JP2008526762A - 組織再生および創傷治癒のための脂肪由来幹細胞 - Google Patents

組織再生および創傷治癒のための脂肪由来幹細胞 Download PDF

Info

Publication number
JP2008526762A
JP2008526762A JP2007549643A JP2007549643A JP2008526762A JP 2008526762 A JP2008526762 A JP 2008526762A JP 2007549643 A JP2007549643 A JP 2007549643A JP 2007549643 A JP2007549643 A JP 2007549643A JP 2008526762 A JP2008526762 A JP 2008526762A
Authority
JP
Japan
Prior art keywords
adsc
cells
tissue regeneration
tissue
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2007549643A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008526762A5 (enExample
Inventor
サイア,ションシー・ビー
シルヴァ,フランシスコ・ジェイ
Original Assignee
プライムジェン バイオテック エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by プライムジェン バイオテック エルエルシー filed Critical プライムジェン バイオテック エルエルシー
Publication of JP2008526762A publication Critical patent/JP2008526762A/ja
Publication of JP2008526762A5 publication Critical patent/JP2008526762A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2007549643A 2004-12-30 2005-12-30 組織再生および創傷治癒のための脂肪由来幹細胞 Pending JP2008526762A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64103404P 2004-12-30 2004-12-30
PCT/US2005/047437 WO2006074075A2 (en) 2004-12-30 2005-12-30 Adipose-derived stem cells for tissue regeneration and wound healing

Publications (2)

Publication Number Publication Date
JP2008526762A true JP2008526762A (ja) 2008-07-24
JP2008526762A5 JP2008526762A5 (enExample) 2009-02-19

Family

ID=36588983

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007549643A Pending JP2008526762A (ja) 2004-12-30 2005-12-30 組織再生および創傷治癒のための脂肪由来幹細胞

Country Status (6)

Country Link
US (1) US8119398B2 (enExample)
EP (1) EP1830862B1 (enExample)
JP (1) JP2008526762A (enExample)
AU (1) AU2005322873B2 (enExample)
CA (1) CA2592840C (enExample)
WO (1) WO2006074075A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539546A (ja) * 2006-06-15 2009-11-19 アールエヌエル バイオ カンパニー,リミティッド ヒト脂肪組織由来成体幹細胞、繊維芽細胞、及び脂肪又は脂肪細胞を含有する皮膚美容又は形成用の組成物
JP2017530151A (ja) * 2014-10-03 2017-10-12 サイトリ セラピューティクス インコーポレイテッド 熱傷の進行の緩和ならびに皮膚移植片の取り込みおよび治癒の改善における再生細胞の使用
KR20190049174A (ko) * 2017-11-01 2019-05-09 연세대학교 산학협력단 이식된 지방세포의 생착 증진용 조성물 및 지방 이식용 세포 치료제 조성물

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9144583B2 (en) 2002-03-29 2015-09-29 Tissue Genesis, Inc. Cell separation apparatus and methods of use
US9074190B2 (en) * 2003-10-07 2015-07-07 Biomaster, Inc. Cell differentiation of adipose-derived precursor cells
US20140193852A9 (en) * 2004-12-23 2014-07-10 Erik Vossman Adipose tissue collection and pre-processing devices for use in liposuction procedure
EP1965814A4 (en) * 2005-09-26 2012-01-11 Univ Columbia SIDE POPULATION CELLS IN CARDIAL REPAIR
EP1984488B1 (en) * 2006-01-30 2017-12-27 University Of Virginia Patent Foundation Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof
WO2008106410A1 (en) 2007-02-26 2008-09-04 Cvac Systems, Inc. Combination pressure therapy for treatment of serum lipid levels, steroid levels, and steroidogenesis
US8899228B2 (en) 2006-02-08 2014-12-02 Cvac Systems, Inc. Combination pressure therapy for treatment of chronic pain
JP5240715B2 (ja) * 2006-08-08 2013-07-17 国立大学法人名古屋大学 脂肪組織由来多分化能幹細胞を含有する細胞製剤
US8835170B2 (en) 2006-10-06 2014-09-16 University Of Virginia Patent Foundation Methods and compositions useful for diabetic wound healing
US11174458B2 (en) 2007-04-23 2021-11-16 Koligo Therapeutics, Inc. Cell separation apparatus and methods of use
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
JP5340564B2 (ja) * 2007-07-05 2013-11-13 ライオン株式会社 人工皮膚およびその製造方法
CN107028981B (zh) 2007-09-19 2021-04-20 普拉里斯坦有限公司 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途
JP2011523357A (ja) * 2008-05-06 2011-08-11 ジョスリン ダイアビーティス センター インコーポレイテッド 褐色脂肪細胞分化を誘導するための方法および組成物
US9144584B2 (en) 2008-06-11 2015-09-29 Cell4Vet Corporation Adipose tissue-derived stem cells for veterinary use
US20100098739A1 (en) * 2008-10-20 2010-04-22 University Of Virginia Patent Foundation Compositions and methods for modular soft tissue repair
WO2010048628A1 (en) * 2008-10-24 2010-04-29 Indiana University Research And Technology Corporation Methods for preventing aggregation of adipose stromal cells
US20120100112A1 (en) * 2009-04-20 2012-04-26 Indiana University Research And Technology Corporation Materials and methods for using adipose stem cells to treat lung injury and disease
WO2010129775A1 (en) 2009-05-06 2010-11-11 University Of Virginia Patent Foundation Self-illuminated handheld lens for retinal examination and photography and related method thereof
KR100995133B1 (ko) * 2010-02-10 2010-11-18 허쉬바이오주식회사 지방조직 유래 줄기세포 및 단핵구로부터 세포성장인자의 생산방법 및 그 이용
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
TWI419970B (zh) * 2010-11-11 2013-12-21 Univ Nat Taiwan 使成體幹細胞產生為一球體細胞群體的方法
ES2939147T3 (es) 2011-03-18 2023-04-19 Microvascular Tissues Inc Tejido microvascular alogénico para tratamientos de tejidos blandos
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US9512405B2 (en) 2011-12-14 2016-12-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Non-enzymatic method for isolating human adipose-derived stromal stem cells
US20140074068A1 (en) * 2012-09-12 2014-03-13 Richard Ty Olmstead Multi-component method for regenerative repair of wounds implementing photonic wound debridement and stem cell deposition
US10596202B2 (en) 2012-09-19 2020-03-24 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US9872937B2 (en) 2012-09-19 2018-01-23 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US11819522B2 (en) 2012-09-19 2023-11-21 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
CA2885419A1 (en) * 2012-09-19 2014-03-27 Microvascular Tissues, Inc. Compositions and methods for treating and preventing tissue injury and disease
US9650608B2 (en) 2013-02-22 2017-05-16 Medivet America, Llc Activating adipose-derived stem cells for transplantation
KR101527880B1 (ko) * 2013-04-19 2015-06-10 창원대학교 산학협력단 지방유래줄기세포에 t 항원을 도입한 adsc-t 세포의 배양액을 유효성분으로 포함하는, 피부재생용, 미백용, 항산화용 또는 상처 치료용 조성물
WO2014171593A1 (ko) * 2013-04-19 2014-10-23 창원대학교 산학협력단 지방유래줄기세포에 t항원을 도입한 adsc-t 세포의 배양액을 유효성분으로 포함하는, 항염증용, 피부재생용, 미백용, 항산화용 또는 상처 치료용 조성물
WO2014190150A1 (en) 2013-05-22 2014-11-27 The Regents Of The University Of California Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications
US20150037436A1 (en) 2013-07-30 2015-02-05 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
US10420802B2 (en) 2015-12-10 2019-09-24 Aesthetics Biomedical, Inc. Topical formulation for skin care
US20170258841A1 (en) * 2016-03-11 2017-09-14 Gwo Xi Stem Cell Applied Technology Co., Ltd. Pharmaceutical compositions for treating arrhythmia and therapeutics of
IL306070A (en) 2018-05-03 2023-11-01 Collplant Ltd Dermal fillers and their uses
US20230346842A1 (en) * 2020-05-07 2023-11-02 Primegen Biotech, Llc Methods and Compositions For Reducing Joint Inflammation Using Mesenchymal Stem Cells
EP3909593A1 (en) 2020-05-15 2021-11-17 Rigshospitalet Stem cells for treating skin lesions
WO2024011258A2 (en) * 2022-07-08 2024-01-11 Trustees Of Tufts College Tissue regenerative multi-drug cocktail and apparatus for delivery thereof
CN119491021B (zh) * 2024-11-13 2025-06-20 中南大学 过表达LncRNA SNHG16慢病毒载体在修复工程材料中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112456A (ja) * 1991-10-22 1993-05-07 Osaka Gas Co Ltd ゲル状軟膏
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003053346A2 (en) * 2001-12-07 2003-07-03 Macropore Biosurgery, Inc. Systems and methods for treating patients with processed lipoaspirate cells

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4792525A (en) * 1982-08-04 1988-12-20 La Jolla Cancer Research Foundation Tetrapeptide
US4988621A (en) * 1985-05-24 1991-01-29 La Jolla Cancer Research Foundation Peptides in cell detachment and aggregation
US4879237A (en) * 1985-05-24 1989-11-07 La Jolla Cancer Research Foundation Use of peptides in control of cell attachment and detachment
US4789734A (en) * 1985-08-06 1988-12-06 La Jolla Cancer Research Foundation Vitronectin specific cell receptor derived from mammalian mesenchymal tissue
US5158881A (en) 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
WO1991010470A1 (en) 1990-01-08 1991-07-25 Brown University Research Foundation Devices and methods for enhanced delivery of active factors
US5149543A (en) * 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5965997A (en) * 1997-08-20 1999-10-12 Benchmarq Microelectronics Battery monitoring circuit with storage of charge and discharge accumulation values accessible therefrom
US6777231B1 (en) * 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
JP2003509044A (ja) 1999-09-14 2003-03-11 チルドレンズ メディカル センター コーポレーション 筋肉由来幹細胞の単離およびその使用
US20030054331A1 (en) * 2001-09-14 2003-03-20 Stemsource, Inc. Preservation of non embryonic cells from non hematopoietic tissues
MXPA05009044A (es) 2003-02-20 2006-03-17 Macropore Biosurgery Inc Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05112456A (ja) * 1991-10-22 1993-05-07 Osaka Gas Co Ltd ゲル状軟膏
JP2002537849A (ja) * 1999-03-10 2002-11-12 ユニヴァーシティ オヴ ピッツバーグ オヴ ザ コモンウェルス システム オヴ ハイアー エデュケーション 脂肪由来の幹細胞および格子
WO2003053346A2 (en) * 2001-12-07 2003-07-03 Macropore Biosurgery, Inc. Systems and methods for treating patients with processed lipoaspirate cells

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6011043043; 松崎有未 他: '幹細胞と再生医学 Side Population-SP細胞-' 臨床病理 Vol.52, 2004, p.43 *
JPN6011043044; 守田陽平 他: '幹細胞研究の最前線と再生医療への応用 発生・分化メカニズムの解明,そして臨床へ 第1章 幹細胞研究の最' 実験医学 Vol.19, No.15, 2001, p.1990-1995 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539546A (ja) * 2006-06-15 2009-11-19 アールエヌエル バイオ カンパニー,リミティッド ヒト脂肪組織由来成体幹細胞、繊維芽細胞、及び脂肪又は脂肪細胞を含有する皮膚美容又は形成用の組成物
JP2017530151A (ja) * 2014-10-03 2017-10-12 サイトリ セラピューティクス インコーポレイテッド 熱傷の進行の緩和ならびに皮膚移植片の取り込みおよび治癒の改善における再生細胞の使用
JP2021105041A (ja) * 2014-10-03 2021-07-26 サイトリ・セラピューティクス株式会社 熱傷の進行の緩和ならびに皮膚移植片の取り込みおよび治癒の改善における再生細胞の使用
JP7303612B2 (ja) 2014-10-03 2023-07-05 サイトリ・セラピューティクス株式会社 熱傷の進行の緩和ならびに皮膚移植片の取り込みおよび治癒の改善における再生細胞の使用
KR20190049174A (ko) * 2017-11-01 2019-05-09 연세대학교 산학협력단 이식된 지방세포의 생착 증진용 조성물 및 지방 이식용 세포 치료제 조성물
KR102017386B1 (ko) * 2017-11-01 2019-09-02 연세대학교 산학협력단 이식된 지방세포의 생착 증진용 조성물 및 지방 이식용 세포 치료제 조성물

Also Published As

Publication number Publication date
AU2005322873A1 (en) 2006-07-13
CA2592840A1 (en) 2006-07-13
WO2006074075A3 (en) 2006-10-12
WO2006074075A2 (en) 2006-07-13
AU2005322873B2 (en) 2011-09-01
CA2592840C (en) 2015-11-24
EP1830862A2 (en) 2007-09-12
US8119398B2 (en) 2012-02-21
US20060147430A1 (en) 2006-07-06
EP1830862B1 (en) 2012-12-19

Similar Documents

Publication Publication Date Title
US8119398B2 (en) Adipose-derived stem cells for tissue regeneration and wound healing
JP5968442B2 (ja) 心筋梗塞の修復再生を誘導する多能性幹細胞
RU2535966C2 (ru) Клеточная терапия ишемической ткани
JP2023138985A (ja) 単離された椎間板細胞、その使用方法、および哺乳動物組織からそれを調製する方法
US20100111897A1 (en) Methods and Compositions Useful for Diabetic Wound Healing
US20200016210A1 (en) Methods of Reducing Teratoma Formation During Allogeneic Stem Cell Therapy
HK1216235A1 (zh) 使用产後衍生细胞治疗外周血管疾病
JP2009500297A (ja) 眼の変性についての細胞療法
JP5937210B2 (ja) 臍帯組織由来細胞を用いた末梢血管疾患の治療
WO2008077094A2 (en) Methods for promoting neovascularization
US20100143476A1 (en) Composition for stimulating formation of vascular structures
US8685724B2 (en) In vitro techniques for use with stem cells
US20150050731A1 (en) Method for producing pluripotent stem cells derived from dental pulp
JPWO2004101775A1 (ja) 新規な成体組織由来の幹細胞およびその用途
AU2015284180B2 (en) Gonad-derived side population stem cells
US20100034794A1 (en) Endothelial progenitor cell compositions and neovascularization
KR102376432B1 (ko) 말초 혈액으로부터 중간엽 줄기 세포 집단을 생성하는 방법 및 그의 용도
US20220313741A1 (en) Pluripotent stem cells inducing osteochondral repair
WO2022123958A1 (en) Pharmaceutical composition for use in prevention and treatment of liver fibrosis and/or liver cirrhosis, comprising adipose-derived regenerative cells (adrcs)
Oliveira et al. Labeling of human mesenchymal stem cells with quantum dots allows tracking of transplanted cells engrafted in infarcted pig hearts
Fukuta et al. Synergistic effect of ex-vivo quality and quantity cultured mononuclear cells and mesenchymal stem cell therapy in ischemic hind limb model mice
US20130287745A1 (en) Compositions and methods to stimulate vascular structure formation
Zhang et al. A novel population of human bone marrow multipotent mesenchymal stem cells regenerates infarcted myocardium in rats
JP2016135791A (ja) 臍帯組織由来細胞を用いた末梢血管疾患の治療
IL193947A (en) Cells cultured as cd31brigi: it, a method for stimuli to differentiate into a congenital / precursor cell population (pcp), use of the same drug preparation population, and implantation device that includes it

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081225

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20081225

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110816

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110909

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120131

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120420

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120621

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120913

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120921

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121219

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20130125