JP2008519858A - エリスロポエチンレセプターに結合する新規ペプチド - Google Patents
エリスロポエチンレセプターに結合する新規ペプチド Download PDFInfo
- Publication number
- JP2008519858A JP2008519858A JP2007541390A JP2007541390A JP2008519858A JP 2008519858 A JP2008519858 A JP 2008519858A JP 2007541390 A JP2007541390 A JP 2007541390A JP 2007541390 A JP2007541390 A JP 2007541390A JP 2008519858 A JP2008519858 A JP 2008519858A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- peg
- daltons
- epo
- dimer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62743304P | 2004-11-11 | 2004-11-11 | |
| PCT/US2005/041113 WO2006060148A2 (en) | 2004-11-11 | 2005-11-11 | Novel peptides that bind to the erythropoietin receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519858A true JP2008519858A (ja) | 2008-06-12 |
| JP2008519858A5 JP2008519858A5 (https=) | 2008-12-18 |
Family
ID=36565509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541390A Pending JP2008519858A (ja) | 2004-11-11 | 2005-11-11 | エリスロポエチンレセプターに結合する新規ペプチド |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20090005292A1 (https=) |
| EP (1) | EP1814910A4 (https=) |
| JP (1) | JP2008519858A (https=) |
| KR (1) | KR20070108140A (https=) |
| CN (1) | CN101142234A (https=) |
| AU (1) | AU2005310189A1 (https=) |
| CA (1) | CA2587382A1 (https=) |
| EA (1) | EA200700990A1 (https=) |
| IL (1) | IL183123A0 (https=) |
| MX (1) | MX2007005777A (https=) |
| NO (1) | NO20072888L (https=) |
| WO (1) | WO2006060148A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2021112249A1 (https=) * | 2019-12-06 | 2021-06-10 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106154B2 (en) * | 2007-01-31 | 2012-01-31 | Affymax, Inc. | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules |
| CN101456911A (zh) * | 2007-12-12 | 2009-06-17 | 江苏豪森药业股份有限公司 | 促红细胞生成素模拟肽衍生物及其可药用盐和其制备方法与用途 |
| KR101148191B1 (ko) * | 2011-09-27 | 2012-05-23 | 김후정 | 에리스로포이에틴-유래 펩타이드 및 그 용도 |
| EP3432908A4 (en) * | 2016-03-21 | 2020-07-29 | Rhode Island Council on Postsecondary Education | PEPTIDES SENSITIVE TO PH |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000513320A (ja) * | 1995-06-07 | 2000-10-10 | オーソ・フアーマシユーチカル・コーポレーシヨン | アゴニストペプチド二量体 |
| WO2001038342A2 (en) * | 1999-11-24 | 2001-05-31 | Glaxo Group Limited | Novel peptide dimers as agonists of the erythropoietin (epo) receptor, and associated methods of synthesis and use |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US633031A (en) * | 1898-05-02 | 1899-09-12 | Gas Motoren Fabrik Deutz | Process of making gas. |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| KR850004274A (ko) * | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
| US4677195A (en) * | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
| EP0545913B1 (en) * | 1986-08-18 | 1999-02-24 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents |
| US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5006333A (en) * | 1987-08-03 | 1991-04-09 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| WO1990008822A1 (en) * | 1989-02-03 | 1990-08-09 | Genetics Institute, Inc. | Erythropoietin receptor |
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5424186A (en) * | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5723286A (en) * | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| US5292654A (en) * | 1990-12-13 | 1994-03-08 | Whitehead Institute For Biomedical Research | Mutant EPO receptor and uses therefor |
| AU643141B2 (en) * | 1991-03-15 | 1993-11-04 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| JP2001524926A (ja) * | 1991-09-18 | 2001-12-04 | アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ | オリゴマーの雑多ライブラリーの集合体を合成する方法 |
| US5614184A (en) * | 1992-07-28 | 1997-03-25 | New England Deaconess Hospital | Recombinant human erythropoietin mutants and therapeutic methods employing them |
| US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
| US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5830851A (en) * | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
| US5773569A (en) * | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
| US5747446A (en) * | 1994-03-22 | 1998-05-05 | Beth Israel Deaconess Medical Center | Modified polypeptides with increased biological activity |
| US5580853A (en) * | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
| US5451569A (en) * | 1994-04-19 | 1995-09-19 | Hong Kong University Of Science And Technology R & D Corporation Limited | Pulmonary drug delivery system |
| CZ391097A3 (cs) * | 1995-06-07 | 1998-07-15 | Ortho Pharmaceutical Corporation | Látky a peptidy vážící se na erythropoietinový receptor |
| US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5654276A (en) * | 1995-06-07 | 1997-08-05 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| US5677280A (en) * | 1995-06-07 | 1997-10-14 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US5668110A (en) * | 1995-06-07 | 1997-09-16 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-5 receptor |
| TR199701526T1 (xx) * | 1995-06-07 | 1998-03-21 | Glaxo Group Limited | Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler. |
| US5683983A (en) * | 1995-06-07 | 1997-11-04 | Glaxo Group Limited | Peptides and compounds that bind to the IL-5 receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| US6346390B1 (en) * | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
| US6103879A (en) * | 1996-06-21 | 2000-08-15 | Axys Pharmaceuticals, Inc. | Bivalent molecules that form an activating complex with an erythropoietin receptor |
| EP1731174A3 (en) * | 1996-08-02 | 2007-01-17 | Ortho-McNeil Pharmaceutical, Inc. | Polypeptides having a covalently bound N-terminal polyethylene glycol via hydrazone or oxime bond |
| US5932546A (en) * | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| US6221608B1 (en) * | 1997-01-22 | 2001-04-24 | Ortho Pharmaceutical Corporation | Methods for identifying erythropoietin receptor binding protein |
| US6074097A (en) * | 1997-04-28 | 2000-06-13 | Dai Nippon Printing Co., Ltd. | Package, package manufacturing method and package manufacturing system for carrying out the package manufacturing method |
| JP4304757B2 (ja) * | 1998-04-24 | 2009-07-29 | 株式会社デンソー | Absアクチュエータ |
| ES2245114T3 (es) * | 1998-08-06 | 2005-12-16 | Mountain View Pharmaceuticals, Inc. | Conjugados de peg-oxidasa de urato y su uso. |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| US6552167B1 (en) * | 1998-08-28 | 2003-04-22 | Gryphon Therapeutics, Inc. | Polyamide chains of precise length |
| US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| JP2002529502A (ja) * | 1998-11-17 | 2002-09-10 | スミスクライン・ビーチャム・コーポレイション | 血小板減少症の治療法 |
| CZ299516B6 (cs) * | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| JO2291B1 (en) * | 1999-07-02 | 2005-09-12 | اف . هوفمان لاروش ايه جي | Erythropoietin derivatives |
| AUPQ873300A0 (en) * | 2000-07-12 | 2000-08-03 | Medvet Science Pty. Ltd. | A binding motif of a receptor (2) |
| ATE350044T1 (de) * | 1999-09-24 | 2007-01-15 | Smithkline Beecham Corp | Thrombopoietinmimetika |
| WO2001023556A1 (en) * | 1999-09-27 | 2001-04-05 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, nr12 |
| US6858630B2 (en) * | 1999-12-06 | 2005-02-22 | Smithkline Beecham Corporation | Naphthimidazole derivatives and their use as thrombopoietin mimetics |
| JP2004512258A (ja) * | 2000-03-21 | 2004-04-22 | ウィスコンシン アルムニ リサーチ ファンデイション | 生物系における細胞応答の調節のための方法および試薬 |
| US6777387B2 (en) * | 2000-03-31 | 2004-08-17 | Enzon Pharmaceuticals, Inc. | Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same |
| PL219131B1 (pl) * | 2000-05-15 | 2015-03-31 | Hoffmann La Roche | Ciekła kompozycja farmaceutyczna, sposób jej wytwarzania oraz jej zastosowanie |
| EP1325324A4 (en) * | 2000-08-02 | 2004-11-10 | Ortho Mcneil Pharm Inc | IMPROVED ANTIVIRAL AND ANTI-CANCER CHEMOTHERAPY USING ERYTHROPOIETIN ADMINISTRATION (EPO) |
| EE200300089A (et) * | 2000-09-08 | 2005-02-15 | Gryphon Therapeutics, Inc. | Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine |
| CA2431964C (en) * | 2000-12-20 | 2013-09-10 | F. Hoffmann-La Roche Ag | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
| US7767643B2 (en) * | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| US6531121B2 (en) * | 2000-12-29 | 2003-03-11 | The Kenneth S. Warren Institute, Inc. | Protection and enhancement of erythropoietin-responsive cells, tissues and organs |
| FR2823220B1 (fr) * | 2001-04-04 | 2003-12-12 | Genodyssee | Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo) |
| US20020169128A1 (en) * | 2001-04-09 | 2002-11-14 | Geroge Sigounas | Erythropoietin ameliorates chemotherapy-induced toxicity in vivo |
| AU2002345938A1 (en) * | 2001-06-28 | 2003-03-03 | Mountain View Pharmaceuticals, Inc. | Polymer stabilized proteinases |
| US6784154B2 (en) * | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
| US20050176627A1 (en) * | 2002-09-09 | 2005-08-11 | Anthony Cerami | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
| NZ541122A (en) * | 2002-12-26 | 2008-09-26 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| EA008866B1 (ru) * | 2002-12-26 | 2007-08-31 | Маунтин Вью Фамэсьютикэлс, Инк. | ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
| JP4266028B2 (ja) * | 2003-05-12 | 2009-05-20 | アフィーマックス・インコーポレイテッド | エリスロポエチン受容体に結合する新規ペプチド |
-
2005
- 2005-11-11 EA EA200700990A patent/EA200700990A1/ru unknown
- 2005-11-11 CN CNA2005800462279A patent/CN101142234A/zh active Pending
- 2005-11-11 MX MX2007005777A patent/MX2007005777A/es active IP Right Grant
- 2005-11-11 CA CA002587382A patent/CA2587382A1/en not_active Abandoned
- 2005-11-11 JP JP2007541390A patent/JP2008519858A/ja active Pending
- 2005-11-11 AU AU2005310189A patent/AU2005310189A1/en not_active Abandoned
- 2005-11-11 KR KR1020077013156A patent/KR20070108140A/ko not_active Withdrawn
- 2005-11-11 US US11/718,998 patent/US20090005292A1/en not_active Abandoned
- 2005-11-11 WO PCT/US2005/041113 patent/WO2006060148A2/en not_active Ceased
- 2005-11-11 EP EP05851595A patent/EP1814910A4/en not_active Withdrawn
-
2007
- 2007-05-10 IL IL183123A patent/IL183123A0/en unknown
- 2007-06-06 NO NO20072888A patent/NO20072888L/no not_active Application Discontinuation
-
2010
- 2010-08-18 US US12/859,204 patent/US20120157660A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000513320A (ja) * | 1995-06-07 | 2000-10-10 | オーソ・フアーマシユーチカル・コーポレーシヨン | アゴニストペプチド二量体 |
| WO2001038342A2 (en) * | 1999-11-24 | 2001-05-31 | Glaxo Group Limited | Novel peptide dimers as agonists of the erythropoietin (epo) receptor, and associated methods of synthesis and use |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2021112249A1 (https=) * | 2019-12-06 | 2021-06-10 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1814910A2 (en) | 2007-08-08 |
| CN101142234A (zh) | 2008-03-12 |
| MX2007005777A (es) | 2007-07-20 |
| CA2587382A1 (en) | 2006-06-08 |
| KR20070108140A (ko) | 2007-11-08 |
| US20090005292A1 (en) | 2009-01-01 |
| NO20072888L (no) | 2007-08-09 |
| EA200700990A1 (ru) | 2008-04-28 |
| IL183123A0 (en) | 2007-09-20 |
| WO2006060148A2 (en) | 2006-06-08 |
| US20120157660A1 (en) | 2012-06-21 |
| EP1814910A4 (en) | 2009-04-29 |
| WO2006060148A3 (en) | 2006-10-05 |
| AU2005310189A1 (en) | 2006-06-08 |
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