JP2008522981A5 - - Google Patents
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- Publication number
- JP2008522981A5 JP2008522981A5 JP2007544636A JP2007544636A JP2008522981A5 JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5 JP 2007544636 A JP2007544636 A JP 2007544636A JP 2007544636 A JP2007544636 A JP 2007544636A JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- hydrogen
- aryl
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63436604P | 2004-12-07 | 2004-12-07 | |
| US60/634,366 | 2004-12-07 | ||
| US65593005P | 2005-02-23 | 2005-02-23 | |
| US60/655,930 | 2005-02-23 | ||
| PCT/US2005/044451 WO2006063154A1 (en) | 2004-12-07 | 2005-12-07 | Composition for proteasome inhibition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522981A JP2008522981A (ja) | 2008-07-03 |
| JP2008522981A5 true JP2008522981A5 (cg-RX-API-DMAC10.html) | 2008-10-02 |
| JP4990155B2 JP4990155B2 (ja) | 2012-08-01 |
Family
ID=36143200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544636A Expired - Lifetime JP4990155B2 (ja) | 2004-12-07 | 2005-12-07 | プロテアソームを阻害するための組成物 |
Country Status (17)
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| WO2005105827A2 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for proteasome enzyme inhibition |
| JP5108509B2 (ja) * | 2004-05-10 | 2012-12-26 | プロテオリックス， インコーポレイテッド | 酵素阻害のための化合物 |
| US9034846B2 (en) * | 2004-10-10 | 2015-05-19 | Universite De Liege | Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases |
| MX2008006090A (es) * | 2005-11-09 | 2008-10-23 | Proteolix Inc | Compuestos para inhibicion de la enzima. |
| RU2450016C2 (ru) | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| KR20160086980A (ko) | 2007-10-04 | 2016-07-20 | 오닉스 세라퓨틱스, 인크. | 결정형 펩티드 에폭시 케톤 프로테아제 저해제 및 아미노산 케토-에폭시드의 합성 |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| WO2010039762A2 (en) * | 2008-10-01 | 2010-04-08 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising boronic acid compounds |
| MX2011004225A (es) * | 2008-10-21 | 2011-06-21 | Onyx Therapeutics Inc | Terapia de combinacion con epoxicetonas peptidicas. |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| EP2238973A1 (en) * | 2009-04-07 | 2010-10-13 | Cephalon France | Lyophilized preparations of proteasome inhibitors |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| NZ596515A (en) | 2009-05-29 | 2014-03-28 | Cydex Pharmaceuticals Inc | Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same |
| WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
| BR112012022060A2 (pt) | 2010-03-01 | 2018-05-08 | Onyx Therapeutics Inc | composto para a inibição de imunoproteassoma |
| EP2555621A4 (en) | 2010-04-07 | 2014-07-02 | Onyx Therapeutics Inc | CRYSTALLINE EPOXYCETONE PEPTIDE IMMUNOPROTEASOME INHIBITOR |
| RU2681835C2 (ru) | 2012-01-23 | 2019-03-13 | Сейдж Терапьютикс, Инк. | Лекарственные формы нейроактивных стероидов и способы лечения нарушений цнс |
| PT3702374T (pt) | 2012-02-15 | 2022-06-23 | Cydex Pharmaceuticals Inc | Processo de fabrico para derivados de ciclodextrina |
| CA2865950C (en) | 2012-02-28 | 2016-12-20 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| EP2827861A4 (en) * | 2012-03-19 | 2016-03-16 | Aposignal Bioscience Llc | COMPOSITION AND METHODS FOR CELLULAR MODULATION |
| SMT202400264T1 (it) * | 2012-05-08 | 2024-07-09 | Onyx Therapeutics Inc | Metodi di complessazione di ciclodestrina per formulare inibitori del proteasoma peptidico |
| WO2013169282A1 (en) * | 2012-05-08 | 2013-11-14 | Onyx Therapeutics, Inc. | Cylodextrin complexation methods for formulating peptide proteasome inhibitors |
| WO2014011695A2 (en) | 2012-07-09 | 2014-01-16 | Onyx Therapeutics, Inc. | Prodrugs of peptide epoxy ketone protease inhibitors |
| MX363455B (es) * | 2012-07-18 | 2019-03-25 | Onyx Therapeutics Inc | Composiciones liposómicas de inhibidores de proteasoma basadas en epoxicetona. |
| WO2014018807A1 (en) * | 2012-07-26 | 2014-01-30 | Centrax International, Inc. | Peptide epoxyketone compounds |
| CN109096370B (zh) * | 2012-07-26 | 2022-03-18 | 圣特莱国际公司 | 多肽环氧酮化合物 |
| US9441012B2 (en) * | 2012-08-14 | 2016-09-13 | Trillium Therapeutics Inc. | Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors |
| US9636376B2 (en) * | 2012-09-11 | 2017-05-02 | Innopharma, Inc. | Stable compositions of peptide epoxy ketones |
| HK1213585A1 (zh) * | 2012-10-22 | 2016-07-08 | Cydex Pharmaceuticals, Inc. | 烷基化环糊精组合物及其制备和使用方法 |
| US20150328320A1 (en) * | 2012-11-30 | 2015-11-19 | Glaxosmithkline Llc | Novel Pharmaceutical Composition |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| PL2968555T3 (pl) | 2013-03-13 | 2020-11-16 | Sanofi | Kompozycje zawierające przeciwciała anty-cd38 i karfilzomib |
| EP2970225B1 (en) | 2013-03-14 | 2018-08-15 | Onyx Therapeutics, Inc. | Dipeptide and tripeptide epoxy ketone protease inhibitors |
| AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| MX372671B (es) | 2013-07-19 | 2020-04-23 | Onyx Therapeutics Inc | Inhibidores de proteasoma de epoxicetona peptídica en combinacion con inhibidores de cinasa pim para el tratamiento de canceres. |
| JP6608442B2 (ja) * | 2014-07-14 | 2019-11-20 | セントラックス インターナショナル，インコーポレイテッド | 酵素阻害に用いられるエポキシケトン化合物 |
| FI3183295T3 (fi) | 2014-08-22 | 2023-09-25 | Cydex Pharmaceuticals Inc | Fraktioidut alkyloidut syklodekstriinikoostumukset ja menetelmät niiden valmistamiseksi ja käyttämiseksi |
| WO2016170489A1 (en) | 2015-04-24 | 2016-10-27 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of proteasome inhibitor |
| KR20180096609A (ko) | 2015-11-17 | 2018-08-29 | 타이페이 메디컬 유니이버시티 | 섬유증 질병의 치료 및/또는 예방을 위한 아미노나프토퀴논 화합물 |
| TWI759301B (zh) | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
| EP3494108B1 (en) | 2016-08-05 | 2020-10-28 | Amgen Inc. | Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof |
| WO2018038687A1 (en) | 2016-08-22 | 2018-03-01 | Mustafa Nevzat Ilaç Sanayii A.Ş. | Pharmaceutical formulations comprising a bortezomib-cyclodextrin complex |
| US10098890B2 (en) | 2016-10-29 | 2018-10-16 | Cipla Limited | Stable carfilzomib formulations |
| US11224631B2 (en) | 2017-01-24 | 2022-01-18 | Orbicular Pharmaceutical Technologies Pvt. Ltd. | Ready-to-use Carfilzomib compositions |
| BR112020005079A2 (pt) | 2017-09-14 | 2020-09-15 | Glaxosmithkline Intellectual Property Development Limited | tratamento de combinação para câncer |
| MX2020004936A (es) | 2017-11-16 | 2020-08-27 | Amgen Inc | Composiciones estables de compuestos de carfilzomib pegilado. |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2024097905A1 (en) | 2022-11-02 | 2024-05-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| WO2025035020A2 (en) | 2023-08-09 | 2025-02-13 | Amgen Inc. | Methods of using carfilzomib |
| WO2025092827A1 (zh) * | 2023-10-30 | 2025-05-08 | 上海汇伦医药股份有限公司 | 一种环氧类化合物及其应用 |
| EP4685151A1 (en) | 2024-07-24 | 2026-01-28 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Proteasome inhibitor |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US5441944A (en) * | 1989-04-23 | 1995-08-15 | The Trustees Of The University Of Pennsylvania | Substituted cyclodextrin sulfates and their uses as growth modulating agents |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5340736A (en) | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
| AU4499697A (en) | 1996-09-13 | 1998-04-02 | New York University | Method for treating parasitic diseases with proteasome inhibitors |
| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| ES2210769T3 (es) * | 1997-06-13 | 2004-07-01 | Cydex Inc. | Compuesto con vida de almacenamiento prolongada que comprende ciclodextrina y medicamentos y promedicamentos que se descomponen en componentes insolubles en agua. |
| US6831099B1 (en) * | 1999-05-12 | 2004-12-14 | Yale University | Enzyme inhibition |
| EP1716861A3 (en) * | 1999-10-20 | 2007-08-29 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone and hair growth |
| WO2003059898A2 (en) * | 2002-01-08 | 2003-07-24 | Eisai Co. Ltd. | Eponemycin and epoxomicin analogs and uses thereof |
| AU2003220685A1 (en) * | 2002-04-09 | 2003-10-27 | Greenville Hospital System | Metastasis modulating activity of highly sulfated oligosaccharides |
| US7232818B2 (en) | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| WO2005105827A2 (en) | 2004-04-15 | 2005-11-10 | Proteolix, Inc. | Compounds for proteasome enzyme inhibition |
| JP5108509B2 (ja) | 2004-05-10 | 2012-12-26 | プロテオリックス， インコーポレイテッド | 酵素阻害のための化合物 |
-
2005
- 2005-12-07 KR KR1020077015316A patent/KR101299821B1/ko not_active Expired - Lifetime
- 2005-12-07 PL PL10178998T patent/PL2260835T3/pl unknown
- 2005-12-07 US US11/299,265 patent/US7737112B2/en active Active
- 2005-12-07 EP EP10178998A patent/EP2260835B1/en not_active Expired - Lifetime
- 2005-12-07 ES ES10178998T patent/ES2408216T3/es not_active Expired - Lifetime
- 2005-12-07 EP EP10179422.0A patent/EP2261236B1/en not_active Expired - Lifetime
- 2005-12-07 JP JP2007544636A patent/JP4990155B2/ja not_active Expired - Lifetime
- 2005-12-07 CN CN2012103747120A patent/CN102847136A/zh active Pending
- 2005-12-07 AT AT05853385T patent/ATE499109T1/de active
- 2005-12-07 DE DE602005026556T patent/DE602005026556D1/de not_active Expired - Lifetime
- 2005-12-07 EP EP05853385A patent/EP1819353B1/en not_active Expired - Lifetime
- 2005-12-07 PL PL05853385T patent/PL1819353T3/pl unknown
- 2005-12-07 WO PCT/US2005/044451 patent/WO2006063154A1/en not_active Ceased
- 2005-12-07 PT PT101789980T patent/PT2260835E/pt unknown
- 2005-12-07 PT PT05853385T patent/PT1819353E/pt unknown
- 2005-12-07 PT PT101794220T patent/PT2261236E/pt unknown
- 2005-12-07 HU HUE10179422A patent/HUE027850T2/en unknown
- 2005-12-07 ES ES10179422.0T patent/ES2549763T3/es not_active Expired - Lifetime
- 2005-12-07 DK DK05853385.2T patent/DK1819353T3/da active
- 2005-12-07 AU AU2005313975A patent/AU2005313975B2/en active Active
- 2005-12-07 CN CNA2005800478775A patent/CN101180071A/zh active Pending
- 2005-12-07 PL PL10179422T patent/PL2261236T3/pl unknown
- 2005-12-07 CA CA2589921A patent/CA2589921C/en not_active Expired - Lifetime
-
2007
- 2007-05-31 IL IL183607A patent/IL183607A/en active IP Right Grant
-
2011
- 2011-04-21 CY CY20111100410T patent/CY1111489T1/el unknown
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