JP2008521929A - 抗核形成剤を含有する医薬組成物 - Google Patents

抗核形成剤を含有する医薬組成物 Download PDF

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Publication number
JP2008521929A
JP2008521929A JP2007544548A JP2007544548A JP2008521929A JP 2008521929 A JP2008521929 A JP 2008521929A JP 2007544548 A JP2007544548 A JP 2007544548A JP 2007544548 A JP2007544548 A JP 2007544548A JP 2008521929 A JP2008521929 A JP 2008521929A
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JP
Japan
Prior art keywords
compound
pharmaceutical composition
weight
alkyl
salt
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Pending
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JP2007544548A
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English (en)
Japanese (ja)
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JP2008521929A5 (enExample
Inventor
クルアネス，マリア・テ
シユイ，ウエイ
アルテイーノ，ローラ・エム
チユー，ホンカン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
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Merck and Co Inc
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36565788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP2008521929(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2008521929A publication Critical patent/JP2008521929A/ja
Publication of JP2008521929A5 publication Critical patent/JP2008521929A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007544548A 2004-12-03 2005-12-02 抗核形成剤を含有する医薬組成物 Pending JP2008521929A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63285904P 2004-12-03 2004-12-03
PCT/US2005/043675 WO2006060681A2 (en) 2004-12-03 2005-12-02 Pharmaceutical composition containing an anti-nucleating agent

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2012116010A Division JP2012184250A (ja) 2004-12-03 2012-05-21 抗核形成剤を含有する医薬組成物
JP2012260995A Division JP2013063999A (ja) 2004-12-03 2012-11-29 抗核形成剤を含有する医薬組成物

Publications (2)

Publication Number Publication Date
JP2008521929A true JP2008521929A (ja) 2008-06-26
JP2008521929A5 JP2008521929A5 (enExample) 2009-01-22

Family

ID=36565788

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007544548A Pending JP2008521929A (ja) 2004-12-03 2005-12-02 抗核形成剤を含有する医薬組成物
JP2012116010A Pending JP2012184250A (ja) 2004-12-03 2012-05-21 抗核形成剤を含有する医薬組成物
JP2012260995A Pending JP2013063999A (ja) 2004-12-03 2012-11-29 抗核形成剤を含有する医薬組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012116010A Pending JP2012184250A (ja) 2004-12-03 2012-05-21 抗核形成剤を含有する医薬組成物
JP2012260995A Pending JP2013063999A (ja) 2004-12-03 2012-11-29 抗核形成剤を含有する医薬組成物

Country Status (9)

Country Link
US (1) US8771733B2 (enExample)
EP (2) EP1819323B2 (enExample)
JP (3) JP2008521929A (enExample)
CN (1) CN101068533B (enExample)
AU (1) AU2005311714B2 (enExample)
CA (1) CA2588465C (enExample)
ES (1) ES2727577T5 (enExample)
TR (1) TR201907729T4 (enExample)
WO (1) WO2006060681A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508395A (ja) * 2009-10-26 2013-03-07 メルク・シャープ・エンド・ドーム・コーポレイション インテグラーゼ阻害剤を含有する固形医薬組成物
JP2013523771A (ja) * 2010-04-01 2013-06-17 テバ ファーマシューティカル インダストリーズ リミティド ラルテグラビル塩およびその結晶形

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070085702A (ko) * 2004-12-03 2007-08-27 머크 앤드 캄파니 인코포레이티드 Ｕｇｔ1ａ1에 의해 대사된 약물의 약력학을 개선시키기위한 아타자나비르의 용도
UA87884C2 (uk) 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
WO2006060711A2 (en) 2004-12-03 2006-06-08 Merck & Co., Inc. Pharmaceutical formulation of carboxamide hiv integrase inhibitors containing a release rate controlling composition
EP1819323B2 (en) 2004-12-03 2023-03-22 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
ES2744816T3 (es) * 2006-10-27 2020-02-26 Capsugel Belgium Nv Cápsulas duras de hidroxipropil metil celulosa y proceso de fabricación
CN101197832B (zh) * 2007-12-13 2012-01-25 华为技术有限公司 一种实现iptv业务的方法、系统、装置
ES2549387T3 (es) 2009-06-02 2015-10-27 Hetero Research Foundation Procedimiento de preparación de raltegravir potásico amorfo
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof
US12472475B2 (en) 2018-02-02 2025-11-18 The General Hospital Corporation Methods of supercooling aqueous samples
US12465565B2 (en) 2020-01-23 2025-11-11 Lupin Limited Pharmaceutical compositions of raltegravir
US20230277587A1 (en) * 2022-03-03 2023-09-07 Dermacisen, S.A. Food supplement for oral administration

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
JPH0348623A (ja) * 1989-07-10 1991-03-01 E R Squibb & Sons Inc フォシノプリル錠剤
JPH0616572A (ja) * 1992-07-01 1994-01-25 Otsuka Pharmaceut Factory Inc 経口吸収用製剤
WO2003035077A1 (en) * 2001-10-26 2003-05-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540566A (en) * 1984-04-02 1985-09-10 Forest Laboratories, Inc. Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
AU6329599A (en) † 1998-09-28 2000-04-17 Glaxo Group Limited Antiviral combinations comprising (s)-2-ethyl -7-fluoro -3-oxo-3, 4-dihydro -2h-quinoxaline -1-carboxylic acid isopropyl ester
US6620841B1 (en) * 1998-12-25 2003-09-16 Shionogi & Co., Ltd. Aromatic heterocycle compounds having HIV integrase inhibiting activities
GB9922963D0 (en) * 1999-09-28 1999-12-01 Pfizer Ltd Polymorphic salt
JP5230050B2 (ja) * 2000-05-08 2013-07-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｈｉｖ複製阻害剤
US7115565B2 (en) † 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
DK1441734T3 (da) * 2001-10-26 2007-06-11 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carboxamid-inhibitorer a HIV-integrase
WO2003086319A2 (en) 2002-04-10 2003-10-23 Merck & Co., Inc. Pharmaceutical compositions containing an hiv integrase inhibitor and a nonionic surfactant
KR20050087865A (ko) 2002-12-27 2005-08-31 이스티투토 디 리세르쉐 디 비올로지아 몰레콜라레 피. 안젤레티에스.피.에이. ＨＩＶ 인테그라제 억제제로서 유용한테트라하이드로-4Ｈ-피리도[1,2-ａ]피리미딘 및 관련화합물
US20040224917A1 (en) † 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
KR20070085702A (ko) 2004-12-03 2007-08-27 머크 앤드 캄파니 인코포레이티드 Ｕｇｔ1ａ1에 의해 대사된 약물의 약력학을 개선시키기위한 아타자나비르의 용도
WO2006060711A2 (en) † 2004-12-03 2006-06-08 Merck & Co., Inc. Pharmaceutical formulation of carboxamide hiv integrase inhibitors containing a release rate controlling composition
EP1819323B2 (en) 2004-12-03 2023-03-22 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US9968607B2 (en) 2011-04-25 2018-05-15 Hetero Research Foundation Pharmaceutical compositions of raltegravir, methods of preparation and methods of use therof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0347124A (ja) * 1989-04-20 1991-02-28 Fujisawa Pharmaceut Co Ltd 経口吸収用製剤
JPH0348623A (ja) * 1989-07-10 1991-03-01 E R Squibb & Sons Inc フォシノプリル錠剤
JPH0616572A (ja) * 1992-07-01 1994-01-25 Otsuka Pharmaceut Factory Inc 経口吸収用製剤
WO2003035077A1 (en) * 2001-10-26 2003-05-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013508395A (ja) * 2009-10-26 2013-03-07 メルク・シャープ・エンド・ドーム・コーポレイション インテグラーゼ阻害剤を含有する固形医薬組成物
JP2016034962A (ja) * 2009-10-26 2016-03-17 メルク・シャープ・エンド・ドーム・コーポレイション インテグラーゼ阻害剤を含有する固形医薬組成物
JP2013523771A (ja) * 2010-04-01 2013-06-17 テバ ファーマシューティカル インダストリーズ リミティド ラルテグラビル塩およびその結晶形

Also Published As

Publication number Publication date
EP1819323B2 (en) 2023-03-22
EP1819323A4 (en) 2012-07-18
JP2012184250A (ja) 2012-09-27
EP3165220A1 (en) 2017-05-10
WO2006060681A3 (en) 2006-10-12
EP3165220B1 (en) 2019-04-03
EP3165220B2 (en) 2024-11-13
CN101068533A (zh) 2007-11-07
TR201907729T4 (tr) 2019-06-21
JP2013063999A (ja) 2013-04-11
EP1819323B1 (en) 2016-11-16
AU2005311714B2 (en) 2010-09-30
US8771733B2 (en) 2014-07-08
ES2727577T3 (es) 2019-10-17
EP1819323A2 (en) 2007-08-22
US20080118559A1 (en) 2008-05-22
CA2588465C (en) 2013-10-01
CA2588465A1 (en) 2006-06-08
ES2727577T5 (en) 2025-04-02
CN101068533B (zh) 2011-04-27
WO2006060681A2 (en) 2006-06-08
AU2005311714A1 (en) 2006-06-08

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