JP2008520589A - シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 - Google Patents
シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 Download PDFInfo
- Publication number
- JP2008520589A JP2008520589A JP2007541601A JP2007541601A JP2008520589A JP 2008520589 A JP2008520589 A JP 2008520589A JP 2007541601 A JP2007541601 A JP 2007541601A JP 2007541601 A JP2007541601 A JP 2007541601A JP 2008520589 A JP2008520589 A JP 2008520589A
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- Prior art keywords
- disease
- compound
- amyloid
- brain
- pharmaceutical composition
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62884004P | 2004-11-17 | 2004-11-17 | |
| PCT/CA2005/001744 WO2006053428A1 (en) | 2004-11-17 | 2005-11-17 | Compositions comprising scyllo-inositol derivatives and methods to treat disorders of protein aggregation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178707A Division JP2012214516A (ja) | 2004-11-17 | 2012-08-10 | シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008520589A true JP2008520589A (ja) | 2008-06-19 |
| JP2008520589A5 JP2008520589A5 (https=) | 2008-12-25 |
Family
ID=36406797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541601A Pending JP2008520589A (ja) | 2004-11-17 | 2005-11-17 | シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 |
| JP2012178707A Pending JP2012214516A (ja) | 2004-11-17 | 2012-08-10 | シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178707A Pending JP2012214516A (ja) | 2004-11-17 | 2012-08-10 | シロイノシトール誘導体を含む組成物およびタンパク質凝集障害を治療するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20060189582A1 (https=) |
| EP (2) | EP2186518A1 (https=) |
| JP (2) | JP2008520589A (https=) |
| CN (2) | CN103301094A (https=) |
| AU (1) | AU2005306531B2 (https=) |
| BR (1) | BRPI0517733A (https=) |
| CA (1) | CA2588423A1 (https=) |
| MX (1) | MX2007005870A (https=) |
| WO (1) | WO2006053428A1 (https=) |
| ZA (1) | ZA200704872B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505162A (ja) * | 2008-10-09 | 2012-03-01 | ワラタ ファーマシューティカルズ, インコーポレイテッド | 黄斑変性症関連障害を処置するためのscyllo−イノシトールの使用 |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
| US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
| US8193250B2 (en) | 2004-10-22 | 2012-06-05 | Mount Sinai School Of Medicine | Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system |
| CA2626005A1 (en) * | 2005-10-13 | 2007-10-25 | Waratah Pharmaceuticals Inc. | Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
| RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
| EP1993523A4 (en) * | 2006-02-17 | 2009-06-10 | Joanne Mclaurin | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS |
| EP1996175A4 (en) * | 2006-03-09 | 2009-06-10 | Waratah Pharmaceuticals Inc | CYCLOHEXAN POLYALKOHOL FORMULATION FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
| US20100292157A1 (en) * | 2006-11-24 | 2010-11-18 | Antonio Cruz | Combination Treatments for Alzheimer's Disease and Similar Diseases |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| HRP20130768T1 (en) * | 2007-04-12 | 2013-10-25 | Waratah Pharmaceuticals, Inc. | Use of cyclohexanehexol derivatives in the treatment of ocular diseases |
| CA2683546A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Use of cyclohexanehexol derivatives in the treatment of .alpha.-synucleinopathies |
| US20110105626A1 (en) * | 2007-04-12 | 2011-05-05 | Mclaurin Joanne | Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases |
| CA2683580A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Treatment of amyotrophic lateral sclerosis |
| US20110098309A1 (en) * | 2007-07-12 | 2011-04-28 | Acumen Pharmaceuticals, Inc. | Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds |
| US9006283B2 (en) * | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
| US8962677B2 (en) * | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
| JP2010538611A (ja) * | 2007-09-07 | 2010-12-16 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | タウタンパク質スクリーニングアッセイ |
| AT506535B1 (de) | 2008-02-22 | 2010-04-15 | Affiris Forschungs & Entwicklungs Gmbh | Vaccine enthaltend alpha-synuclein-mimotope auf basis von peptiden |
| CA2978149C (en) * | 2008-03-21 | 2019-02-12 | The General Hospital Corporation | Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders |
| WO2010031051A1 (en) | 2008-09-15 | 2010-03-18 | Elan Pharmaceuticals, Inc. | Methods of treatment of hyperuricemia and associated disease states |
| US20110081428A1 (en) * | 2009-09-16 | 2011-04-07 | The Buck Institute For Age Research | Use of thioflavin-like compounds to increase life span and/or health span |
| ES2684475T3 (es) | 2010-04-15 | 2018-10-03 | Abbvie Inc. | Proteínas que se unen a beta amiloide |
| US9320793B2 (en) * | 2010-07-14 | 2016-04-26 | Acumen Pharmaceuticals, Inc. | Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42 |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| US20140056901A1 (en) * | 2012-08-21 | 2014-02-27 | The Institute For Molecular Medicine | Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies |
| WO2021055670A1 (en) | 2019-09-20 | 2021-03-25 | Avx Corporation | Somatic cell-based electrical biosensor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| WO2004075882A1 (en) * | 2003-02-27 | 2004-09-10 | Ellipsis Biotherapeutics Corporation | Methods of preventing, treating and diagnosing disorders of protein aggregation |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4454151A (en) * | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4515722A (en) * | 1982-03-30 | 1985-05-07 | Merck & Co., Inc. | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents |
| US4474806A (en) * | 1982-05-10 | 1984-10-02 | Merck & Co., Inc. | Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents |
| IT1164225B (it) | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| US4952396A (en) * | 1986-11-19 | 1990-08-28 | Linus Pauling Institute Of Science & Medicine | Method of using phytic acid for inhibiting tumor growth |
| US4847082A (en) * | 1987-01-21 | 1989-07-11 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| SE8904355D0 (sv) * | 1989-12-21 | 1989-12-21 | Perstorp Ab | Medicament |
| US5217959A (en) * | 1990-09-06 | 1993-06-08 | Robert Sabin | Method of treating multiple sclerosis with phytic acid |
| US5112814A (en) * | 1990-10-24 | 1992-05-12 | Robert Sabin | Method of treatment of Parkinson's disease using phytic acid |
| KR0185215B1 (ko) * | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| SE9102068L (sv) * | 1991-07-03 | 1993-01-04 | Perstorp Ab | Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav |
| SE469260B (sv) * | 1992-02-25 | 1993-06-14 | Perstorp Ab | En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat |
| ATE292131T1 (de) * | 1992-10-05 | 2005-04-15 | Virginia Tech Intell Prop | Zwischenprodukt zur herstellung von d-chiro- inosose und (+)-d-chiro-inositol |
| US5643562A (en) * | 1993-03-29 | 1997-07-01 | Queen's University Of Kingston | Method for treating amyloidosis |
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| US5972328A (en) * | 1993-03-29 | 1999-10-26 | Queen's University At Kingston | Method for treating amyloidosis |
| DE69333071T2 (de) * | 1993-04-05 | 2004-05-06 | Aveve N.V. | Phytate-Hydrolyse und enzymatische Zusammensetzung für die Hydrolyse von Phytat |
| CA2168953A1 (en) * | 1993-08-11 | 1995-02-16 | Kiyoshi Sato | Process for producing d-chiro-inositol |
| SE502574C2 (sv) * | 1994-01-25 | 1995-11-13 | Perstorp Ab | En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat |
| US5858326A (en) * | 1995-06-06 | 1999-01-12 | Neurochem, Inc. | Methods of increasing amyloid deposition |
| US5756541A (en) * | 1996-03-11 | 1998-05-26 | Qlt Phototherapeutics Inc | Vision through photodynamic therapy of the eye |
| US6232486B1 (en) * | 1996-06-11 | 2001-05-15 | Nutrimed Biotech | Molecular probes and modulators for PI-PLC and PI 3-kinase |
| US5880099A (en) * | 1996-09-20 | 1999-03-09 | The Regents Of The University Of California | Inositol polyphosphates and methods of using same |
| US5977078A (en) * | 1996-09-20 | 1999-11-02 | The Regents Of The Univesity Of California | Inositol polyphosphate derivatives and methods of using same |
| US5998485A (en) * | 1997-06-16 | 1999-12-07 | Cedars-Sinai Medical Center | Method for modulating immune response with inositol |
| US6153603A (en) * | 1997-06-27 | 2000-11-28 | Perstorp Ab | Method of treating angiogenesis in tumor tissue |
| US6331891B1 (en) * | 1998-04-07 | 2001-12-18 | Fujitsu Limited | Apparatus and method for assembling semiconductor device and semiconductor device thus fabricated |
| US6310073B1 (en) * | 1998-07-28 | 2001-10-30 | Queen's University At Kingston | Methods and compositions to treat glycosaminoglycan-associated molecular interactions |
| US6818430B1 (en) * | 1999-06-07 | 2004-11-16 | Hokko Chemical Industry Co., Ltd. | Process for producing L-epi-2-inosose and novel process for producing epi-inositol |
| US6329256B1 (en) * | 1999-09-24 | 2001-12-11 | Advanced Micro Devices, Inc. | Self-aligned damascene gate formation with low gate resistance |
| WO2001028356A2 (en) * | 1999-10-18 | 2001-04-26 | Muscletech Research And Development Inc. | Food supplement for increasing lean mass and strength |
| US6331313B1 (en) * | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| DE10031955A1 (de) * | 2000-06-30 | 2002-01-17 | Deutsches Krebsforsch | Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel |
| US8034803B2 (en) * | 2001-02-06 | 2011-10-11 | Qlt Inc. | Photodynamic therapy of occult age-related macular degeneration |
| WO2002062385A2 (en) * | 2001-02-06 | 2002-08-15 | Qlt, Inc. | Method to prevent vision loss |
| US20030181531A1 (en) * | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| US6599891B2 (en) * | 2001-07-20 | 2003-07-29 | Qlt Inc. | Treatment of macular edema |
| US20040058313A1 (en) * | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| ATE458042T1 (de) * | 2003-10-14 | 2010-03-15 | Hokko Chem Ind Co | Verfahren zur herstellung von scyllo-inositol |
-
2005
- 2005-11-17 CN CN2013101874554A patent/CN103301094A/zh active Pending
- 2005-11-17 ZA ZA200704872A patent/ZA200704872B/xx unknown
- 2005-11-17 US US11/280,818 patent/US20060189582A1/en not_active Abandoned
- 2005-11-17 EP EP10000985A patent/EP2186518A1/en not_active Withdrawn
- 2005-11-17 AU AU2005306531A patent/AU2005306531B2/en not_active Expired
- 2005-11-17 WO PCT/CA2005/001744 patent/WO2006053428A1/en not_active Ceased
- 2005-11-17 US US11/667,822 patent/US20080306166A1/en not_active Abandoned
- 2005-11-17 CA CA002588423A patent/CA2588423A1/en not_active Abandoned
- 2005-11-17 EP EP05808109A patent/EP1824496A4/en not_active Withdrawn
- 2005-11-17 BR BRPI0517733-2A patent/BRPI0517733A/pt not_active IP Right Cessation
- 2005-11-17 MX MX2007005870A patent/MX2007005870A/es not_active Application Discontinuation
- 2005-11-17 JP JP2007541601A patent/JP2008520589A/ja active Pending
- 2005-11-17 CN CNA2005800467018A patent/CN101102779A/zh active Pending
-
2008
- 2008-05-22 US US12/125,498 patent/US20090062403A1/en not_active Abandoned
-
2010
- 2010-09-15 US US12/882,250 patent/US20110201694A1/en not_active Abandoned
-
2012
- 2012-08-10 JP JP2012178707A patent/JP2012214516A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758430A (en) * | 1987-01-21 | 1988-07-19 | Robert Sabin | Method of treatment of Alzheimer's disease using phytic acid |
| WO2004075882A1 (en) * | 2003-02-27 | 2004-09-10 | Ellipsis Biotherapeutics Corporation | Methods of preventing, treating and diagnosing disorders of protein aggregation |
Non-Patent Citations (2)
| Title |
|---|
| JPN6010036288; J. Biol. Chem. 275(4), 2000, pages 18495-18502 * |
| JPN6010036290; 日本化学会第81春季年会2002年講演予稿集II , 2002, page 1418 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012505162A (ja) * | 2008-10-09 | 2012-03-01 | ワラタ ファーマシューティカルズ, インコーポレイテッド | 黄斑変性症関連障害を処置するためのscyllo−イノシトールの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005306531A1 (en) | 2006-05-26 |
| ZA200704872B (en) | 2008-12-31 |
| US20110201694A1 (en) | 2011-08-18 |
| EP1824496A1 (en) | 2007-08-29 |
| WO2006053428A1 (en) | 2006-05-26 |
| US20090062403A1 (en) | 2009-03-05 |
| CA2588423A1 (en) | 2006-05-26 |
| EP1824496A4 (en) | 2008-07-16 |
| CN101102779A (zh) | 2008-01-09 |
| AU2005306531B2 (en) | 2012-02-23 |
| BRPI0517733A (pt) | 2008-10-21 |
| US20080306166A1 (en) | 2008-12-11 |
| EP2186518A1 (en) | 2010-05-19 |
| MX2007005870A (es) | 2007-10-10 |
| JP2012214516A (ja) | 2012-11-08 |
| CN103301094A (zh) | 2013-09-18 |
| US20060189582A1 (en) | 2006-08-24 |
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