JP2008524165A5 - - Google Patents
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- Publication number
- JP2008524165A5 JP2008524165A5 JP2007546068A JP2007546068A JP2008524165A5 JP 2008524165 A5 JP2008524165 A5 JP 2008524165A5 JP 2007546068 A JP2007546068 A JP 2007546068A JP 2007546068 A JP2007546068 A JP 2007546068A JP 2008524165 A5 JP2008524165 A5 JP 2008524165A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- hydroxy
- heteroalicyclic
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 18
- -1 nitro, thiocyanato Chemical group 0.000 claims 18
- 125000001475 halogen functional group Chemical group 0.000 claims 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 150000003573 thiols Chemical class 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000004104 aryloxy group Chemical group 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000005841 biaryl group Chemical group 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000000824 cytostatic agent Substances 0.000 claims 2
- 230000001085 cytostatic effect Effects 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- OLSOYUUAJUQDIO-UHFFFAOYSA-N n-isothiocyanato-1-oxomethanimine Chemical compound O=C=NN=C=S OLSOYUUAJUQDIO-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical group C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims 1
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical group C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- 125000002015 acyclic group Chemical group 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000005336 allyloxy group Chemical group 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000004802 cyanophenyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04029981 | 2004-12-17 | ||
| PCT/EP2005/056821 WO2006064044A1 (en) | 2004-12-17 | 2005-12-15 | Indolinones and their use as antiproliferative agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008524165A JP2008524165A (ja) | 2008-07-10 |
| JP2008524165A5 true JP2008524165A5 (enExample) | 2009-02-12 |
Family
ID=34927830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007546068A Pending JP2008524165A (ja) | 2004-12-17 | 2005-12-15 | インドリノン及びその抗増殖薬としての使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20060135592A1 (enExample) |
| EP (1) | EP1828123A1 (enExample) |
| JP (1) | JP2008524165A (enExample) |
| CA (1) | CA2589501A1 (enExample) |
| WO (1) | WO2006064044A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759383B2 (en) | 2005-02-22 | 2010-07-20 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| TWI333959B (en) * | 2005-08-31 | 2010-12-01 | Academia Sinica | Methods and reagents for the analysis and purification of polysaccharides |
| CN102491932A (zh) * | 2011-12-26 | 2012-06-13 | 天津科技大学 | 一种3-吲哚啉酮类衍生物及其制备方法及其应用 |
| JP6378308B2 (ja) * | 2013-03-13 | 2018-08-22 | ボストン バイオメディカル， インコーポレイテッド | がんの処置のための、がん幹細胞経路キナーゼの阻害剤としての３−（アリールまたはヘテロアリール）メチレンインドリン−２−オン誘導体 |
| US9745253B2 (en) | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
| CN106854173A (zh) * | 2016-12-23 | 2017-06-16 | 山东轩德医药科技有限公司 | 一种2‑羰基吲哚酮‑6‑羧酸甲酯的制备方法 |
| CN113549000A (zh) * | 2020-04-23 | 2021-10-26 | 复旦大学 | 用于预防或治疗脂质代谢相关疾病的化合物 |
| CN122295328A (zh) * | 2023-12-05 | 2026-06-26 | 先正达农作物保护股份公司 | 除草衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1051452C (zh) * | 1994-07-26 | 2000-04-19 | 中国医学科学院血液学研究所 | 3-取代芳基氧化吲哚类化合物的应用 |
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| US6689806B1 (en) * | 1999-03-24 | 2004-02-10 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
| AU3770000A (en) * | 1999-03-24 | 2000-10-09 | Sugen, Inc. | Indolinone compounds as kinase inhibitors |
-
2005
- 2005-12-15 EP EP05817469A patent/EP1828123A1/en not_active Withdrawn
- 2005-12-15 JP JP2007546068A patent/JP2008524165A/ja active Pending
- 2005-12-15 WO PCT/EP2005/056821 patent/WO2006064044A1/en not_active Ceased
- 2005-12-15 CA CA002589501A patent/CA2589501A1/en not_active Abandoned
- 2005-12-16 US US11/303,168 patent/US20060135592A1/en not_active Abandoned
-
2006
- 2006-11-13 US US11/558,953 patent/US20070088051A1/en not_active Abandoned
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