JP2008524253A5 - - Google Patents
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- Publication number
- JP2008524253A5 JP2008524253A5 JP2007547000A JP2007547000A JP2008524253A5 JP 2008524253 A5 JP2008524253 A5 JP 2008524253A5 JP 2007547000 A JP2007547000 A JP 2007547000A JP 2007547000 A JP2007547000 A JP 2007547000A JP 2008524253 A5 JP2008524253 A5 JP 2008524253A5
- Authority
- JP
- Japan
- Prior art keywords
- citrate
- methyl
- ethyl
- cycloheptene
- dibenzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 22
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 21
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 15
- 239000013078 crystal Substances 0.000 claims 14
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 12
- 238000000634 powder X-ray diffraction Methods 0.000 claims 12
- 150000001860 citric acid derivatives Chemical class 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- HDOWRFHMPULYOA-UHFFFAOYSA-N piperidin-4-ol Chemical compound OC1CCNCC1 HDOWRFHMPULYOA-UHFFFAOYSA-N 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 4
- 208000035475 disorder Diseases 0.000 claims 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 238000002425 crystallisation Methods 0.000 claims 3
- 230000008025 crystallization Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- -1 piperidin-4-citrate Chemical compound 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63721304P | 2004-12-17 | 2004-12-17 | |
| US60/637,213 | 2004-12-17 | ||
| PCT/US2005/045915 WO2006066200A2 (en) | 2004-12-17 | 2005-12-19 | Solid forms of a chemokine receptor antagonist and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012172003A Division JP2012211197A (ja) | 2004-12-17 | 2012-08-02 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008524253A JP2008524253A (ja) | 2008-07-10 |
| JP2008524253A5 true JP2008524253A5 (enExample) | 2008-11-27 |
| JP5308030B2 JP5308030B2 (ja) | 2013-10-09 |
Family
ID=36588631
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007547000A Expired - Fee Related JP5308030B2 (ja) | 2004-12-17 | 2005-12-19 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
| JP2012172003A Withdrawn JP2012211197A (ja) | 2004-12-17 | 2012-08-02 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
| JP2014258340A Pending JP2015057445A (ja) | 2004-12-17 | 2014-12-22 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012172003A Withdrawn JP2012211197A (ja) | 2004-12-17 | 2012-08-02 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
| JP2014258340A Pending JP2015057445A (ja) | 2004-12-17 | 2014-12-22 | ケモカインレセプターアンタゴニストの固体形態およびその使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7960549B2 (enExample) |
| EP (1) | EP1841429B1 (enExample) |
| JP (3) | JP5308030B2 (enExample) |
| CN (1) | CN101119725B (enExample) |
| AT (1) | ATE553761T1 (enExample) |
| AU (1) | AU2005316340B2 (enExample) |
| CA (1) | CA2590157C (enExample) |
| ES (1) | ES2386029T3 (enExample) |
| WO (1) | WO2006066200A2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023505116A (ja) * | 2019-11-29 | 2023-02-08 | ▲広▼▲東▼▲東▼▲陽▼光▲薬▼▲業▼有限公司 | 三環式含窒素化合物の結晶形及びその用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6509346B2 (en) | 1998-01-21 | 2003-01-21 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6613905B1 (en) | 1998-01-21 | 2003-09-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| AU2335699A (en) | 1998-01-21 | 1999-08-09 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| CN1289336A (zh) | 1998-01-21 | 2001-03-28 | 千禧药品公司 | 趋化因子受体拮抗剂和其使用方法 |
| US6503926B2 (en) | 1998-09-04 | 2003-01-07 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| HU228314B1 (hu) | 1998-09-04 | 2013-03-28 | Millennium Pharmaceuticals | Kemokin receptor antagonisták, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| JP2002524461A (ja) | 1998-09-04 | 2002-08-06 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | ケモカイン受容体アンタゴニストおよびその使用方法 |
| US7271176B2 (en) | 1998-09-04 | 2007-09-18 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use thereof |
| US6288083B1 (en) | 1998-09-04 | 2001-09-11 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US20020169155A1 (en) * | 1998-09-04 | 2002-11-14 | Millennium Pharmaceuticals, Inc. | Chemokine receptor anagonists and methods of use therefor |
| AU6503900A (en) | 1999-07-28 | 2001-02-19 | Kyowa Hakko Kogyo Co. Ltd. | Chemokine receptor antagonists and methods of use therefor |
| US7541365B2 (en) | 2001-11-21 | 2009-06-02 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| TWI291467B (en) * | 2002-11-13 | 2007-12-21 | Millennium Pharm Inc | CCR1 antagonists and methods of use therefor |
-
2005
- 2005-12-19 WO PCT/US2005/045915 patent/WO2006066200A2/en not_active Ceased
- 2005-12-19 CN CN2005800481176A patent/CN101119725B/zh not_active Expired - Fee Related
- 2005-12-19 JP JP2007547000A patent/JP5308030B2/ja not_active Expired - Fee Related
- 2005-12-19 EP EP05854594A patent/EP1841429B1/en not_active Expired - Lifetime
- 2005-12-19 ES ES05854594T patent/ES2386029T3/es not_active Expired - Lifetime
- 2005-12-19 US US11/311,574 patent/US7960549B2/en not_active Expired - Fee Related
- 2005-12-19 AT AT05854594T patent/ATE553761T1/de active
- 2005-12-19 AU AU2005316340A patent/AU2005316340B2/en not_active Ceased
- 2005-12-19 CA CA2590157A patent/CA2590157C/en not_active Expired - Fee Related
-
2011
- 2011-05-26 US US13/116,130 patent/US8481737B2/en not_active Expired - Fee Related
-
2012
- 2012-08-02 JP JP2012172003A patent/JP2012211197A/ja not_active Withdrawn
-
2014
- 2014-12-22 JP JP2014258340A patent/JP2015057445A/ja active Pending
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