JP2008526761A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008526761A5 JP2008526761A5 JP2007549640A JP2007549640A JP2008526761A5 JP 2008526761 A5 JP2008526761 A5 JP 2008526761A5 JP 2007549640 A JP2007549640 A JP 2007549640A JP 2007549640 A JP2007549640 A JP 2007549640A JP 2008526761 A5 JP2008526761 A5 JP 2008526761A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 332
- 125000000217 alkyl group Chemical group 0.000 claims 241
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 204
- 125000003710 aryl alkyl group Chemical group 0.000 claims 131
- 229910052739 hydrogen Inorganic materials 0.000 claims 128
- 239000001257 hydrogen Substances 0.000 claims 128
- 125000003118 aryl group Chemical group 0.000 claims 114
- 150000002431 hydrogen Chemical class 0.000 claims 108
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 96
- 125000001072 heteroaryl group Chemical group 0.000 claims 92
- 229910052717 sulfur Inorganic materials 0.000 claims 92
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 89
- 125000000753 cycloalkyl group Chemical group 0.000 claims 83
- 125000001188 haloalkyl group Chemical group 0.000 claims 72
- 229910052799 carbon Inorganic materials 0.000 claims 53
- 125000000304 alkynyl group Chemical group 0.000 claims 50
- 125000003342 alkenyl group Chemical group 0.000 claims 46
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 46
- 125000005843 halogen group Chemical group 0.000 claims 45
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 42
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 42
- 125000004103 aminoalkyl group Chemical group 0.000 claims 40
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 40
- 229910052760 oxygen Inorganic materials 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 34
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 32
- 125000005842 heteroatom Chemical group 0.000 claims 31
- 229910052757 nitrogen Inorganic materials 0.000 claims 30
- 125000004432 carbon atom Chemical group C* 0.000 claims 27
- -1 and Chemical group 0.000 claims 25
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 20
- 125000002619 bicyclic group Chemical group 0.000 claims 20
- 125000004122 cyclic group Chemical group 0.000 claims 20
- 229940079593 drug Drugs 0.000 claims 14
- 239000003814 drug Substances 0.000 claims 14
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 11
- 229920006395 saturated elastomer Polymers 0.000 claims 10
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 150000001204 N-oxides Chemical class 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 230000001404 mediated effect Effects 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 6
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 6
- BBVIDBNAYOIXOE-UHFFFAOYSA-N 1,2,4-oxadiazole Chemical compound C=1N=CON=1 BBVIDBNAYOIXOE-UHFFFAOYSA-N 0.000 claims 4
- AGIJRRREJXSQJR-UHFFFAOYSA-N 2h-thiazine Chemical compound N1SC=CC=C1 AGIJRRREJXSQJR-UHFFFAOYSA-N 0.000 claims 4
- 102000019034 Chemokines Human genes 0.000 claims 4
- 108010012236 Chemokines Proteins 0.000 claims 4
- 229940123907 Disease modifying antirheumatic drug Drugs 0.000 claims 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 4
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 4
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 4
- 239000002988 disease modifying antirheumatic drug Substances 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 239000000367 immunologic factor Substances 0.000 claims 4
- 229960003444 immunosuppressant agent Drugs 0.000 claims 4
- 239000003018 immunosuppressive agent Substances 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 4
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 4
- 150000003431 steroids Chemical class 0.000 claims 4
- 102100027995 Collagenase 3 Human genes 0.000 claims 3
- 108050005238 Collagenase 3 Proteins 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 3
- 108090000790 Enzymes Proteins 0.000 claims 3
- 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 claims 3
- 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 claims 3
- 229940111134 coxibs Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical compound C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 claims 2
- YGTAZGSLCXNBQL-UHFFFAOYSA-N 1,2,4-thiadiazole Chemical compound C=1N=CSN=1 YGTAZGSLCXNBQL-UHFFFAOYSA-N 0.000 claims 2
- FYADHXFMURLYQI-UHFFFAOYSA-N 1,2,4-triazine Chemical compound C1=CN=NC=N1 FYADHXFMURLYQI-UHFFFAOYSA-N 0.000 claims 2
- UDGKZGLPXCRRAM-UHFFFAOYSA-N 1,2,5-thiadiazole Chemical compound C=1C=NSN=1 UDGKZGLPXCRRAM-UHFFFAOYSA-N 0.000 claims 2
- FKASFBLJDCHBNZ-UHFFFAOYSA-N 1,3,4-oxadiazole Chemical compound C1=NN=CO1 FKASFBLJDCHBNZ-UHFFFAOYSA-N 0.000 claims 2
- MBIZXFATKUQOOA-UHFFFAOYSA-N 1,3,4-thiadiazole Chemical compound C1=NN=CS1 MBIZXFATKUQOOA-UHFFFAOYSA-N 0.000 claims 2
- JIHQDMXYYFUGFV-UHFFFAOYSA-N 1,3,5-triazine Chemical compound C1=NC=NC=N1 JIHQDMXYYFUGFV-UHFFFAOYSA-N 0.000 claims 2
- ABADUMLIAZCWJD-UHFFFAOYSA-N 1,3-dioxole Chemical compound C1OC=CO1 ABADUMLIAZCWJD-UHFFFAOYSA-N 0.000 claims 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 2
- JECYNCQXXKQDJN-UHFFFAOYSA-N 2-(2-methylhexan-2-yloxymethyl)oxirane Chemical compound CCCCC(C)(C)OCC1CO1 JECYNCQXXKQDJN-UHFFFAOYSA-N 0.000 claims 2
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 claims 2
- PCJFEVUKVKQSSL-UHFFFAOYSA-N 2h-1,2,4-oxadiazol-5-one Chemical compound O=C1N=CNO1 PCJFEVUKVKQSSL-UHFFFAOYSA-N 0.000 claims 2
- IGAVZWMNOPFOCW-UHFFFAOYSA-N 2h-1,2,4-thiadiazol-5-one Chemical compound O=C1NC=NS1 IGAVZWMNOPFOCW-UHFFFAOYSA-N 0.000 claims 2
- KGWNRZLPXLBMPS-UHFFFAOYSA-N 2h-1,3-oxazine Chemical compound C1OC=CC=N1 KGWNRZLPXLBMPS-UHFFFAOYSA-N 0.000 claims 2
- NTYABNDBNKVWOO-UHFFFAOYSA-N 2h-1,3-thiazine Chemical compound C1SC=CC=N1 NTYABNDBNKVWOO-UHFFFAOYSA-N 0.000 claims 2
- YHWMFDLNZGIJSD-UHFFFAOYSA-N 2h-1,4-oxazine Chemical compound C1OC=CN=C1 YHWMFDLNZGIJSD-UHFFFAOYSA-N 0.000 claims 2
- ZAISDHPZTZIFQF-UHFFFAOYSA-N 2h-1,4-thiazine Chemical compound C1SC=CN=C1 ZAISDHPZTZIFQF-UHFFFAOYSA-N 0.000 claims 2
- BCHZICNRHXRCHY-UHFFFAOYSA-N 2h-oxazine Chemical compound N1OC=CC=C1 BCHZICNRHXRCHY-UHFFFAOYSA-N 0.000 claims 2
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 claims 2
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 2
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 2
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 150000003536 tetrazoles Chemical class 0.000 claims 2
- YGNGABUJMXJPIJ-UHFFFAOYSA-N thiatriazole Chemical compound C1=NN=NS1 YGNGABUJMXJPIJ-UHFFFAOYSA-N 0.000 claims 2
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 2
- 229930192474 thiophene Natural products 0.000 claims 2
- IBBLKSWSCDAPIF-UHFFFAOYSA-N thiopyran Chemical compound S1C=CC=C=C1 IBBLKSWSCDAPIF-UHFFFAOYSA-N 0.000 claims 2
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims 1
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims 1
- 239000003260 cyclooxygenase 1 inhibitor Substances 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 0 *C1C(C(C*(*C2C3)N)N(*)C(c4ncnc(C(N(*)*)=O)c4)=O)[C@]23C1* Chemical compound *C1C(C(C*(*C2C3)N)N(*)C(c4ncnc(C(N(*)*)=O)c4)=O)[C@]23C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64079504P | 2004-12-31 | 2004-12-31 | |
| US70626705P | 2005-08-08 | 2005-08-08 | |
| PCT/US2005/047421 WO2006083454A1 (en) | 2004-12-31 | 2005-12-31 | Multicyclic bis-amide mmp inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526761A JP2008526761A (ja) | 2008-07-24 |
| JP2008526761A5 true JP2008526761A5 (US07928230-20110419-C00107.png) | 2009-02-19 |
Family
ID=36283720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549640A Abandoned JP2008526761A (ja) | 2004-12-31 | 2005-12-31 | 多環式ビス−アミドｍｍｐ阻害剤 |
Country Status (7)
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20060293345A1 (en) * | 2005-05-20 | 2006-12-28 | Christoph Steeneck | Heterobicyclic metalloprotease inhibitors |
| EP1981855A2 (en) * | 2005-12-30 | 2008-10-22 | Alantos Pharmaceuticals Holding, Inc. | Substituted bis-amide metalloprotease inhibitors |
| CA2658362A1 (en) * | 2006-06-29 | 2008-01-03 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors |
| EP2077846B1 (en) * | 2006-11-02 | 2011-10-12 | Piramal Life Sciences Limited | Benzoxazepine compounds, their preparation and use |
| EP2102211A2 (en) * | 2006-11-20 | 2009-09-23 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
| WO2008063669A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic matrix metalloprotease inhibitors |
| US20080221094A1 (en) * | 2007-03-07 | 2008-09-11 | Harald Bluhm | Metalloprotease inhibitors containing a squaramide moiety |
| WO2008149191A1 (en) * | 2007-06-05 | 2008-12-11 | Pfizer Inc. | Hetero bicyclic carboxamide derivatives and their pharmaceutical use and compositions |
| CA2747670A1 (en) | 2008-12-19 | 2010-07-15 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
| EP3868377A1 (en) | 2009-11-13 | 2021-08-25 | Receptos Llc | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
| KR101781233B1 (ko) | 2009-11-13 | 2017-09-22 | 셀진 인터내셔널 Ii 에스에이알엘 | 스핑고신 1 포스페이트 수용체 조절자 및 카이랄 합성 방법 |
| DK2498609T3 (en) * | 2009-11-13 | 2018-06-18 | Celgene Int Ii Sarl | SELECTIVE HETEROCYCLIC SPHINGOSIN-1 PHOSPHATRECEPTOR MODULATORS |
| WO2012046869A1 (ja) | 2010-10-08 | 2012-04-12 | 持田製薬株式会社 | 環状アミド誘導体 |
| JP5420796B2 (ja) | 2011-04-27 | 2014-02-19 | 持田製薬株式会社 | 新規３−ヒドロキシイソチアゾール１−オキシド誘導体 |
| JPWO2012147516A1 (ja) | 2011-04-28 | 2014-07-28 | 持田製薬株式会社 | 環状アミド誘導体 |
| US9481659B2 (en) | 2011-05-13 | 2016-11-01 | Celgene International Ii Sàrl | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
| WO2012177896A1 (en) | 2011-06-24 | 2012-12-27 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| JP2014527511A (ja) | 2011-06-24 | 2014-10-16 | アムジエン・インコーポレーテツド | Ｔｒｐｍ８拮抗剤及び治療におけるそれらの使用 |
| US8952009B2 (en) | 2012-08-06 | 2015-02-10 | Amgen Inc. | Chroman derivatives as TRPM8 inhibitors |
| JP6584956B2 (ja) | 2012-12-21 | 2019-10-02 | アステラス インスティテュート フォー リジェネレイティブ メディシン | 多能性幹細胞から血小板を生産するための方法およびその組成物 |
| RU2757571C2 (ru) * | 2016-11-01 | 2021-10-18 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ПИРИДАЗИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ RORc |
| WO2019100106A1 (en) * | 2017-11-24 | 2019-05-31 | The University Of Sydney | Antibacterial compounds and methods of use thereof |
| MX2020007532A (es) * | 2018-01-19 | 2020-09-09 | Cytokinetics Inc | Inhibidores de sarcomero cardiaco. |
| JP7438148B2 (ja) * | 2018-06-26 | 2024-02-26 | サイトキネティックス， インコーポレイテッド | 心臓サルコメア阻害剤 |
| BR112021003496A2 (pt) | 2018-08-31 | 2021-05-18 | Cytokinetics, Inc. | composto, composição farmacêutica, e, métodos para tratar doença cardíaca, para tratar uma doença ou afecção associada à cardiomiopatia hipertrófica, ou afecção que está associada ao espessamento secundário da parede do ventrículo esquerdo, ou afecção que está associada à pequena cavidade do ventículo esquerdo e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia miocárdica ou fibrose cardíaca, ou afecção selecionada dentre distrofias musculares e doenças de armazenamento de glicogênio, para inibir o sarcômero cardíaco |
| GB201908453D0 (en) * | 2019-06-12 | 2019-07-24 | Enterprise Therapeutics Ltd | Compounds for treating respiratory disease |
| JP2024508526A (ja) | 2021-03-04 | 2024-02-27 | サイトキネティックス， インコーポレイテッド | 心筋サルコメア阻害剤 |
| IL310592A (en) | 2021-08-03 | 2024-04-01 | Cytokinetics Inc | The process of preparing apicamtan |
| WO2023080258A1 (ja) * | 2021-11-08 | 2023-05-11 | 旭化成株式会社 | カルボニル化合物、カルボニル化合物の製造方法、イソシアネート化合物の製造方法、及びイソシアネート組成物 |
| CN115778930B (zh) * | 2022-12-08 | 2024-02-27 | 陕西中医药大学 | 一种具有血管舒张活性的二硫缩醛类化合物在制备具有血管舒张活性药物方面的应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03004920A (es) * | 2001-02-14 | 2003-09-05 | Warner Lambert Co | Pirimidinas inhibidoras de metaloproteinasas de matriz. |
| DE10160357A1 (de) * | 2001-12-08 | 2003-06-18 | Aventis Pharma Gmbh | Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen |
| BR0315055A (pt) * | 2002-11-02 | 2005-08-16 | Aventis Pharma Gmbh | Diamidas de ácido pirimidin-4,6-dicarboxìilco para a inibição seletiva de colagenases |
| DE10300017A1 (de) * | 2003-01-03 | 2004-07-15 | Aventis Pharma Deutschland Gmbh | Selektive MMP 13 Inhibitoren |
-
2005
- 2005-12-30 US US11/324,037 patent/US20060173183A1/en not_active Abandoned
- 2005-12-31 EP EP05855910A patent/EP1843820A1/en not_active Withdrawn
- 2005-12-31 AU AU2005326659A patent/AU2005326659A1/en not_active Abandoned
- 2005-12-31 CA CA002589328A patent/CA2589328A1/en not_active Abandoned
- 2005-12-31 WO PCT/US2005/047421 patent/WO2006083454A1/en active Application Filing
- 2005-12-31 MX MX2007007895A patent/MX2007007895A/es not_active Application Discontinuation
- 2005-12-31 JP JP2007549640A patent/JP2008526761A/ja not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008526761A5 (US07928230-20110419-C00107.png) | ||
| RU2394028C2 (ru) | Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы | |
| JP2009522295A5 (US07928230-20110419-C00107.png) | ||
| AU2012209295B2 (en) | Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same | |
| RU2006146970A (ru) | Бициклические гетероциклы и их применение в качестве ингибиторов вич интегразы | |
| ES2556822T3 (es) | Derivados de trifluorometil-oxadiazol novedosos y su uso en el tratamiento de enfermedad | |
| RU2455288C2 (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
| ES2536191T3 (es) | Derivados de sulfonamida | |
| JP2008501018A5 (US07928230-20110419-C00107.png) | ||
| JP2010513322A5 (US07928230-20110419-C00107.png) | ||
| JP6500010B2 (ja) | 新規ピリジン誘導体 | |
| JP2008501691A5 (US07928230-20110419-C00107.png) | ||
| AU2012209295A1 (en) | Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same | |
| JP2006511552A5 (US07928230-20110419-C00107.png) | ||
| JP2011500562A5 (US07928230-20110419-C00107.png) | ||
| EP2925322A1 (en) | Inhibitors of the renal outer medullary potassium channel | |
| JP2006514950A5 (US07928230-20110419-C00107.png) | ||
| RU2005136368A (ru) | Производные пиперазина и их применение для лечения неврологических и психиатрических заболеваний | |
| JP2019521097A5 (US07928230-20110419-C00107.png) | ||
| JP2006523234A5 (US07928230-20110419-C00107.png) | ||
| FR2903405A1 (fr) | Composes a effet potentialisateur de l'activite de l'ethionamide et leurs applications | |
| KR101373911B1 (ko) | Ｂｃｌ 단백질과 결합 파트너의 상호작용을 억제하기 위한화합물 및 방법 | |
| WO2004101529A1 (ja) | 含窒素複素環化合物およびその医薬用途 | |
| JP2005526696A5 (US07928230-20110419-C00107.png) | ||
| CA2647603A1 (en) | Ureide derivative and use thereof for medical purposes |
