CA2592840C - Adipose-derived stem cells for tissue regeneration and wound healing - Google Patents
Adipose-derived stem cells for tissue regeneration and wound healing Download PDFInfo
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- CA2592840C CA2592840C CA2592840A CA2592840A CA2592840C CA 2592840 C CA2592840 C CA 2592840C CA 2592840 A CA2592840 A CA 2592840A CA 2592840 A CA2592840 A CA 2592840A CA 2592840 C CA2592840 C CA 2592840C
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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Landscapes
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Applications Claiming Priority (3)
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| US64103404P | 2004-12-30 | 2004-12-30 | |
| US60/641,034 | 2004-12-30 | ||
| PCT/US2005/047437 WO2006074075A2 (en) | 2004-12-30 | 2005-12-30 | Adipose-derived stem cells for tissue regeneration and wound healing |
Publications (2)
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| CA2592840A1 CA2592840A1 (en) | 2006-07-13 |
| CA2592840C true CA2592840C (en) | 2015-11-24 |
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| CA2592840A Expired - Fee Related CA2592840C (en) | 2004-12-30 | 2005-12-30 | Adipose-derived stem cells for tissue regeneration and wound healing |
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| US (1) | US8119398B2 (enExample) |
| EP (1) | EP1830862B1 (enExample) |
| JP (1) | JP2008526762A (enExample) |
| AU (1) | AU2005322873B2 (enExample) |
| CA (1) | CA2592840C (enExample) |
| WO (1) | WO2006074075A2 (enExample) |
Families Citing this family (50)
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| US9144583B2 (en) | 2002-03-29 | 2015-09-29 | Tissue Genesis, Inc. | Cell separation apparatus and methods of use |
| US9074190B2 (en) * | 2003-10-07 | 2015-07-07 | Biomaster, Inc. | Cell differentiation of adipose-derived precursor cells |
| US20140193852A9 (en) * | 2004-12-23 | 2014-07-10 | Erik Vossman | Adipose tissue collection and pre-processing devices for use in liposuction procedure |
| EP1965814A4 (en) * | 2005-09-26 | 2012-01-11 | Univ Columbia | SIDE POPULATION CELLS IN CARDIAL REPAIR |
| EP1984488B1 (en) * | 2006-01-30 | 2017-12-27 | University Of Virginia Patent Foundation | Methods of preparing and characterizing mesenchymal stem cell aggregates and uses thereof |
| WO2008106410A1 (en) | 2007-02-26 | 2008-09-04 | Cvac Systems, Inc. | Combination pressure therapy for treatment of serum lipid levels, steroid levels, and steroidogenesis |
| US8899228B2 (en) | 2006-02-08 | 2014-12-02 | Cvac Systems, Inc. | Combination pressure therapy for treatment of chronic pain |
| WO2007145438A1 (en) * | 2006-06-15 | 2007-12-21 | Rnl Bio Co., Ltd | Cosmetic or plastic composition comprising multipotent stem cells derived from human adipose tissue, fibroblast, and adipose or adiopocyte |
| JP5240715B2 (ja) * | 2006-08-08 | 2013-07-17 | 国立大学法人名古屋大学 | 脂肪組織由来多分化能幹細胞を含有する細胞製剤 |
| US8835170B2 (en) | 2006-10-06 | 2014-09-16 | University Of Virginia Patent Foundation | Methods and compositions useful for diabetic wound healing |
| US11174458B2 (en) | 2007-04-23 | 2021-11-16 | Koligo Therapeutics, Inc. | Cell separation apparatus and methods of use |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| JP5340564B2 (ja) * | 2007-07-05 | 2013-11-13 | ライオン株式会社 | 人工皮膚およびその製造方法 |
| CN107028981B (zh) | 2007-09-19 | 2021-04-20 | 普拉里斯坦有限公司 | 来自脂肪或胎盘组织的粘附细胞及其在治疗中的用途 |
| JP2011523357A (ja) * | 2008-05-06 | 2011-08-11 | ジョスリン ダイアビーティス センター インコーポレイテッド | 褐色脂肪細胞分化を誘導するための方法および組成物 |
| US9144584B2 (en) | 2008-06-11 | 2015-09-29 | Cell4Vet Corporation | Adipose tissue-derived stem cells for veterinary use |
| US20100098739A1 (en) * | 2008-10-20 | 2010-04-22 | University Of Virginia Patent Foundation | Compositions and methods for modular soft tissue repair |
| WO2010048628A1 (en) * | 2008-10-24 | 2010-04-29 | Indiana University Research And Technology Corporation | Methods for preventing aggregation of adipose stromal cells |
| US20120100112A1 (en) * | 2009-04-20 | 2012-04-26 | Indiana University Research And Technology Corporation | Materials and methods for using adipose stem cells to treat lung injury and disease |
| WO2010129775A1 (en) | 2009-05-06 | 2010-11-11 | University Of Virginia Patent Foundation | Self-illuminated handheld lens for retinal examination and photography and related method thereof |
| KR100995133B1 (ko) * | 2010-02-10 | 2010-11-18 | 허쉬바이오주식회사 | 지방조직 유래 줄기세포 및 단핵구로부터 세포성장인자의 생산방법 및 그 이용 |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| TWI419970B (zh) * | 2010-11-11 | 2013-12-21 | Univ Nat Taiwan | 使成體幹細胞產生為一球體細胞群體的方法 |
| ES2939147T3 (es) | 2011-03-18 | 2023-04-19 | Microvascular Tissues Inc | Tejido microvascular alogénico para tratamientos de tejidos blandos |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US9512405B2 (en) | 2011-12-14 | 2016-12-06 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Non-enzymatic method for isolating human adipose-derived stromal stem cells |
| US20140074068A1 (en) * | 2012-09-12 | 2014-03-13 | Richard Ty Olmstead | Multi-component method for regenerative repair of wounds implementing photonic wound debridement and stem cell deposition |
| US10596202B2 (en) | 2012-09-19 | 2020-03-24 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9872937B2 (en) | 2012-09-19 | 2018-01-23 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US11819522B2 (en) | 2012-09-19 | 2023-11-21 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| CA2885419A1 (en) * | 2012-09-19 | 2014-03-27 | Microvascular Tissues, Inc. | Compositions and methods for treating and preventing tissue injury and disease |
| US9650608B2 (en) | 2013-02-22 | 2017-05-16 | Medivet America, Llc | Activating adipose-derived stem cells for transplantation |
| KR101527880B1 (ko) * | 2013-04-19 | 2015-06-10 | 창원대학교 산학협력단 | 지방유래줄기세포에 t 항원을 도입한 adsc-t 세포의 배양액을 유효성분으로 포함하는, 피부재생용, 미백용, 항산화용 또는 상처 치료용 조성물 |
| WO2014171593A1 (ko) * | 2013-04-19 | 2014-10-23 | 창원대학교 산학협력단 | 지방유래줄기세포에 t항원을 도입한 adsc-t 세포의 배양액을 유효성분으로 포함하는, 항염증용, 피부재생용, 미백용, 항산화용 또는 상처 치료용 조성물 |
| WO2014190150A1 (en) | 2013-05-22 | 2014-11-27 | The Regents Of The University Of California | Pluripotent human adipose adult stem cells: isolation, characterization and clinical implications |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| EP3200843A4 (en) * | 2014-10-03 | 2018-06-20 | Cytori Therapeutics, Inc. | Use of regenerative cells in mitigating burn progression and improving skin graft incorporation and healing |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| US10420802B2 (en) | 2015-12-10 | 2019-09-24 | Aesthetics Biomedical, Inc. | Topical formulation for skin care |
| US20170258841A1 (en) * | 2016-03-11 | 2017-09-14 | Gwo Xi Stem Cell Applied Technology Co., Ltd. | Pharmaceutical compositions for treating arrhythmia and therapeutics of |
| KR102017386B1 (ko) * | 2017-11-01 | 2019-09-02 | 연세대학교 산학협력단 | 이식된 지방세포의 생착 증진용 조성물 및 지방 이식용 세포 치료제 조성물 |
| IL306070A (en) | 2018-05-03 | 2023-11-01 | Collplant Ltd | Dermal fillers and their uses |
| US20230346842A1 (en) * | 2020-05-07 | 2023-11-02 | Primegen Biotech, Llc | Methods and Compositions For Reducing Joint Inflammation Using Mesenchymal Stem Cells |
| EP3909593A1 (en) | 2020-05-15 | 2021-11-17 | Rigshospitalet | Stem cells for treating skin lesions |
| WO2024011258A2 (en) * | 2022-07-08 | 2024-01-11 | Trustees Of Tufts College | Tissue regenerative multi-drug cocktail and apparatus for delivery thereof |
| CN119491021B (zh) * | 2024-11-13 | 2025-06-20 | 中南大学 | 过表达LncRNA SNHG16慢病毒载体在修复工程材料中的应用 |
Family Cites Families (19)
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| US4298002A (en) * | 1979-09-10 | 1981-11-03 | National Patent Development Corporation | Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation |
| US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
| US4988621A (en) * | 1985-05-24 | 1991-01-29 | La Jolla Cancer Research Foundation | Peptides in cell detachment and aggregation |
| US4879237A (en) * | 1985-05-24 | 1989-11-07 | La Jolla Cancer Research Foundation | Use of peptides in control of cell attachment and detachment |
| US4789734A (en) * | 1985-08-06 | 1988-12-06 | La Jolla Cancer Research Foundation | Vitronectin specific cell receptor derived from mammalian mesenchymal tissue |
| US5158881A (en) | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| WO1991010470A1 (en) | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
| US5149543A (en) * | 1990-10-05 | 1992-09-22 | Massachusetts Institute Of Technology | Ionically cross-linked polymeric microcapsules |
| JPH05112456A (ja) * | 1991-10-22 | 1993-05-07 | Osaka Gas Co Ltd | ゲル状軟膏 |
| US5965997A (en) * | 1997-08-20 | 1999-10-12 | Benchmarq Microelectronics | Battery monitoring circuit with storage of charge and discharge accumulation values accessible therefrom |
| CN1352696A (zh) | 1999-03-10 | 2002-06-05 | 匹兹堡大学联邦制高等教育 | 脂肪来源的干细胞和网格 |
| US6777231B1 (en) * | 1999-03-10 | 2004-08-17 | The Regents Of The University Of California | Adipose-derived stem cells and lattices |
| US20030082152A1 (en) * | 1999-03-10 | 2003-05-01 | Hedrick Marc H. | Adipose-derived stem cells and lattices |
| JP2003509044A (ja) | 1999-09-14 | 2003-03-11 | チルドレンズ メディカル センター コーポレーション | 筋肉由来幹細胞の単離およびその使用 |
| US20030054331A1 (en) * | 2001-09-14 | 2003-03-20 | Stemsource, Inc. | Preservation of non embryonic cells from non hematopoietic tissues |
| US20030161816A1 (en) | 2001-12-07 | 2003-08-28 | Fraser John K. | Systems and methods for treating patients with processed lipoaspirate cells |
| MXPA05009044A (es) | 2003-02-20 | 2006-03-17 | Macropore Biosurgery Inc | Metodos para utilizar celulas derivadas de tejido adiposo en el tratamiento de condiciones cardiovasculares. |
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| CA2592840A1 (en) | 2006-07-13 |
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| WO2006074075A2 (en) | 2006-07-13 |
| AU2005322873B2 (en) | 2011-09-01 |
| EP1830862A2 (en) | 2007-09-12 |
| US8119398B2 (en) | 2012-02-21 |
| US20060147430A1 (en) | 2006-07-06 |
| EP1830862B1 (en) | 2012-12-19 |
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