JP2008522585A5 - - Google Patents
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- Publication number
- JP2008522585A5 JP2008522585A5 JP2007536777A JP2007536777A JP2008522585A5 JP 2008522585 A5 JP2008522585 A5 JP 2008522585A5 JP 2007536777 A JP2007536777 A JP 2007536777A JP 2007536777 A JP2007536777 A JP 2007536777A JP 2008522585 A5 JP2008522585 A5 JP 2008522585A5
- Authority
- JP
- Japan
- Prior art keywords
- mirna
- target sequence
- nucleic acid
- modified
- plant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 108091070501 miRNA Proteins 0.000 claims 44
- 239000002679 microRNA Substances 0.000 claims 42
- 102000039446 nucleic acids Human genes 0.000 claims 30
- 108020004707 nucleic acids Proteins 0.000 claims 30
- 150000007523 nucleic acids Chemical class 0.000 claims 30
- 241000196324 Embryophyta Species 0.000 claims 19
- 230000000295 complement effect Effects 0.000 claims 18
- 238000000034 method Methods 0.000 claims 17
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 239000002243 precursor Substances 0.000 claims 13
- 108091033319 polynucleotide Proteins 0.000 claims 9
- 102000040430 polynucleotide Human genes 0.000 claims 9
- 239000002157 polynucleotide Substances 0.000 claims 9
- 241000219194 Arabidopsis Species 0.000 claims 5
- 244000068988 Glycine max Species 0.000 claims 5
- 235000010469 Glycine max Nutrition 0.000 claims 5
- 240000007594 Oryza sativa Species 0.000 claims 5
- 235000007164 Oryza sativa Nutrition 0.000 claims 5
- 240000008042 Zea mays Species 0.000 claims 5
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 5
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims 5
- 235000005822 corn Nutrition 0.000 claims 5
- 239000002773 nucleotide Substances 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- 235000009566 rice Nutrition 0.000 claims 5
- 230000003612 virological effect Effects 0.000 claims 5
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 4
- 108091036078 conserved sequence Proteins 0.000 claims 4
- 235000007319 Avena orientalis Nutrition 0.000 claims 3
- 241000209763 Avena sativa Species 0.000 claims 3
- 235000007558 Avena sp Nutrition 0.000 claims 3
- 235000014698 Brassica juncea var multisecta Nutrition 0.000 claims 3
- 235000006008 Brassica napus var napus Nutrition 0.000 claims 3
- 240000000385 Brassica napus var. napus Species 0.000 claims 3
- 235000006618 Brassica rapa subsp oleifera Nutrition 0.000 claims 3
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims 3
- 244000020518 Carthamus tinctorius Species 0.000 claims 3
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims 3
- 229920000742 Cotton Polymers 0.000 claims 3
- 241000219146 Gossypium Species 0.000 claims 3
- 244000020551 Helianthus annuus Species 0.000 claims 3
- 235000003222 Helianthus annuus Nutrition 0.000 claims 3
- 240000005979 Hordeum vulgare Species 0.000 claims 3
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 3
- 240000004658 Medicago sativa Species 0.000 claims 3
- 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 3
- 244000061176 Nicotiana tabacum Species 0.000 claims 3
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 3
- 240000006394 Sorghum bicolor Species 0.000 claims 3
- 235000011684 Sorghum saccharatum Nutrition 0.000 claims 3
- 244000062793 Sorghum vulgare Species 0.000 claims 3
- 108700019146 Transgenes Proteins 0.000 claims 3
- 241000209140 Triticum Species 0.000 claims 3
- 235000021307 Triticum Nutrition 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- 235000019713 millet Nutrition 0.000 claims 3
- 244000000003 plant pathogen Species 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 230000009261 transgenic effect Effects 0.000 claims 3
- 108091026890 Coding region Proteins 0.000 claims 2
- 101800000653 Helper component proteinase Proteins 0.000 claims 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 2
- 108091092724 Noncoding DNA Proteins 0.000 claims 2
- 240000003768 Solanum lycopersicum Species 0.000 claims 2
- 108700005077 Viral Genes Proteins 0.000 claims 2
- 241000726445 Viroids Species 0.000 claims 2
- 230000002222 downregulating effect Effects 0.000 claims 2
- 230000030279 gene silencing Effects 0.000 claims 2
- 238000012226 gene silencing method Methods 0.000 claims 2
- 229920000140 heteropolymer Polymers 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| USPCT/US2004/033379 | 2004-10-12 | ||
| US67108905P | 2005-04-14 | 2005-04-14 | |
| PCT/US2005/036373 WO2006044322A2 (en) | 2004-10-12 | 2005-10-12 | Micrornas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008522585A JP2008522585A (ja) | 2008-07-03 |
| JP2008522585A5 true JP2008522585A5 (https=) | 2008-11-20 |
Family
ID=36203437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536777A Withdrawn JP2008522585A (ja) | 2004-10-12 | 2005-10-12 | マイクロｒｎａ |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8975471B2 (https=) |
| EP (1) | EP1809748B1 (https=) |
| JP (1) | JP2008522585A (https=) |
| CN (1) | CN101076592B (https=) |
| AR (1) | AR050972A1 (https=) |
| AU (1) | AU2005295948A1 (https=) |
| BR (1) | BRPI0516874A (https=) |
| CA (1) | CA2583690C (https=) |
| MX (1) | MX2007004321A (https=) |
| WO (1) | WO2006044322A2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8237017B2 (en) | 2006-05-12 | 2012-08-07 | Bayer Cropscience Nv | Stress-related microRNA molecules and uses thereof |
| WO2008027592A2 (en) * | 2006-08-31 | 2008-03-06 | Monsanto Technology, Llc | Phased small rnas |
| US20080081330A1 (en) * | 2006-09-28 | 2008-04-03 | Helicos Biosciences Corporation | Method and devices for analyzing small RNA molecules |
| US20080189805A1 (en) * | 2006-12-13 | 2008-08-07 | Serbin John J | Novel genes and rna molecules that confer stress tolerance |
| US9057073B2 (en) | 2007-01-11 | 2015-06-16 | Bayer Cropscience N.V. | Differential expression of subgenome specific alleles in cotton and uses thereof |
| CA2675954A1 (en) * | 2007-01-18 | 2008-07-24 | Plant Bioscience Limited (Pbl) | Methods and compositions for modulating the mirna pathway |
| WO2008103643A1 (en) * | 2007-02-20 | 2008-08-28 | Monsanto Technology, Llc | Invertebrate micrornas |
| US8258286B2 (en) | 2007-04-26 | 2012-09-04 | University Of Iowa Research Foundation | Reduction of off-target RNA interference toxicity |
| WO2008143786A1 (en) * | 2007-05-14 | 2008-11-27 | The Rockefeller University | Production of artificial micrornas using synthetic microrna precursors |
| US20100292099A1 (en) * | 2007-08-23 | 2010-11-18 | Keren Pharmaceutical, Inc. | Targeting of rna with external guide sequences |
| US8115055B2 (en) * | 2007-12-18 | 2012-02-14 | E.I. Du Pont De Nemours And Company | Down-regulation of gene expression using artificial microRNAs |
| AU2009221899B2 (en) | 2008-03-04 | 2015-09-03 | Washington State University | Compositions and methods for differential regulation of fatty acid unsaturation in membrane lipids and seed oil |
| MX2010012883A (es) | 2008-05-26 | 2010-12-14 | Bayer Bioscience Nv | Metodos y medios para modificar la resistencia de las fibras en plantas que producen fibras. |
| US20110247094A1 (en) * | 2008-10-08 | 2011-10-06 | Edward Allen | Transgenic Plants with Enhanced Agronomic Traits |
| US8309530B2 (en) | 2009-02-04 | 2012-11-13 | Washington State University | Compositions and methods for modulating ghrelin-mediated conditions |
| CN107129998A (zh) | 2009-06-10 | 2017-09-05 | 淡马锡生命科学研究院有限公司 | 用于棉花中基因功能性分析的病毒诱导的基因沉默(vigs) |
| CN101710362B (zh) * | 2009-12-10 | 2011-07-20 | 浙江大学 | 一种基于支持向量机的microRNA靶位点预测的方法 |
| WO2012001626A1 (en) * | 2010-06-30 | 2012-01-05 | Basf Plant Science Company Gmbh | Novel microrna precursor and use thereof in regulation of target gene expression |
| CN101976296B (zh) * | 2010-09-10 | 2012-05-23 | 浙江大学 | 结合基于下一代测序数据的植物microRNA靶位互作网络预测的方法 |
| CN103270158A (zh) * | 2010-10-15 | 2013-08-28 | 昆士兰大学 | 小的病毒rna分子及其用途 |
| ES2739804T3 (es) | 2011-02-12 | 2020-02-04 | Univ Iowa Res Found | Compuestos terapéuticos |
| AR085759A1 (es) * | 2011-04-21 | 2013-10-23 | Basf Plant Science Co Gmbh | Metodos para modificar la biosintesis de la lignina y mejorar la digestibilidad |
| EP2807258B1 (en) * | 2012-01-23 | 2017-04-26 | E. I. du Pont de Nemours and Company | Down-regulation of gene expression using artificial micrornas for silencing fatty acid biosynthestic genes |
| EP2825209B1 (en) | 2012-03-14 | 2018-08-29 | University of Central Florida Research Foundation, Inc. | Neurofibromatoses therapeutic agents and screening for same |
| IN2014KN02312A (https=) | 2012-04-19 | 2015-05-01 | Temasek Life Sciences Lab Ltd | |
| CN102703500B (zh) * | 2012-05-30 | 2014-03-12 | 清华大学 | 利用植物病毒载体进行miRNA靶标模拟序列构建和表达的方法 |
| US20140030792A1 (en) * | 2012-07-23 | 2014-01-30 | Radhakrishnan Rathnachalam | Therapeutic Anti-Virus VLPS |
| US10190126B2 (en) * | 2012-10-28 | 2019-01-29 | A.B. Seeds Ltd. | Transgenic plants with modified sugar content and methods of generating same |
| CN103088061B (zh) * | 2013-01-15 | 2016-08-03 | 中国科学院微生物研究所 | 一种rna及载体在制备预防和/或治疗肝癌产品中的应用 |
| CN105899663B (zh) | 2013-12-26 | 2019-07-26 | 学校法人东京医科大学 | 用于基因表达控制的人工模拟miRNA及其用途 |
| SG10201913570XA (en) | 2013-12-27 | 2020-03-30 | Bonac Corp | Artificial match-type mirna for controlling gene expression and use therefor |
| JP6663859B2 (ja) | 2014-05-20 | 2020-03-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | ハンチントン病の治療化合物 |
| AU2015313886A1 (en) * | 2014-09-10 | 2017-02-23 | The New Zealand Institute For Plant And Food Research Limited | Methods and materials for producing fruit of altered size |
| EP3206696A4 (en) * | 2014-10-14 | 2018-08-08 | Texas Tech University System | Multiplexed shrnas and uses thereof |
| WO2016064347A1 (en) | 2014-10-22 | 2016-04-28 | Temasek Life Sciences Laboratory Limited | Terpene synthases from ylang ylang (cananga odorata var. fruticosa) |
| SG11201705223XA (en) | 2014-12-27 | 2017-07-28 | Bonac Corp | NATURALLY OCCURING miRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
| CN104774837B (zh) * | 2015-03-13 | 2018-02-02 | 浙江省医学科学院 | 9种植物微小核糖核苷酸及其应用 |
| JP6602847B2 (ja) | 2015-03-27 | 2019-11-06 | 株式会社ボナック | デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子 |
| CN106167801B (zh) * | 2016-09-30 | 2018-08-28 | 山东大学 | 大豆威廉姆斯82中NAC膜结合转录因子基因GmNTL1及其应用 |
| WO2019103581A1 (ko) * | 2017-11-27 | 2019-05-31 | (주)프로스테믹스 | 이중 가닥의 올리고뉴클레오티드 및 그 제조 방법 |
| CN111621588A (zh) * | 2020-06-08 | 2020-09-04 | 华中农业大学 | 光亮果皮番茄品种选育的分子标记及其应用 |
| CN112210555B (zh) * | 2020-09-18 | 2022-02-22 | 大连理工大学 | 番茄抗晚疫病基因Sly-miR166b及其克隆方法与应用方法 |
| CN114908089B (zh) * | 2021-02-08 | 2024-03-15 | 上海细胞治疗集团有限公司 | 3’utr的构建方法和应用 |
| CN114606236B (zh) * | 2022-04-21 | 2024-01-05 | 南通大学 | 一种翘芪复方中药汤剂来源的微小核糖核酸及其制备方法和应用 |
| CN115083516B (zh) * | 2022-07-13 | 2023-03-21 | 北京先声医学检验实验室有限公司 | 一种基于靶向RNA测序技术检测基因融合的Panel设计和评估方法 |
| CN117210463B (zh) * | 2023-09-12 | 2024-03-19 | 扬州大学 | 一种与莲藕根状茎淀粉合成相关的miRNA及其应用 |
| CN118516400B (zh) * | 2024-07-24 | 2024-10-29 | 吉林农业大学 | gma-miR169c基因在调控植物脂肪酸合成中的应用 |
| CN120648688B (zh) * | 2025-08-21 | 2025-11-07 | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 与植物抗病毒相关的miR159a及其在提高植物对病毒抗性中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| NZ507093A (en) | 1998-04-08 | 2003-08-29 | Commw Scient Ind Res Org | Methods and means for reducing the phenotypic expression of a nucleic acid of interest in a plant |
| CA2386270A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| WO2003070918A2 (en) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Rna interference by modified short interfering nucleic acid |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| EP2345720A3 (en) | 2001-07-12 | 2012-01-25 | University of Massachusetts | In vivo production of small interfering RNAs that mediate gene silencing |
| AU2002329667A1 (en) | 2001-07-30 | 2003-02-17 | Uta Griesenbach | Specific inhibition of gene expression by small double stranded rnas |
| US7166771B2 (en) | 2002-06-21 | 2007-01-23 | Monsanto Technology Llc | Coordinated decrease and increase of gene expression of more than one gene using transgenic constructs |
| WO2003093441A2 (en) * | 2002-05-03 | 2003-11-13 | Duke University | A method of regulating gene expression |
| US7803984B2 (en) | 2002-07-10 | 2010-09-28 | Kansas State University Research Foundation | Compositions and methods for controlling plant parasitic nematodes |
| US20040268441A1 (en) * | 2002-07-19 | 2004-12-30 | University Of South Carolina | Compositions and methods for the modulation of gene expression in plants |
| WO2004066183A2 (en) | 2003-01-22 | 2004-08-05 | European Molecular Biology Laboratory | Microrna |
| DK1633767T3 (en) | 2003-06-02 | 2019-03-25 | Univ Massachusetts | METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING |
| US7750144B2 (en) | 2003-06-02 | 2010-07-06 | University Of Massachusetts | Methods and compositions for enhancing the efficacy and specificity of RNA silencing |
| ES2357116T5 (es) | 2003-06-02 | 2021-09-03 | Univ Massachusetts | Métodos y composiciones para mejorar la eficacia y especificad de FNAi |
| US20050144669A1 (en) | 2003-07-01 | 2005-06-30 | Whitehead Institute For Biomedical Research | MicroRNAs in plants |
| US7071380B1 (en) * | 2003-08-29 | 2006-07-04 | Agrigenesis Biosciences Limited | Control of floral induction |
| US20050120415A1 (en) | 2003-10-09 | 2005-06-02 | E.I. Du Pont De Nemours And Company | Gene silencing |
-
2005
- 2005-10-12 WO PCT/US2005/036373 patent/WO2006044322A2/en not_active Ceased
- 2005-10-12 BR BRPI0516874-0A patent/BRPI0516874A/pt not_active IP Right Cessation
- 2005-10-12 EP EP05808412A patent/EP1809748B1/en not_active Expired - Lifetime
- 2005-10-12 US US11/247,587 patent/US8975471B2/en not_active Expired - Fee Related
- 2005-10-12 JP JP2007536777A patent/JP2008522585A/ja not_active Withdrawn
- 2005-10-12 MX MX2007004321A patent/MX2007004321A/es active IP Right Grant
- 2005-10-12 AU AU2005295948A patent/AU2005295948A1/en not_active Abandoned
- 2005-10-12 CA CA2583690A patent/CA2583690C/en not_active Expired - Fee Related
- 2005-10-12 CN CN2005800425477A patent/CN101076592B/zh not_active Expired - Fee Related
- 2005-10-13 AR ARP050104285A patent/AR050972A1/es unknown
-
2015
- 2015-02-20 US US14/627,543 patent/US20150159157A1/en not_active Abandoned
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