JP2008519853A5 - - Google Patents
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- Publication number
- JP2008519853A5 JP2008519853A5 JP2007541373A JP2007541373A JP2008519853A5 JP 2008519853 A5 JP2008519853 A5 JP 2008519853A5 JP 2007541373 A JP2007541373 A JP 2007541373A JP 2007541373 A JP2007541373 A JP 2007541373A JP 2008519853 A5 JP2008519853 A5 JP 2008519853A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- group
- alkenyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 5
- 229940040461 Lipase Drugs 0.000 claims 4
- 239000004367 Lipase Substances 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 102000004882 lipase Human genes 0.000 claims 4
- 108090001060 lipase Proteins 0.000 claims 4
- 235000019421 lipase Nutrition 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N nicotinic acid Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- -1 R 6 is H Chemical group 0.000 claims 1
- 102100004193 LIPG Human genes 0.000 claims 1
- 101700058972 LIPG Proteins 0.000 claims 1
- 230000036740 Metabolism Effects 0.000 claims 1
- ZADPBFCGQRWHPN-UHFFFAOYSA-N OBO Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- 125000005024 alkenyl aryl group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000005466 alkylenyl group Chemical group 0.000 claims 1
- 125000005025 alkynylaryl group Chemical group 0.000 claims 1
- 230000001708 anti-dyslipidemic Effects 0.000 claims 1
- 239000003472 antidiabetic agent Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 230000033228 biological regulation Effects 0.000 claims 1
- 125000005620 boronic acid group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 230000035786 metabolism Effects 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000003352 sequestering agent Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62747604P | 2004-11-12 | 2004-11-12 | |
| PCT/US2005/041022 WO2006053250A2 (en) | 2004-11-12 | 2005-11-14 | Lipase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519853A JP2008519853A (ja) | 2008-06-12 |
| JP2008519853A5 true JP2008519853A5 (US20070167479A1-20070719-C00034.png) | 2009-01-08 |
Family
ID=36337276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007541373A Pending JP2008519853A (ja) | 2004-11-12 | 2005-11-14 | リパーゼ阻害物質 |
Country Status (11)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3598B1 (ar) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني |
| US8653258B2 (en) * | 2007-06-08 | 2014-02-18 | Georgia State University Research Foundation, Inc. | Compositions for regulating or modulating quorum sensing in bacteria, methods of using the compounds, and methods of regulating or modulating quorum sensing in bacteria |
| PE20091838A1 (es) | 2008-04-09 | 2009-12-18 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso |
| JP5605844B2 (ja) | 2008-10-17 | 2014-10-15 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| ES2493916T3 (es) | 2009-04-07 | 2014-09-12 | Infinity Pharmaceuticals, Inc. | Inhibidores de hidrolasa de amida de ácidos grasos |
| US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| EP2243423B1 (de) * | 2009-04-23 | 2012-05-02 | Roche Diagnostics GmbH | Verfahren und Gerät zur Ermittlung von Empfehlungen für Wirkstoffdosierungen anhand von Messserien zumindest eines physiologischen Parameters eines Patienten |
| US8754113B2 (en) | 2009-12-15 | 2014-06-17 | Shionogi & Co., Ltd. | Oxadiazole derivative having endothelial lipase inhibitory activity |
| MX336742B (es) | 2010-02-03 | 2016-01-29 | Infinity Pharmaceuticals Inc | Inhibidores de amida hidrolasa de acido graso. |
| EP2575823A1 (en) * | 2010-05-31 | 2013-04-10 | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. | 3-substituted vinylboronates and uses thereof |
| CN105806967B (zh) * | 2014-12-31 | 2018-02-06 | 广州朗圣药业有限公司 | 依折麦布关键中间体4‑[[(4‑氟苯基)亚胺]甲基]‑苯酚的分析方法 |
| CN105572252A (zh) * | 2015-12-18 | 2016-05-11 | 武汉武药科技有限公司 | 一种分析/分离依折麦布(r,r,s)型的光学异构体的方法 |
| EP3765006A4 (en) * | 2018-03-13 | 2022-02-23 | Merck Sharp & Dohme Corp. | ARGINASE INHIBITORS AND METHODS OF USE |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
| JP3456511B2 (ja) * | 1997-01-27 | 2003-10-14 | 昭和電工株式会社 | 陰イオンの分析法及び陰イオン分析セット |
| JPH10210999A (ja) * | 1997-01-29 | 1998-08-11 | Eiken Chem Co Ltd | エステル加水分解酵素活性の阻害方法 |
| TW458977B (en) | 1997-04-16 | 2001-10-11 | Abbott Lab | 6,7-disubstituted-4-aminopyrido[2,3-D] pyrimidine compounds |
| US6858592B2 (en) * | 2001-06-29 | 2005-02-22 | Genzyme Corporation | Aryl boronic acids for treating obesity |
-
2005
- 2005-11-14 JP JP2007541373A patent/JP2008519853A/ja active Pending
- 2005-11-14 US US11/719,159 patent/US20090209492A1/en not_active Abandoned
- 2005-11-14 KR KR1020077013216A patent/KR20070086076A/ko not_active Application Discontinuation
- 2005-11-14 CN CNA2005800464039A patent/CN101356179A/zh active Pending
- 2005-11-14 BR BRPI0517840-1A patent/BRPI0517840A/pt not_active IP Right Cessation
- 2005-11-14 EP EP05851568A patent/EP1824861A2/en not_active Withdrawn
- 2005-11-14 CA CA002586479A patent/CA2586479A1/en not_active Abandoned
- 2005-11-14 WO PCT/US2005/041022 patent/WO2006053250A2/en active Application Filing
- 2005-11-14 AU AU2005304318A patent/AU2005304318A1/en not_active Abandoned
-
2007
- 2007-05-10 IL IL183129A patent/IL183129A0/en unknown
- 2007-06-12 NO NO20073011A patent/NO20073011L/no not_active Application Discontinuation
-
2011
- 2011-10-28 US US13/284,230 patent/US20120101062A1/en not_active Abandoned
