JP2008525317A5 - - Google Patents
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- Publication number
- JP2008525317A5 JP2008525317A5 JP2007542970A JP2007542970A JP2008525317A5 JP 2008525317 A5 JP2008525317 A5 JP 2008525317A5 JP 2007542970 A JP2007542970 A JP 2007542970A JP 2007542970 A JP2007542970 A JP 2007542970A JP 2008525317 A5 JP2008525317 A5 JP 2008525317A5
- Authority
- JP
- Japan
- Prior art keywords
- pregnane
- diol
- 3beta
- beta
- 5beta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YWYQTGBBEZQBGO-UHFFFAOYSA-N UC1011 Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(O)C)C1(C)CC2 YWYQTGBBEZQBGO-UHFFFAOYSA-N 0.000 claims 21
- YWYQTGBBEZQBGO-HUTKLZKUSA-N 5beta-pregnane-3beta,20alpha-diol Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-HUTKLZKUSA-N 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 239000000126 substance Substances 0.000 claims 13
- YWYQTGBBEZQBGO-XFHAOOBSSA-N (3s,5s,8r,9s,10s,13s,14s,17s)-17-[(1r)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-XFHAOOBSSA-N 0.000 claims 8
- YWYQTGBBEZQBGO-ZVPCKFNKSA-N (3s,5s,8r,9s,10s,13s,14s,17s)-17-[(1s)-1-hydroxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical group C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-ZVPCKFNKSA-N 0.000 claims 7
- 102000004300 GABA-A Receptors Human genes 0.000 claims 6
- 108090000839 GABA-A Receptors Proteins 0.000 claims 6
- 208000015114 central nervous system disease Diseases 0.000 claims 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 4
- 230000003042 antagnostic effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 3
- AURFZBICLPNKBZ-FZCSVUEKSA-N 3beta-hydroxy-5alpha-pregnan-20-one Chemical compound C([C@@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-FZCSVUEKSA-N 0.000 claims 2
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims 2
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims 1
- YWYQTGBBEZQBGO-BERLURQNSA-N Pregnanediol Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-BERLURQNSA-N 0.000 claims 1
- UESYMIFUVPHBHL-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O.CC(O)=O.CC(O)=O UESYMIFUVPHBHL-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62951104P | 2004-11-18 | 2004-11-18 | |
| US60/629,511 | 2004-11-18 | ||
| PCT/SE2005/001671 WO2006054938A1 (en) | 2004-11-18 | 2005-11-07 | Gaba-steroid antagonists and their use for the treatment of cns disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008525317A JP2008525317A (ja) | 2008-07-17 |
| JP2008525317A5 true JP2008525317A5 (OSRAM) | 2008-12-25 |
| JP4914368B2 JP4914368B2 (ja) | 2012-04-11 |
Family
ID=36407411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007542970A Expired - Fee Related JP4914368B2 (ja) | 2004-11-18 | 2005-11-07 | Ｇａｂａ−ステロイド拮抗剤およびｃｎｓ疾患の治療のためのその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8114860B2 (OSRAM) |
| EP (1) | EP1812009B1 (OSRAM) |
| JP (1) | JP4914368B2 (OSRAM) |
| CN (1) | CN101076340B (OSRAM) |
| AU (1) | AU2005307151B2 (OSRAM) |
| BR (1) | BRPI0518359A2 (OSRAM) |
| CA (1) | CA2585359C (OSRAM) |
| DK (1) | DK1812009T3 (OSRAM) |
| ES (1) | ES2423493T3 (OSRAM) |
| MX (1) | MX2007006032A (OSRAM) |
| WO (1) | WO2006054938A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006054938A1 (en) | 2004-11-18 | 2006-05-26 | Umecrine Ab | Gaba-steroid antagonists and their use for the treatment of cns disorders |
| HUE036410T2 (hu) * | 2006-11-21 | 2018-07-30 | Asarina Pharma Ab | Pregnán és androsztán szteroidok alkalmazása CNS rendellenességek kezelésére szolgáló gyógyszerkészítmény elõállítására |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| US20110086828A1 (en) * | 2009-10-07 | 2011-04-14 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors |
| MX2012008257A (es) | 2010-01-14 | 2012-11-21 | Umecrine Mood Ab | Una composicion farmaceutica que comprende 3-beta-hidroxi-5-alfa-p regnan-20-ona con propiedades mejoradas de almacenamiento y solubilidad. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614499A (en) * | 1985-04-29 | 1986-09-30 | Universite Laval | Simulator for use as a neurosurgical aid in determining potential paths for the implantation of probes through the human body |
| WO1999045931A1 (en) * | 1998-03-11 | 1999-09-16 | Baeckstroem Torbjoern | Epiallopregnanolone in the treatment of cns disorders |
| FR2806303B1 (fr) * | 2000-03-17 | 2002-09-27 | Inst Nat Sante Rech Med | Composes capables de se lier a des proteines constituantes ou associees aux elements du cytosquelette et leurs applications pour la fabrication de medicaments |
| US20030125311A1 (en) * | 2000-03-17 | 2003-07-03 | Etienne-Emile Baulieu | Compounds capable of binding with the cytoskeleton |
| SE0104423D0 (sv) * | 2001-12-27 | 2001-12-27 | Umecrine Ab | Pregnane steroids and their use in the treatment of CNS disorders |
| WO2006054938A1 (en) | 2004-11-18 | 2006-05-26 | Umecrine Ab | Gaba-steroid antagonists and their use for the treatment of cns disorders |
-
2005
- 2005-11-07 WO PCT/SE2005/001671 patent/WO2006054938A1/en not_active Ceased
- 2005-11-07 AU AU2005307151A patent/AU2005307151B2/en not_active Ceased
- 2005-11-07 BR BRPI0518359-6A patent/BRPI0518359A2/pt not_active IP Right Cessation
- 2005-11-07 ES ES05801885T patent/ES2423493T3/es not_active Expired - Lifetime
- 2005-11-07 DK DK05801885.4T patent/DK1812009T3/da active
- 2005-11-07 CA CA2585359A patent/CA2585359C/en not_active Expired - Fee Related
- 2005-11-07 CN CN2005800394888A patent/CN101076340B/zh not_active Expired - Fee Related
- 2005-11-07 JP JP2007542970A patent/JP4914368B2/ja not_active Expired - Fee Related
- 2005-11-07 US US11/791,160 patent/US8114860B2/en not_active Expired - Fee Related
- 2005-11-07 EP EP05801885.4A patent/EP1812009B1/en not_active Expired - Lifetime
- 2005-11-07 MX MX2007006032A patent/MX2007006032A/es active IP Right Grant
-
2012
- 2012-02-13 US US13/372,389 patent/US8372824B2/en not_active Expired - Fee Related
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