MX2007006032A - Antagonistas de gaba-esteroide y su uso para el tratamiento de trastornos del sistema nervioso central. - Google Patents
Antagonistas de gaba-esteroide y su uso para el tratamiento de trastornos del sistema nervioso central.Info
- Publication number
- MX2007006032A MX2007006032A MX2007006032A MX2007006032A MX2007006032A MX 2007006032 A MX2007006032 A MX 2007006032A MX 2007006032 A MX2007006032 A MX 2007006032A MX 2007006032 A MX2007006032 A MX 2007006032A MX 2007006032 A MX2007006032 A MX 2007006032A
- Authority
- MX
- Mexico
- Prior art keywords
- pregnan
- gaba
- diol
- receptor
- hydroxy
- Prior art date
Links
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- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000008587 neuronal excitability Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 210000002394 ovarian follicle Anatomy 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 210000004681 ovum Anatomy 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 description 1
- 229960000249 pregnenolone Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000651 prodrug Substances 0.000 description 1
- 229940002612 prodrug Drugs 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000001739 rebound effect Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 239000002469 receptor inverse agonist Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 238000007391 self-medication Methods 0.000 description 1
- 208000022925 sleep disturbance Diseases 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 150000003515 testosterones Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62951104P | 2004-11-18 | 2004-11-18 | |
| PCT/SE2005/001671 WO2006054938A1 (en) | 2004-11-18 | 2005-11-07 | Gaba-steroid antagonists and their use for the treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007006032A true MX2007006032A (es) | 2007-10-17 |
Family
ID=36407411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007006032A MX2007006032A (es) | 2004-11-18 | 2005-11-07 | Antagonistas de gaba-esteroide y su uso para el tratamiento de trastornos del sistema nervioso central. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8114860B2 (OSRAM) |
| EP (1) | EP1812009B1 (OSRAM) |
| JP (1) | JP4914368B2 (OSRAM) |
| CN (1) | CN101076340B (OSRAM) |
| AU (1) | AU2005307151B2 (OSRAM) |
| BR (1) | BRPI0518359A2 (OSRAM) |
| CA (1) | CA2585359C (OSRAM) |
| DK (1) | DK1812009T3 (OSRAM) |
| ES (1) | ES2423493T3 (OSRAM) |
| MX (1) | MX2007006032A (OSRAM) |
| WO (1) | WO2006054938A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006054938A1 (en) | 2004-11-18 | 2006-05-26 | Umecrine Ab | Gaba-steroid antagonists and their use for the treatment of cns disorders |
| HUE036410T2 (hu) * | 2006-11-21 | 2018-07-30 | Asarina Pharma Ab | Pregnán és androsztán szteroidok alkalmazása CNS rendellenességek kezelésére szolgáló gyógyszerkészítmény elõállítására |
| CN101585862B (zh) * | 2008-05-20 | 2014-12-17 | 梅克芳股份公司 | 甾族化合物 |
| US20110086828A1 (en) * | 2009-10-07 | 2011-04-14 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Treatment of alcohol abuse and alcoholism using modulators of neurosteroid binding sites on gabaa receptors |
| MX2012008257A (es) | 2010-01-14 | 2012-11-21 | Umecrine Mood Ab | Una composicion farmaceutica que comprende 3-beta-hidroxi-5-alfa-p regnan-20-ona con propiedades mejoradas de almacenamiento y solubilidad. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4614499A (en) * | 1985-04-29 | 1986-09-30 | Universite Laval | Simulator for use as a neurosurgical aid in determining potential paths for the implantation of probes through the human body |
| WO1999045931A1 (en) * | 1998-03-11 | 1999-09-16 | Baeckstroem Torbjoern | Epiallopregnanolone in the treatment of cns disorders |
| FR2806303B1 (fr) * | 2000-03-17 | 2002-09-27 | Inst Nat Sante Rech Med | Composes capables de se lier a des proteines constituantes ou associees aux elements du cytosquelette et leurs applications pour la fabrication de medicaments |
| US20030125311A1 (en) * | 2000-03-17 | 2003-07-03 | Etienne-Emile Baulieu | Compounds capable of binding with the cytoskeleton |
| SE0104423D0 (sv) * | 2001-12-27 | 2001-12-27 | Umecrine Ab | Pregnane steroids and their use in the treatment of CNS disorders |
| WO2006054938A1 (en) | 2004-11-18 | 2006-05-26 | Umecrine Ab | Gaba-steroid antagonists and their use for the treatment of cns disorders |
-
2005
- 2005-11-07 WO PCT/SE2005/001671 patent/WO2006054938A1/en not_active Ceased
- 2005-11-07 AU AU2005307151A patent/AU2005307151B2/en not_active Ceased
- 2005-11-07 BR BRPI0518359-6A patent/BRPI0518359A2/pt not_active IP Right Cessation
- 2005-11-07 ES ES05801885T patent/ES2423493T3/es not_active Expired - Lifetime
- 2005-11-07 DK DK05801885.4T patent/DK1812009T3/da active
- 2005-11-07 CA CA2585359A patent/CA2585359C/en not_active Expired - Fee Related
- 2005-11-07 CN CN2005800394888A patent/CN101076340B/zh not_active Expired - Fee Related
- 2005-11-07 JP JP2007542970A patent/JP4914368B2/ja not_active Expired - Fee Related
- 2005-11-07 US US11/791,160 patent/US8114860B2/en not_active Expired - Fee Related
- 2005-11-07 EP EP05801885.4A patent/EP1812009B1/en not_active Expired - Lifetime
- 2005-11-07 MX MX2007006032A patent/MX2007006032A/es active IP Right Grant
-
2012
- 2012-02-13 US US13/372,389 patent/US8372824B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006054938A1 (en) | 2006-05-26 |
| ES2423493T3 (es) | 2013-09-20 |
| JP4914368B2 (ja) | 2012-04-11 |
| CN101076340B (zh) | 2011-01-12 |
| US8114860B2 (en) | 2012-02-14 |
| DK1812009T3 (da) | 2013-08-05 |
| CN101076340A (zh) | 2007-11-21 |
| EP1812009B1 (en) | 2013-05-15 |
| EP1812009A1 (en) | 2007-08-01 |
| US8372824B2 (en) | 2013-02-12 |
| AU2005307151B2 (en) | 2011-10-20 |
| EP1812009A4 (en) | 2010-08-11 |
| US20120142657A1 (en) | 2012-06-07 |
| BRPI0518359A2 (pt) | 2008-11-18 |
| JP2008525317A (ja) | 2008-07-17 |
| CA2585359C (en) | 2013-01-08 |
| AU2005307151A1 (en) | 2006-05-26 |
| US20080070876A1 (en) | 2008-03-20 |
| CA2585359A1 (en) | 2006-05-26 |
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