publication Critical patent/RU2007127668A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Acoustics & Sound (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
RU2007127668/15A 2005-01-10 2005-09-02 Фторуглеродный эмульсионный активатор для высокоинтенсивной фокусированной ультразвуковой терапии и его применение RU2388492C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200510000343A CN100574809C (zh) 2005-01-10 2005-01-10 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN200510000343.9 2005-01-10

Publications (2)

Publication Number Publication Date
RU2007127668A RU2007127668A (ru) 2009-01-27
RU2388492C2 true RU2388492C2 (ru) 2010-05-10

Family

ID=36647408

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007127668/15A RU2388492C2 (ru) 2005-01-10 2005-09-02 Фторуглеродный эмульсионный активатор для высокоинтенсивной фокусированной ультразвуковой терапии и его применение

Country Status (13)

Country Link
US (1) US20080138290A1 (enExample)
EP (1) EP1839677B1 (enExample)
JP (1) JP2008526786A (enExample)
KR (1) KR20070094621A (enExample)
CN (1) CN100574809C (enExample)
AT (1) ATE491476T1 (enExample)
AU (1) AU2005324273B2 (enExample)
BR (1) BRPI0518494A2 (enExample)
CA (1) CA2593644C (enExample)
DE (1) DE602005025408D1 (enExample)
ES (1) ES2355038T3 (enExample)
RU (1) RU2388492C2 (enExample)
WO (1) WO2006072200A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2948024B1 (fr) * 2009-07-17 2020-01-10 Centre National De La Recherche Scientifique - Cnrs - Emulsion activable par ultrasons et son procede de fabrication.
US8852103B2 (en) 2011-10-17 2014-10-07 Butterfly Network, Inc. Transmissive imaging and related apparatus and methods
US9667889B2 (en) 2013-04-03 2017-05-30 Butterfly Network, Inc. Portable electronic devices with integrated imaging capabilities
CN103877598B (zh) * 2014-03-18 2016-04-27 苏晓婷 一种超声造影剂及其制备方法
CN105330786B (zh) * 2014-07-03 2017-07-14 重庆海扶医疗科技股份有限公司 一种治疗用超声耦合介质材料及其制备方法
CN105169420B (zh) * 2015-09-02 2018-01-05 上海市第十人民医院 一种新型射频诊疗剂及其制备方法
FR3082422B1 (fr) * 2018-06-14 2021-01-22 Univ D'avignon Et Des Pays De Vaucluse Emulsion pour la chirurgie d'ablation ultrasonore
CN117919402A (zh) * 2023-12-19 2024-04-26 中国科学院宁波材料技术与工程研究所 一种高强度聚焦超声用敏化剂及其制备方法和应用

Citations (6)

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US4767610A (en) * 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
CN1148814A (zh) * 1995-03-23 1997-04-30 巴克斯特国际有限公司 制造和储存溶液的方法
CN1213972A (zh) * 1996-02-19 1999-04-14 奈科姆成像有限公司 造影剂或有关造影剂的改进
CN1404878A (zh) * 2002-09-06 2003-03-26 中国人民解放军第三军医大学 新型脂质体超声造影剂及其制备方法
US6551576B1 (en) * 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications

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JPS5832829A (ja) * 1981-08-22 1983-02-25 Green Cross Corp:The 血管造影剤
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
DE4127442C2 (de) * 1991-08-17 1996-08-22 Udo Dr Gros Wäßrige Dispersion Fluorcarbon enthaltender Phospholipid-Vesikel und ein Verfahren zu ihrer Herstellung
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
US5716597A (en) * 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
AU2076895A (en) * 1994-03-28 1995-10-17 Daiichi Pharmaceutical Co., Ltd. Liposomes
US6165442A (en) * 1996-02-19 2000-12-26 Nycomed Imaging As Thermally stabilized ultrasound contrast agent
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4767610A (en) * 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US6551576B1 (en) * 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
CN1148814A (zh) * 1995-03-23 1997-04-30 巴克斯特国际有限公司 制造和储存溶液的方法
CN1213972A (zh) * 1996-02-19 1999-04-14 奈科姆成像有限公司 造影剂或有关造影剂的改进
CN1404878A (zh) * 2002-09-06 2003-03-26 中国人民解放军第三军医大学 新型脂质体超声造影剂及其制备方法

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XIAOJUAN J.I. et al. The use of ultrasound contrast-agent in HIFU against tumors. CHINA J. ULTRASONOGR, v.12, №12, Dec.2003, p.748-750. *

Also Published As

Publication number Publication date
ATE491476T1 (de) 2011-01-15
EP1839677B1 (en) 2010-12-15
EP1839677A1 (en) 2007-10-03
RU2007127668A (ru) 2009-01-27
AU2005324273A1 (en) 2006-07-13
BRPI0518494A2 (pt) 2008-11-25
CA2593644A1 (en) 2006-07-13
JP2008526786A (ja) 2008-07-24
AU2005324273B2 (en) 2008-08-14
EP1839677A4 (en) 2008-03-19
ES2355038T3 (es) 2011-03-22
CN1803196A (zh) 2006-07-19
KR20070094621A (ko) 2007-09-20
WO2006072200A1 (fr) 2006-07-13
CA2593644C (en) 2011-06-07
CN100574809C (zh) 2009-12-30
US20080138290A1 (en) 2008-06-12
DE602005025408D1 (de) 2011-01-27

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20190903